LOCUS       NM_170695               3631 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens TGFB induced factor homeobox 1 (TGIF1), transcript
            variant 1, mRNA.
ACCESSION   NM_170695
VERSION     NM_170695.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3631)
  AUTHORS   Minchenko,O.H., Khita,O.O., Krasnytska,D.A., Viletska,Y.M.,
            Rudnytska,O.V., Hnatiuk,O.S. and Minchenko,D.O.
  TITLE     Inhibition of ERN1 affects the expression of TGIF1 and other
            homeobox gene expressions in U87MG glioblastoma cells
  JOURNAL   Arch Biochem Biophys 758, 110073 (2024)
   PUBMED   38914217
  REMARK    GeneRIF: Inhibition of ERN1 affects the expression of TGIF1 and
            other homeobox gene expressions in U87MG glioblastoma cells.
REFERENCE   2  (bases 1 to 3631)
  AUTHORS   Chang,Y.H., Tseng,Y.H., Wang,J.M., Tsai,Y.S. and Huang,H.S.
  TITLE     TG-interacting factor 1 regulates mitotic clonal expansion during
            adipocyte differentiation
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1869 (5), 159492 (2024)
   PUBMED   38575107
  REMARK    GeneRIF: TG-interacting factor 1 regulates mitotic clonal expansion
            during adipocyte differentiation.
REFERENCE   3  (bases 1 to 3631)
  AUTHORS   Tan,H., Ren,R., Wang,X., Hu,W. and Yang,B.
  TITLE     Genetic polymorphisms of rs73620203 in the transforming growth
            interacting factor gene associated with rheumatoid arthritis in a
            Chinese population
  JOURNAL   Immunobiology 228 (6), 152741 (2023)
   PUBMED   37716127
  REMARK    GeneRIF: Genetic polymorphisms of rs73620203 in the transforming
            growth interacting factor gene associated with rheumatoid arthritis
            in a Chinese population.
REFERENCE   4  (bases 1 to 3631)
  AUTHORS   Wang,B., Ma,Q., Wang,X., Guo,K., Liu,Z. and Li,G.
  TITLE     TGIF1 overexpression promotes glioma progression and worsens
            patient prognosis
  JOURNAL   Cancer Med 11 (24), 5113-5128 (2022)
   PUBMED   35569122
  REMARK    GeneRIF: TGIF1 overexpression promotes glioma progression and
            worsens patient prognosis.
REFERENCE   5  (bases 1 to 3631)
  AUTHORS   Hamid,R., Patterson,J. and Brandt,S.J.
  TITLE     Genomic structure, alternative splicing and expression of
            TG-interacting factor, in human myeloid leukemia blasts and cell
            lines
  JOURNAL   Biochim Biophys Acta 1779 (5), 347-355 (2008)
   PUBMED   18455519
  REMARK    GeneRIF: A detailed description of the TGIF locus characterizing 12
            TGIF splice isoforms.
REFERENCE   6  (bases 1 to 3631)
  AUTHORS   Yang,Y., Hwang,C.K., D'Souza,U.M., Lee,S.H., Junn,E. and
            Mouradian,M.M.
  TITLE     Three-amino acid extension loop homeodomain proteins Meis2 and TGIF
            differentially regulate transcription
  JOURNAL   J Biol Chem 275 (27), 20734-20741 (2000)
   PUBMED   10764806
REFERENCE   7  (bases 1 to 3631)
  AUTHORS   Wotton,D., Lo,R.S., Lee,S. and Massague,J.
  TITLE     A Smad transcriptional corepressor
  JOURNAL   Cell 97 (1), 29-39 (1999)
   PUBMED   10199400
REFERENCE   8  (bases 1 to 3631)
  AUTHORS   Bertolino,E., Reimund,B., Wildt-Perinic,D. and Clerc,R.G.
  TITLE     A novel homeobox protein which recognizes a TGT core and
            functionally interferes with a retinoid-responsive motif
  JOURNAL   J Biol Chem 270 (52), 31178-31188 (1995)
   PUBMED   8537382
REFERENCE   9  (bases 1 to 3631)
  AUTHORS   Overhauser,J., Mitchell,H.F., Zackai,E.H., Tick,D.B., Rojas,K. and
            Muenke,M.
  TITLE     Physical mapping of the holoprosencephaly critical region in
            18p11.3
  JOURNAL   Am J Hum Genet 57 (5), 1080-1085 (1995)
   PUBMED   7485158
REFERENCE   10 (bases 1 to 3631)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001025.6.
            
            On Sep 25, 2019 this sequence version replaced NM_170695.4.
            
            Summary: The protein encoded by this gene is a member of the
            three-amino acid loop extension (TALE) superclass of atypical
            homeodomains. TALE homeobox proteins are highly conserved
            transcription regulators. This particular homeodomain binds to a
            previously characterized retinoid X receptor responsive element
            from the cellular retinol-binding protein II promoter. In addition
            to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha
            transcription activation of the retinoic acid responsive element,
            the protein is an active transcriptional co-repressor of SMAD2 and
            may participate in the transmission of nuclear signals during
            development and in the adult. Mutations in this gene are associated
            with holoprosencephaly type 4, which is a structural anomaly of the
            brain. Alternative splicing has been observed at this locus and
            multiple splice variants encoding distinct isoforms are described.
            [provided by RefSeq, Jul 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031268.1, SRR14038191.1293188.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-790               AP001025.6         187491-188280
            791-1017            AP001025.6         192252-192478
            1018-3631           AP001025.6         193263-195876
FEATURES             Location/Qualifiers
     source          1..3631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..3631
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="TGFB induced factor homeobox 1"
                     /db_xref="GeneID:7050"
                     /db_xref="HGNC:HGNC:11776"
                     /db_xref="MIM:602630"
     exon            1..790
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1017
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             835..1593
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="isoform d is encoded by transcript variant 1;
                     homeobox protein TGIF1; TALE homeobox TG-interacting
                     factor; transforming growth factor-beta-induced factor;
                     5'-TG-3'-interacting factor 1"
                     /codon_start=1
                     /product="homeobox protein TGIF1 isoform d"
                     /protein_id="NP_733796.3"
                     /db_xref="CCDS:CCDS11835.1"
                     /db_xref="GeneID:7050"
                     /db_xref="HGNC:HGNC:11776"
                     /db_xref="MIM:602630"
                     /translation="MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPS
                     EQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSS
                     VESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTA
                     LKDVPFSLCQSVGVGQNTDIQQIAAKNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPP
                     TPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA"
     exon            1018..3631
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1975..1980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      2002
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
     regulatory      2043..2048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      2064
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="major polyA site"
     regulatory      2587..2592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      2607
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
     regulatory      3197..3202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      3218
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
ORIGIN      
        1 acattctttc agacccggcc cgctgcgggg cgttcctggg gggtagcctc aaggccagcg
       61 gggttccttc ggctgcgttt ctgtgggagg ccctgaaacg cgcggagctt ccctctgcct
      121 ccaggctttc ccagcgagag tgaaattaaa cttgaaactc ggatcaactg gcagtcgttg
      181 ttggtagaac gccctaagga cccctccccg cgggacggag ggaggactcg ggacagggaa
      241 ttggccctgg gagaaaacgc gcggggggcg tccgagacgc cccgtgaaag ccgtgccgac
      301 ccttgggagg actgacaggt ctagagacac gcgctgtctg ttgtggtggg cctcccggga
      361 ataagtgagg ggctctgtgt ttcgaggatg gttctagcgc agagccgggt gtctgccggg
      421 gtgggctccc cgcattgttc gggctccggc gggggcggct ctgattcctt tccatggccc
      481 gcctcccacc ccgggaatcc ccagtgctcc ttttccacgg cttttctggc gtccccccga
      541 ctctcccgcg gcactttggc ctaccttccc ccagcgccgt ggtcctccct ggcgaccccc
      601 tctgcgctcc tggggtcctc ctgcgccccc cctcctccac cggcgcgctg cccacagccg
      661 cgtgccctct ccccggagct ggggaccaag gctgggcccc gccggccgca tcggtgggaa
      721 cttccgcggt ccccatccca gggcgcacag ggtccagctc ctcggcgccg actcctggaa
      781 acaatgaaag gtattgttgc agcatctggc agtgagactg aggatgagga cagcatggac
      841 attcccttgg acctttcttc atccgctggc tcaggcaaga gaaggagaag gggcaaccta
      901 cccaaggagt ctgtgcagat tcttcgggat tggctgtatg agcaccgtta caatgcctat
      961 ccttcagagc aagaaaaagc gttgctgtcc cagcaaacac acctgtctac gctacaggtc
     1021 tgtaactggt tcatcaacgc ccgccgcagg ctcctccctg acatgctgag aaaggatggc
     1081 aaagatccaa atcagttcac aatttcccgc cgtggggcca agatttctga aacgagctct
     1141 gtggagtccg tgatgggcat caaaaacttc atgccagctc tagaggagac cccatttcat
     1201 tcctgtacag ctgggccaaa cccaacccta gggaggccac tgtctcctaa gccgtcatcc
     1261 ccgggatcag ttttggctcg tccatcagtg atctgccata ccactgtgac tgcattgaaa
     1321 gatgtccctt tctctctctg ccagtcggtc ggtgtgggac aaaacacaga tatacagcag
     1381 atagcggcca aaaacttcac agacacctct ctcatgtacc cagaggacac ttgtaaatct
     1441 ggaccaagta cgaatacaca gagtggtctt ttcaacactc ctccccctac tccaccggac
     1501 ctcaaccagg acttcagtgg atttcagctt ctagtggatg ttgcactcaa acgggctgca
     1561 gagatggagc ttcaggcaaa acttacagct taacccattt tcaagcaaaa cagttctcag
     1621 aaatgtcatg attgccgggg tgaaggcaag agatgaattg cattatttta tatatttttt
     1681 attaatattt gcacatggga ttgctaaaac agcttcctgt tactgagatg tcttcaatgg
     1741 aatacagtca ttccaagaac tataaactta aagctactgt agaaacaaag ggttttcttt
     1801 tttaaatgtt tcttggtaga ttattcataa tgtgagatgg ttcccaatat catgtgattt
     1861 tttttttcct ccccttccct ttttttgtta ttttttcaga ctgtgcaata cttagagaac
     1921 ctatagcatc ttctcattcc catgtggaac aggatgccca catactgtct aattaataaa
     1981 ttttccattt tttttcaaac aagtatgaat ctagttggtt gatgcctttt ttttcatgac
     2041 ataataaagt attttcttta aaaattgttg taattcagag tatttctgtt gagggaggtg
     2101 cttcttaaaa ataagtagga atatagcacc ccagtgagca ggaagctggg ggggtagggt
     2161 gcagtgttag ggggtgtcac cagctctttg aaaacctgtg gacaacaagc cagtttgcat
     2221 aaacaggatg tgtgatattt actcttgata ggaggcatag caggccctta gagctttact
     2281 taaactgcat ggcaaattga aatgaatcat tttagtgttt agctagccac taaatccctt
     2341 gctgatctgt cctgcgtagt ttaaaacgtg gccatgttat aaagaaaagt cttgaagcat
     2401 ccggttattg ctgagttttc agaagaaaac aacgcaagca atctcttgcc ctttttccac
     2461 gttacccttt aaaataacct ttgttcagtg gtacatttag ttaaggcatt tgtattcaaa
     2521 tgtagcatag tatttgcaga gaaattacct tttaaaacat ctcaaaagtg ttttctaaaa
     2581 tgatgaaata aacggtgggg ttctgtctat ggtgggattg tcagtttatt aggtgagtat
     2641 tttccaaggt ctcagtttgt gaaaaaatgg tgctatgtac aagtggagtt tgttgggata
     2701 gacaatcact tacaaagccc agatggccag aagggaattg gtgttgctcc tttcacttgt
     2761 atggttgagc agatttgtca catgccacaa aaccattctt tgtagtcatg cttagtatga
     2821 gcttgctttg ttgttacggt catgttcttt ccagccctgc cccagctatg aattgtctaa
     2881 gtgtgaggga gcatcagagc ttcagtattg tttaaagaat gtagaaaaat acaaatttgt
     2941 ctaattttga aactatttta gaaagtccct actgtagaaa gagctaaact caaagacttt
     3001 ccttgtaagt gaaagaaaaa aactgctgat gattaccaag aggcgtaaga aaattaggtg
     3061 agggaatgtt gtgctctagc ctgtggggtg cagcttcgta gggcacatca gcttagaatg
     3121 gtctggcctc acctcagaga gtcacagaaa tagacaaaaa cccaaaaagt actagtaaag
     3181 taaatacaag gaacaaaata aacattaata aaaatgaatg acgcaaaggt gatccagaat
     3241 cattacttgc tccaacagct agatcaaagg ctgaacattt tgctttagta tagatgaggg
     3301 aaatgagcaa gtcctaaaag gtttgccctg ttacggtgtt tcatcactca tactggaagg
     3361 agaaggaaag gagccatatg actcatttaa aagaaaaact gtaagtcacc ttaaattccc
     3421 tatgttttac ttcatttttt ccctattgag gttgttacag gtcatggttg ataatagttg
     3481 gtgttgaatg aatgtaatcc attatttaaa aacaggtaca tttaagtgaa aagataaatg
     3541 taaaaagctg ttcatatcaa agccaaatag aaatgatttt tatgcttata atttacatgg
     3601 tgcaatatat ctttttaatt tgtttacttt t
//
