LOCUS       NM_001199535            1129 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens TGIF2-RAB5IF readthrough (TGIF2-RAB5IF), mRNA.
ACCESSION   NM_001199535
VERSION     NM_001199535.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1129)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL050318.13.
            
            On Jun 2, 2019 this sequence version replaced NM_001199535.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring TGIF2 (TGFB-induced factor
            homeobox 2) and C20orf24 (chromosome 20 open reading frame 24)
            genes. The read-through transcript encodes a fusion protein that
            shares sequence identity with each individual gene product.
            [provided by RefSeq, Dec 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.259195.1, BX377269.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMN03267767
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 55969, 60436
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL050318.13        85233-85353
            122-347             AL050318.13        89459-89684
            348-451             AL050318.13        118433-118536
            452-581             AL050318.13        120319-120448
            582-1129            AL050318.13        122728-123275
FEATURES             Location/Qualifiers
     source          1..1129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..1129
                     /gene="TGIF2-RAB5IF"
                     /gene_synonym="TGIF2-C20orf24"
                     /note="TGIF2-RAB5IF readthrough"
                     /db_xref="GeneID:100527943"
                     /db_xref="HGNC:HGNC:44664"
     exon            1..121
                     /gene="TGIF2-RAB5IF"
                     /gene_synonym="TGIF2-C20orf24"
                     /inference="alignment:Splign:2.1.0"
     exon            122..347
                     /gene="TGIF2-RAB5IF"
                     /gene_synonym="TGIF2-C20orf24"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..623
                     /gene="TGIF2-RAB5IF"
                     /gene_synonym="TGIF2-C20orf24"
                     /note="TGIF2-C20orf24 readthrough"
                     /codon_start=1
                     /product="TGIF2-C20orf24 protein"
                     /protein_id="NP_001186464.1"
                     /db_xref="GeneID:100527943"
                     /db_xref="HGNC:HGNC:44664"
                     /translation="MSDSDLGEDEGLLSLAGKRKRRGNLPKESVKILRDWLYLHRYNA
                     YPSEQEKLSLSGQTNLSVLQDEFLDVIYWFRQIIAVVLGVIWGVLPLRGFLGIAGFCL
                     INAGVLYLYFSNYLQIDEEEYGGTWELTKEGFMTSFALFMVIWIIFYTAIHYD"
     exon            348..451
                     /gene="TGIF2-RAB5IF"
                     /gene_synonym="TGIF2-C20orf24"
                     /inference="alignment:Splign:2.1.0"
     exon            452..581
                     /gene="TGIF2-RAB5IF"
                     /gene_synonym="TGIF2-C20orf24"
                     /inference="alignment:Splign:2.1.0"
     exon            582..1129
                     /gene="TGIF2-RAB5IF"
                     /gene_synonym="TGIF2-C20orf24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      944..949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF2-RAB5IF"
                     /gene_synonym="TGIF2-C20orf24"
                     /note="hexamer: ATTAAA"
     polyA_site      967
                     /gene="TGIF2-RAB5IF"
                     /gene_synonym="TGIF2-C20orf24"
                     /note="major polyA site"
     regulatory      1105..1110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF2-RAB5IF"
                     /gene_synonym="TGIF2-C20orf24"
                     /note="hexamer: AATAAA"
     polyA_site      1129
                     /gene="TGIF2-RAB5IF"
                     /gene_synonym="TGIF2-C20orf24"
                     /note="major polyA site"
ORIGIN      
        1 agttcggagc acaaagccga gcgcgcacgc tccgccgtcc ccgcgccccg aagagtcggc
       61 cagccccgaa ctgccggagt aggggtggga accaaacttt ttcctgcccc gggacagaca
      121 cgtttaccca aggtccagcc tagcccctag gcaccatgtc ggacagtgat ctaggtgagg
      181 acgaaggcct cctctccctg gcgggcaaaa ggaagcgcag ggggaacctg cccaaggagt
      241 cggtgaagat cctccgggac tggctgtact tgcaccgcta caacgcctac ccctcagagc
      301 aggagaagct gagcctttct ggacagacca acctgtcagt gctgcaagat gaatttttag
      361 atgtgatcta ctggttccga cagatcattg ctgtggtcct gggtgtcatt tggggagttt
      421 tgccattacg agggttcttg ggaatagcag gattctgcct gatcaatgca ggagtcctgt
      481 acctctactt cagcaattac ctacagattg atgaggaaga atatggtggc acgtgggagc
      541 tcacgaagga agggtttatg acctcttttg ccttgttcat ggtcatttgg atcatctttt
      601 acactgccat ccattatgac tgatggtgta cagctcccaa gtgctcccta tccagtccaa
      661 aggaccctct tgattacagc acaggaactt gatcgttggg gaaccccagc cccttggaac
      721 ttggaagacc cgtgtttcct ggaccgcgaa tcagtgtgtt gggcatcagt gttttctgca
      781 agggttgtga cctgaaactt tttaaaaacc acccaccttt ggggaagcat ttctgaattt
      841 atccatcacc aaccatttct tcttggatac catcaagtaa cagctattat ttgccaagtg
      901 gagctgtcat ttaatttgat gcacctctgg attcagatga aacattaaat tgtcttcctc
      961 gattctccat cgggtgtaga gtttttaaac tatcaatggc atttcaagtc ttctgaaaca
     1021 gcatggctgt atgtgcgtgg tccatagcac agtacatgca gcatctaata agagtttcca
     1081 ttgtagaatg ttttcacata cttgaataaa tcaaatcttt aattgagaa
//
