LOCUS       NP_003235                272 aa            linear   PRI 29-APR-2025
DEFINITION  homeobox protein TGIF1 isoform c [Homo sapiens].
ACCESSION   NP_003235
VERSION     NP_003235.1
DBSOURCE    REFSEQ: accession NM_003244.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 272)
  AUTHORS   Minchenko,O.H., Khita,O.O., Krasnytska,D.A., Viletska,Y.M.,
            Rudnytska,O.V., Hnatiuk,O.S. and Minchenko,D.O.
  TITLE     Inhibition of ERN1 affects the expression of TGIF1 and other
            homeobox gene expressions in U87MG glioblastoma cells
  JOURNAL   Arch Biochem Biophys 758, 110073 (2024)
   PUBMED   38914217
  REMARK    GeneRIF: Inhibition of ERN1 affects the expression of TGIF1 and
            other homeobox gene expressions in U87MG glioblastoma cells.
REFERENCE   2  (residues 1 to 272)
  AUTHORS   Chang,Y.H., Tseng,Y.H., Wang,J.M., Tsai,Y.S. and Huang,H.S.
  TITLE     TG-interacting factor 1 regulates mitotic clonal expansion during
            adipocyte differentiation
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1869 (5), 159492 (2024)
   PUBMED   38575107
  REMARK    GeneRIF: TG-interacting factor 1 regulates mitotic clonal expansion
            during adipocyte differentiation.
REFERENCE   3  (residues 1 to 272)
  AUTHORS   Tan,H., Ren,R., Wang,X., Hu,W. and Yang,B.
  TITLE     Genetic polymorphisms of rs73620203 in the transforming growth
            interacting factor gene associated with rheumatoid arthritis in a
            Chinese population
  JOURNAL   Immunobiology 228 (6), 152741 (2023)
   PUBMED   37716127
  REMARK    GeneRIF: Genetic polymorphisms of rs73620203 in the transforming
            growth interacting factor gene associated with rheumatoid arthritis
            in a Chinese population.
REFERENCE   4  (residues 1 to 272)
  AUTHORS   Wang,B., Ma,Q., Wang,X., Guo,K., Liu,Z. and Li,G.
  TITLE     TGIF1 overexpression promotes glioma progression and worsens
            patient prognosis
  JOURNAL   Cancer Med 11 (24), 5113-5128 (2022)
   PUBMED   35569122
  REMARK    GeneRIF: TGIF1 overexpression promotes glioma progression and
            worsens patient prognosis.
REFERENCE   5  (residues 1 to 272)
  AUTHORS   Hamid,R., Patterson,J. and Brandt,S.J.
  TITLE     Genomic structure, alternative splicing and expression of
            TG-interacting factor, in human myeloid leukemia blasts and cell
            lines
  JOURNAL   Biochim Biophys Acta 1779 (5), 347-355 (2008)
   PUBMED   18455519
  REMARK    GeneRIF: A detailed description of the TGIF locus characterizing 12
            TGIF splice isoforms.
REFERENCE   6  (residues 1 to 272)
  AUTHORS   Yang,Y., Hwang,C.K., D'Souza,U.M., Lee,S.H., Junn,E. and
            Mouradian,M.M.
  TITLE     Three-amino acid extension loop homeodomain proteins Meis2 and TGIF
            differentially regulate transcription
  JOURNAL   J Biol Chem 275 (27), 20734-20741 (2000)
   PUBMED   10764806
REFERENCE   7  (residues 1 to 272)
  AUTHORS   Wotton,D., Lo,R.S., Lee,S. and Massague,J.
  TITLE     A Smad transcriptional corepressor
  JOURNAL   Cell 97 (1), 29-39 (1999)
   PUBMED   10199400
REFERENCE   8  (residues 1 to 272)
  AUTHORS   Bertolino,E., Reimund,B., Wildt-Perinic,D. and Clerc,R.G.
  TITLE     A novel homeobox protein which recognizes a TGT core and
            functionally interferes with a retinoid-responsive motif
  JOURNAL   J Biol Chem 270 (52), 31178-31188 (1995)
   PUBMED   8537382
REFERENCE   9  (residues 1 to 272)
  AUTHORS   Overhauser,J., Mitchell,H.F., Zackai,E.H., Tick,D.B., Rojas,K. and
            Muenke,M.
  TITLE     Physical mapping of the holoprosencephaly critical region in
            18p11.3
  JOURNAL   Am J Hum Genet 57 (5), 1080-1085 (1995)
   PUBMED   7485158
REFERENCE   10 (residues 1 to 272)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001025.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is a member of the
            three-amino acid loop extension (TALE) superclass of atypical
            homeodomains. TALE homeobox proteins are highly conserved
            transcription regulators. This particular homeodomain binds to a
            previously characterized retinoid X receptor responsive element
            from the cellular retinol-binding protein II promoter. In addition
            to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha
            transcription activation of the retinoic acid responsive element,
            the protein is an active transcriptional co-repressor of SMAD2 and
            may participate in the transmission of nuclear signals during
            development and in the adult. Mutations in this gene are associated
            with holoprosencephaly type 4, which is a structural anomaly of the
            brain. Alternative splicing has been observed at this locus and
            multiple splice variants encoding distinct isoforms are described.
            [provided by RefSeq, Jul 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.15337.1, X89750.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343820.10/ ENSP00000339631.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..272
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     Protein         1..272
                     /product="homeobox protein TGIF1 isoform c"
                     /note="homeobox protein TGIF1; TALE homeobox
                     TG-interacting factor; transforming growth
                     factor-beta-induced factor; 5'-TG-3'-interacting factor 1"
                     /calculated_mol_wt=29606
     Site            order(36..40,42,62,68,81,83..84,87..88,90..92)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(38,41,84,87..88,91)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     Region          54..92
                     /region_name="Homeobox_KN"
                     /note="Homeobox KN domain; pfam05920"
                     /db_xref="CDD:428673"
     CDS             1..272
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /coded_by="NM_003244.4:319..1137"
                     /note="isoform c is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS11833.1"
                     /db_xref="GeneID:7050"
                     /db_xref="HGNC:HGNC:11776"
                     /db_xref="MIM:602630"
ORIGIN      
        1 mkgkkgivaa sgsetededs mdipldlsss agsgkrrrrg nlpkesvqil rdwlyehryn
       61 aypseqekal lsqqthlstl qvcnwfinar rrllpdmlrk dgkdpnqfti srrgakiset
      121 ssvesvmgik nfmpaleetp fhsctagpnp tlgrplspkp sspgsvlarp svichttvta
      181 lkdvpfslcq svgvgqntdi qqiaaknftd tslmypedtc ksgpstntqs glfntppptp
      241 pdlnqdfsgf qllvdvalkr aaemelqakl ta
//
