LOCUS       NM_003243               6339 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens transforming growth factor beta receptor 3 (TGFBR3),
            transcript variant 1, mRNA.
ACCESSION   NM_003243
VERSION     NM_003243.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6339)
  AUTHORS   Shevchenko,A.V., Prokofiev,V.F., Konenkov,V.I., Chernykh,V.V. and
            Trunov,A.N.
  TITLE     Polymorphism of Transforming Growth Factor TGFB and Its Receptors
            TGFBRI, TGFBRII, TGFBRIIII Genes in Western Siberia Patients with
            Open-Angle Glaucoma
  JOURNAL   Bull Exp Biol Med 176 (5), 603-606 (2024)
   PUBMED   38730107
  REMARK    GeneRIF: Polymorphism of Transforming Growth Factor TGFB and Its
            Receptors TGFBRI, TGFBRII, TGFBRIIII Genes in Western Siberia
            Patients with Open-Angle Glaucoma.
REFERENCE   2  (bases 1 to 6339)
  AUTHORS   Deng,X., Ma,N., He,J., Xu,F. and Zou,G.
  TITLE     The Role of TGFBR3 in the Development of Lung Cancer
  JOURNAL   Protein Pept Lett 31 (7), 491-503 (2024)
   PUBMED   39092729
  REMARK    GeneRIF: The Role of TGFBR3 in the Development of Lung Cancer.
            Review article
REFERENCE   3  (bases 1 to 6339)
  AUTHORS   Liu,J.X., Chen,A.N., Yu,Q., Shi,K.T., Liu,Y.B., Guo,C.L.,
            Wang,Z.Z., Yao,Y., Pan,L., Lu,X., Xu,K., Wang,H., Zeng,M., Liu,C.,
            Schleimer,R.P., Wu,N., Liao,B. and Liu,Z.
  TITLE     MEX3B inhibits collagen production in eosinophilic nasal polyps by
            downregulating epithelial cell TGFBR3 mRNA stability
  JOURNAL   JCI Insight 8 (9), e159058 (2023)
   PUBMED   36976645
  REMARK    GeneRIF: MEX3B inhibits collagen production in eosinophilic nasal
            polyps by downregulating epithelial cell TGFBR3 mRNA stability.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6339)
  AUTHORS   Gatza,C.E., Oh,S.Y. and Blobe,G.C.
  TITLE     Roles for the type III TGF-beta receptor in human cancer
  JOURNAL   Cell Signal 22 (8), 1163-1174 (2010)
   PUBMED   20153821
  REMARK    GeneRIF: A review on the role of TbetaRIII as a suppressor of
            cancer progression and/or as a metastasis suppressor.
            Review article
REFERENCE   5  (bases 1 to 6339)
  AUTHORS   Hempel,N., How,T., Cooper,S.J., Green,T.R., Dong,M., Copland,J.A.,
            Wood,C.G. and Blobe,G.C.
  TITLE     Expression of the type III TGF-beta receptor is negatively
            regulated by TGF-beta
  JOURNAL   Carcinogenesis 29 (5), 905-912 (2008)
   PUBMED   18299279
  REMARK    GeneRIF: TGF-beta1-mediates downregulation of TbetaRIII mRNA
            expression through effects on the ALK5/Smad2/3 pathway.
REFERENCE   6  (bases 1 to 6339)
  AUTHORS   Johnson,D.W., Qumsiyeh,M., Benkhalifa,M. and Marchuk,D.A.
  TITLE     Assignment of human transforming growth factor-beta type I and type
            III receptor genes (TGFBR1 and TGFBR3) to 9q33-q34 and 1p32-p33,
            respectively
  JOURNAL   Genomics 28 (2), 356-357 (1995)
   PUBMED   8530052
REFERENCE   7  (bases 1 to 6339)
  AUTHORS   Moren,A., Ichijo,H. and Miyazono,K.
  TITLE     Molecular cloning and characterization of the human and porcine
            transforming growth factor-beta type III receptors
  JOURNAL   Biochem Biophys Res Commun 189 (1), 356-362 (1992)
   PUBMED   1333192
REFERENCE   8  (bases 1 to 6339)
  AUTHORS   Massague,J.
  TITLE     Receptors for the TGF-beta family
  JOURNAL   Cell 69 (7), 1067-1070 (1992)
   PUBMED   1319842
  REMARK    Review article
REFERENCE   9  (bases 1 to 6339)
  AUTHORS   Wang,X.F., Lin,H.Y., Ng-Eaton,E., Downward,J., Lodish,H.F. and
            Weinberg,R.A.
  TITLE     Expression cloning and characterization of the TGF-beta type III
            receptor
  JOURNAL   Cell 67 (4), 797-805 (1991)
   PUBMED   1657407
REFERENCE   10 (bases 1 to 6339)
  AUTHORS   Lopez-Casillas,F., Cheifetz,S., Doody,J., Andres,J.L., Lane,W.S.
            and Massague,J.
  TITLE     Structure and expression of the membrane proteoglycan betaglycan, a
            component of the TGF-beta receptor system
  JOURNAL   Cell 67 (4), 785-795 (1991)
   PUBMED   1657406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA854401.1, DR002506.1,
            BC136295.1, AK291345.1, AC099334.2 and AI090023.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003243.4.
            
            Summary: This locus encodes the transforming growth factor
            (TGF)-beta type III receptor. The encoded receptor is a membrane
            proteoglycan that often functions as a co-receptor with other
            TGF-beta receptor superfamily members. Ectodomain shedding produces
            soluble TGFBR3, which may inhibit TGFB signaling. Decreased
            expression of this receptor has been observed in various cancers.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified for this gene.[provided by RefSeq,
            Sep 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126116.1, AK291345.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000212355.9/ ENSP00000212355.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                DA854401.1         80-128
            50-603              DR002506.1         9-562
            604-2633            BC136295.1         385-2414
            2634-2634           AK291345.1         2403-2403
            2635-4011           BC136295.1         2416-3792
            4012-6286           AC099334.2         77262-79536         c
            6287-6339           AI090023.1         9-61                c
FEATURES             Location/Qualifiers
     source          1..6339
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..6339
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /note="transforming growth factor beta receptor 3"
                     /db_xref="GeneID:7049"
                     /db_xref="HGNC:HGNC:11774"
                     /db_xref="MIM:600742"
     exon            1..274
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            275..448
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..2943
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; betaglycan proteoglycan; TGF-beta receptor type
                     III; TGFR-3; TGF-beta receptor type 3; transforming growth
                     factor beta receptor III"
                     /codon_start=1
                     /product="transforming growth factor beta receptor type 3
                     isoform a precursor"
                     /protein_id="NP_003234.2"
                     /db_xref="CCDS:CCDS30770.1"
                     /db_xref="GeneID:7049"
                     /db_xref="HGNC:HGNC:11774"
                     /db_xref="MIM:600742"
                     /translation="MTSHYVIAIFALMSSCLATAGPEPGALCELSPVSASHPVQALME
                     SFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVF
                     LLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHL
                     LNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAA
                     EGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCK
                     KSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDN
                     GYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIR
                     GGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDI
                     ALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTR
                     PRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPE
                     IVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVS
                     VTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQAD
                     MDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWA
                     MMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIG
                     ALLTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA"
     exon            449..633
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            634..771
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            772..955
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1124
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1272
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1462
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1800
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1953
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2094
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2253
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2553
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2674
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2716
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2824
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..6339
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6313..6318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /note="hexamer: AATAAA"
     polyA_site      6339
                     /gene="TGFBR3"
                     /gene_synonym="betaglycan; BGCAN"
                     /note="major polyA site"
ORIGIN      
        1 aatcgagggt ttcggggacg ccgagcggca ctttcctctt cccagcgagt gaaggagggc
       61 agtcggcggc tctcgcgccc cggccacttt ccctgcgcga ttcccggagc tccctgcagg
      121 aggtgagagt ccccagcggg tccggatggc gtagttttgc cgcggcgcag cagctgccgg
      181 agctcgccgc cgccgagcgc tgggcgggga aacttgccgc cgctttcctc caacttgctg
      241 cgggtggatc tccgctggac acaccgcctc cgaggcagtt tgaaaattgc aaggagggac
      301 tttaagacta cttctgattt gcaaagattg tctgtgctct gagcaggctg aagtgactgg
      361 acgagacgca ctgttggaga aataaaaatg acttcccatt atgtgattgc catctttgcc
      421 ctgatgagct cctgtttagc cactgcaggt ccagagcctg gtgcactgtg tgaactgtca
      481 cctgtcagtg cctcccatcc tgtccaggcc ttgatggaga gcttcactgt tttgtcaggc
      541 tgtgccagca gaggcacaac tgggctgcca caggaggtgc atgtcctgaa tctccgcact
      601 gcaggccagg ggcctggcca gctacagaga gaggtcacac ttcacctgaa tcccatctcc
      661 tcagtccaca tccaccacaa gtctgttgtg ttcctgctca actccccaca ccccctggtg
      721 tggcatctga agacagagag acttgccact ggggtctcca gactgttttt ggtgtctgag
      781 ggttctgtgg tccagttttc atcagcaaac ttctccttga cagcagaaac agaagaaagg
      841 aacttccccc atggaaatga acatctgtta aattgggccc gaaaagagta tggagcagtt
      901 acttcattca ccgaactcaa gatagcaaga aacatttata ttaaagtggg ggaagatcaa
      961 gtgttccctc caaagtgcaa catagggaag aattttctct cactcaatta ccttgctgag
     1021 taccttcaac ccaaagcagc agaagggtgt gtgatgtcca gccagcccca gaatgaggaa
     1081 gtacacatca tcgagctaat cacccccaac tctaacccct acagtgcttt ccaggtggat
     1141 ataacaattg atataagacc ttctcaagag gatcttgaag tggtcaaaaa tctcatcctg
     1201 atcttgaagt gcaaaaagtc tgtcaactgg gtgatcaaat cttttgatgt taagggaagc
     1261 ctgaaaatta ttgctcctaa cagtattggc tttggaaaag agagtgaaag atctatgaca
     1321 atgaccaaat caataagaga tgacattcct tcaacccaag ggaatctggt gaagtgggct
     1381 ttggacaatg gctatagtcc aataacttca tacacaatgg ctcctgtggc taatagattt
     1441 catcttcggc ttgaaaataa tgcagaggag atgggagatg aggaagtcca cactattcct
     1501 cctgagctac ggatcctgct ggaccctggt gccctgcctg ccctgcagaa cccgcccatc
     1561 cggggagggg aaggccaaaa tggaggcctt ccgtttcctt tcccagatat ttccaggaga
     1621 gtctggaatg aagagggaga agatgggctc cctcggccaa aggaccctgt cattcccagc
     1681 atacaactgt ttcctggtct cagagagcca gaagaggtgc aagggagcgt ggatattgcc
     1741 ctgtctgtca aatgtgacaa tgagaagatg atcgtggctg tagaaaaaga ttcttttcag
     1801 gccagtggct actcggggat ggacgtcacc ctgttggatc ctacctgcaa ggccaagatg
     1861 aatggcacac actttgtttt ggagtctcct ctgaatggct gcggtactcg gccccggtgg
     1921 tcagcccttg atggtgtggt ctactataac tccattgtga tacaggttcc agcccttggg
     1981 gacagtagtg gttggccaga tggttatgaa gatctggagt caggtgataa tggatttccg
     2041 ggagatatgg atgaaggaga tgcttccctg ttcacccgac ctgaaatcgt ggtgtttaat
     2101 tgcagccttc agcaggtgag gaaccccagc agcttccagg aacagcccca cggaaacatc
     2161 accttcaaca tggagctata caacactgac ctctttttgg tgccctccca gggcgtcttc
     2221 tctgtgccag agaatggaca cgtttatgtt gaggtatctg ttactaaggc tgaacaagaa
     2281 ctgggatttg ccatccaaac gtgctttatc tctccatatt cgaaccctga taggatgtct
     2341 cattacacca ttattgagaa tatttgtcct aaagatgaat ctgtgaaatt ctacagtccc
     2401 aagagagtgc actttcctat cccgcaagct gacatggata agaagcgatt cagctttgtc
     2461 ttcaagcctg tcttcaacac ctcactgctc tttctacagt gtgagctgac gctgtgtacg
     2521 aagatggaga agcaccccca gaagttgcct aagtgtgtgc ctcctgacga agcctgcacc
     2581 tcgctggacg cctcgataat ctgggccatg atgcagaata agaagacgtt cactaagccc
     2641 cttgctgtga tccaccatga agcagaatct aaagaaaaag gtccaagcat gaaggaacca
     2701 aatccaattt ctccaccaat tttccatggt ctggacaccc taaccgtgat gggcattgcg
     2761 tttgcagcct ttgtgatcgg agcactcctg acgggggcct tgtggtacat ctattctcac
     2821 acaggggaga cagcaggaag gcagcaagtc cccacctccc cgccagcctc ggaaaacagc
     2881 agtgctgccc acagcatcgg cagcacgcag agcacgcctt gctccagcag cagcacggcc
     2941 tagcccaacc cagcccaacc cggcccaacc cagcccagcc cagctcagct cagctactgc
     3001 caagggcagg accaatggct gagcctcgtg tccagactca gagggctgga ttttggttcc
     3061 cttgtaaaga cagagtgaat ttcagtataa agatcacccg ttgtattcac cccacaccca
     3121 gggctagtat aaacatgacc ctgggcttct gtaccacact agaattcatg tgagaaagct
     3181 aaaatggtgg tcttctccac cagcccctca caggcttggg ggttttcaat gtgaaacaca
     3241 tgccagtttt taaaatgctg ctttgtccag gtgagaacat ccataatttg gggccctgag
     3301 ttttacccag actcaaggag ttggtaaagg gttaatagcc agatagtaga accagtgagg
     3361 agatgcggcc aaagattctt tatatctgaa ccaagatgta aaacaagaaa tgctttgagg
     3421 ctttctaagc gatcctcctg tctaatttgc acctttgtct ggatgcacac ttctgacctt
     3481 gctgccacaa cctgtggggt ctgatgtgtc ccttgatggg tgctgccctc agggactgca
     3541 ccctgacaag tgttaaggca acattccttt cttgtgccct gggccaaaac caatgctgat
     3601 gaccttatca gcttcctgtt tcttcccata cttgcataca ccactgcaaa atgtcttaat
     3661 gcaaattttg tatttcttac aggcctacag aaattgaaaa tgaccaaaat caggaaccac
     3721 agatttgtgc ccattcctaa tattttgttc tgcaaattaa tgtataattt gaggtgaaat
     3781 tcagttataa agtcaaggac gaatttgcac agtgatatat ttctatgtgt atgcaagtac
     3841 aagtatataa tatgtcacct ggcacattca ttttctcagt tgaagaagag aaaatttgaa
     3901 aatgtcctta tgcttttaga gttgcaactt aagtatattt ggtagggtga gtgtttccac
     3961 tcaaaatatg tcaacttaaa aaaaaatagg ccctttcata aaaaccaaac tgtagcaaga
     4021 tgcaaatgca tggcaaatcc tgtcggtctc cagttggtta tctgaatagt gtcaccaatt
     4081 ccaccaagac agtgctgaga ttggaaaagg gcactcattt ggattgcctt acttctcttg
     4141 ccttaaatat atcccatata tttaatatgt caaaaagggc ttgaggtgaa tttcattaaa
     4201 tggaataata tgatgccact ttgcagctaa aataagctca gtgatacctc cttgttaaaa
     4261 aaaaaaaaaa aaaaaaagaa tgccaggggg gaattatcat gctaaattat tttactgctg
     4321 aagatagctt cattgcaaat tattcttttt ccagaatttc ccccaaacaa cttagaattc
     4381 cataagtaga acaagataga ttctaccccc aaaatattca taagcaaatc ccactgccct
     4441 taaaataagg aagttatgcc tggttgtctg tgaatggaac ctcagtaggt aatcctgatg
     4501 aagcttaaaa ccttagggca gtgtctacat gggaaacaag tatgtggaaa ttgacaatca
     4561 tttttaccaa atcgttgagt aataatatga cttacctgat agatatacac attcaataag
     4621 gaacattttt ttttttcaat aaggaacatt ttaactaaaa cattacttta gggctgagat
     4681 ttccaggcta tctacattga tctactgaaa aatttctaga tttccatata caaacgaaga
     4741 agacatgagt ttagagaatt tttttccttt aatttttttt taacagaagg gtatcagagt
     4801 ggaggaccta gattacgcta cctgtgtttg aaaatattgc gctttgccta accttcggtg
     4861 gaatgtattg tttcagcata ttctatgtat aaaaaagttt aaagatgtct tcaaagaaga
     4921 ctagagtctt taagtcactt atagctatat tttactacaa aatttgtgta taaagatata
     4981 tttaagtgtt ttagataaat ttaagttact ccatatgaaa tgtttaattt cagctactgt
     5041 gaattctttc gatcagtcct ttgctttttt aaaaaatctt ttccatcgtg ttaaaaagaa
     5101 aattagctat taggagatat taaaagattg atgtcttaga aggacagggt taaaaccttc
     5161 tgtaatatat ttaaatatat atttttaaga gagatgctac attgccaatg attttataaa
     5221 taatttaaaa ttaatttaca aatttataga tgcaaaccaa aagatctttt taaaagagag
     5281 agagaggaaa aaaatcacct tttatttgtt tgggtctcat tgtcagaatt attattcaga
     5341 tcaagaaatc tgtgtcgata aaacctaatc tcatattgga gagtgaatgt cgttaagtat
     5401 ttctgaaatg tttctaaaaa atgaacatga aaaaaataag gtattttctc cctagcttct
     5461 cattacagta tttctaattg cttcacactt tacagtttta atacaaagta caagctctac
     5521 ttttataacg tgtactacaa gtttctttaa aagtattgtt gtatttcagc tgaactcttg
     5581 tatctgcagt cttttgttat ttctgcaggc tacaccctta atttgcagag gccattttgt
     5641 tgtttgtttg atgctgaagc tgttgttaaa atgccccaaa ctccaaggca gattgtctgt
     5701 ataatacgct atagcttttc accatgtggt gtttaccagc tgttactctg tattttaaaa
     5761 agccagagat ttcttctgtc taaactgttt ctatagcatt ttctaaacaa aaaaaatggt
     5821 ttttttcttt gccttgtaat aagattgtaa atccatttcc tgcttgtgtt cttagtgggc
     5881 atgattgtga gtgtgtgtgg ggtgctcaca cgcgtgccag tctttttgta ctgtaactac
     5941 ctcatggttt gaatgatgat tgtactgctg gttgtgttaa cagagcacat tttgttgggt
     6001 gagtcctatg tgattttttt catgtttgtt ttatctgggg gttgttcatg aaactgacag
     6061 atgtttttct aaaaaggact attatcagtt tccaaataca atacttctct cttctggttt
     6121 ttcctgaatg agcctgattt tgttgctggt tttcatcatc tatgagggta aaacgagtac
     6181 ccttaaaatc cctgtggcca gtttgaacac ccctgttgta ttcttttctc tgttcagtgt
     6241 gtcagctatt ttgtgaagat gcttagatgt atagttttga taaccacagt tttaaatctt
     6301 ttatctgtgc ataataaaaa gatatatatc agttattaa
//
