LOCUS       NM_001407426            6597 bp    mRNA    linear   PRI 14-OCT-2024
DEFINITION  Homo sapiens transforming growth factor beta receptor 1 (TGFBR1),
            transcript variant 13, mRNA.
ACCESSION   NM_001407426
VERSION     NM_001407426.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6597)
  AUTHORS   Huang,W., Zhang,Z., Li,X., Zheng,Q., Wu,C., Liu,L., Chen,Y.,
            Zhang,J. and Jiang,X.
  TITLE     CD9 promotes TbetaR2-TbetaR1 association driving the transition of
            human dermal fibroblasts to myofibroblast under hypoxia
  JOURNAL   Mol Med 30 (1), 162 (2024)
   PUBMED   39333849
  REMARK    GeneRIF: CD9 promotes TbetaR2-TbetaR1 association driving the
            transition of human dermal fibroblasts to myofibroblast under
            hypoxia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6597)
  AUTHORS   Liu,K., Tian,F., Chen,X., Liu,B., Tian,S., Hou,Y., Wang,L., Han,M.,
            Peng,S., Tan,Y., Pan,Y., Chu,Z., Li,J., Che,L., Chen,D., Wen,L.,
            Qin,Z., Li,X., Xiang,J., Bian,X.W., Liu,Q., Ye,X., Wang,T. and
            Wang,B.
  TITLE     Stabilization of TGF-beta Receptor 1 by a Receptor-Associated
            Adaptor Dictates Feedback Activation of the TGF-beta Signaling
            Pathway to Maintain Liver Cancer Stemness and Drug Resistance
  JOURNAL   Adv Sci (Weinh) 11 (34), e2402327 (2024)
   PUBMED   38981014
  REMARK    GeneRIF: Stabilization of TGF-beta Receptor 1 by a
            Receptor-Associated Adaptor Dictates Feedback Activation of the
            TGF-beta Signaling Pathway to Maintain Liver Cancer Stemness and
            Drug Resistance.
REFERENCE   3  (bases 1 to 6597)
  AUTHORS   Cui,N., Liu,C., Tang,X., Song,L., Xiao,Z., Wang,C., Wu,Y., Zhou,Y.,
            Peng,C., Liu,Y., Zheng,L., Liu,X., Huang,K. and Chen,H.
  TITLE     ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD
            transition by promoting TGFbetaR1 ISGylation
  JOURNAL   Theranostics 14 (11), 4536-4553 (2024)
   PUBMED   39113797
  REMARK    GeneRIF: ISG15 accelerates acute kidney injury and the subsequent
            AKI-to-CKD transition by promoting TGFbetaR1 ISGylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6597)
  AUTHORS   Du,Q., Zhang,D., Zhuang,Y., Xia,Q., Wen,T. and Jia,H.
  TITLE     The Molecular Genetics of Marfan Syndrome
  JOURNAL   Int J Med Sci 18 (13), 2752-2766 (2021)
   PUBMED   34220303
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6597)
  AUTHORS   Tzavlaki,K. and Moustakas,A.
  TITLE     TGF-beta Signaling
  JOURNAL   Biomolecules 10 (3), 487 (2020)
   PUBMED   32210029
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6597)
  AUTHORS   Vander Ark,A., Cao,J. and Li,X.
  TITLE     TGF-beta receptors: In and beyond TGF-beta signaling
  JOURNAL   Cell Signal 52, 112-120 (2018)
   PUBMED   30184463
  REMARK    Review article
REFERENCE   7  (bases 1 to 6597)
  AUTHORS   Loeys,B.L. and Dietz,H.C.
  TITLE     Loeys-Dietz Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301312
REFERENCE   8  (bases 1 to 6597)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
REFERENCE   9  (bases 1 to 6597)
  AUTHORS   Cheifetz,S., Bellon,T., Cales,C., Vera,S., Bernabeu,C., Massague,J.
            and Letarte,M.
  TITLE     Endoglin is a component of the transforming growth factor-beta
            receptor system in human endothelial cells
  JOURNAL   J Biol Chem 267 (27), 19027-19030 (1992)
   PUBMED   1326540
REFERENCE   10 (bases 1 to 6597)
  AUTHORS   Massague,J.
  TITLE     Receptors for the TGF-beta family
  JOURNAL   Cell 69 (7), 1067-1070 (1992)
   PUBMED   1319842
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162427.24.
            
            Summary: The protein encoded by this gene forms a heteromeric
            complex with type II TGF-beta receptors when bound to TGF-beta,
            transducing the TGF-beta signal from the cell surface to the
            cytoplasm. The encoded protein is a serine/threonine protein
            kinase. Mutations in this gene have been associated with
            Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2589580.1,
                                           SRR14038191.2066217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AL162427.24        88038-88227         c
            191-295             AL162427.24        86200-86304         c
            296-541             AL162427.24        64240-64485         c
            542-772             AL162427.24        60601-60831         c
            773-1003            AL162427.24        55251-55481         c
            1004-1171           AL162427.24        50637-50804         c
            1172-1328           AL162427.24        48452-48608         c
            1329-1453           AL162427.24        46731-46855         c
            1454-1584           AL162427.24        45556-45686         c
            1585-6597           AL162427.24        39148-44160         c
FEATURES             Location/Qualifiers
     source          1..6597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..6597
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="transforming growth factor beta receptor 1"
                     /db_xref="GeneID:7046"
                     /db_xref="HGNC:HGNC:11772"
                     /db_xref="MIM:190181"
     exon            1..190
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..295
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..541
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             406..1710
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /EC_number="2.7.11.30"
                     /note="isoform 7 is encoded by transcript variant 13;
                     activin A receptor type II-like kinase, 53kDa; TGF-beta
                     receptor type-1; activin receptor-like kinase 5;
                     serine/threonine-protein kinase receptor R4; transforming
                     growth factor beta receptor I; transforming growth
                     factor-beta receptor type I; activin A receptor type
                     II-like protein kinase of 53kD; mutant transforming growth
                     factor beta receptor I"
                     /codon_start=1
                     /product="TGF-beta receptor type-1 isoform 7"
                     /protein_id="NP_001394355.1"
                     /db_xref="GeneID:7046"
                     /db_xref="HGNC:HGNC:11772"
                     /db_xref="MIM:190181"
                     /translation="MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPT
                     TVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFI
                     SEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEV
                     AVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGS
                     LFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNG
                     TCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYA
                     MGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSC
                     EALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"
     exon            542..772
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1003
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1171
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1328
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1453
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1584
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..6597
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6034..6039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: AATAAA"
     polyA_site      6054
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="major polyA site"
     regulatory      6075..6080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: AATAAA"
     polyA_site      6095
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
     regulatory      6463..6468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: ATTAAA"
     polyA_site      6488
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
     regulatory      6576..6581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: ATTAAA"
     polyA_site      6597
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
ORIGIN      
        1 ggcggctagg gaggtggggc gaggcgaggt ttgctggggt gaggcagcgg cgcggccggg
       61 ccgggccggg ccacaggcgg tggcggcggg accatggagg cggcggtcgc tgctccgcgt
      121 ccccggctgc tcctcctcgt gctggcggcg gcggcggcgg cggcggcggc gctgctcccg
      181 ggggcgacgg aagtagcaca agaagcgttc atgtattcaa gtaacagtag tggacttagt
      241 tgaagacaca gaacattgct cagtccatgt cctggaggag tttacagtct ccatgcgtta
      301 cagtgtttct gccacctctg tacaaaagac aattttactt gtgtgacaga tgggctctgc
      361 tttgtctctg tcacagagac cacagacaaa gttatacaca acagcatgtg tatagctgaa
      421 attgacttaa ttcctcgaga taggccgttt gtatgtgcac cctcttcaaa aactgggtct
      481 gtgactacaa catattgctg caatcaggac cattgcaata aaatagaact tccaactact
      541 gtaaagtcat cacctggcct tggtcctgtg gaactggcag ctgtcattgc tggaccagtg
      601 tgcttcgtct gcatctcact catgttgatg gtctatatct gccacaaccg cactgtcatt
      661 caccatcgag tgccaaatga agaggaccct tcattagatc gcccttttat ttcagagggt
      721 actacgttga aagacttaat ttatgatatg acaacgtcag gttctggctc aggtttacca
      781 ttgcttgttc agagaacaat tgcgagaact attgtgttac aagaaagcat tggcaaaggt
      841 cgatttggag aagtttggag aggaaagtgg cggggagaag aagttgctgt taagatattc
      901 tcctctagag aagaacgttc gtggttccgt gaggcagaga tttatcaaac tgtaatgtta
      961 cgtcatgaaa acatcctggg atttatagca gcagacaata aagacaatgg tacttggact
     1021 cagctctggt tggtgtcaga ttatcatgag catggatccc tttttgatta cttaaacaga
     1081 tacacagtta ctgtggaagg aatgataaaa cttgctctgt ccacggcgag cggtcttgcc
     1141 catcttcaca tggagattgt tggtacccaa ggaaagccag ccattgctca tagagatttg
     1201 aaatcaaaga atatcttggt aaagaagaat ggaacttgct gtattgcaga cttaggactg
     1261 gcagtaagac atgattcagc cacagatacc attgatattg ctccaaacca cagagtggga
     1321 acaaaaaggt acatggcccc tgaagttctc gatgattcca taaatatgaa acattttgaa
     1381 tccttcaaac gtgctgacat ctatgcaatg ggcttagtat tctgggaaat tgctcgacga
     1441 tgttccattg gtggaattca tgaagattac caactgcctt attatgatct tgtaccttct
     1501 gacccatcag ttgaagaaat gagaaaagtt gtttgtgaac agaagttaag gccaaatatc
     1561 ccaaacagat ggcagagctg tgaagccttg agagtaatgg ctaaaattat gagagaatgt
     1621 tggtatgcca atggagcagc taggcttaca gcattgcgga ttaagaaaac attatcgcaa
     1681 ctcagtcaac aggaaggcat caaaatgtaa ttctacagct ttgcctgaac tctccttttt
     1741 tcttcagatc tgctcctggg ttttaatttg ggaggtcaat tgttctacct cactgagagg
     1801 gaacagaagg atattgcttc cttttgcagc agtgtaataa agtcaattaa aaacttccca
     1861 ggatttcttt ggacccagga aacagccatg tgggtccttt ctgtgcacta tgaacgcttc
     1921 tttcccagga cagaaaatgt gtagtctacc tttatttttt attaacaaaa cttgtttttt
     1981 aaaaagatga ttgctggtct taactttagg taactctgct gtgctggaga tcatctttaa
     2041 gggcaaagga gttggattgc tgaattacaa tgaaacatgt cttattacta aagaaagtga
     2101 tttactcctg gttagtacat tctcagagga ttctgaacca ctagagtttc cttgattcag
     2161 actttgaatg tactgttcta tagtttttca ggatcttaaa actaacactt ataaaactct
     2221 tatcttgagt ctaaaaatga cctcatatag tagtgaggaa cataattcat gcaattgtat
     2281 tttgtatact attattgttc tttcacttat tcagaacatt acatgccttc aaaatgggat
     2341 tgtactatac cagtaagtgc cacttctgtg tctttctaat ggaaatgagt agaattgctg
     2401 aaagtctcta tgttaaaacc tatagtgttt gaattcaaaa agcttattta tctgggtaac
     2461 ccaaactttt tctgttttgt ttttggaagg gtttttgtgg tatgtcattt ggtattctat
     2521 tctgaaaatg cctttctcct accaaaatgt gcttaagcca ctaaagaaat gaagtggcat
     2581 taattagtaa attattagca tggtcatgtt tgaatattct cacatcaagc ttttgcattt
     2641 taattgtgtt gtctaagtat acttttaaaa aatcaagtgg cactctagat gcttatagta
     2701 ctttaatatt tgtagcatac agactaattt ttctaaaagg gaaagtctgt ctagctgctt
     2761 gtgaaaagtt atgtggtatt ctgtaagcca tttttttctt tatctgttca aagacttatt
     2821 ttttaagaca tgaattacat ttaaaattag aatatggtta atattaaata ataggccttt
     2881 ttctaggaag gcgaaggtag ttaataattt gaatagataa cagatgtgca agaaagtcac
     2941 atttgttatg tatgtaggag taaacgttcg gtggatcctc tgtctttgta actgaggtta
     3001 gagctagtgt ggttttgagg tctcactaca ctttgaggaa ggcagctttt aattcagtgt
     3061 ttccttatgt gtgcgtacat tgcaactgct tacatgtaat ttatgtaatg cattcagtgc
     3121 acccttgtta cttgggagag gtggtagcta aagaacattc tgagtatagg tttttctcca
     3181 tttacagatg tctttggtca aatattgaaa gcaaacttgt catggtcttc ttacattaag
     3241 ttgaaactag cttataataa ctggttttta cttccaatgc tatgaagtct ctgcagggct
     3301 tttacagttt tcgaagtcct tttatcactg tgatcttatt ctgaggggag aaaaaactat
     3361 catagctctg aggcaagact tcgactttat agtgctatca gttccccgat acagggtcag
     3421 agtaacccat acagtatttt ggtcaggaag agaaagtggc catttacact gaatgagttg
     3481 cattctgata atgtcttatc tcttatacgt agaataaatt tgaaagacta tttgatctta
     3541 aaaccaaagt aattttagaa tgagtgacat attacatagg aatttagtgt caatttcatg
     3601 tgtttaaaaa catcatggga aaaatgctta gaggttacta ttttgactac aaagttgagt
     3661 ttttttctgt agttaccata atttcattga agcaaatgaa tgagtttgag aggtttgttt
     3721 ttatagttgt gttgtattac ttgtttaata ataatctcta attctgtgat caggtacttt
     3781 ttttgtgggg gttttttttt tgtttttttt tttttgttgt tgtttttggg ccatttctaa
     3841 gcctaccaga tctgctttat gaaatccagg ggaccaatgc attttatcac taaaactatt
     3901 tttatataat tttaagaata taccaaaagt tgtctgattt aaagttgtaa tacatgattt
     3961 ctcactttca tgtaaggtta tccacttttg ctgaagatat tttttattga atcaaagatt
     4021 gagttacaat tatacttttc ttacctaagt ggataaaatg tacttttgat gaatcaggga
     4081 atttttttaa agttggagtt tagttctaaa ttgactttac gtattactgc agttaattcc
     4141 ttttttggct agggatggtt tgataaacca caattggctg atattgaaaa tgaaagaaac
     4201 ttaaaaggtg ggatggatca tgattactgt cgataactgc agataaattt gattagagta
     4261 ataattttgt catttaaaaa cacagttgtt tatactgccc atcctaggat gctcaccttc
     4321 caagattcaa cgtggctaaa acatcttctg gtaaattgtg cgtccatatt cattttgtca
     4381 gtagccagga gaaatgggga tgggggaaat acgacttagt gaggcataga catccctggt
     4441 ccatcctttc tgtctccagc tgtttcttgg aacctgctct cctgcttgct ggtccctgac
     4501 gcagagaccg ttgcctcccc cacagccgtt tgactgaagg ctgctctgga gacctagagt
     4561 aaaacggctg atggaagttg tgggacccac ttccatttcc ttcagtcatt agaggtggaa
     4621 gggaggggtc tccaagtttg gagattgagc agatgaggct tgggatgccc ctgctttgac
     4681 ttcagccatg gatgaggagt gggatggcag caaggtggct cctgtggcag tggagttgtg
     4741 ccagaaacag tggccagttg tatcgcctat aagacagggt aaggtctgaa gagctgagcc
     4801 tgtaattctg ctgtaataat gatagtgctc aagaagtgcc ttgagttggt gtacagtgcc
     4861 atggccatca agaatcccag atttcaggtt ttattacaaa atgtaagtgg tcacttggcg
     4921 attttgtagt acatgcatga gttacctttt ttctctatgt ctgagaactg tcagattaaa
     4981 acaagatggc aaagagatcg ttagagtgca caacaaaatc actatcccat tagacacatc
     5041 atcaaaagct tatttttatt cttgcactgg aagaatcgta agtcaactgt ttcttgacca
     5101 tggcagtgtt ctggctccaa atggtagtga ttccaaataa tggttctgtt aacactttgg
     5161 cagaaaatgc cagctcagat attttgagat actaaggatt atctttggac atgtactgca
     5221 gcttcttgtc tctgttttgg attactggaa tacccatggg ccctctcaag agtgctggac
     5281 ttctaggaca ttaagatgat tgtcagtaca ttaaactttt caatcccatt atgcaatctt
     5341 gtttgtaaat gtaaacttct aaaaatatgg ttaataacat tcaacctgtt tattacaact
     5401 taaaaggaac ttcagtgaat ttgtttttat tttttaacaa gatttgtgaa ctgaatatca
     5461 tgaaccatgt tttgataccc ctttttcacg ttgtgccaac ggaatagggt gtttgatatt
     5521 tcttcatatg ttaaggagat gcttcaaaat gtcaattgct ttaaacttaa attacctctc
     5581 aagagaccaa ggtacattta cctcattgtg tatataatgt ttaatatttg tcagagcatt
     5641 ctccaggttt gcagttttat ttctataaag tatgggtatt atgttgctca gttactcaaa
     5701 tggtactgta ttgtttatat ttgtacccca aataacatcg tctgtacttt ctgttttctg
     5761 tattgtattt gtgcaggatt ctttaggctt tatcagtgta atctctgcct tttaagatat
     5821 gtacagaaaa tgtccatata aatttccatt gaagtcgaat gatactgaga agcctgtaaa
     5881 gaggagaaaa aaacataagc tgtgtttccc cataagtttt tttaaattgt atattgtatt
     5941 tgtagtaata ttccaaaaga atgtaaatag gaaatagaag agtgatgctt atgttaagtc
     6001 ctaacactac agtagaagaa tggaagcagt gcaaataaat tacatttttc ccaagtgcca
     6061 gtggcatatt ttaaaataaa gtgtatacgt tggaatgagt catgccatat gtagttgctg
     6121 tagatggcaa ctagaacctt tgagttacaa gagtctttag aagttttcta accctgccta
     6181 gtgcaagtta caatattata gcgtgttcgg ggagtgccct cctgtctgca ggtgtgtctc
     6241 tgtgcctggg ggcttttctc cacatgctta ggggtgtggg tcttccattg gggcatgatg
     6301 gacctgtcta caggtgatct ctgttgcctt tgggtcagca catttgttag tctcctgggg
     6361 gtgaaaactt ggcttacaag agaactggaa aaatgatgag atgtggtccc caaacccttg
     6421 attgactctg gggaggggct ttgtgaatag gattgctctc acattaaaga tagttacttc
     6481 aatttgaagg ctggatttag ggattttttt ttttccttat aacaaagaca tcaccaggat
     6541 atgaagcttt tgttgaaagt tggaaaaaaa gtgaaattaa agacattccc agacaaa
//
