LOCUS       NM_001407434            6337 bp    mRNA    linear   PRI 14-OCT-2024
DEFINITION  Homo sapiens transforming growth factor beta receptor 1 (TGFBR1),
            transcript variant 20, mRNA.
ACCESSION   NM_001407434
VERSION     NM_001407434.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6337)
  AUTHORS   Huang,W., Zhang,Z., Li,X., Zheng,Q., Wu,C., Liu,L., Chen,Y.,
            Zhang,J. and Jiang,X.
  TITLE     CD9 promotes TbetaR2-TbetaR1 association driving the transition of
            human dermal fibroblasts to myofibroblast under hypoxia
  JOURNAL   Mol Med 30 (1), 162 (2024)
   PUBMED   39333849
  REMARK    GeneRIF: CD9 promotes TbetaR2-TbetaR1 association driving the
            transition of human dermal fibroblasts to myofibroblast under
            hypoxia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6337)
  AUTHORS   Liu,K., Tian,F., Chen,X., Liu,B., Tian,S., Hou,Y., Wang,L., Han,M.,
            Peng,S., Tan,Y., Pan,Y., Chu,Z., Li,J., Che,L., Chen,D., Wen,L.,
            Qin,Z., Li,X., Xiang,J., Bian,X.W., Liu,Q., Ye,X., Wang,T. and
            Wang,B.
  TITLE     Stabilization of TGF-beta Receptor 1 by a Receptor-Associated
            Adaptor Dictates Feedback Activation of the TGF-beta Signaling
            Pathway to Maintain Liver Cancer Stemness and Drug Resistance
  JOURNAL   Adv Sci (Weinh) 11 (34), e2402327 (2024)
   PUBMED   38981014
  REMARK    GeneRIF: Stabilization of TGF-beta Receptor 1 by a
            Receptor-Associated Adaptor Dictates Feedback Activation of the
            TGF-beta Signaling Pathway to Maintain Liver Cancer Stemness and
            Drug Resistance.
REFERENCE   3  (bases 1 to 6337)
  AUTHORS   Cui,N., Liu,C., Tang,X., Song,L., Xiao,Z., Wang,C., Wu,Y., Zhou,Y.,
            Peng,C., Liu,Y., Zheng,L., Liu,X., Huang,K. and Chen,H.
  TITLE     ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD
            transition by promoting TGFbetaR1 ISGylation
  JOURNAL   Theranostics 14 (11), 4536-4553 (2024)
   PUBMED   39113797
  REMARK    GeneRIF: ISG15 accelerates acute kidney injury and the subsequent
            AKI-to-CKD transition by promoting TGFbetaR1 ISGylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6337)
  AUTHORS   Du,Q., Zhang,D., Zhuang,Y., Xia,Q., Wen,T. and Jia,H.
  TITLE     The Molecular Genetics of Marfan Syndrome
  JOURNAL   Int J Med Sci 18 (13), 2752-2766 (2021)
   PUBMED   34220303
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6337)
  AUTHORS   Tzavlaki,K. and Moustakas,A.
  TITLE     TGF-beta Signaling
  JOURNAL   Biomolecules 10 (3), 487 (2020)
   PUBMED   32210029
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6337)
  AUTHORS   Vander Ark,A., Cao,J. and Li,X.
  TITLE     TGF-beta receptors: In and beyond TGF-beta signaling
  JOURNAL   Cell Signal 52, 112-120 (2018)
   PUBMED   30184463
  REMARK    Review article
REFERENCE   7  (bases 1 to 6337)
  AUTHORS   Loeys,B.L. and Dietz,H.C.
  TITLE     Loeys-Dietz Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301312
REFERENCE   8  (bases 1 to 6337)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
REFERENCE   9  (bases 1 to 6337)
  AUTHORS   Cheifetz,S., Bellon,T., Cales,C., Vera,S., Bernabeu,C., Massague,J.
            and Letarte,M.
  TITLE     Endoglin is a component of the transforming growth factor-beta
            receptor system in human endothelial cells
  JOURNAL   J Biol Chem 267 (27), 19027-19030 (1992)
   PUBMED   1326540
REFERENCE   10 (bases 1 to 6337)
  AUTHORS   Massague,J.
  TITLE     Receptors for the TGF-beta family
  JOURNAL   Cell 69 (7), 1067-1070 (1992)
   PUBMED   1319842
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162427.24.
            
            Summary: The protein encoded by this gene forms a heteromeric
            complex with type II TGF-beta receptors when bound to TGF-beta,
            transducing the TGF-beta signal from the cell surface to the
            cytoplasm. The encoded protein is a serine/threonine protein
            kinase. Mutations in this gene have been associated with
            Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.2620015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL162427.24        88614-88648         c
            36-281              AL162427.24        64240-64485         c
            282-512             AL162427.24        60601-60831         c
            513-743             AL162427.24        55251-55481         c
            744-911             AL162427.24        50637-50804         c
            912-1068            AL162427.24        48452-48608         c
            1069-1193           AL162427.24        46731-46855         c
            1194-1324           AL162427.24        45556-45686         c
            1325-6337           AL162427.24        39148-44160         c
FEATURES             Location/Qualifiers
     source          1..6337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..6337
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="transforming growth factor beta receptor 1"
                     /db_xref="GeneID:7046"
                     /db_xref="HGNC:HGNC:11772"
                     /db_xref="MIM:190181"
     exon            1..35
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            36..281
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1450
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /EC_number="2.7.11.30"
                     /note="isoform 7 is encoded by transcript variant 20;
                     activin A receptor type II-like kinase, 53kDa; TGF-beta
                     receptor type-1; activin receptor-like kinase 5;
                     serine/threonine-protein kinase receptor R4; transforming
                     growth factor beta receptor I; transforming growth
                     factor-beta receptor type I; activin A receptor type
                     II-like protein kinase of 53kD; mutant transforming growth
                     factor beta receptor I"
                     /codon_start=1
                     /product="TGF-beta receptor type-1 isoform 7"
                     /protein_id="NP_001394363.1"
                     /db_xref="GeneID:7046"
                     /db_xref="HGNC:HGNC:11772"
                     /db_xref="MIM:190181"
                     /translation="MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPT
                     TVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFI
                     SEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEV
                     AVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGS
                     LFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNG
                     TCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYA
                     MGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSC
                     EALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"
     exon            282..512
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..743
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..911
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1068
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1193
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1324
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..6337
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5774..5779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: AATAAA"
     polyA_site      5794
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="major polyA site"
     regulatory      5815..5820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: AATAAA"
     polyA_site      5835
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
     regulatory      6203..6208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: ATTAAA"
     polyA_site      6228
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
     regulatory      6316..6321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: ATTAAA"
     polyA_site      6337
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
ORIGIN      
        1 ctgaggcagt accagatctt ccgcgcctag aggagcgtta cagtgtttct gccacctctg
       61 tacaaaagac aattttactt gtgtgacaga tgggctctgc tttgtctctg tcacagagac
      121 cacagacaaa gttatacaca acagcatgtg tatagctgaa attgacttaa ttcctcgaga
      181 taggccgttt gtatgtgcac cctcttcaaa aactgggtct gtgactacaa catattgctg
      241 caatcaggac cattgcaata aaatagaact tccaactact gtaaagtcat cacctggcct
      301 tggtcctgtg gaactggcag ctgtcattgc tggaccagtg tgcttcgtct gcatctcact
      361 catgttgatg gtctatatct gccacaaccg cactgtcatt caccatcgag tgccaaatga
      421 agaggaccct tcattagatc gcccttttat ttcagagggt actacgttga aagacttaat
      481 ttatgatatg acaacgtcag gttctggctc aggtttacca ttgcttgttc agagaacaat
      541 tgcgagaact attgtgttac aagaaagcat tggcaaaggt cgatttggag aagtttggag
      601 aggaaagtgg cggggagaag aagttgctgt taagatattc tcctctagag aagaacgttc
      661 gtggttccgt gaggcagaga tttatcaaac tgtaatgtta cgtcatgaaa acatcctggg
      721 atttatagca gcagacaata aagacaatgg tacttggact cagctctggt tggtgtcaga
      781 ttatcatgag catggatccc tttttgatta cttaaacaga tacacagtta ctgtggaagg
      841 aatgataaaa cttgctctgt ccacggcgag cggtcttgcc catcttcaca tggagattgt
      901 tggtacccaa ggaaagccag ccattgctca tagagatttg aaatcaaaga atatcttggt
      961 aaagaagaat ggaacttgct gtattgcaga cttaggactg gcagtaagac atgattcagc
     1021 cacagatacc attgatattg ctccaaacca cagagtggga acaaaaaggt acatggcccc
     1081 tgaagttctc gatgattcca taaatatgaa acattttgaa tccttcaaac gtgctgacat
     1141 ctatgcaatg ggcttagtat tctgggaaat tgctcgacga tgttccattg gtggaattca
     1201 tgaagattac caactgcctt attatgatct tgtaccttct gacccatcag ttgaagaaat
     1261 gagaaaagtt gtttgtgaac agaagttaag gccaaatatc ccaaacagat ggcagagctg
     1321 tgaagccttg agagtaatgg ctaaaattat gagagaatgt tggtatgcca atggagcagc
     1381 taggcttaca gcattgcgga ttaagaaaac attatcgcaa ctcagtcaac aggaaggcat
     1441 caaaatgtaa ttctacagct ttgcctgaac tctccttttt tcttcagatc tgctcctggg
     1501 ttttaatttg ggaggtcaat tgttctacct cactgagagg gaacagaagg atattgcttc
     1561 cttttgcagc agtgtaataa agtcaattaa aaacttccca ggatttcttt ggacccagga
     1621 aacagccatg tgggtccttt ctgtgcacta tgaacgcttc tttcccagga cagaaaatgt
     1681 gtagtctacc tttatttttt attaacaaaa cttgtttttt aaaaagatga ttgctggtct
     1741 taactttagg taactctgct gtgctggaga tcatctttaa gggcaaagga gttggattgc
     1801 tgaattacaa tgaaacatgt cttattacta aagaaagtga tttactcctg gttagtacat
     1861 tctcagagga ttctgaacca ctagagtttc cttgattcag actttgaatg tactgttcta
     1921 tagtttttca ggatcttaaa actaacactt ataaaactct tatcttgagt ctaaaaatga
     1981 cctcatatag tagtgaggaa cataattcat gcaattgtat tttgtatact attattgttc
     2041 tttcacttat tcagaacatt acatgccttc aaaatgggat tgtactatac cagtaagtgc
     2101 cacttctgtg tctttctaat ggaaatgagt agaattgctg aaagtctcta tgttaaaacc
     2161 tatagtgttt gaattcaaaa agcttattta tctgggtaac ccaaactttt tctgttttgt
     2221 ttttggaagg gtttttgtgg tatgtcattt ggtattctat tctgaaaatg cctttctcct
     2281 accaaaatgt gcttaagcca ctaaagaaat gaagtggcat taattagtaa attattagca
     2341 tggtcatgtt tgaatattct cacatcaagc ttttgcattt taattgtgtt gtctaagtat
     2401 acttttaaaa aatcaagtgg cactctagat gcttatagta ctttaatatt tgtagcatac
     2461 agactaattt ttctaaaagg gaaagtctgt ctagctgctt gtgaaaagtt atgtggtatt
     2521 ctgtaagcca tttttttctt tatctgttca aagacttatt ttttaagaca tgaattacat
     2581 ttaaaattag aatatggtta atattaaata ataggccttt ttctaggaag gcgaaggtag
     2641 ttaataattt gaatagataa cagatgtgca agaaagtcac atttgttatg tatgtaggag
     2701 taaacgttcg gtggatcctc tgtctttgta actgaggtta gagctagtgt ggttttgagg
     2761 tctcactaca ctttgaggaa ggcagctttt aattcagtgt ttccttatgt gtgcgtacat
     2821 tgcaactgct tacatgtaat ttatgtaatg cattcagtgc acccttgtta cttgggagag
     2881 gtggtagcta aagaacattc tgagtatagg tttttctcca tttacagatg tctttggtca
     2941 aatattgaaa gcaaacttgt catggtcttc ttacattaag ttgaaactag cttataataa
     3001 ctggttttta cttccaatgc tatgaagtct ctgcagggct tttacagttt tcgaagtcct
     3061 tttatcactg tgatcttatt ctgaggggag aaaaaactat catagctctg aggcaagact
     3121 tcgactttat agtgctatca gttccccgat acagggtcag agtaacccat acagtatttt
     3181 ggtcaggaag agaaagtggc catttacact gaatgagttg cattctgata atgtcttatc
     3241 tcttatacgt agaataaatt tgaaagacta tttgatctta aaaccaaagt aattttagaa
     3301 tgagtgacat attacatagg aatttagtgt caatttcatg tgtttaaaaa catcatggga
     3361 aaaatgctta gaggttacta ttttgactac aaagttgagt ttttttctgt agttaccata
     3421 atttcattga agcaaatgaa tgagtttgag aggtttgttt ttatagttgt gttgtattac
     3481 ttgtttaata ataatctcta attctgtgat caggtacttt ttttgtgggg gttttttttt
     3541 tgtttttttt tttttgttgt tgtttttggg ccatttctaa gcctaccaga tctgctttat
     3601 gaaatccagg ggaccaatgc attttatcac taaaactatt tttatataat tttaagaata
     3661 taccaaaagt tgtctgattt aaagttgtaa tacatgattt ctcactttca tgtaaggtta
     3721 tccacttttg ctgaagatat tttttattga atcaaagatt gagttacaat tatacttttc
     3781 ttacctaagt ggataaaatg tacttttgat gaatcaggga atttttttaa agttggagtt
     3841 tagttctaaa ttgactttac gtattactgc agttaattcc ttttttggct agggatggtt
     3901 tgataaacca caattggctg atattgaaaa tgaaagaaac ttaaaaggtg ggatggatca
     3961 tgattactgt cgataactgc agataaattt gattagagta ataattttgt catttaaaaa
     4021 cacagttgtt tatactgccc atcctaggat gctcaccttc caagattcaa cgtggctaaa
     4081 acatcttctg gtaaattgtg cgtccatatt cattttgtca gtagccagga gaaatgggga
     4141 tgggggaaat acgacttagt gaggcataga catccctggt ccatcctttc tgtctccagc
     4201 tgtttcttgg aacctgctct cctgcttgct ggtccctgac gcagagaccg ttgcctcccc
     4261 cacagccgtt tgactgaagg ctgctctgga gacctagagt aaaacggctg atggaagttg
     4321 tgggacccac ttccatttcc ttcagtcatt agaggtggaa gggaggggtc tccaagtttg
     4381 gagattgagc agatgaggct tgggatgccc ctgctttgac ttcagccatg gatgaggagt
     4441 gggatggcag caaggtggct cctgtggcag tggagttgtg ccagaaacag tggccagttg
     4501 tatcgcctat aagacagggt aaggtctgaa gagctgagcc tgtaattctg ctgtaataat
     4561 gatagtgctc aagaagtgcc ttgagttggt gtacagtgcc atggccatca agaatcccag
     4621 atttcaggtt ttattacaaa atgtaagtgg tcacttggcg attttgtagt acatgcatga
     4681 gttacctttt ttctctatgt ctgagaactg tcagattaaa acaagatggc aaagagatcg
     4741 ttagagtgca caacaaaatc actatcccat tagacacatc atcaaaagct tatttttatt
     4801 cttgcactgg aagaatcgta agtcaactgt ttcttgacca tggcagtgtt ctggctccaa
     4861 atggtagtga ttccaaataa tggttctgtt aacactttgg cagaaaatgc cagctcagat
     4921 attttgagat actaaggatt atctttggac atgtactgca gcttcttgtc tctgttttgg
     4981 attactggaa tacccatggg ccctctcaag agtgctggac ttctaggaca ttaagatgat
     5041 tgtcagtaca ttaaactttt caatcccatt atgcaatctt gtttgtaaat gtaaacttct
     5101 aaaaatatgg ttaataacat tcaacctgtt tattacaact taaaaggaac ttcagtgaat
     5161 ttgtttttat tttttaacaa gatttgtgaa ctgaatatca tgaaccatgt tttgataccc
     5221 ctttttcacg ttgtgccaac ggaatagggt gtttgatatt tcttcatatg ttaaggagat
     5281 gcttcaaaat gtcaattgct ttaaacttaa attacctctc aagagaccaa ggtacattta
     5341 cctcattgtg tatataatgt ttaatatttg tcagagcatt ctccaggttt gcagttttat
     5401 ttctataaag tatgggtatt atgttgctca gttactcaaa tggtactgta ttgtttatat
     5461 ttgtacccca aataacatcg tctgtacttt ctgttttctg tattgtattt gtgcaggatt
     5521 ctttaggctt tatcagtgta atctctgcct tttaagatat gtacagaaaa tgtccatata
     5581 aatttccatt gaagtcgaat gatactgaga agcctgtaaa gaggagaaaa aaacataagc
     5641 tgtgtttccc cataagtttt tttaaattgt atattgtatt tgtagtaata ttccaaaaga
     5701 atgtaaatag gaaatagaag agtgatgctt atgttaagtc ctaacactac agtagaagaa
     5761 tggaagcagt gcaaataaat tacatttttc ccaagtgcca gtggcatatt ttaaaataaa
     5821 gtgtatacgt tggaatgagt catgccatat gtagttgctg tagatggcaa ctagaacctt
     5881 tgagttacaa gagtctttag aagttttcta accctgccta gtgcaagtta caatattata
     5941 gcgtgttcgg ggagtgccct cctgtctgca ggtgtgtctc tgtgcctggg ggcttttctc
     6001 cacatgctta ggggtgtggg tcttccattg gggcatgatg gacctgtcta caggtgatct
     6061 ctgttgcctt tgggtcagca catttgttag tctcctgggg gtgaaaactt ggcttacaag
     6121 agaactggaa aaatgatgag atgtggtccc caaacccttg attgactctg gggaggggct
     6181 ttgtgaatag gattgctctc acattaaaga tagttacttc aatttgaagg ctggatttag
     6241 ggattttttt ttttccttat aacaaagaca tcaccaggat atgaagcttt tgttgaaagt
     6301 tggaaaaaaa gtgaaattaa agacattccc agacaaa
//
