LOCUS       NM_173211               2924 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens TGFB induced factor homeobox 1 (TGIF1), transcript
            variant 7, mRNA.
ACCESSION   NM_173211
VERSION     NM_173211.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2924)
  AUTHORS   Minchenko,O.H., Khita,O.O., Krasnytska,D.A., Viletska,Y.M.,
            Rudnytska,O.V., Hnatiuk,O.S. and Minchenko,D.O.
  TITLE     Inhibition of ERN1 affects the expression of TGIF1 and other
            homeobox gene expressions in U87MG glioblastoma cells
  JOURNAL   Arch Biochem Biophys 758, 110073 (2024)
   PUBMED   38914217
  REMARK    GeneRIF: Inhibition of ERN1 affects the expression of TGIF1 and
            other homeobox gene expressions in U87MG glioblastoma cells.
REFERENCE   2  (bases 1 to 2924)
  AUTHORS   Chang,Y.H., Tseng,Y.H., Wang,J.M., Tsai,Y.S. and Huang,H.S.
  TITLE     TG-interacting factor 1 regulates mitotic clonal expansion during
            adipocyte differentiation
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1869 (5), 159492 (2024)
   PUBMED   38575107
  REMARK    GeneRIF: TG-interacting factor 1 regulates mitotic clonal expansion
            during adipocyte differentiation.
REFERENCE   3  (bases 1 to 2924)
  AUTHORS   Tan,H., Ren,R., Wang,X., Hu,W. and Yang,B.
  TITLE     Genetic polymorphisms of rs73620203 in the transforming growth
            interacting factor gene associated with rheumatoid arthritis in a
            Chinese population
  JOURNAL   Immunobiology 228 (6), 152741 (2023)
   PUBMED   37716127
  REMARK    GeneRIF: Genetic polymorphisms of rs73620203 in the transforming
            growth interacting factor gene associated with rheumatoid arthritis
            in a Chinese population.
REFERENCE   4  (bases 1 to 2924)
  AUTHORS   Wang,B., Ma,Q., Wang,X., Guo,K., Liu,Z. and Li,G.
  TITLE     TGIF1 overexpression promotes glioma progression and worsens
            patient prognosis
  JOURNAL   Cancer Med 11 (24), 5113-5128 (2022)
   PUBMED   35569122
  REMARK    GeneRIF: TGIF1 overexpression promotes glioma progression and
            worsens patient prognosis.
REFERENCE   5  (bases 1 to 2924)
  AUTHORS   Hamid,R., Patterson,J. and Brandt,S.J.
  TITLE     Genomic structure, alternative splicing and expression of
            TG-interacting factor, in human myeloid leukemia blasts and cell
            lines
  JOURNAL   Biochim Biophys Acta 1779 (5), 347-355 (2008)
   PUBMED   18455519
  REMARK    GeneRIF: A detailed description of the TGIF locus characterizing 12
            TGIF splice isoforms.
REFERENCE   6  (bases 1 to 2924)
  AUTHORS   Yang,Y., Hwang,C.K., D'Souza,U.M., Lee,S.H., Junn,E. and
            Mouradian,M.M.
  TITLE     Three-amino acid extension loop homeodomain proteins Meis2 and TGIF
            differentially regulate transcription
  JOURNAL   J Biol Chem 275 (27), 20734-20741 (2000)
   PUBMED   10764806
REFERENCE   7  (bases 1 to 2924)
  AUTHORS   Wotton,D., Lo,R.S., Lee,S. and Massague,J.
  TITLE     A Smad transcriptional corepressor
  JOURNAL   Cell 97 (1), 29-39 (1999)
   PUBMED   10199400
REFERENCE   8  (bases 1 to 2924)
  AUTHORS   Bertolino,E., Reimund,B., Wildt-Perinic,D. and Clerc,R.G.
  TITLE     A novel homeobox protein which recognizes a TGT core and
            functionally interferes with a retinoid-responsive motif
  JOURNAL   J Biol Chem 270 (52), 31178-31188 (1995)
   PUBMED   8537382
REFERENCE   9  (bases 1 to 2924)
  AUTHORS   Overhauser,J., Mitchell,H.F., Zackai,E.H., Tick,D.B., Rojas,K. and
            Muenke,M.
  TITLE     Physical mapping of the holoprosencephaly critical region in
            18p11.3
  JOURNAL   Am J Hum Genet 57 (5), 1080-1085 (1995)
   PUBMED   7485158
REFERENCE   10 (bases 1 to 2924)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001025.6.
            
            On Sep 25, 2019 this sequence version replaced NM_173211.1.
            
            Summary: The protein encoded by this gene is a member of the
            three-amino acid loop extension (TALE) superclass of atypical
            homeodomains. TALE homeobox proteins are highly conserved
            transcription regulators. This particular homeodomain binds to a
            previously characterized retinoid X receptor responsive element
            from the cellular retinol-binding protein II promoter. In addition
            to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha
            transcription activation of the retinoic acid responsive element,
            the protein is an active transcriptional co-repressor of SMAD2 and
            may participate in the transmission of nuclear signals during
            development and in the adult. Mutations in this gene are associated
            with holoprosencephaly type 4, which is a structural anomaly of the
            brain. Alternative splicing has been observed at this locus and
            multiple splice variants encoding distinct isoforms are described.
            [provided by RefSeq, Jul 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D82120.1, SRR14038193.3000697.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AP001025.6         189672-189754
            84-310              AP001025.6         192252-192478
            311-2924            AP001025.6         193263-195876
FEATURES             Location/Qualifiers
     source          1..2924
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..2924
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="TGFB induced factor homeobox 1"
                     /db_xref="GeneID:7050"
                     /db_xref="HGNC:HGNC:11776"
                     /db_xref="MIM:602630"
     exon            1..83
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            84..310
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..886
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="isoform d is encoded by transcript variant 7;
                     homeobox protein TGIF1; TALE homeobox TG-interacting
                     factor; transforming growth factor-beta-induced factor;
                     5'-TG-3'-interacting factor 1"
                     /codon_start=1
                     /product="homeobox protein TGIF1 isoform d"
                     /protein_id="NP_775303.1"
                     /db_xref="CCDS:CCDS11835.1"
                     /db_xref="GeneID:7050"
                     /db_xref="HGNC:HGNC:11776"
                     /db_xref="MIM:602630"
                     /translation="MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPS
                     EQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSS
                     VESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTA
                     LKDVPFSLCQSVGVGQNTDIQQIAAKNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPP
                     TPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA"
     exon            311..2924
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1268..1273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      1295
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      1357
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="major polyA site"
     regulatory      1880..1885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      1900
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
     regulatory      2490..2495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      2511
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
ORIGIN      
        1 cacaacattt ccttgtatgt ggatagcgtg aaagaagctt gtgatcctgc ccccaccctc
       61 cccaccgcca cattttttaa agtgtattgt tgcagcatct ggcagtgaga ctgaggatga
      121 ggacagcatg gacattccct tggacctttc ttcatccgct ggctcaggca agagaaggag
      181 aaggggcaac ctacccaagg agtctgtgca gattcttcgg gattggctgt atgagcaccg
      241 ttacaatgcc tatccttcag agcaagaaaa agcgttgctg tcccagcaaa cacacctgtc
      301 tacgctacag gtctgtaact ggttcatcaa cgcccgccgc aggctcctcc ctgacatgct
      361 gagaaaggat ggcaaagatc caaatcagtt cacaatttcc cgccgtgggg ccaagatttc
      421 tgaaacgagc tctgtggagt ccgtgatggg catcaaaaac ttcatgccag ctctagagga
      481 gaccccattt cattcctgta cagctgggcc aaacccaacc ctagggaggc cactgtctcc
      541 taagccgtca tccccgggat cagttttggc tcgtccatca gtgatctgcc ataccactgt
      601 gactgcattg aaagatgtcc ctttctctct ctgccagtcg gtcggtgtgg gacaaaacac
      661 agatatacag cagatagcgg ccaaaaactt cacagacacc tctctcatgt acccagagga
      721 cacttgtaaa tctggaccaa gtacgaatac acagagtggt cttttcaaca ctcctccccc
      781 tactccaccg gacctcaacc aggacttcag tggatttcag cttctagtgg atgttgcact
      841 caaacgggct gcagagatgg agcttcaggc aaaacttaca gcttaaccca ttttcaagca
      901 aaacagttct cagaaatgtc atgattgccg gggtgaaggc aagagatgaa ttgcattatt
      961 ttatatattt tttattaata tttgcacatg ggattgctaa aacagcttcc tgttactgag
     1021 atgtcttcaa tggaatacag tcattccaag aactataaac ttaaagctac tgtagaaaca
     1081 aagggttttc ttttttaaat gtttcttggt agattattca taatgtgaga tggttcccaa
     1141 tatcatgtga tttttttttt cctccccttc cctttttttg ttattttttc agactgtgca
     1201 atacttagag aacctatagc atcttctcat tcccatgtgg aacaggatgc ccacatactg
     1261 tctaattaat aaattttcca ttttttttca aacaagtatg aatctagttg gttgatgcct
     1321 tttttttcat gacataataa agtattttct ttaaaaattg ttgtaattca gagtatttct
     1381 gttgagggag gtgcttctta aaaataagta ggaatatagc accccagtga gcaggaagct
     1441 gggggggtag ggtgcagtgt tagggggtgt caccagctct ttgaaaacct gtggacaaca
     1501 agccagtttg cataaacagg atgtgtgata tttactcttg ataggaggca tagcaggccc
     1561 ttagagcttt acttaaactg catggcaaat tgaaatgaat cattttagtg tttagctagc
     1621 cactaaatcc cttgctgatc tgtcctgcgt agtttaaaac gtggccatgt tataaagaaa
     1681 agtcttgaag catccggtta ttgctgagtt ttcagaagaa aacaacgcaa gcaatctctt
     1741 gccctttttc cacgttaccc tttaaaataa cctttgttca gtggtacatt tagttaaggc
     1801 atttgtattc aaatgtagca tagtatttgc agagaaatta ccttttaaaa catctcaaaa
     1861 gtgttttcta aaatgatgaa ataaacggtg gggttctgtc tatggtggga ttgtcagttt
     1921 attaggtgag tattttccaa ggtctcagtt tgtgaaaaaa tggtgctatg tacaagtgga
     1981 gtttgttggg atagacaatc acttacaaag cccagatggc cagaagggaa ttggtgttgc
     2041 tcctttcact tgtatggttg agcagatttg tcacatgcca caaaaccatt ctttgtagtc
     2101 atgcttagta tgagcttgct ttgttgttac ggtcatgttc tttccagccc tgccccagct
     2161 atgaattgtc taagtgtgag ggagcatcag agcttcagta ttgtttaaag aatgtagaaa
     2221 aatacaaatt tgtctaattt tgaaactatt ttagaaagtc cctactgtag aaagagctaa
     2281 actcaaagac tttccttgta agtgaaagaa aaaaactgct gatgattacc aagaggcgta
     2341 agaaaattag gtgagggaat gttgtgctct agcctgtggg gtgcagcttc gtagggcaca
     2401 tcagcttaga atggtctggc ctcacctcag agagtcacag aaatagacaa aaacccaaaa
     2461 agtactagta aagtaaatac aaggaacaaa ataaacatta ataaaaatga atgacgcaaa
     2521 ggtgatccag aatcattact tgctccaaca gctagatcaa aggctgaaca ttttgcttta
     2581 gtatagatga gggaaatgag caagtcctaa aaggtttgcc ctgttacggt gtttcatcac
     2641 tcatactgga aggagaagga aaggagccat atgactcatt taaaagaaaa actgtaagtc
     2701 accttaaatt ccctatgttt tacttcattt tttccctatt gaggttgtta caggtcatgg
     2761 ttgataatag ttggtgttga atgaatgtaa tccattattt aaaaacaggt acatttaagt
     2821 gaaaagataa atgtaaaaag ctgttcatat caaagccaaa tagaaatgat ttttatgctt
     2881 ataatttaca tggtgcaata tatcttttta atttgtttac tttt
//
