LOCUS       NM_001407433            6345 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens transforming growth factor beta receptor 1 (TGFBR1),
            transcript variant 19, mRNA.
ACCESSION   NM_001407433
VERSION     NM_001407433.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6345)
  AUTHORS   Huang,W., Zhang,Z., Li,X., Zheng,Q., Wu,C., Liu,L., Chen,Y.,
            Zhang,J. and Jiang,X.
  TITLE     CD9 promotes TbetaR2-TbetaR1 association driving the transition of
            human dermal fibroblasts to myofibroblast under hypoxia
  JOURNAL   Mol Med 30 (1), 162 (2024)
   PUBMED   39333849
  REMARK    GeneRIF: CD9 promotes TbetaR2-TbetaR1 association driving the
            transition of human dermal fibroblasts to myofibroblast under
            hypoxia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6345)
  AUTHORS   Liu,K., Tian,F., Chen,X., Liu,B., Tian,S., Hou,Y., Wang,L., Han,M.,
            Peng,S., Tan,Y., Pan,Y., Chu,Z., Li,J., Che,L., Chen,D., Wen,L.,
            Qin,Z., Li,X., Xiang,J., Bian,X.W., Liu,Q., Ye,X., Wang,T. and
            Wang,B.
  TITLE     Stabilization of TGF-beta Receptor 1 by a Receptor-Associated
            Adaptor Dictates Feedback Activation of the TGF-beta Signaling
            Pathway to Maintain Liver Cancer Stemness and Drug Resistance
  JOURNAL   Adv Sci (Weinh) 11 (34), e2402327 (2024)
   PUBMED   38981014
  REMARK    GeneRIF: Stabilization of TGF-beta Receptor 1 by a
            Receptor-Associated Adaptor Dictates Feedback Activation of the
            TGF-beta Signaling Pathway to Maintain Liver Cancer Stemness and
            Drug Resistance.
REFERENCE   3  (bases 1 to 6345)
  AUTHORS   Cui,N., Liu,C., Tang,X., Song,L., Xiao,Z., Wang,C., Wu,Y., Zhou,Y.,
            Peng,C., Liu,Y., Zheng,L., Liu,X., Huang,K. and Chen,H.
  TITLE     ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD
            transition by promoting TGFbetaR1 ISGylation
  JOURNAL   Theranostics 14 (11), 4536-4553 (2024)
   PUBMED   39113797
  REMARK    GeneRIF: ISG15 accelerates acute kidney injury and the subsequent
            AKI-to-CKD transition by promoting TGFbetaR1 ISGylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6345)
  AUTHORS   Du,Q., Zhang,D., Zhuang,Y., Xia,Q., Wen,T. and Jia,H.
  TITLE     The Molecular Genetics of Marfan Syndrome
  JOURNAL   Int J Med Sci 18 (13), 2752-2766 (2021)
   PUBMED   34220303
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6345)
  AUTHORS   Tzavlaki,K. and Moustakas,A.
  TITLE     TGF-beta Signaling
  JOURNAL   Biomolecules 10 (3), 487 (2020)
   PUBMED   32210029
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6345)
  AUTHORS   Vander Ark,A., Cao,J. and Li,X.
  TITLE     TGF-beta receptors: In and beyond TGF-beta signaling
  JOURNAL   Cell Signal 52, 112-120 (2018)
   PUBMED   30184463
  REMARK    Review article
REFERENCE   7  (bases 1 to 6345)
  AUTHORS   Loeys,B.L. and Dietz,H.C.
  TITLE     Loeys-Dietz Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301312
REFERENCE   8  (bases 1 to 6345)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
REFERENCE   9  (bases 1 to 6345)
  AUTHORS   Cheifetz,S., Bellon,T., Cales,C., Vera,S., Bernabeu,C., Massague,J.
            and Letarte,M.
  TITLE     Endoglin is a component of the transforming growth factor-beta
            receptor system in human endothelial cells
  JOURNAL   J Biol Chem 267 (27), 19027-19030 (1992)
   PUBMED   1326540
REFERENCE   10 (bases 1 to 6345)
  AUTHORS   Massague,J.
  TITLE     Receptors for the TGF-beta family
  JOURNAL   Cell 69 (7), 1067-1070 (1992)
   PUBMED   1319842
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162427.24.
            
            Summary: The protein encoded by this gene forms a heteromeric
            complex with type II TGF-beta receptors when bound to TGF-beta,
            transducing the TGF-beta signal from the cell surface to the
            cytoplasm. The encoded protein is a serine/threonine protein
            kinase. Mutations in this gene have been associated with
            Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.306194.1,
                                           SRR14038193.2441506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL162427.24        88215-88257         c
            44-289              AL162427.24        64240-64485         c
            290-520             AL162427.24        60601-60831         c
            521-751             AL162427.24        55251-55481         c
            752-919             AL162427.24        50637-50804         c
            920-1076            AL162427.24        48452-48608         c
            1077-1201           AL162427.24        46731-46855         c
            1202-1332           AL162427.24        45556-45686         c
            1333-6345           AL162427.24        39148-44160         c
FEATURES             Location/Qualifiers
     source          1..6345
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..6345
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="transforming growth factor beta receptor 1"
                     /db_xref="GeneID:7046"
                     /db_xref="HGNC:HGNC:11772"
                     /db_xref="MIM:190181"
     exon            1..43
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            44..289
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1458
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /EC_number="2.7.11.30"
                     /note="isoform 7 is encoded by transcript variant 19;
                     activin A receptor type II-like kinase, 53kDa; TGF-beta
                     receptor type-1; activin receptor-like kinase 5;
                     serine/threonine-protein kinase receptor R4; transforming
                     growth factor beta receptor I; transforming growth
                     factor-beta receptor type I; activin A receptor type
                     II-like protein kinase of 53kD; mutant transforming growth
                     factor beta receptor I"
                     /codon_start=1
                     /product="TGF-beta receptor type-1 isoform 7"
                     /protein_id="NP_001394362.1"
                     /db_xref="GeneID:7046"
                     /db_xref="HGNC:HGNC:11772"
                     /db_xref="MIM:190181"
                     /translation="MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPT
                     TVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFI
                     SEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEV
                     AVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGS
                     LFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNG
                     TCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYA
                     MGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSC
                     EALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"
     exon            290..520
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..751
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..919
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1076
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1201
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1332
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..6345
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5782..5787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: AATAAA"
     polyA_site      5802
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="major polyA site"
     regulatory      5823..5828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: AATAAA"
     polyA_site      5843
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
     regulatory      6211..6216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: ATTAAA"
     polyA_site      6236
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
     regulatory      6324..6329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: ATTAAA"
     polyA_site      6345
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
ORIGIN      
        1 agttacaaag ggccggagcg aggccgccgc ggcggctagg gagcgttaca gtgtttctgc
       61 cacctctgta caaaagacaa ttttacttgt gtgacagatg ggctctgctt tgtctctgtc
      121 acagagacca cagacaaagt tatacacaac agcatgtgta tagctgaaat tgacttaatt
      181 cctcgagata ggccgtttgt atgtgcaccc tcttcaaaaa ctgggtctgt gactacaaca
      241 tattgctgca atcaggacca ttgcaataaa atagaacttc caactactgt aaagtcatca
      301 cctggccttg gtcctgtgga actggcagct gtcattgctg gaccagtgtg cttcgtctgc
      361 atctcactca tgttgatggt ctatatctgc cacaaccgca ctgtcattca ccatcgagtg
      421 ccaaatgaag aggacccttc attagatcgc ccttttattt cagagggtac tacgttgaaa
      481 gacttaattt atgatatgac aacgtcaggt tctggctcag gtttaccatt gcttgttcag
      541 agaacaattg cgagaactat tgtgttacaa gaaagcattg gcaaaggtcg atttggagaa
      601 gtttggagag gaaagtggcg gggagaagaa gttgctgtta agatattctc ctctagagaa
      661 gaacgttcgt ggttccgtga ggcagagatt tatcaaactg taatgttacg tcatgaaaac
      721 atcctgggat ttatagcagc agacaataaa gacaatggta cttggactca gctctggttg
      781 gtgtcagatt atcatgagca tggatccctt tttgattact taaacagata cacagttact
      841 gtggaaggaa tgataaaact tgctctgtcc acggcgagcg gtcttgccca tcttcacatg
      901 gagattgttg gtacccaagg aaagccagcc attgctcata gagatttgaa atcaaagaat
      961 atcttggtaa agaagaatgg aacttgctgt attgcagact taggactggc agtaagacat
     1021 gattcagcca cagataccat tgatattgct ccaaaccaca gagtgggaac aaaaaggtac
     1081 atggcccctg aagttctcga tgattccata aatatgaaac attttgaatc cttcaaacgt
     1141 gctgacatct atgcaatggg cttagtattc tgggaaattg ctcgacgatg ttccattggt
     1201 ggaattcatg aagattacca actgccttat tatgatcttg taccttctga cccatcagtt
     1261 gaagaaatga gaaaagttgt ttgtgaacag aagttaaggc caaatatccc aaacagatgg
     1321 cagagctgtg aagccttgag agtaatggct aaaattatga gagaatgttg gtatgccaat
     1381 ggagcagcta ggcttacagc attgcggatt aagaaaacat tatcgcaact cagtcaacag
     1441 gaaggcatca aaatgtaatt ctacagcttt gcctgaactc tccttttttc ttcagatctg
     1501 ctcctgggtt ttaatttggg aggtcaattg ttctacctca ctgagaggga acagaaggat
     1561 attgcttcct tttgcagcag tgtaataaag tcaattaaaa acttcccagg atttctttgg
     1621 acccaggaaa cagccatgtg ggtcctttct gtgcactatg aacgcttctt tcccaggaca
     1681 gaaaatgtgt agtctacctt tattttttat taacaaaact tgttttttaa aaagatgatt
     1741 gctggtctta actttaggta actctgctgt gctggagatc atctttaagg gcaaaggagt
     1801 tggattgctg aattacaatg aaacatgtct tattactaaa gaaagtgatt tactcctggt
     1861 tagtacattc tcagaggatt ctgaaccact agagtttcct tgattcagac tttgaatgta
     1921 ctgttctata gtttttcagg atcttaaaac taacacttat aaaactctta tcttgagtct
     1981 aaaaatgacc tcatatagta gtgaggaaca taattcatgc aattgtattt tgtatactat
     2041 tattgttctt tcacttattc agaacattac atgccttcaa aatgggattg tactatacca
     2101 gtaagtgcca cttctgtgtc tttctaatgg aaatgagtag aattgctgaa agtctctatg
     2161 ttaaaaccta tagtgtttga attcaaaaag cttatttatc tgggtaaccc aaactttttc
     2221 tgttttgttt ttggaagggt ttttgtggta tgtcatttgg tattctattc tgaaaatgcc
     2281 tttctcctac caaaatgtgc ttaagccact aaagaaatga agtggcatta attagtaaat
     2341 tattagcatg gtcatgtttg aatattctca catcaagctt ttgcatttta attgtgttgt
     2401 ctaagtatac ttttaaaaaa tcaagtggca ctctagatgc ttatagtact ttaatatttg
     2461 tagcatacag actaattttt ctaaaaggga aagtctgtct agctgcttgt gaaaagttat
     2521 gtggtattct gtaagccatt tttttcttta tctgttcaaa gacttatttt ttaagacatg
     2581 aattacattt aaaattagaa tatggttaat attaaataat aggccttttt ctaggaaggc
     2641 gaaggtagtt aataatttga atagataaca gatgtgcaag aaagtcacat ttgttatgta
     2701 tgtaggagta aacgttcggt ggatcctctg tctttgtaac tgaggttaga gctagtgtgg
     2761 ttttgaggtc tcactacact ttgaggaagg cagcttttaa ttcagtgttt ccttatgtgt
     2821 gcgtacattg caactgctta catgtaattt atgtaatgca ttcagtgcac ccttgttact
     2881 tgggagaggt ggtagctaaa gaacattctg agtataggtt tttctccatt tacagatgtc
     2941 tttggtcaaa tattgaaagc aaacttgtca tggtcttctt acattaagtt gaaactagct
     3001 tataataact ggtttttact tccaatgcta tgaagtctct gcagggcttt tacagttttc
     3061 gaagtccttt tatcactgtg atcttattct gaggggagaa aaaactatca tagctctgag
     3121 gcaagacttc gactttatag tgctatcagt tccccgatac agggtcagag taacccatac
     3181 agtattttgg tcaggaagag aaagtggcca tttacactga atgagttgca ttctgataat
     3241 gtcttatctc ttatacgtag aataaatttg aaagactatt tgatcttaaa accaaagtaa
     3301 ttttagaatg agtgacatat tacataggaa tttagtgtca atttcatgtg tttaaaaaca
     3361 tcatgggaaa aatgcttaga ggttactatt ttgactacaa agttgagttt ttttctgtag
     3421 ttaccataat ttcattgaag caaatgaatg agtttgagag gtttgttttt atagttgtgt
     3481 tgtattactt gtttaataat aatctctaat tctgtgatca ggtacttttt ttgtgggggt
     3541 tttttttttg tttttttttt tttgttgttg tttttgggcc atttctaagc ctaccagatc
     3601 tgctttatga aatccagggg accaatgcat tttatcacta aaactatttt tatataattt
     3661 taagaatata ccaaaagttg tctgatttaa agttgtaata catgatttct cactttcatg
     3721 taaggttatc cacttttgct gaagatattt tttattgaat caaagattga gttacaatta
     3781 tacttttctt acctaagtgg ataaaatgta cttttgatga atcagggaat ttttttaaag
     3841 ttggagttta gttctaaatt gactttacgt attactgcag ttaattcctt ttttggctag
     3901 ggatggtttg ataaaccaca attggctgat attgaaaatg aaagaaactt aaaaggtggg
     3961 atggatcatg attactgtcg ataactgcag ataaatttga ttagagtaat aattttgtca
     4021 tttaaaaaca cagttgttta tactgcccat cctaggatgc tcaccttcca agattcaacg
     4081 tggctaaaac atcttctggt aaattgtgcg tccatattca ttttgtcagt agccaggaga
     4141 aatggggatg ggggaaatac gacttagtga ggcatagaca tccctggtcc atcctttctg
     4201 tctccagctg tttcttggaa cctgctctcc tgcttgctgg tccctgacgc agagaccgtt
     4261 gcctccccca cagccgtttg actgaaggct gctctggaga cctagagtaa aacggctgat
     4321 ggaagttgtg ggacccactt ccatttcctt cagtcattag aggtggaagg gaggggtctc
     4381 caagtttgga gattgagcag atgaggcttg ggatgcccct gctttgactt cagccatgga
     4441 tgaggagtgg gatggcagca aggtggctcc tgtggcagtg gagttgtgcc agaaacagtg
     4501 gccagttgta tcgcctataa gacagggtaa ggtctgaaga gctgagcctg taattctgct
     4561 gtaataatga tagtgctcaa gaagtgcctt gagttggtgt acagtgccat ggccatcaag
     4621 aatcccagat ttcaggtttt attacaaaat gtaagtggtc acttggcgat tttgtagtac
     4681 atgcatgagt tacctttttt ctctatgtct gagaactgtc agattaaaac aagatggcaa
     4741 agagatcgtt agagtgcaca acaaaatcac tatcccatta gacacatcat caaaagctta
     4801 tttttattct tgcactggaa gaatcgtaag tcaactgttt cttgaccatg gcagtgttct
     4861 ggctccaaat ggtagtgatt ccaaataatg gttctgttaa cactttggca gaaaatgcca
     4921 gctcagatat tttgagatac taaggattat ctttggacat gtactgcagc ttcttgtctc
     4981 tgttttggat tactggaata cccatgggcc ctctcaagag tgctggactt ctaggacatt
     5041 aagatgattg tcagtacatt aaacttttca atcccattat gcaatcttgt ttgtaaatgt
     5101 aaacttctaa aaatatggtt aataacattc aacctgttta ttacaactta aaaggaactt
     5161 cagtgaattt gtttttattt tttaacaaga tttgtgaact gaatatcatg aaccatgttt
     5221 tgatacccct ttttcacgtt gtgccaacgg aatagggtgt ttgatatttc ttcatatgtt
     5281 aaggagatgc ttcaaaatgt caattgcttt aaacttaaat tacctctcaa gagaccaagg
     5341 tacatttacc tcattgtgta tataatgttt aatatttgtc agagcattct ccaggtttgc
     5401 agttttattt ctataaagta tgggtattat gttgctcagt tactcaaatg gtactgtatt
     5461 gtttatattt gtaccccaaa taacatcgtc tgtactttct gttttctgta ttgtatttgt
     5521 gcaggattct ttaggcttta tcagtgtaat ctctgccttt taagatatgt acagaaaatg
     5581 tccatataaa tttccattga agtcgaatga tactgagaag cctgtaaaga ggagaaaaaa
     5641 acataagctg tgtttcccca taagtttttt taaattgtat attgtatttg tagtaatatt
     5701 ccaaaagaat gtaaatagga aatagaagag tgatgcttat gttaagtcct aacactacag
     5761 tagaagaatg gaagcagtgc aaataaatta catttttccc aagtgccagt ggcatatttt
     5821 aaaataaagt gtatacgttg gaatgagtca tgccatatgt agttgctgta gatggcaact
     5881 agaacctttg agttacaaga gtctttagaa gttttctaac cctgcctagt gcaagttaca
     5941 atattatagc gtgttcgggg agtgccctcc tgtctgcagg tgtgtctctg tgcctggggg
     6001 cttttctcca catgcttagg ggtgtgggtc ttccattggg gcatgatgga cctgtctaca
     6061 ggtgatctct gttgcctttg ggtcagcaca tttgttagtc tcctgggggt gaaaacttgg
     6121 cttacaagag aactggaaaa atgatgagat gtggtcccca aacccttgat tgactctggg
     6181 gaggggcttt gtgaatagga ttgctctcac attaaagata gttacttcaa tttgaaggct
     6241 ggatttaggg attttttttt ttccttataa caaagacatc accaggatat gaagcttttg
     6301 ttgaaagttg gaaaaaaagt gaaattaaag acattcccag acaaa
//
