LOCUS       NM_003244               3175 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens TGFB induced factor homeobox 1 (TGIF1), transcript
            variant 4, mRNA.
ACCESSION   NM_003244
VERSION     NM_003244.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3175)
  AUTHORS   Minchenko,O.H., Khita,O.O., Krasnytska,D.A., Viletska,Y.M.,
            Rudnytska,O.V., Hnatiuk,O.S. and Minchenko,D.O.
  TITLE     Inhibition of ERN1 affects the expression of TGIF1 and other
            homeobox gene expressions in U87MG glioblastoma cells
  JOURNAL   Arch Biochem Biophys 758, 110073 (2024)
   PUBMED   38914217
  REMARK    GeneRIF: Inhibition of ERN1 affects the expression of TGIF1 and
            other homeobox gene expressions in U87MG glioblastoma cells.
REFERENCE   2  (bases 1 to 3175)
  AUTHORS   Chang,Y.H., Tseng,Y.H., Wang,J.M., Tsai,Y.S. and Huang,H.S.
  TITLE     TG-interacting factor 1 regulates mitotic clonal expansion during
            adipocyte differentiation
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1869 (5), 159492 (2024)
   PUBMED   38575107
  REMARK    GeneRIF: TG-interacting factor 1 regulates mitotic clonal expansion
            during adipocyte differentiation.
REFERENCE   3  (bases 1 to 3175)
  AUTHORS   Tan,H., Ren,R., Wang,X., Hu,W. and Yang,B.
  TITLE     Genetic polymorphisms of rs73620203 in the transforming growth
            interacting factor gene associated with rheumatoid arthritis in a
            Chinese population
  JOURNAL   Immunobiology 228 (6), 152741 (2023)
   PUBMED   37716127
  REMARK    GeneRIF: Genetic polymorphisms of rs73620203 in the transforming
            growth interacting factor gene associated with rheumatoid arthritis
            in a Chinese population.
REFERENCE   4  (bases 1 to 3175)
  AUTHORS   Wang,B., Ma,Q., Wang,X., Guo,K., Liu,Z. and Li,G.
  TITLE     TGIF1 overexpression promotes glioma progression and worsens
            patient prognosis
  JOURNAL   Cancer Med 11 (24), 5113-5128 (2022)
   PUBMED   35569122
  REMARK    GeneRIF: TGIF1 overexpression promotes glioma progression and
            worsens patient prognosis.
REFERENCE   5  (bases 1 to 3175)
  AUTHORS   Hamid,R., Patterson,J. and Brandt,S.J.
  TITLE     Genomic structure, alternative splicing and expression of
            TG-interacting factor, in human myeloid leukemia blasts and cell
            lines
  JOURNAL   Biochim Biophys Acta 1779 (5), 347-355 (2008)
   PUBMED   18455519
  REMARK    GeneRIF: A detailed description of the TGIF locus characterizing 12
            TGIF splice isoforms.
REFERENCE   6  (bases 1 to 3175)
  AUTHORS   Yang,Y., Hwang,C.K., D'Souza,U.M., Lee,S.H., Junn,E. and
            Mouradian,M.M.
  TITLE     Three-amino acid extension loop homeodomain proteins Meis2 and TGIF
            differentially regulate transcription
  JOURNAL   J Biol Chem 275 (27), 20734-20741 (2000)
   PUBMED   10764806
REFERENCE   7  (bases 1 to 3175)
  AUTHORS   Wotton,D., Lo,R.S., Lee,S. and Massague,J.
  TITLE     A Smad transcriptional corepressor
  JOURNAL   Cell 97 (1), 29-39 (1999)
   PUBMED   10199400
REFERENCE   8  (bases 1 to 3175)
  AUTHORS   Bertolino,E., Reimund,B., Wildt-Perinic,D. and Clerc,R.G.
  TITLE     A novel homeobox protein which recognizes a TGT core and
            functionally interferes with a retinoid-responsive motif
  JOURNAL   J Biol Chem 270 (52), 31178-31188 (1995)
   PUBMED   8537382
REFERENCE   9  (bases 1 to 3175)
  AUTHORS   Overhauser,J., Mitchell,H.F., Zackai,E.H., Tick,D.B., Rojas,K. and
            Muenke,M.
  TITLE     Physical mapping of the holoprosencephaly critical region in
            18p11.3
  JOURNAL   Am J Hum Genet 57 (5), 1080-1085 (1995)
   PUBMED   7485158
REFERENCE   10 (bases 1 to 3175)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001025.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 25, 2019 this sequence version replaced NM_003244.3.
            
            Summary: The protein encoded by this gene is a member of the
            three-amino acid loop extension (TALE) superclass of atypical
            homeodomains. TALE homeobox proteins are highly conserved
            transcription regulators. This particular homeodomain binds to a
            previously characterized retinoid X receptor responsive element
            from the cellular retinol-binding protein II promoter. In addition
            to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha
            transcription activation of the retinoic acid responsive element,
            the protein is an active transcriptional co-repressor of SMAD2 and
            may participate in the transmission of nuclear signals during
            development and in the adult. Mutations in this gene are associated
            with holoprosencephaly type 4, which is a structural anomaly of the
            brain. Alternative splicing has been observed at this locus and
            multiple splice variants encoding distinct isoforms are described.
            [provided by RefSeq, Jul 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.15337.1, X89750.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343820.10/ ENSP00000339631.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               AP001025.6         186070-186403
            335-561             AP001025.6         192252-192478
            562-3175            AP001025.6         193263-195876
FEATURES             Location/Qualifiers
     source          1..3175
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..3175
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="TGFB induced factor homeobox 1"
                     /db_xref="GeneID:7050"
                     /db_xref="HGNC:HGNC:11776"
                     /db_xref="MIM:602630"
     exon            1..334
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..1137
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="isoform c is encoded by transcript variant 4;
                     homeobox protein TGIF1; TALE homeobox TG-interacting
                     factor; transforming growth factor-beta-induced factor;
                     5'-TG-3'-interacting factor 1"
                     /codon_start=1
                     /product="homeobox protein TGIF1 isoform c"
                     /protein_id="NP_003235.1"
                     /db_xref="CCDS:CCDS11833.1"
                     /db_xref="GeneID:7050"
                     /db_xref="HGNC:HGNC:11776"
                     /db_xref="MIM:602630"
                     /translation="MKGKKGIVAASGSETEDEDSMDIPLDLSSSAGSGKRRRRGNLPK
                     ESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDG
                     KDPNQFTISRRGAKISETSSVESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKP
                     SSPGSVLARPSVICHTTVTALKDVPFSLCQSVGVGQNTDIQQIAAKNFTDTSLMYPED
                     TCKSGPSTNTQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA"
     exon            335..561
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            562..3175
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1519..1524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      1546
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
     regulatory      1587..1592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      1608
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="major polyA site"
     regulatory      2131..2136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      2151
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
     regulatory      2741..2746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      2762
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
ORIGIN      
        1 actctgacag cgccgaggtg cgccgagcag gagcagggaa caaaggagcg gagaggggag
       61 gggagagagt tgggcgaggg agagcccccg gccggctgcc agaagatccc ggcgggagga
      121 agcccaagtg tcacttgaat tccacccaag gagcgggcgc ctgggatcag agcgtcctgt
      181 ttagcaataa cggctggagc acgtcctaca agttacggga gagtcggctg tgaaggagac
      241 gttcgcttat cccctgtgtc cccgctcctg gcccctccag acccccgcct tgcctcgcgc
      301 tgggagggga gatccagaat gaaaggcaag aaaggtattg ttgcagcatc tggcagtgag
      361 actgaggatg aggacagcat ggacattccc ttggaccttt cttcatccgc tggctcaggc
      421 aagagaagga gaaggggcaa cctacccaag gagtctgtgc agattcttcg ggattggctg
      481 tatgagcacc gttacaatgc ctatccttca gagcaagaaa aagcgttgct gtcccagcaa
      541 acacacctgt ctacgctaca ggtctgtaac tggttcatca acgcccgccg caggctcctc
      601 cctgacatgc tgagaaagga tggcaaagat ccaaatcagt tcacaatttc ccgccgtggg
      661 gccaagattt ctgaaacgag ctctgtggag tccgtgatgg gcatcaaaaa cttcatgcca
      721 gctctagagg agaccccatt tcattcctgt acagctgggc caaacccaac cctagggagg
      781 ccactgtctc ctaagccgtc atccccggga tcagttttgg ctcgtccatc agtgatctgc
      841 cataccactg tgactgcatt gaaagatgtc cctttctctc tctgccagtc ggtcggtgtg
      901 ggacaaaaca cagatataca gcagatagcg gccaaaaact tcacagacac ctctctcatg
      961 tacccagagg acacttgtaa atctggacca agtacgaata cacagagtgg tcttttcaac
     1021 actcctcccc ctactccacc ggacctcaac caggacttca gtggatttca gcttctagtg
     1081 gatgttgcac tcaaacgggc tgcagagatg gagcttcagg caaaacttac agcttaaccc
     1141 attttcaagc aaaacagttc tcagaaatgt catgattgcc ggggtgaagg caagagatga
     1201 attgcattat tttatatatt ttttattaat atttgcacat gggattgcta aaacagcttc
     1261 ctgttactga gatgtcttca atggaataca gtcattccaa gaactataaa cttaaagcta
     1321 ctgtagaaac aaagggtttt cttttttaaa tgtttcttgg tagattattc ataatgtgag
     1381 atggttccca atatcatgtg attttttttt tcctcccctt cccttttttt gttatttttt
     1441 cagactgtgc aatacttaga gaacctatag catcttctca ttcccatgtg gaacaggatg
     1501 cccacatact gtctaattaa taaattttcc attttttttc aaacaagtat gaatctagtt
     1561 ggttgatgcc ttttttttca tgacataata aagtattttc tttaaaaatt gttgtaattc
     1621 agagtatttc tgttgaggga ggtgcttctt aaaaataagt aggaatatag caccccagtg
     1681 agcaggaagc tgggggggta gggtgcagtg ttagggggtg tcaccagctc tttgaaaacc
     1741 tgtggacaac aagccagttt gcataaacag gatgtgtgat atttactctt gataggaggc
     1801 atagcaggcc cttagagctt tacttaaact gcatggcaaa ttgaaatgaa tcattttagt
     1861 gtttagctag ccactaaatc ccttgctgat ctgtcctgcg tagtttaaaa cgtggccatg
     1921 ttataaagaa aagtcttgaa gcatccggtt attgctgagt tttcagaaga aaacaacgca
     1981 agcaatctct tgcccttttt ccacgttacc ctttaaaata acctttgttc agtggtacat
     2041 ttagttaagg catttgtatt caaatgtagc atagtatttg cagagaaatt accttttaaa
     2101 acatctcaaa agtgttttct aaaatgatga aataaacggt ggggttctgt ctatggtggg
     2161 attgtcagtt tattaggtga gtattttcca aggtctcagt ttgtgaaaaa atggtgctat
     2221 gtacaagtgg agtttgttgg gatagacaat cacttacaaa gcccagatgg ccagaaggga
     2281 attggtgttg ctcctttcac ttgtatggtt gagcagattt gtcacatgcc acaaaaccat
     2341 tctttgtagt catgcttagt atgagcttgc tttgttgtta cggtcatgtt ctttccagcc
     2401 ctgccccagc tatgaattgt ctaagtgtga gggagcatca gagcttcagt attgtttaaa
     2461 gaatgtagaa aaatacaaat ttgtctaatt ttgaaactat tttagaaagt ccctactgta
     2521 gaaagagcta aactcaaaga ctttccttgt aagtgaaaga aaaaaactgc tgatgattac
     2581 caagaggcgt aagaaaatta ggtgagggaa tgttgtgctc tagcctgtgg ggtgcagctt
     2641 cgtagggcac atcagcttag aatggtctgg cctcacctca gagagtcaca gaaatagaca
     2701 aaaacccaaa aagtactagt aaagtaaata caaggaacaa aataaacatt aataaaaatg
     2761 aatgacgcaa aggtgatcca gaatcattac ttgctccaac agctagatca aaggctgaac
     2821 attttgcttt agtatagatg agggaaatga gcaagtccta aaaggtttgc cctgttacgg
     2881 tgtttcatca ctcatactgg aaggagaagg aaaggagcca tatgactcat ttaaaagaaa
     2941 aactgtaagt caccttaaat tccctatgtt ttacttcatt ttttccctat tgaggttgtt
     3001 acaggtcatg gttgataata gttggtgttg aatgaatgta atccattatt taaaaacagg
     3061 tacatttaag tgaaaagata aatgtaaaaa gctgttcata tcaaagccaa atagaaatga
     3121 tttttatgct tataatttac atggtgcaat atatcttttt aatttgttta ctttt
//
