LOCUS       NM_001407423            6397 bp    mRNA    linear   PRI 14-OCT-2024
DEFINITION  Homo sapiens transforming growth factor beta receptor 1 (TGFBR1),
            transcript variant 10, mRNA.
ACCESSION   NM_001407423
VERSION     NM_001407423.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6397)
  AUTHORS   Huang,W., Zhang,Z., Li,X., Zheng,Q., Wu,C., Liu,L., Chen,Y.,
            Zhang,J. and Jiang,X.
  TITLE     CD9 promotes TbetaR2-TbetaR1 association driving the transition of
            human dermal fibroblasts to myofibroblast under hypoxia
  JOURNAL   Mol Med 30 (1), 162 (2024)
   PUBMED   39333849
  REMARK    GeneRIF: CD9 promotes TbetaR2-TbetaR1 association driving the
            transition of human dermal fibroblasts to myofibroblast under
            hypoxia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6397)
  AUTHORS   Liu,K., Tian,F., Chen,X., Liu,B., Tian,S., Hou,Y., Wang,L., Han,M.,
            Peng,S., Tan,Y., Pan,Y., Chu,Z., Li,J., Che,L., Chen,D., Wen,L.,
            Qin,Z., Li,X., Xiang,J., Bian,X.W., Liu,Q., Ye,X., Wang,T. and
            Wang,B.
  TITLE     Stabilization of TGF-beta Receptor 1 by a Receptor-Associated
            Adaptor Dictates Feedback Activation of the TGF-beta Signaling
            Pathway to Maintain Liver Cancer Stemness and Drug Resistance
  JOURNAL   Adv Sci (Weinh) 11 (34), e2402327 (2024)
   PUBMED   38981014
  REMARK    GeneRIF: Stabilization of TGF-beta Receptor 1 by a
            Receptor-Associated Adaptor Dictates Feedback Activation of the
            TGF-beta Signaling Pathway to Maintain Liver Cancer Stemness and
            Drug Resistance.
REFERENCE   3  (bases 1 to 6397)
  AUTHORS   Cui,N., Liu,C., Tang,X., Song,L., Xiao,Z., Wang,C., Wu,Y., Zhou,Y.,
            Peng,C., Liu,Y., Zheng,L., Liu,X., Huang,K. and Chen,H.
  TITLE     ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD
            transition by promoting TGFbetaR1 ISGylation
  JOURNAL   Theranostics 14 (11), 4536-4553 (2024)
   PUBMED   39113797
  REMARK    GeneRIF: ISG15 accelerates acute kidney injury and the subsequent
            AKI-to-CKD transition by promoting TGFbetaR1 ISGylation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6397)
  AUTHORS   Du,Q., Zhang,D., Zhuang,Y., Xia,Q., Wen,T. and Jia,H.
  TITLE     The Molecular Genetics of Marfan Syndrome
  JOURNAL   Int J Med Sci 18 (13), 2752-2766 (2021)
   PUBMED   34220303
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6397)
  AUTHORS   Tzavlaki,K. and Moustakas,A.
  TITLE     TGF-beta Signaling
  JOURNAL   Biomolecules 10 (3), 487 (2020)
   PUBMED   32210029
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6397)
  AUTHORS   Vander Ark,A., Cao,J. and Li,X.
  TITLE     TGF-beta receptors: In and beyond TGF-beta signaling
  JOURNAL   Cell Signal 52, 112-120 (2018)
   PUBMED   30184463
  REMARK    Review article
REFERENCE   7  (bases 1 to 6397)
  AUTHORS   Loeys,B.L. and Dietz,H.C.
  TITLE     Loeys-Dietz Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301312
REFERENCE   8  (bases 1 to 6397)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
REFERENCE   9  (bases 1 to 6397)
  AUTHORS   Cheifetz,S., Bellon,T., Cales,C., Vera,S., Bernabeu,C., Massague,J.
            and Letarte,M.
  TITLE     Endoglin is a component of the transforming growth factor-beta
            receptor system in human endothelial cells
  JOURNAL   J Biol Chem 267 (27), 19027-19030 (1992)
   PUBMED   1326540
REFERENCE   10 (bases 1 to 6397)
  AUTHORS   Massague,J.
  TITLE     Receptors for the TGF-beta family
  JOURNAL   Cell 69 (7), 1067-1070 (1992)
   PUBMED   1319842
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162427.24.
            
            Summary: The protein encoded by this gene forms a heteromeric
            complex with type II TGF-beta receptors when bound to TGF-beta,
            transducing the TGF-beta signal from the cell surface to the
            cytoplasm. The encoded protein is a serine/threonine protein
            kinase. Mutations in this gene have been associated with
            Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14478891.619757.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AL162427.24        89599-89693         c
            96-341              AL162427.24        64240-64485         c
            342-572             AL162427.24        60601-60831         c
            573-803             AL162427.24        55251-55481         c
            804-971             AL162427.24        50637-50804         c
            972-1128            AL162427.24        48452-48608         c
            1129-1253           AL162427.24        46731-46855         c
            1254-1384           AL162427.24        45556-45686         c
            1385-6397           AL162427.24        39148-44160         c
FEATURES             Location/Qualifiers
     source          1..6397
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..6397
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="transforming growth factor beta receptor 1"
                     /db_xref="GeneID:7046"
                     /db_xref="HGNC:HGNC:11772"
                     /db_xref="MIM:190181"
     exon            1..95
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            96..341
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1510
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /EC_number="2.7.11.30"
                     /note="isoform 7 is encoded by transcript variant 10;
                     activin A receptor type II-like kinase, 53kDa; TGF-beta
                     receptor type-1; activin receptor-like kinase 5;
                     serine/threonine-protein kinase receptor R4; transforming
                     growth factor beta receptor I; transforming growth
                     factor-beta receptor type I; activin A receptor type
                     II-like protein kinase of 53kD; mutant transforming growth
                     factor beta receptor I"
                     /codon_start=1
                     /product="TGF-beta receptor type-1 isoform 7"
                     /protein_id="NP_001394352.1"
                     /db_xref="GeneID:7046"
                     /db_xref="HGNC:HGNC:11772"
                     /db_xref="MIM:190181"
                     /translation="MCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPT
                     TVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFI
                     SEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEV
                     AVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGS
                     LFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNG
                     TCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYA
                     MGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSC
                     EALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM"
     exon            342..572
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..803
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..971
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1128
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1253
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1384
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..6397
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5834..5839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: AATAAA"
     polyA_site      5854
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="major polyA site"
     regulatory      5875..5880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: AATAAA"
     polyA_site      5895
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
     regulatory      6263..6268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: ATTAAA"
     polyA_site      6288
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
     regulatory      6376..6381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
                     /note="hexamer: ATTAAA"
     polyA_site      6397
                     /gene="TGFBR1"
                     /gene_synonym="AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1;
                     LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1"
ORIGIN      
        1 gagtttgctg ctgaggctgc tggagctgcg gtgtagagca agttgcaggc ctctgagcct
       61 gttggaggtt cagaaaggtt agctgacttg cttaacgtta cagtgtttct gccacctctg
      121 tacaaaagac aattttactt gtgtgacaga tgggctctgc tttgtctctg tcacagagac
      181 cacagacaaa gttatacaca acagcatgtg tatagctgaa attgacttaa ttcctcgaga
      241 taggccgttt gtatgtgcac cctcttcaaa aactgggtct gtgactacaa catattgctg
      301 caatcaggac cattgcaata aaatagaact tccaactact gtaaagtcat cacctggcct
      361 tggtcctgtg gaactggcag ctgtcattgc tggaccagtg tgcttcgtct gcatctcact
      421 catgttgatg gtctatatct gccacaaccg cactgtcatt caccatcgag tgccaaatga
      481 agaggaccct tcattagatc gcccttttat ttcagagggt actacgttga aagacttaat
      541 ttatgatatg acaacgtcag gttctggctc aggtttacca ttgcttgttc agagaacaat
      601 tgcgagaact attgtgttac aagaaagcat tggcaaaggt cgatttggag aagtttggag
      661 aggaaagtgg cggggagaag aagttgctgt taagatattc tcctctagag aagaacgttc
      721 gtggttccgt gaggcagaga tttatcaaac tgtaatgtta cgtcatgaaa acatcctggg
      781 atttatagca gcagacaata aagacaatgg tacttggact cagctctggt tggtgtcaga
      841 ttatcatgag catggatccc tttttgatta cttaaacaga tacacagtta ctgtggaagg
      901 aatgataaaa cttgctctgt ccacggcgag cggtcttgcc catcttcaca tggagattgt
      961 tggtacccaa ggaaagccag ccattgctca tagagatttg aaatcaaaga atatcttggt
     1021 aaagaagaat ggaacttgct gtattgcaga cttaggactg gcagtaagac atgattcagc
     1081 cacagatacc attgatattg ctccaaacca cagagtggga acaaaaaggt acatggcccc
     1141 tgaagttctc gatgattcca taaatatgaa acattttgaa tccttcaaac gtgctgacat
     1201 ctatgcaatg ggcttagtat tctgggaaat tgctcgacga tgttccattg gtggaattca
     1261 tgaagattac caactgcctt attatgatct tgtaccttct gacccatcag ttgaagaaat
     1321 gagaaaagtt gtttgtgaac agaagttaag gccaaatatc ccaaacagat ggcagagctg
     1381 tgaagccttg agagtaatgg ctaaaattat gagagaatgt tggtatgcca atggagcagc
     1441 taggcttaca gcattgcgga ttaagaaaac attatcgcaa ctcagtcaac aggaaggcat
     1501 caaaatgtaa ttctacagct ttgcctgaac tctccttttt tcttcagatc tgctcctggg
     1561 ttttaatttg ggaggtcaat tgttctacct cactgagagg gaacagaagg atattgcttc
     1621 cttttgcagc agtgtaataa agtcaattaa aaacttccca ggatttcttt ggacccagga
     1681 aacagccatg tgggtccttt ctgtgcacta tgaacgcttc tttcccagga cagaaaatgt
     1741 gtagtctacc tttatttttt attaacaaaa cttgtttttt aaaaagatga ttgctggtct
     1801 taactttagg taactctgct gtgctggaga tcatctttaa gggcaaagga gttggattgc
     1861 tgaattacaa tgaaacatgt cttattacta aagaaagtga tttactcctg gttagtacat
     1921 tctcagagga ttctgaacca ctagagtttc cttgattcag actttgaatg tactgttcta
     1981 tagtttttca ggatcttaaa actaacactt ataaaactct tatcttgagt ctaaaaatga
     2041 cctcatatag tagtgaggaa cataattcat gcaattgtat tttgtatact attattgttc
     2101 tttcacttat tcagaacatt acatgccttc aaaatgggat tgtactatac cagtaagtgc
     2161 cacttctgtg tctttctaat ggaaatgagt agaattgctg aaagtctcta tgttaaaacc
     2221 tatagtgttt gaattcaaaa agcttattta tctgggtaac ccaaactttt tctgttttgt
     2281 ttttggaagg gtttttgtgg tatgtcattt ggtattctat tctgaaaatg cctttctcct
     2341 accaaaatgt gcttaagcca ctaaagaaat gaagtggcat taattagtaa attattagca
     2401 tggtcatgtt tgaatattct cacatcaagc ttttgcattt taattgtgtt gtctaagtat
     2461 acttttaaaa aatcaagtgg cactctagat gcttatagta ctttaatatt tgtagcatac
     2521 agactaattt ttctaaaagg gaaagtctgt ctagctgctt gtgaaaagtt atgtggtatt
     2581 ctgtaagcca tttttttctt tatctgttca aagacttatt ttttaagaca tgaattacat
     2641 ttaaaattag aatatggtta atattaaata ataggccttt ttctaggaag gcgaaggtag
     2701 ttaataattt gaatagataa cagatgtgca agaaagtcac atttgttatg tatgtaggag
     2761 taaacgttcg gtggatcctc tgtctttgta actgaggtta gagctagtgt ggttttgagg
     2821 tctcactaca ctttgaggaa ggcagctttt aattcagtgt ttccttatgt gtgcgtacat
     2881 tgcaactgct tacatgtaat ttatgtaatg cattcagtgc acccttgtta cttgggagag
     2941 gtggtagcta aagaacattc tgagtatagg tttttctcca tttacagatg tctttggtca
     3001 aatattgaaa gcaaacttgt catggtcttc ttacattaag ttgaaactag cttataataa
     3061 ctggttttta cttccaatgc tatgaagtct ctgcagggct tttacagttt tcgaagtcct
     3121 tttatcactg tgatcttatt ctgaggggag aaaaaactat catagctctg aggcaagact
     3181 tcgactttat agtgctatca gttccccgat acagggtcag agtaacccat acagtatttt
     3241 ggtcaggaag agaaagtggc catttacact gaatgagttg cattctgata atgtcttatc
     3301 tcttatacgt agaataaatt tgaaagacta tttgatctta aaaccaaagt aattttagaa
     3361 tgagtgacat attacatagg aatttagtgt caatttcatg tgtttaaaaa catcatggga
     3421 aaaatgctta gaggttacta ttttgactac aaagttgagt ttttttctgt agttaccata
     3481 atttcattga agcaaatgaa tgagtttgag aggtttgttt ttatagttgt gttgtattac
     3541 ttgtttaata ataatctcta attctgtgat caggtacttt ttttgtgggg gttttttttt
     3601 tgtttttttt tttttgttgt tgtttttggg ccatttctaa gcctaccaga tctgctttat
     3661 gaaatccagg ggaccaatgc attttatcac taaaactatt tttatataat tttaagaata
     3721 taccaaaagt tgtctgattt aaagttgtaa tacatgattt ctcactttca tgtaaggtta
     3781 tccacttttg ctgaagatat tttttattga atcaaagatt gagttacaat tatacttttc
     3841 ttacctaagt ggataaaatg tacttttgat gaatcaggga atttttttaa agttggagtt
     3901 tagttctaaa ttgactttac gtattactgc agttaattcc ttttttggct agggatggtt
     3961 tgataaacca caattggctg atattgaaaa tgaaagaaac ttaaaaggtg ggatggatca
     4021 tgattactgt cgataactgc agataaattt gattagagta ataattttgt catttaaaaa
     4081 cacagttgtt tatactgccc atcctaggat gctcaccttc caagattcaa cgtggctaaa
     4141 acatcttctg gtaaattgtg cgtccatatt cattttgtca gtagccagga gaaatgggga
     4201 tgggggaaat acgacttagt gaggcataga catccctggt ccatcctttc tgtctccagc
     4261 tgtttcttgg aacctgctct cctgcttgct ggtccctgac gcagagaccg ttgcctcccc
     4321 cacagccgtt tgactgaagg ctgctctgga gacctagagt aaaacggctg atggaagttg
     4381 tgggacccac ttccatttcc ttcagtcatt agaggtggaa gggaggggtc tccaagtttg
     4441 gagattgagc agatgaggct tgggatgccc ctgctttgac ttcagccatg gatgaggagt
     4501 gggatggcag caaggtggct cctgtggcag tggagttgtg ccagaaacag tggccagttg
     4561 tatcgcctat aagacagggt aaggtctgaa gagctgagcc tgtaattctg ctgtaataat
     4621 gatagtgctc aagaagtgcc ttgagttggt gtacagtgcc atggccatca agaatcccag
     4681 atttcaggtt ttattacaaa atgtaagtgg tcacttggcg attttgtagt acatgcatga
     4741 gttacctttt ttctctatgt ctgagaactg tcagattaaa acaagatggc aaagagatcg
     4801 ttagagtgca caacaaaatc actatcccat tagacacatc atcaaaagct tatttttatt
     4861 cttgcactgg aagaatcgta agtcaactgt ttcttgacca tggcagtgtt ctggctccaa
     4921 atggtagtga ttccaaataa tggttctgtt aacactttgg cagaaaatgc cagctcagat
     4981 attttgagat actaaggatt atctttggac atgtactgca gcttcttgtc tctgttttgg
     5041 attactggaa tacccatggg ccctctcaag agtgctggac ttctaggaca ttaagatgat
     5101 tgtcagtaca ttaaactttt caatcccatt atgcaatctt gtttgtaaat gtaaacttct
     5161 aaaaatatgg ttaataacat tcaacctgtt tattacaact taaaaggaac ttcagtgaat
     5221 ttgtttttat tttttaacaa gatttgtgaa ctgaatatca tgaaccatgt tttgataccc
     5281 ctttttcacg ttgtgccaac ggaatagggt gtttgatatt tcttcatatg ttaaggagat
     5341 gcttcaaaat gtcaattgct ttaaacttaa attacctctc aagagaccaa ggtacattta
     5401 cctcattgtg tatataatgt ttaatatttg tcagagcatt ctccaggttt gcagttttat
     5461 ttctataaag tatgggtatt atgttgctca gttactcaaa tggtactgta ttgtttatat
     5521 ttgtacccca aataacatcg tctgtacttt ctgttttctg tattgtattt gtgcaggatt
     5581 ctttaggctt tatcagtgta atctctgcct tttaagatat gtacagaaaa tgtccatata
     5641 aatttccatt gaagtcgaat gatactgaga agcctgtaaa gaggagaaaa aaacataagc
     5701 tgtgtttccc cataagtttt tttaaattgt atattgtatt tgtagtaata ttccaaaaga
     5761 atgtaaatag gaaatagaag agtgatgctt atgttaagtc ctaacactac agtagaagaa
     5821 tggaagcagt gcaaataaat tacatttttc ccaagtgcca gtggcatatt ttaaaataaa
     5881 gtgtatacgt tggaatgagt catgccatat gtagttgctg tagatggcaa ctagaacctt
     5941 tgagttacaa gagtctttag aagttttcta accctgccta gtgcaagtta caatattata
     6001 gcgtgttcgg ggagtgccct cctgtctgca ggtgtgtctc tgtgcctggg ggcttttctc
     6061 cacatgctta ggggtgtggg tcttccattg gggcatgatg gacctgtcta caggtgatct
     6121 ctgttgcctt tgggtcagca catttgttag tctcctgggg gtgaaaactt ggcttacaag
     6181 agaactggaa aaatgatgag atgtggtccc caaacccttg attgactctg gggaggggct
     6241 ttgtgaatag gattgctctc acattaaaga tagttacttc aatttgaagg ctggatttag
     6301 ggattttttt ttttccttat aacaaagaca tcaccaggat atgaagcttt tgttgaaagt
     6361 tggaaaaaaa gtgaaattaa agacattccc agacaaa
//
