LOCUS       NM_138960                880 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens TGFB induced factor homeobox 2 like X-linked
            (TGIF2LX), mRNA.
ACCESSION   NM_138960
VERSION     NM_138960.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 880)
  AUTHORS   Tabarestani,F.O., Akbari,A., Karizi,S.Z. and
            Sotoodehnejadnematalahi,F.
  TITLE     Regulation of long non-coding RNAs XIST and ROR induced by
            homeodomain protein TGIF2LX in colorectal cancer
  JOURNAL   J Cancer Res Ther 18 (Supplement), S359-S366 (2022)
   PUBMED   36510989
  REMARK    GeneRIF: Regulation of long non-coding RNAs XIST and ROR induced by
            homeodomain protein TGIF2LX in colorectal cancer.
REFERENCE   2  (bases 1 to 880)
  AUTHORS   Mobini,G.R., Ghafari,A., Amanpour,S., Fateh,R., Ghahremani,M.H.,
            Muhammadnejad,S., Dehpour,A.R., Akbari,A., Hoseiniharouni,S.M.,
            Kazemirad,E., Bolhassani,M. and Heidari,M.
  TITLE     In vivo identification of novel TGIF2LX target genes in colorectal
            adenocarcinoma using the cDNA-AFLP method
  JOURNAL   Arab J Gastroenterol 19 (2), 65-70 (2018)
   PUBMED   29960902
  REMARK    GeneRIF: To the best of our knowledge, this is the first report
            that proposes Nir1, Nir2, and Fhit genes might be regulated by
            homeodomain protein TGIF2LX in colorectal adenocarcinoma cells.
REFERENCE   3  (bases 1 to 880)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 880)
  AUTHORS   Lyons,P.A., Rayner,T.F., Trivedi,S., Holle,J.U., Watts,R.A.,
            Jayne,D.R., Baslund,B., Brenchley,P., Bruchfeld,A., Chaudhry,A.N.,
            Cohen Tervaert,J.W., Deloukas,P., Feighery,C., Gross,W.L.,
            Guillevin,L., Gunnarsson,I., Harper,L., Hruskova,Z., Little,M.A.,
            Martorana,D., Neumann,T., Ohlsson,S., Padmanabhan,S., Pusey,C.D.,
            Salama,A.D., Sanders,J.S., Savage,C.O., Segelmark,M.,
            Stegeman,C.A., Tesar,V., Vaglio,A., Wieczorek,S., Wilde,B.,
            Zwerina,J., Rees,A.J., Clayton,D.G. and Smith,K.G.
  TITLE     Genetically distinct subsets within ANCA-associated vasculitis
  JOURNAL   N Engl J Med 367 (3), 214-223 (2012)
   PUBMED   22808956
REFERENCE   5  (bases 1 to 880)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 880)
  AUTHORS   Ousati Ashtiani,Z., Ayati,M., Modarresi,M.H., Raoofian,R., Sabah
            Goulian,B., Greene,W.K. and Heidari,M.
  TITLE     Association of TGIFLX/Y mRNA expression with prostate cancer
  JOURNAL   Med Oncol 26 (1), 73-77 (2009)
   PUBMED   18663611
  REMARK    GeneRIF: most prostate tumors (73.5%) express at least one of these
            genes (TGIFLX and TGIFLY), although different patterns of mRNA
            expression were observed. These results suggest an association of
            TGIFLX/Y expression with the progression of prostate cancer.
REFERENCE   7  (bases 1 to 880)
  AUTHORS   Aarabi,M., Ousati-Ashtiani,Z., Nazarian,A., Modarressi,M.H. and
            Heidari,M.
  TITLE     Association of TGIFLX/Y mRNA expression with azoospermia in
            infertile men
  JOURNAL   Mol Reprod Dev 75 (12), 1761-1766 (2008)
   PUBMED   18384077
  REMARK    GeneRIF: Association of TGIFLX/Y mRNA expression with azoospermia
            in infertile men.(
REFERENCE   8  (bases 1 to 880)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   9  (bases 1 to 880)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   10 (bases 1 to 880)
  AUTHORS   Blanco-Arias,P., Sargent,C.A. and Affara,N.A.
  TITLE     The human-specific Yp11.2/Xq21.3 homology block encodes a
            potentially functional testis-specific TGIF-like retroposon
  JOURNAL   Mamm Genome 13 (8), 463-468 (2002)
   PUBMED   12226713
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590041.9.
            
            On May 17, 2019 this sequence version replaced NM_138960.3.
            
            Summary: This gene encodes a member of the TALE/TGIF homeobox
            family of transcription factors. Testis-specific expression
            suggests that this gene may play a role in spermatogenesis. A
            homolog of this gene lies within the male specific region of
            chromosome Y, in a block of sequence that is thought to be the
            result of a large X-to-Y transposition. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.12168.1,
                                           SRR5189667.50511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283891.6/ ENSP00000355119.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AL590041.9         28823-28883
            62-880              AL590041.9         28980-29798
FEATURES             Location/Qualifiers
     source          1..880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.31"
     gene            1..880
                     /gene="TGIF2LX"
                     /gene_synonym="TGIFLX"
                     /note="TGFB induced factor homeobox 2 like X-linked"
                     /db_xref="GeneID:90316"
                     /db_xref="HGNC:HGNC:18570"
                     /db_xref="MIM:300411"
     exon            1..61
                     /gene="TGIF2LX"
                     /gene_synonym="TGIFLX"
                     /inference="alignment:Splign:2.1.0"
     exon            62..880
                     /gene="TGIF2LX"
                     /gene_synonym="TGIFLX"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..808
                     /gene="TGIF2LX"
                     /gene_synonym="TGIFLX"
                     /note="TGFB-induced factor 2-like, X-linked; TGIF-like on
                     the X; TGFB-induced factor 2-like protein, X-linked;
                     TGF-beta-induced transcription factor 2-like protein"
                     /codon_start=1
                     /product="homeobox protein TGIF2LX"
                     /protein_id="NP_620410.3"
                     /db_xref="CCDS:CCDS14459.1"
                     /db_xref="GeneID:90316"
                     /db_xref="HGNC:HGNC:18570"
                     /db_xref="MIM:300411"
                     /translation="MEAAADGPAETQSPVEKDSPAKTQSPAQDTSIMSRNNADTGRVL
                     ALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLSLLQISNWFI
                     NARRRILPDMLQQRRNDPIIGHKTGKDAHATHLQSTEASVPAKSGPSGPDNVQSLPLW
                     PLPKGQMSREKQPDPESAPSQKLTGIAQPKKKVKVSVTSPSSPELVSPEEHADFSSFL
                     LLVDAAVQRAAELELEKKQEPNP"
ORIGIN      
        1 aaccagctcg gctgttagca actctgttag caacgctgtt tgtctttctc ggaaacaaca
       61 gtaacgataa gcctcttgga atatggaggc cgctgcggac ggcccggctg agacccaaag
      121 cccggtggaa aaagacagcc cggcgaagac ccaaagccca gcccaagaca cctcaatcat
      181 gtcgagaaat aacgcagata caggcagagt tcttgcctta ccagagcaca agaagaagcg
      241 caagggaaac ttgccagccg agtccgttaa gatcctccgc gactggatgt ataagcatcg
      301 gtttaaggcc tacccttcag aagaagagaa gcaaatgctg tcagagaaga ccaatttgtc
      361 tttgttgcag atttctaact ggtttatcaa tgctcgcaga cgcattctcc cggatatgct
      421 tcaacagcgt agaaacgacc ccatcattgg ccacaaaacg ggcaaagatg cccatgccac
      481 ccacctgcag agcaccgagg cgtctgtgcc ggccaagtca gggcccagtg gtccagacaa
      541 tgtacaaagc ctgcccctgt ggcccttgcc aaagggccag atgtcaagag agaagcaacc
      601 agatccggag tcggccccta gccagaagct caccggaata gcccagccga agaaaaaggt
      661 caaggtttct gtcacatccc cgtcttctcc agaacttgtg tctccagagg agcacgccga
      721 cttcagcagc ttcctgctgc tagtcgatgc agcagtacaa agggctgccg agctggagct
      781 agagaagaag caagagccta atccatgatt gatgatgttc caaaaaccca agtagtcagt
      841 cccttatgta ctgtggtaaa cctgtttatg ttcaccccaa
//
