LOCUS       NM_021809               3416 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript
            variant 2, mRNA.
ACCESSION   NM_021809
VERSION     NM_021809.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3416)
  AUTHORS   Du,R., Wang,C., Liu,J., Wang,K., Dai,L. and Shen,W.
  TITLE     Phosphorylation of TGIF2 represents a therapeutic target that
            drives EMT and metastasis of lung adenocarcinoma
  JOURNAL   BMC Cancer 23 (1), 52 (2023)
   PUBMED   36647029
  REMARK    GeneRIF: Phosphorylation of TGIF2 represents a therapeutic target
            that drives EMT and metastasis of lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3416)
  AUTHORS   Zhang,K., Wang,Q., Zhao,D. and Liu,Z.
  TITLE     Circular RNA circMMP1 Contributes to the Progression of Glioma
            Through Regulating TGIF2 Expression by Sponging miR-195-5p
  JOURNAL   Biochem Genet 60 (2), 770-789 (2022)
   PUBMED   34471941
  REMARK    GeneRIF: Circular RNA circMMP1 Contributes to the Progression of
            Glioma Through Regulating TGIF2 Expression by Sponging miR-195-5p.
REFERENCE   3  (bases 1 to 3416)
  AUTHORS   Tao,W., Cao,C., Ren,G. and Zhou,D.
  TITLE     Circular RNA circCPA4 promotes tumorigenesis by regulating
            miR-214-3p/TGIF2 in lung cancer
  JOURNAL   Thorac Cancer 12 (24), 3356-3369 (2021)
   PUBMED   34741437
  REMARK    GeneRIF: Circular RNA circCPA4 promotes tumorigenesis by regulating
            miR-214-3p/TGIF2 in lung cancer.
REFERENCE   4  (bases 1 to 3416)
  AUTHORS   Chen,Y., Li,S., Wei,Y., Xu,Z. and Wu,X.
  TITLE     Circ-RNF13, as an oncogene, regulates malignant progression of
            HBV-associated hepatocellular carcinoma cells and HBV infection
            through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2
  JOURNAL   Bosn J Basic Med Sci 21 (5), 555-568 (2021)
   PUBMED   33714261
  REMARK    GeneRIF: Circ-RNF13, as an oncogene, regulates malignant
            progression of HBV-associated hepatocellular carcinoma cells and
            HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3416)
  AUTHORS   Liu,C. and Yi,X.
  TITLE     miR-541 serves as a prognostic biomarker of osteosarcoma and its
            regulatory effect on tumor cell proliferation, migration and
            invasion by targeting TGIF2
  JOURNAL   Diagn Pathol 15 (1), 96 (2020)
   PUBMED   32709240
  REMARK    GeneRIF: miR-541 serves as a prognostic biomarker of osteosarcoma
            and its regulatory effect on tumor cell proliferation, migration
            and invasion by targeting TGIF2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3416)
  AUTHORS   Melhuish,T.A. and Wotton,D.
  TITLE     The Tgif2 gene contains a retained intron within the coding
            sequence
  JOURNAL   BMC Mol Biol 7, 2 (2006)
   PUBMED   16436215
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3416)
  AUTHORS   Chung,C.M., Man,C., Jin,Y., Jin,C., Guan,X.Y., Wang,Q., Wan,T.S.,
            Cheung,A.L. and Tsao,S.W.
  TITLE     Amplification and overexpression of aurora kinase A (AURKA) in
            immortalized human ovarian epithelial (HOSE) cells
  JOURNAL   Mol Carcinog 43 (3), 165-174 (2005)
   PUBMED   15880741
REFERENCE   8  (bases 1 to 3416)
  AUTHORS   Watanabe,T., Imoto,I., Katahira,T., Hirasawa,A., Ishiwata,I.,
            Emi,M., Takayama,M., Sato,A. and Inazawa,J.
  TITLE     Differentially regulated genes as putative targets of
            amplifications at 20q in ovarian cancers
  JOURNAL   Jpn J Cancer Res 93 (10), 1114-1122 (2002)
   PUBMED   12417041
REFERENCE   9  (bases 1 to 3416)
  AUTHORS   Melhuish,T.A., Gallo,C.M. and Wotton,D.
  TITLE     TGIF2 interacts with histone deacetylase 1 and represses
            transcription
  JOURNAL   J Biol Chem 276 (34), 32109-32114 (2001)
   PUBMED   11427533
REFERENCE   10 (bases 1 to 3416)
  AUTHORS   Imoto,I., Pimkhaokham,A., Watanabe,T., Saito-Ohara,F., Soeda,E. and
            Inazawa,J.
  TITLE     Amplification and overexpression of TGIF2, a novel homeobox gene of
            the TALE superclass, in ovarian cancer cell lines
  JOURNAL   Biochem Biophys Res Commun 276 (1), 264-270 (2000)
   PUBMED   11006116
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL050318.13.
            
            On Jun 2, 2019 this sequence version replaced NM_021809.6.
            
            Summary: The protein encoded by this gene is a DNA-binding homeobox
            protein and a transcriptional repressor, which appears to repress
            transcription by recruiting histone deacetylases to TGF
            beta-responsive genes. This gene is amplified and over-expressed in
            some ovarian cancers. Alternative splicing results in multiple
            transcript variants. A related pseudogene has been identified on
            chromosome 1. Read-through transcription also exists between this
            gene and the neighboring downstream C20orf24 (chromosome 20 open
            reading frame 24) gene. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All variants (1-4) encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006549.2, SRR6380202.60869.7
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373872.9/ ENSP00000362979.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AL050318.13        84315-84463
            150-375             AL050318.13        89459-89684
            376-3416            AL050318.13        101628-104668
FEATURES             Location/Qualifiers
     source          1..3416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..3416
                     /gene="TGIF2"
                     /note="TGFB induced factor homeobox 2"
                     /db_xref="GeneID:60436"
                     /db_xref="HGNC:HGNC:15764"
                     /db_xref="MIM:607294"
     exon            1..149
                     /gene="TGIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            150..375
                     /gene="TGIF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..897
                     /gene="TGIF2"
                     /note="TGF(beta)-induced transcription factor 2;
                     TGFB-induced factor 2 (TALE family homeobox);
                     transcription growth factor-beta-induced factor 2;
                     5'-TG-3' interacting factor 2"
                     /codon_start=1
                     /product="homeobox protein TGIF2"
                     /protein_id="NP_068581.1"
                     /db_xref="CCDS:CCDS13278.1"
                     /db_xref="GeneID:60436"
                     /db_xref="HGNC:HGNC:15764"
                     /db_xref="MIM:607294"
                     /translation="MSDSDLGEDEGLLSLAGKRKRRGNLPKESVKILRDWLYLHRYNA
                     YPSEQEKLSLSGQTNLSVLQICNWFINARRRLLPDMLRKDGKDPNQFTISRRGGKASD
                     VALPRGSSPSVLAVSVPAPTNVLSLSVCSMPLHSGQGEKPAAPFPRGELESPKPLVTP
                     GSTLTLLTRAEAGSPTGGLFNTPPPTPPEQDKEDFSSFQLLVEVALQRAAEMELQKQQ
                     DPSLPLLHTPIPLVSENPQ"
     exon            376..3416
                     /gene="TGIF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3384..3389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF2"
                     /note="hexamer: AATAAA"
     polyA_site      3416
                     /gene="TGIF2"
                     /note="major polyA site"
ORIGIN      
        1 aggccgcgag gtgctttcca gccgcgagct gtcaggccga gtgtcaggcc gggcaggtac
       61 gcggcgcgcg cccccggcgc cccccgctcc ccgccgggac gccccgcgcc gagccggagg
      121 ccgcgtggac ccgaaagccg ctgggaaaag tttacccaag gtccagccta gcccctaggc
      181 accatgtcgg acagtgatct aggtgaggac gaaggcctcc tctccctggc gggcaaaagg
      241 aagcgcaggg ggaacctgcc caaggagtcg gtgaagatcc tccgggactg gctgtacttg
      301 caccgctaca acgcctaccc ctcagagcag gagaagctga gcctttctgg acagaccaac
      361 ctgtcagtgc tgcaaatatg taactggttc atcaatgccc ggcggcggct tctcccagac
      421 atgcttcgga aggatggcaa agaccctaat cagtttacca tttcccgccg cgggggtaag
      481 gcctcagatg tggccctccc ccgtggcagc agcccctcag tgctggctgt gtctgtccca
      541 gcccccacca atgtgctctc cctgtctgtg tgctccatgc cgcttcactc aggccagggg
      601 gaaaagccag cagccccttt cccacgtggg gagctggagt ctcccaagcc cctggtgacc
      661 cctggtagca cacttactct gctgaccagg gctgaggctg gaagccccac aggtggactc
      721 ttcaacacgc caccacccac acccccagag caggacaaag aggacttcag cagcttccag
      781 ctgctggtgg aggtggcgct acagagggct gctgagatgg agcttcagaa gcagcaggac
      841 ccatcactcc cattactgca cactcccatc cctttagtct ctgaaaatcc ccagtaggca
      901 tctgccaaga agggtgctga aggctccagc cagctgtcct gggtttccgt tttggttccc
      961 tttcatacag agggttttct atggatcact gccaaacatt gggatcatct cctctgtcca
     1021 gaggtcttca acaggaagat gccagctggc accactgcac tgtgatgggg gccctctcct
     1081 ctgctgactc tgccgtttct ccaggcctcc gctcagtgat gagaccaaga gatcggagac
     1141 aagcatggtg ctgctgcttc tgctgcttct ccagaaaatc cctgggacac ctttgttcca
     1201 gcctggtttc ctgggctggg ctcaggaaag ctgccaaatt cagtcctatg ttgggtccaa
     1261 gctgcccctg tgctgtttct gtcaagccag gtgtggacat tccaagttca tatgcgtgaa
     1321 caaaagaaaa gaggaaccca gtggatgtaa cagaaccgac tccagttgaa tgtttagatt
     1381 tttgctaaac tgttttcttt ttcccttttt tgctgtggtt tgcattcacg gcagtagtta
     1441 gcccaggtgt ggggaacgag agtgcactgc atgatagcgt tctggtgagc tgggaaggac
     1501 ccaccactgc cactgaggat tgttttggaa gaaaggaata tttttatctt ggggaccagc
     1561 taagtctctg cagtagtgtg aaattccaaa tggttgtttt atcattggtt tggtttacca
     1621 aaaaaaaggc agggaaaaaa aaaaaaaaca accgtatgag cgcattggct tgtctgccgc
     1681 aggcacagaa gggtagaaag ccacagcagg gggcagtcca gcagactctg actcaacttt
     1741 ctaggcacct agcagagaaa gataagatca aaaggtgttt ggtttttctt ttaattttta
     1801 ttgtagtttt tttgggtggg tgggggaagt aaactagact gaagcgatgg attttttttt
     1861 tctttttttt ctttagtgtt tttccctttg ttcttgaaca cttttgccct gcagcctcag
     1921 ttttgaattc ttttagcaac ttggattaga ggggcccata tgtcagaagc tcccagcacc
     1981 tcctacttgg gagaaaagtg agccatctgc tggtcaggaa gtcctccaga gaggcagctt
     2041 ttcccacaat ggtggcagga aactttgggg aaagcaggaa tggtgtccac tgctgcggag
     2101 gaactgcctt cagagaaggt ggggctggaa aagggttaga agcctcctag ctgggattgt
     2161 ctttgtttca cctttcttta aattagaatt acagaagccc ctgcccagtg aacagataac
     2221 gattggtctt atgctcctcc ctttccccca ttttttcttt tgctgttttg ttttttgttt
     2281 tttgtttgtt tgtttgtttt tttgagacag agtcatgctc tgtcacccgg gctggagtgc
     2341 agtggtgcga tctcagctca ctgtaacctc cgcctcccgg gttcaagcaa ttatttgcct
     2401 cagcctcccg agtagctggg attataggca cccgccacca tgtctggctt ttagtagaga
     2461 cggggtttca ccatcttggc caggctggtc ttggaactcc tgacctcgtg agccaccacg
     2521 cccagcctct tttgctgttt cattgctgac agtgttcaac aatatgcccc atctttatat
     2581 atcctaagaa acactaatcc taggttattg ctagccaaaa tatttttgtc ctgagtagtg
     2641 tcactgggcc aaaagataga tcaggacgac agcctttagt tttcctgaaa tcaccaggtc
     2701 aggcacaagg agaaaaggtt cctggatact gactaacttg ggtgggtgga tctagccagg
     2761 agaaagacag taacatgtgt tctgtacttt ctgggaagat ccctgaagcc atcacagagg
     2821 ctccccaact tctgagtcgc ccatctgttg ctgtgggagt gtgaacggat cgctgaagga
     2881 gagggagctt tgctctctct aggtgggcaa gtttcctggg ctctctgtgt tgcctccctc
     2941 tggcttcttc ctcccgtgcc ctctccccgt gtgccccagg gggatcaggg atcctcaccc
     3001 tcctgaggcc cagtggggaa gaatgaacat ggcttcatcc aggttaactg atgctgccat
     3061 ttgcccagcc tcttccatcc cagccctgtc agtgagccca ggtctggtgc aactgctgca
     3121 ggatgcctgt agtagggaac tctggaagtg tattgggctg aggtgggatt ttccctcccc
     3181 acagtgcact gagcaatgga gggtggtgag ggagccatgc tgctgaattc tggttggcat
     3241 ttccccatta tgtaaaatgg ggtgttgggt agggcagact ctgcttgggt ttggttgtaa
     3301 gataaacctg gaggagaagc acagttgtcc cattgaatta tttgagcaaa aactactgta
     3361 aataactttt ttgtcttttg tcaaataaaa tttttttttg tttttttaag cagaaa
//
