LOCUS       NM_001042454            1805 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens transforming growth factor beta 1 induced transcript 1
            (TGFB1I1), transcript variant 1, mRNA.
ACCESSION   NM_001042454
VERSION     NM_001042454.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Liang,P.I., Wei,Y.C., Chen,H.D., Ma,Y.C., Ke,H.L., Chien,C.C. and
            Chuang,H.W.
  TITLE     TGFB1I1 promotes cell proliferation and migration in urothelial
            carcinoma
  JOURNAL   Kaohsiung J Med Sci 40 (3), 269-279 (2024)
   PUBMED   38180299
  REMARK    GeneRIF: TGFB1I1 promotes cell proliferation and migration in
            urothelial carcinoma.
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Fang,M., Liu,X., Xu,W., Wang,X., Xu,L., Zhao,T.J., Li,P. and
            Yang,H.
  TITLE     Paxillin family proteins Hic-5 and LPXN promote lipid storage by
            regulating the ubiquitination degradation of CIDEC
  JOURNAL   J Biol Chem 300 (2), 105610 (2024)
   PUBMED   38159847
  REMARK    GeneRIF: Paxillin family proteins Hic-5 and LPXN promote lipid
            storage by regulating the ubiquitination degradation of CIDEC.
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Sha,L., Ma,D. and Chen,C.
  TITLE     Exosome-mediated Hic-5 regulates proliferation and apoptosis of
            osteosarcoma via Wnt/beta-catenin signal pathway
  JOURNAL   Aging (Albany NY) 12 (23), 23598-23608 (2020)
   PUBMED   33310972
  REMARK    GeneRIF: Exosome-mediated Hic-5 regulates proliferation and
            apoptosis of osteosarcoma via Wnt/beta-catenin signal pathway.
REFERENCE   5  (bases 1 to 1805)
  AUTHORS   Alpha,K.M., Xu,W. and Turner,C.E.
  TITLE     Paxillin family of focal adhesion adaptor proteins and regulation
            of cancer cell invasion
  JOURNAL   Int Rev Cell Mol Biol 355, 1-52 (2020)
   PUBMED   32859368
  REMARK    GeneRIF: Paxillin family of focal adhesion adaptor proteins and
            regulation of cancer cell invasion.
REFERENCE   6  (bases 1 to 1805)
  AUTHORS   Fujimoto,N., Yeh,S., Kang,H.Y., Inui,S., Chang,H.C., Mizokami,A.
            and Chang,C.
  TITLE     Cloning and characterization of androgen receptor coactivator,
            ARA55, in human prostate
  JOURNAL   J Biol Chem 274 (12), 8316-8321 (1999)
   PUBMED   10075738
REFERENCE   7  (bases 1 to 1805)
  AUTHORS   Matsuya,M., Sasaki,H., Aoto,H., Mitaka,T., Nagura,K., Ohba,T.,
            Ishino,M., Takahashi,S., Suzuki,R. and Sasaki,T.
  TITLE     Cell adhesion kinase beta forms a complex with a new member, Hic-5,
            of proteins localized at focal adhesions
  JOURNAL   J Biol Chem 273 (2), 1003-1014 (1998)
   PUBMED   9422762
REFERENCE   8  (bases 1 to 1805)
  AUTHORS   Shibanuma,M., Mochizuki,E., Maniwa,R., Mashimo,J., Nishiya,N.,
            Imai,S., Takano,T., Oshimura,M. and Nose,K.
  TITLE     Induction of senescence-like phenotypes by forced expression of
            hic-5, which encodes a novel LIM motif protein, in immortalized
            human fibroblasts
  JOURNAL   Mol Cell Biol 17 (3), 1224-1235 (1997)
   PUBMED   9032249
REFERENCE   9  (bases 1 to 1805)
  AUTHORS   Shibanuma,M., Mashimo,J., Kuroki,T. and Nose,K.
  TITLE     Characterization of the TGF beta 1-inducible hic-5 gene that
            encodes a putative novel zinc finger protein and its possible
            involvement in cellular senescence
  JOURNAL   J Biol Chem 269 (43), 26767-26774 (1994)
   PUBMED   7929412
REFERENCE   10 (bases 1 to 1805)
  AUTHORS   Wilson,S.E. and Lloyd,S.A.
  TITLE     Epidermal growth factor and its receptor, basic fibroblast growth
            factor, transforming growth factor beta-1, and interleukin-1 alpha
            messenger RNA production in human corneal endothelial cells
  JOURNAL   Invest Ophthalmol Vis Sci 32 (10), 2747-2756 (1991)
   PUBMED   1716619
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026471.6 and AK313327.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001042454.2.
            
            Summary: This gene encodes a coactivator of the androgen receptor,
            a transcription factor which is activated by androgen and has a key
            role in male sexual differentiation. The encoded protein is thought
            to regulate androgen receptor activity and may have a role to play
            in the treatment of prostate cancer. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313327.1, ERR279837.962.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394863.8/ ENSP00000378332.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC026471.6         141782-141784
            4-1423              AK313327.1         1-1420
            1424-1805           AC026471.6         147207-147588
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1805
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /note="transforming growth factor beta 1 induced
                     transcript 1"
                     /db_xref="GeneID:7041"
                     /db_xref="HGNC:HGNC:11767"
                     /db_xref="MIM:602353"
     exon            1..50
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1423
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     androgen receptor coactivator ARA55; transforming growth
                     factor beta-1-induced transcript 1 protein; hydrogen
                     peroxide-inducible clone 5 protein; androgen
                     receptor-associated protein of 55 kDa; androgen receptor
                     coactivator 55 kDa protein; hydrogen peroxide-inducible
                     clone-5"
                     /codon_start=1
                     /product="transforming growth factor beta-1-induced
                     transcript 1 protein isoform 1"
                     /protein_id="NP_001035919.1"
                     /db_xref="CCDS:CCDS42156.1"
                     /db_xref="GeneID:7041"
                     /db_xref="HGNC:HGNC:11767"
                     /db_xref="MIM:602353"
                     /translation="MEDLDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQT
                     GSGESSGASGDKDHLYSTVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNA
                     TQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDR
                     LMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRR
                     GVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCP
                     ECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYC
                     RRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPL
                     CENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKP
                     YCQPCFLKLFG"
     exon            51..166
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            167..219
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            220..362
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            363..450
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            451..556
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            557..751
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            752..925
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1007
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1156
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1805
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1783..1788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /note="hexamer: CATAAA"
     polyA_site      1805
                     /gene="TGFB1I1"
                     /gene_synonym="ARA55; HIC-5; HIC5; TSC-5"
                     /note="major polyA site"
ORIGIN      
        1 gccctgttcg ccccgcgcca ccggcccgcg ccccgccatg gaggacctgg atgccctgct
       61 ctctgacctg gagactacca cctcgcacat gccaaggtca ggggctccca aagagcgccc
      121 tgcggagcct ctcacccctc ccccatccta tggccaccag ccacagacag ggtctgggga
      181 gtcttcagga gcctcggggg acaaggacca cctgtacagc acggtatgca agcctcggtc
      241 cccaaagcct gcagccccgg cggcccctcc attctcctct tccagcggtg tcttgggtac
      301 cgggctctgt gagctagatc ggttgcttca ggaacttaat gccactcagt tcaacatcac
      361 agatgaaatc atgtctcagt tcccatctag caaggtggct tcaggagagc agaaggagga
      421 ccagtctgaa gataagaaaa gacccagcct cccttccagc ccgtctcctg gcctcccaaa
      481 ggcttctgcc acctcagcca ctctggagct ggatagactg atggcctcac tctctgactt
      541 ccgcgttcaa aaccatcttc cagcctctgg gccaactcag ccaccggtgg tgagctccac
      601 aaatgagggc tccccatccc caccagagcc gactggcaag ggcagcctag acaccatgct
      661 ggggctgctg cagtccgacc tcagccgccg gggtgttccc acccaggcca aaggcctctg
      721 tggctcctgc aataaaccta ttgctgggca agtggtgacg gctctgggcc gcgcctggca
      781 ccccgagcac ttcgtttgcg gaggctgttc caccgccctg ggaggcagca gcttcttcga
      841 gaaggatgga gcccccttct gccccgagtg ctactttgag cgcttctcgc caagatgtgg
      901 cttctgcaac cagcccatcc gacacaagat ggtgaccgcc ttgggcactc actggcaccc
      961 agagcatttc tgctgcgtca gttgcgggga gcccttcgga gatgagggtt tccacgagcg
     1021 cgagggccgc ccctactgcc gccgggactt cctgcagctg ttcgccccgc gctgccaggg
     1081 ctgccagggc cccatcctgg ataactacat ctcggcgctc agcgcgctct ggcacccgga
     1141 ctgtttcgtc tgcagggaat gcttcgcgcc cttctcggga ggcagctttt tcgagcacga
     1201 gggccgcccg ttgtgcgaga accacttcca cgcacgacgc ggctcgctgt gcgccacgtg
     1261 tggcctccct gtgaccggcc gctgcgtgtc ggccctgggt cgccgcttcc acccggacca
     1321 cttcacatgc accttctgcc tgcgcccgct caccaagggg tccttccagg agcgcgccgg
     1381 caagccctac tgccagccct gcttcctgaa gctcttcggc tgacagcccg ctcggctcgc
     1441 cctctccccc ggaggccgcg ccctcccgga aaagccgggt cctccagacc ccgaggcctt
     1501 gctctcagag cgggaggccc cacccactgg agagccccgc ccctaaggta ctatgagtcc
     1561 tcaggggtca agttcagaaa cggcccagcc agacctaaac ccacacgccc acaaagtgga
     1621 ttgcacacag acaagaactc ccgtgcgggc ctccactcta ttcccaccct tgagggagcc
     1681 cccttactgg gggagggtcc ttgcaattcc agcgaatcgg aggccaggcc aggacgtcct
     1741 tgctccctgc accctcactg ttctgtgcac tttttctacc tacataaaca cacgcattcc
     1801 acctc
//
