LOCUS       NM_001419781            1092 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens transforming growth factor beta receptor 3 like
            (TGFBR3L), transcript variant 1, mRNA.
ACCESSION   NM_001419781
VERSION     NM_001419781.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1092)
  AUTHORS   Kolnes,A.J., Oystese,K.A.B., Sjostedt,E., Olarescu,N.C., Heck,A.,
            Pahnke,J., Dahlberg,D., Berg-Johnsen,J., Ringstad,G.,
            Casar-Borota,O., Bollerslev,J. and Jorgensen,A.P.
  TITLE     TGFBR3L is associated with gonadotropin production in
            non-functioning gonadotroph pituitary neuroendocrine tumours
  JOURNAL   Pituitary 26 (2), 227-236 (2023)
   PUBMED   36952069
  REMARK    GeneRIF: TGFBR3L is associated with gonadotropin production in
            non-functioning gonadotroph pituitary neuroendocrine tumours.
REFERENCE   2  (bases 1 to 1092)
  AUTHORS   Brule,E., Wang,Y., Li,Y., Lin,Y.F., Zhou,X., Ongaro,L.,
            Alonso,C.A.I., Buddle,E.R.S., Schneyer,A.L., Byeon,C.H.,
            Hinck,C.S., Mendelev,N., Russell,J.P., Cowan,M., Boehm,U.,
            Ruf-Zamojski,F., Zamojski,M., Andoniadou,C.L., Sealfon,S.C.,
            Harrison,C.A., Walton,K.L., Hinck,A.P. and Bernard,D.J.
  TITLE     TGFBR3L is an inhibin B co-receptor that regulates female fertility
  JOURNAL   Sci Adv 7 (51), eabl4391 (2021)
   PUBMED   34910520
REFERENCE   3  (bases 1 to 1092)
  AUTHORS   Sjostedt,E., Kolnes,A.J., Olarescu,N.C., Mitsios,N., Hikmet,F.,
            Sivertsson,A., Lindskog,C., Oystese,K.A.B., Jorgensen,A.P.,
            Bollerslev,J. and Casar-Borota,O.
  TITLE     TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein
            Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour
            Tissue
  JOURNAL   Cancers (Basel) 13 (1), 114 (2020)
   PUBMED   33396509
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1092)
  AUTHORS   Jin,Y., Wang,H., Han,W., Lu,J., Chu,P., Han,S., Ni,X., Ning,B.,
            Yu,D. and Guo,Y.
  TITLE     Single nucleotide polymorphism rs11669203 in TGFBR3L is associated
            with the risk of neuroblastoma in a Chinese population
  JOURNAL   Tumour Biol 37 (3), 3739-3747 (2016)
   PUBMED   26468016
  REMARK    GeneRIF: Data show that the rs11669203 G>C polymorphism, located in
            transforming growth factor-beta receptor type 3-like protein
            (TGFBR3L) promoter, is significantly associated with the risk of
            neuroblastoma (NB).
REFERENCE   5  (bases 1 to 1092)
  AUTHORS   Dalla,E., Mignone,F., Verardo,R., Marchionni,L., Marzinotto,S.,
            Lazarevic,D., Reid,J.F., Marzio,R., Klaric,E., Licastro,D.,
            Marcuzzi,G., Gambetta,R., Pierotti,M.A., Pesole,G. and Schneider,C.
  TITLE     Discovery of 342 putative new genes from the analysis of
            5'-end-sequenced full-length-enriched cDNA human transcripts
  JOURNAL   Genomics 85 (6), 739-751 (2005)
   PUBMED   15885500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010336.8.
            
            ##Evidence-Data-START##
            Transcript exon combination :: MW464126.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000713907.1/ ENSP00000519206.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC010336.8         96041-96134
            95-231              AC010336.8         97618-97754
            232-552             AC010336.8         97833-98153
            553-679             AC010336.8         98684-98810
            680-838             AC010336.8         98912-99070
            839-911             AC010336.8         99268-99340
            912-1092            AC010336.8         100128-100308
FEATURES             Location/Qualifiers
     source          1..1092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1092
                     /gene="TGFBR3L"
                     /gene_synonym="GEMP; TGFR-3L"
                     /note="transforming growth factor beta receptor 3 like"
                     /db_xref="GeneID:100507588"
                     /db_xref="HGNC:HGNC:44152"
     exon            1..94
                     /gene="TGFBR3L"
                     /gene_synonym="GEMP; TGFR-3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..906
                     /gene="TGFBR3L"
                     /gene_synonym="GEMP; TGFR-3L"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; TGF-beta receptor type-3-like protein; TGF-beta
                     receptor type III-like protein; transforming growth
                     factor-beta receptor type III-like protein; transforming
                     growth factor-beta receptor type 3-like protein;
                     transforming growth factor, beta receptor III-like;
                     gonadotroph enriched membrane protein"
                     /codon_start=1
                     /product="transforming growth factor-beta receptor type
                     3-like protein isoform 1 precursor"
                     /protein_id="NP_001406710.1"
                     /db_xref="GeneID:100507588"
                     /db_xref="HGNC:HGNC:44152"
                     /translation="MLGTVLLLALLPGITTLPSGPPAPPFPAAPGPWLRRPLFSLKLS
                     DTEDVFPRRAGPLEVPADSRVFVQAALARPSPRWGLALHRCSVTPSSRPAPGPALALL
                     REGCPADTSVAFPPPPPPSPGAARPARFSFRLRPVFNASVQFLHCQLSRCRRLRGVRR
                     APAPLTPPPPPPPSRCLPQDEACADTGSGSAEGLAADGPHLHTLTQPIVVTVPRPPPR
                     PPKSVPGRAVRPEPPAPAPAALEPAPVVALVLAAFVLGAALAAGLGLVCAHSAPHAPG
                     PPARASPSGPQPRRSQ"
     exon            95..231
                     /gene="TGFBR3L"
                     /gene_synonym="GEMP; TGFR-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            232..552
                     /gene="TGFBR3L"
                     /gene_synonym="GEMP; TGFR-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            553..679
                     /gene="TGFBR3L"
                     /gene_synonym="GEMP; TGFR-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            680..838
                     /gene="TGFBR3L"
                     /gene_synonym="GEMP; TGFR-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            839..911
                     /gene="TGFBR3L"
                     /gene_synonym="GEMP; TGFR-3L"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1092
                     /gene="TGFBR3L"
                     /gene_synonym="GEMP; TGFR-3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1067..1072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR3L"
                     /gene_synonym="GEMP; TGFR-3L"
                     /note="hexamer: AATAAA"
     polyA_site      1092
                     /gene="TGFBR3L"
                     /gene_synonym="GEMP; TGFR-3L"
                     /note="major polyA site"
ORIGIN      
        1 aaacactccg acctcagctg gtccagcatg ctgggcaccg tgctgctgct ggccctgctc
       61 ccagggatca ccaccttacc cagcgggcca cctgctcccc cgttccccgc ggcgcccggc
      121 ccctggctgc gcagacccct cttcagcctg aagctgtccg acacagagga cgtctttcct
      181 cgccgcgcgg ggccgctcga ggtcccggcc gacagccgcg tgttcgtgca ggcggccttg
      241 gcccgtccct ccccgcgctg gggcctggcc ctgcaccgct gctcagtgac gccgtcctca
      301 cgcccggccc cggggcccgc cctggctctg ctgcgtgagg gctgccccgc cgacacctct
      361 gtcgccttcc cgccaccgcc gccgccgagc ccgggtgccg cccgccccgc gcgtttcagc
      421 ttccgcctgc gcccggtctt caacgcctcg gtgcagttcc tgcactgcca gctgagccgc
      481 tgccgccgcc tccggggagt ccgccgggcg cctgcgcctc tgacgccgcc gccgccgccg
      541 ccgccatcgc ggtgtctgcc tcaggacgag gcgtgcgccg acactggcag tggcagcgcc
      601 gagggcctgg ctgctgacgg cccccacctg cacacgctga cgcagcctat cgtggtcacc
      661 gtgccgcggc cgccccccag gccgcccaag agtgtccccg gccgtgcagt gcgccctgag
      721 cctcccgcgc cggcccccgc ggccctggaa cccgcgccgg tggtggcgct ggtgttggca
      781 gccttcgtgc tgggcgccgc gctggccgcc gggctgggtc tcgtctgtgc gcactcagcg
      841 ccccacgccc ctggcccgcc cgcgagagcc tcgcccagcg gtccccagcc caggaggtcc
      901 cagtgaggaa gggatggtgc gcccccaaca tggtccggag atacacccag ctaccaattc
      961 gggaccagga ccaacaggac cggacccgcc tccctggacc tcggacctga tgaggccacg
     1021 acccctgcgc ttctctcctc cccctgtccc tcccacctgt gctcaaaata aacctctgga
     1081 ctgaccggct aa
//
