LOCUS       NM_001278686            3110 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens TGFB induced factor homeobox 1 (TGIF1), transcript
            variant 11, mRNA.
ACCESSION   NM_001278686
VERSION     NM_001278686.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3110)
  AUTHORS   Minchenko,O.H., Khita,O.O., Krasnytska,D.A., Viletska,Y.M.,
            Rudnytska,O.V., Hnatiuk,O.S. and Minchenko,D.O.
  TITLE     Inhibition of ERN1 affects the expression of TGIF1 and other
            homeobox gene expressions in U87MG glioblastoma cells
  JOURNAL   Arch Biochem Biophys 758, 110073 (2024)
   PUBMED   38914217
  REMARK    GeneRIF: Inhibition of ERN1 affects the expression of TGIF1 and
            other homeobox gene expressions in U87MG glioblastoma cells.
REFERENCE   2  (bases 1 to 3110)
  AUTHORS   Chang,Y.H., Tseng,Y.H., Wang,J.M., Tsai,Y.S. and Huang,H.S.
  TITLE     TG-interacting factor 1 regulates mitotic clonal expansion during
            adipocyte differentiation
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1869 (5), 159492 (2024)
   PUBMED   38575107
  REMARK    GeneRIF: TG-interacting factor 1 regulates mitotic clonal expansion
            during adipocyte differentiation.
REFERENCE   3  (bases 1 to 3110)
  AUTHORS   Tan,H., Ren,R., Wang,X., Hu,W. and Yang,B.
  TITLE     Genetic polymorphisms of rs73620203 in the transforming growth
            interacting factor gene associated with rheumatoid arthritis in a
            Chinese population
  JOURNAL   Immunobiology 228 (6), 152741 (2023)
   PUBMED   37716127
  REMARK    GeneRIF: Genetic polymorphisms of rs73620203 in the transforming
            growth interacting factor gene associated with rheumatoid arthritis
            in a Chinese population.
REFERENCE   4  (bases 1 to 3110)
  AUTHORS   Wang,B., Ma,Q., Wang,X., Guo,K., Liu,Z. and Li,G.
  TITLE     TGIF1 overexpression promotes glioma progression and worsens
            patient prognosis
  JOURNAL   Cancer Med 11 (24), 5113-5128 (2022)
   PUBMED   35569122
  REMARK    GeneRIF: TGIF1 overexpression promotes glioma progression and
            worsens patient prognosis.
REFERENCE   5  (bases 1 to 3110)
  AUTHORS   Hamid,R., Patterson,J. and Brandt,S.J.
  TITLE     Genomic structure, alternative splicing and expression of
            TG-interacting factor, in human myeloid leukemia blasts and cell
            lines
  JOURNAL   Biochim Biophys Acta 1779 (5), 347-355 (2008)
   PUBMED   18455519
  REMARK    GeneRIF: A detailed description of the TGIF locus characterizing 12
            TGIF splice isoforms.
REFERENCE   6  (bases 1 to 3110)
  AUTHORS   Yang,Y., Hwang,C.K., D'Souza,U.M., Lee,S.H., Junn,E. and
            Mouradian,M.M.
  TITLE     Three-amino acid extension loop homeodomain proteins Meis2 and TGIF
            differentially regulate transcription
  JOURNAL   J Biol Chem 275 (27), 20734-20741 (2000)
   PUBMED   10764806
REFERENCE   7  (bases 1 to 3110)
  AUTHORS   Wotton,D., Lo,R.S., Lee,S. and Massague,J.
  TITLE     A Smad transcriptional corepressor
  JOURNAL   Cell 97 (1), 29-39 (1999)
   PUBMED   10199400
REFERENCE   8  (bases 1 to 3110)
  AUTHORS   Bertolino,E., Reimund,B., Wildt-Perinic,D. and Clerc,R.G.
  TITLE     A novel homeobox protein which recognizes a TGT core and
            functionally interferes with a retinoid-responsive motif
  JOURNAL   J Biol Chem 270 (52), 31178-31188 (1995)
   PUBMED   8537382
REFERENCE   9  (bases 1 to 3110)
  AUTHORS   Overhauser,J., Mitchell,H.F., Zackai,E.H., Tick,D.B., Rojas,K. and
            Muenke,M.
  TITLE     Physical mapping of the holoprosencephaly critical region in
            18p11.3
  JOURNAL   Am J Hum Genet 57 (5), 1080-1085 (1995)
   PUBMED   7485158
REFERENCE   10 (bases 1 to 3110)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001025.6.
            
            On Aug 13, 2020 this sequence version replaced NM_001278686.2.
            
            Summary: The protein encoded by this gene is a member of the
            three-amino acid loop extension (TALE) superclass of atypical
            homeodomains. TALE homeobox proteins are highly conserved
            transcription regulators. This particular homeodomain binds to a
            previously characterized retinoid X receptor responsive element
            from the cellular retinol-binding protein II promoter. In addition
            to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha
            transcription activation of the retinoic acid responsive element,
            the protein is an active transcriptional co-repressor of SMAD2 and
            may participate in the transmission of nuclear signals during
            development and in the adult. Mutations in this gene are associated
            with holoprosencephaly type 4, which is a structural anomaly of the
            brain. Alternative splicing has been observed at this locus and
            multiple splice variants encoding distinct isoforms are described.
            [provided by RefSeq, Jul 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM849453.1, SRR14243140.3069490.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2163459
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AP001025.6         148752-148947
            197-269             AP001025.6         154041-154113
            270-496             AP001025.6         192252-192478
            497-3110            AP001025.6         193263-195876
FEATURES             Location/Qualifiers
     source          1..3110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..3110
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="TGFB induced factor homeobox 1"
                     /db_xref="GeneID:7050"
                     /db_xref="HGNC:HGNC:11776"
                     /db_xref="MIM:602630"
     exon            1..196
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            197..269
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     exon            270..496
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1072
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="isoform d is encoded by transcript variant 11;
                     homeobox protein TGIF1; TALE homeobox TG-interacting
                     factor; transforming growth factor-beta-induced factor;
                     5'-TG-3'-interacting factor 1"
                     /codon_start=1
                     /product="homeobox protein TGIF1 isoform d"
                     /protein_id="NP_001265615.1"
                     /db_xref="CCDS:CCDS11835.1"
                     /db_xref="GeneID:7050"
                     /db_xref="HGNC:HGNC:11776"
                     /db_xref="MIM:602630"
                     /translation="MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPS
                     EQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSS
                     VESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTA
                     LKDVPFSLCQSVGVGQNTDIQQIAAKNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPP
                     TPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA"
     exon            497..3110
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1454..1459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      1481
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
     regulatory      1522..1527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      1543
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="major polyA site"
     regulatory      2066..2071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      2086
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
     regulatory      2676..2681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
                     /note="hexamer: AATAAA"
     polyA_site      2697
                     /gene="TGIF1"
                     /gene_synonym="HPE4; TGIF"
ORIGIN      
        1 taagaaaata aaatattagc cgagtgtggc gtcacacgcc tgtagtccta tctacttggg
       61 aggctgagac aggaggatct cttgagctca ggagttcaag actgcagtga gctgtgatgg
      121 cgtcactgca ctccagcctg ggcgacaaaa cgaggctctg tccccaaaca ccaaaaacct
      181 cacaaggctc ttccaggttg gtgtcttttc cacgtggtag aagctggcta acctccactt
      241 ccacattcca gcccaaggga aagtccaagg tattgttgca gcatctggca gtgagactga
      301 ggatgaggac agcatggaca ttcccttgga cctttcttca tccgctggct caggcaagag
      361 aaggagaagg ggcaacctac ccaaggagtc tgtgcagatt cttcgggatt ggctgtatga
      421 gcaccgttac aatgcctatc cttcagagca agaaaaagcg ttgctgtccc agcaaacaca
      481 cctgtctacg ctacaggtct gtaactggtt catcaacgcc cgccgcaggc tcctccctga
      541 catgctgaga aaggatggca aagatccaaa tcagttcaca atttcccgcc gtggggccaa
      601 gatttctgaa acgagctctg tggagtccgt gatgggcatc aaaaacttca tgccagctct
      661 agaggagacc ccatttcatt cctgtacagc tgggccaaac ccaaccctag ggaggccact
      721 gtctcctaag ccgtcatccc cgggatcagt tttggctcgt ccatcagtga tctgccatac
      781 cactgtgact gcattgaaag atgtcccttt ctctctctgc cagtcggtcg gtgtgggaca
      841 aaacacagat atacagcaga tagcggccaa aaacttcaca gacacctctc tcatgtaccc
      901 agaggacact tgtaaatctg gaccaagtac gaatacacag agtggtcttt tcaacactcc
      961 tccccctact ccaccggacc tcaaccagga cttcagtgga tttcagcttc tagtggatgt
     1021 tgcactcaaa cgggctgcag agatggagct tcaggcaaaa cttacagctt aacccatttt
     1081 caagcaaaac agttctcaga aatgtcatga ttgccggggt gaaggcaaga gatgaattgc
     1141 attattttat atatttttta ttaatatttg cacatgggat tgctaaaaca gcttcctgtt
     1201 actgagatgt cttcaatgga atacagtcat tccaagaact ataaacttaa agctactgta
     1261 gaaacaaagg gttttctttt ttaaatgttt cttggtagat tattcataat gtgagatggt
     1321 tcccaatatc atgtgatttt ttttttcctc cccttccctt tttttgttat tttttcagac
     1381 tgtgcaatac ttagagaacc tatagcatct tctcattccc atgtggaaca ggatgcccac
     1441 atactgtcta attaataaat tttccatttt ttttcaaaca agtatgaatc tagttggttg
     1501 atgccttttt tttcatgaca taataaagta ttttctttaa aaattgttgt aattcagagt
     1561 atttctgttg agggaggtgc ttcttaaaaa taagtaggaa tatagcaccc cagtgagcag
     1621 gaagctgggg gggtagggtg cagtgttagg gggtgtcacc agctctttga aaacctgtgg
     1681 acaacaagcc agtttgcata aacaggatgt gtgatattta ctcttgatag gaggcatagc
     1741 aggcccttag agctttactt aaactgcatg gcaaattgaa atgaatcatt ttagtgttta
     1801 gctagccact aaatcccttg ctgatctgtc ctgcgtagtt taaaacgtgg ccatgttata
     1861 aagaaaagtc ttgaagcatc cggttattgc tgagttttca gaagaaaaca acgcaagcaa
     1921 tctcttgccc tttttccacg ttacccttta aaataacctt tgttcagtgg tacatttagt
     1981 taaggcattt gtattcaaat gtagcatagt atttgcagag aaattacctt ttaaaacatc
     2041 tcaaaagtgt tttctaaaat gatgaaataa acggtggggt tctgtctatg gtgggattgt
     2101 cagtttatta ggtgagtatt ttccaaggtc tcagtttgtg aaaaaatggt gctatgtaca
     2161 agtggagttt gttgggatag acaatcactt acaaagccca gatggccaga agggaattgg
     2221 tgttgctcct ttcacttgta tggttgagca gatttgtcac atgccacaaa accattcttt
     2281 gtagtcatgc ttagtatgag cttgctttgt tgttacggtc atgttctttc cagccctgcc
     2341 ccagctatga attgtctaag tgtgagggag catcagagct tcagtattgt ttaaagaatg
     2401 tagaaaaata caaatttgtc taattttgaa actattttag aaagtcccta ctgtagaaag
     2461 agctaaactc aaagactttc cttgtaagtg aaagaaaaaa actgctgatg attaccaaga
     2521 ggcgtaagaa aattaggtga gggaatgttg tgctctagcc tgtggggtgc agcttcgtag
     2581 ggcacatcag cttagaatgg tctggcctca cctcagagag tcacagaaat agacaaaaac
     2641 ccaaaaagta ctagtaaagt aaatacaagg aacaaaataa acattaataa aaatgaatga
     2701 cgcaaaggtg atccagaatc attacttgct ccaacagcta gatcaaaggc tgaacatttt
     2761 gctttagtat agatgaggga aatgagcaag tcctaaaagg tttgccctgt tacggtgttt
     2821 catcactcat actggaagga gaaggaaagg agccatatga ctcatttaaa agaaaaactg
     2881 taagtcacct taaattccct atgttttact tcattttttc cctattgagg ttgttacagg
     2941 tcatggttga taatagttgg tgttgaatga atgtaatcca ttatttaaaa acaggtacat
     3001 ttaagtgaaa agataaatgt aaaaagctgt tcatatcaaa gccaaataga aatgattttt
     3061 atgcttataa tttacatggt gcaatatatc tttttaattt gtttactttt
//
