LOCUS       NM_001374396            2950 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens TGFB induced factor homeobox 1 (TGIF1), transcript
            variant 12, mRNA.
ACCESSION   NM_001374396 XM_017025959
VERSION     NM_001374396.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2950)
  AUTHORS   Minchenko,O.H., Khita,O.O., Krasnytska,D.A., Viletska,Y.M.,
            Rudnytska,O.V., Hnatiuk,O.S. and Minchenko,D.O.
  TITLE     Inhibition of ERN1 affects the expression of TGIF1 and other
            homeobox gene expressions in U87MG glioblastoma cells
  JOURNAL   Arch Biochem Biophys 758, 110073 (2024)
   PUBMED   38914217
  REMARK    GeneRIF: Inhibition of ERN1 affects the expression of TGIF1 and
            other homeobox gene expressions in U87MG glioblastoma cells.
REFERENCE   2  (bases 1 to 2950)
  AUTHORS   Chang,Y.H., Tseng,Y.H., Wang,J.M., Tsai,Y.S. and Huang,H.S.
  TITLE     TG-interacting factor 1 regulates mitotic clonal expansion during
            adipocyte differentiation
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1869 (5), 159492 (2024)
   PUBMED   38575107
  REMARK    GeneRIF: TG-interacting factor 1 regulates mitotic clonal expansion
            during adipocyte differentiation.
REFERENCE   3  (bases 1 to 2950)
  AUTHORS   Tan,H., Ren,R., Wang,X., Hu,W. and Yang,B.
  TITLE     Genetic polymorphisms of rs73620203 in the transforming growth
            interacting factor gene associated with rheumatoid arthritis in a
            Chinese population
  JOURNAL   Immunobiology 228 (6), 152741 (2023)
   PUBMED   37716127
  REMARK    GeneRIF: Genetic polymorphisms of rs73620203 in the transforming
            growth interacting factor gene associated with rheumatoid arthritis
            in a Chinese population.
REFERENCE   4  (bases 1 to 2950)
  AUTHORS   Wang,B., Ma,Q., Wang,X., Guo,K., Liu,Z. and Li,G.
  TITLE     TGIF1 overexpression promotes glioma progression and worsens
            patient prognosis
  JOURNAL   Cancer Med 11 (24), 5113-5128 (2022)
   PUBMED   35569122
  REMARK    GeneRIF: TGIF1 overexpression promotes glioma progression and
            worsens patient prognosis.
REFERENCE   5  (bases 1 to 2950)
  AUTHORS   Hamid,R., Patterson,J. and Brandt,S.J.
  TITLE     Genomic structure, alternative splicing and expression of
            TG-interacting factor, in human myeloid leukemia blasts and cell
            lines
  JOURNAL   Biochim Biophys Acta 1779 (5), 347-355 (2008)
   PUBMED   18455519
  REMARK    GeneRIF: A detailed description of the TGIF locus characterizing 12
            TGIF splice isoforms.
REFERENCE   6  (bases 1 to 2950)
  AUTHORS   Yang,Y., Hwang,C.K., D'Souza,U.M., Lee,S.H., Junn,E. and
            Mouradian,M.M.
  TITLE     Three-amino acid extension loop homeodomain proteins Meis2 and TGIF
            differentially regulate transcription
  JOURNAL   J Biol Chem 275 (27), 20734-20741 (2000)
   PUBMED   10764806
REFERENCE   7  (bases 1 to 2950)
  AUTHORS   Wotton,D., Lo,R.S., Lee,S. and Massague,J.
  TITLE     A Smad transcriptional corepressor
  JOURNAL   Cell 97 (1), 29-39 (1999)
   PUBMED   10199400
REFERENCE   8  (bases 1 to 2950)
  AUTHORS   Bertolino,E., Reimund,B., Wildt-Perinic,D. and Clerc,R.G.
  TITLE     A novel homeobox protein which recognizes a TGT core and
            functionally interferes with a retinoid-responsive motif
  JOURNAL   J Biol Chem 270 (52), 31178-31188 (1995)
   PUBMED   8537382
REFERENCE   9  (bases 1 to 2950)
  AUTHORS   Overhauser,J., Mitchell,H.F., Zackai,E.H., Tick,D.B., Rojas,K. and
            Muenke,M.
  TITLE     Physical mapping of the holoprosencephaly critical region in
            18p11.3
  JOURNAL   Am J Hum Genet 57 (5), 1080-1085 (1995)
   PUBMED   7485158
REFERENCE   10 (bases 1 to 2950)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001025.6.
            
            On Sep 25, 2019 this sequence version replaced XM_017025959.1.
            
            Summary: The protein encoded by this gene is a member of the
            three-amino acid loop extension (TALE) superclass of atypical
            homeodomains. TALE homeobox proteins are highly conserved
            transcription regulators. This particular homeodomain binds to a
            previously characterized retinoid X receptor responsive element
            from the cellular retinol-binding protein II promoter. In addition
            to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha
            transcription activation of the retinoic acid responsive element,
            the protein is an active transcriptional co-repressor of SMAD2 and
            may participate in the transmission of nuclear signals during
            development and in the adult. Mutations in this gene are associated
            with holoprosencephaly type 4, which is a structural anomaly of the
            brain. Alternative splicing has been observed at this locus and
            multiple splice variants encoding distinct isoforms are described.
            [provided by RefSeq, Jul 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.119706.1,
                                           SRR14038191.1185712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AP001025.6         184329-184437
            110-336             AP001025.6         192252-192478
            337-2950            AP001025.6         193263-195876
FEATURES             Location/Qualifiers
     source          1..2950
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..2950
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="TGFB induced factor homeobox 1"
                     /db_xref="GeneID:7050"
                     /db_xref="HGNC:HGNC:11776"
                     /db_xref="MIM:602630"
     exon            1..109
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            110..336
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..912
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="isoform d is encoded by transcript variant 12;
                     homeobox protein TGIF1; TALE homeobox TG-interacting
                     factor; transforming growth factor-beta-induced factor;
                     5'-TG-3'-interacting factor 1"
                     /codon_start=1
                     /product="homeobox protein TGIF1 isoform d"
                     /protein_id="NP_001361325.1"
                     /db_xref="CCDS:CCDS11835.1"
                     /db_xref="GeneID:7050"
                     /db_xref="HGNC:HGNC:11776"
                     /db_xref="MIM:602630"
                     /translation="MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPS
                     EQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSS
                     VESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTA
                     LKDVPFSLCQSVGVGQNTDIQQIAAKNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPP
                     TPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA"
     exon            337..2950
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1294..1299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      1321
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
     regulatory      1362..1367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      1383
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="major polyA site"
     regulatory      1906..1911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      1926
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
     regulatory      2516..2521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      2537
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
ORIGIN      
        1 gattcatctg cagccaggtc cgggaaggaa ctgtgctccc ggcagttgca gggcagcgtc
       61 cgggcgggtg gcttgtcccc aggaccgcgc tccccccgag ccgttttagg tattgttgca
      121 gcatctggca gtgagactga ggatgaggac agcatggaca ttcccttgga cctttcttca
      181 tccgctggct caggcaagag aaggagaagg ggcaacctac ccaaggagtc tgtgcagatt
      241 cttcgggatt ggctgtatga gcaccgttac aatgcctatc cttcagagca agaaaaagcg
      301 ttgctgtccc agcaaacaca cctgtctacg ctacaggtct gtaactggtt catcaacgcc
      361 cgccgcaggc tcctccctga catgctgaga aaggatggca aagatccaaa tcagttcaca
      421 atttcccgcc gtggggccaa gatttctgaa acgagctctg tggagtccgt gatgggcatc
      481 aaaaacttca tgccagctct agaggagacc ccatttcatt cctgtacagc tgggccaaac
      541 ccaaccctag ggaggccact gtctcctaag ccgtcatccc cgggatcagt tttggctcgt
      601 ccatcagtga tctgccatac cactgtgact gcattgaaag atgtcccttt ctctctctgc
      661 cagtcggtcg gtgtgggaca aaacacagat atacagcaga tagcggccaa aaacttcaca
      721 gacacctctc tcatgtaccc agaggacact tgtaaatctg gaccaagtac gaatacacag
      781 agtggtcttt tcaacactcc tccccctact ccaccggacc tcaaccagga cttcagtgga
      841 tttcagcttc tagtggatgt tgcactcaaa cgggctgcag agatggagct tcaggcaaaa
      901 cttacagctt aacccatttt caagcaaaac agttctcaga aatgtcatga ttgccggggt
      961 gaaggcaaga gatgaattgc attattttat atatttttta ttaatatttg cacatgggat
     1021 tgctaaaaca gcttcctgtt actgagatgt cttcaatgga atacagtcat tccaagaact
     1081 ataaacttaa agctactgta gaaacaaagg gttttctttt ttaaatgttt cttggtagat
     1141 tattcataat gtgagatggt tcccaatatc atgtgatttt ttttttcctc cccttccctt
     1201 tttttgttat tttttcagac tgtgcaatac ttagagaacc tatagcatct tctcattccc
     1261 atgtggaaca ggatgcccac atactgtcta attaataaat tttccatttt ttttcaaaca
     1321 agtatgaatc tagttggttg atgccttttt tttcatgaca taataaagta ttttctttaa
     1381 aaattgttgt aattcagagt atttctgttg agggaggtgc ttcttaaaaa taagtaggaa
     1441 tatagcaccc cagtgagcag gaagctgggg gggtagggtg cagtgttagg gggtgtcacc
     1501 agctctttga aaacctgtgg acaacaagcc agtttgcata aacaggatgt gtgatattta
     1561 ctcttgatag gaggcatagc aggcccttag agctttactt aaactgcatg gcaaattgaa
     1621 atgaatcatt ttagtgttta gctagccact aaatcccttg ctgatctgtc ctgcgtagtt
     1681 taaaacgtgg ccatgttata aagaaaagtc ttgaagcatc cggttattgc tgagttttca
     1741 gaagaaaaca acgcaagcaa tctcttgccc tttttccacg ttacccttta aaataacctt
     1801 tgttcagtgg tacatttagt taaggcattt gtattcaaat gtagcatagt atttgcagag
     1861 aaattacctt ttaaaacatc tcaaaagtgt tttctaaaat gatgaaataa acggtggggt
     1921 tctgtctatg gtgggattgt cagtttatta ggtgagtatt ttccaaggtc tcagtttgtg
     1981 aaaaaatggt gctatgtaca agtggagttt gttgggatag acaatcactt acaaagccca
     2041 gatggccaga agggaattgg tgttgctcct ttcacttgta tggttgagca gatttgtcac
     2101 atgccacaaa accattcttt gtagtcatgc ttagtatgag cttgctttgt tgttacggtc
     2161 atgttctttc cagccctgcc ccagctatga attgtctaag tgtgagggag catcagagct
     2221 tcagtattgt ttaaagaatg tagaaaaata caaatttgtc taattttgaa actattttag
     2281 aaagtcccta ctgtagaaag agctaaactc aaagactttc cttgtaagtg aaagaaaaaa
     2341 actgctgatg attaccaaga ggcgtaagaa aattaggtga gggaatgttg tgctctagcc
     2401 tgtggggtgc agcttcgtag ggcacatcag cttagaatgg tctggcctca cctcagagag
     2461 tcacagaaat agacaaaaac ccaaaaagta ctagtaaagt aaatacaagg aacaaaataa
     2521 acattaataa aaatgaatga cgcaaaggtg atccagaatc attacttgct ccaacagcta
     2581 gatcaaaggc tgaacatttt gctttagtat agatgaggga aatgagcaag tcctaaaagg
     2641 tttgccctgt tacggtgttt catcactcat actggaagga gaaggaaagg agccatatga
     2701 ctcatttaaa agaaaaactg taagtcacct taaattccct atgttttact tcattttttc
     2761 cctattgagg ttgttacagg tcatggttga taatagttgg tgttgaatga atgtaatcca
     2821 ttatttaaaa acaggtacat ttaagtgaaa agataaatgt aaaaagctgt tcatatcaaa
     2881 gccaaataga aatgattttt atgcttataa tttacatggt gcaatatatc tttttaattt
     2941 gtttactttt
//
