LOCUS       NM_003234               5224 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens transferrin receptor (TFRC), transcript variant 1,
            mRNA.
ACCESSION   NM_003234
VERSION     NM_003234.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5224)
  AUTHORS   Xing,P., Zhou,M., Sun,J., Wang,D., Huang,W. and An,P.
  TITLE     NAT10-mediated ac4C acetylation of TFRC promotes sepsis-induced
            pulmonary injury through regulating ferroptosis
  JOURNAL   Mol Med 30 (1), 140 (2024)
   PUBMED   39251905
  REMARK    GeneRIF: NAT10-mediated ac[4]C acetylation of TFRC promotes
            sepsis-induced pulmonary injury through regulating ferroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5224)
  AUTHORS   Ji,W., Zhang,W., Zhang,X. and Ke,Y.
  TITLE     TRIM33 enhances the ubiquitination of TFRC to enhance the
            susceptibility of liver cancer cells to ferroptosis
  JOURNAL   Cell Signal 121, 111268 (2024)
   PUBMED   38909931
  REMARK    GeneRIF: TRIM33 enhances the ubiquitination of TFRC to enhance the
            susceptibility of liver cancer cells to ferroptosis.
REFERENCE   3  (bases 1 to 5224)
  AUTHORS   Shang,X., Wang,H., Gu,J., Zhao,X., Zhang,J., Sun,B. and Zhu,X.
  TITLE     Ferroptosis-related gene transferrin receptor protein 1 expression
            correlates with the prognosis and tumor immune microenvironment in
            cervical cancer
  JOURNAL   PeerJ 12, e17842 (2024)
   PUBMED   39131609
  REMARK    GeneRIF: Ferroptosis-related gene transferrin receptor protein 1
            expression correlates with the prognosis and tumor immune
            microenvironment in cervical cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5224)
  AUTHORS   Qin,J., Li,Z., Su,L., Wen,X., Tang,X., Huang,M. and Wu,J.
  TITLE     Expression of transferrin receptor/TFRC protein in bladder cancer
            cell T24 and its role in inducing iron death in bladder cancer
  JOURNAL   Int J Biol Macromol 274 (Pt 1), 133323 (2024)
   PUBMED   38908617
  REMARK    GeneRIF: Expression of transferrin receptor/TFRC protein in bladder
            cancer cell T24 and its role in inducing iron death in bladder
            cancer.
REFERENCE   5  (bases 1 to 5224)
  AUTHORS   Pacella,I., Pinzon Grimaldos,A., Rossi,A., Tucci,G., Zagaglioni,M.,
            Potenza,E., Pinna,V., Rotella,I., Cammarata,I., Cancila,V.,
            Belmonte,B., Tripodo,C., Pietropaolo,G., Di Censo,C., Sciume,G.,
            Licursi,V., Peruzzi,G., Antonucci,Y., Campello,S., Guerrieri,F.,
            Iebba,V., Prota,R., Di Chiara,M., Terrin,G., De Peppo,V.,
            Grazi,G.L., Barnaba,V. and Piconese,S.
  TITLE     Iron capture through CD71 drives perinatal and tumor-associated
            Treg expansion
  JOURNAL   JCI Insight 9 (15), e167967 (2024)
   PUBMED   38954474
  REMARK    GeneRIF: Iron capture through CD71 drives perinatal and
            tumor-associated Treg expansion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5224)
  AUTHORS   Chicz,R.M., Urban,R.G., Lane,W.S., Gorga,J.C., Stern,L.J.,
            Vignali,D.A. and Strominger,J.L.
  TITLE     Predominant naturally processed peptides bound to HLA-DR1 are
            derived from MHC-related molecules and are heterogeneous in size
  JOURNAL   Nature 358 (6389), 764-768 (1992)
   PUBMED   1380674
REFERENCE   7  (bases 1 to 5224)
  AUTHORS   Hayes,G.R., Enns,C.A. and Lucas,J.J.
  TITLE     Identification of the O-linked glycosylation site of the human
            transferrin receptor
  JOURNAL   Glycobiology 2 (4), 355-359 (1992)
   PUBMED   1421757
REFERENCE   8  (bases 1 to 5224)
  AUTHORS   Do,S.I. and Cummings,R.D.
  TITLE     Presence of O-linked oligosaccharide on a threonine residue in the
            human transferrin receptor
  JOURNAL   Glycobiology 2 (4), 345-353 (1992)
   PUBMED   1421756
REFERENCE   9  (bases 1 to 5224)
  AUTHORS   Baynes,R.D., Shih,Y.J., Hudson,B.G. and Cook,J.D.
  TITLE     Characterization of transferrin receptor released by K562
            erythroleukemia cells
  JOURNAL   Proc Soc Exp Biol Med 197 (4), 416-423 (1991)
   PUBMED   1871153
REFERENCE   10 (bases 1 to 5224)
  AUTHORS   Shih,Y.J., Baynes,R.D., Hudson,B.G., Flowers,C.H., Skikne,B.S. and
            Cook,J.D.
  TITLE     Serum transferrin receptor is a truncated form of tissue receptor
  JOURNAL   J Biol Chem 265 (31), 19077-19081 (1990)
   PUBMED   2229063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291723.1, BC001188.1,
            X01060.1 and BX537966.1.
            
            On May 31, 2019 this sequence version replaced NM_003234.3.
            
            Summary: This gene encodes a cell surface receptor necessary for
            cellular iron uptake by the process of receptor-mediated
            endocytosis. This receptor is required for erythropoiesis and
            neurologic development. Multiple alternatively spliced variants
            have been identified. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 2
            encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.128948.1, AK291723.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AK291723.1         1-279
            280-4402            BC001188.1         53-4175
            4403-4539           X01060.1           4381-4517
            4540-5138           BC001188.1         4313-4911
            5139-5223           BX537966.1         4724-4808
            5224-5224           BC001188.1         4997-4997
FEATURES             Location/Qualifiers
     source          1..5224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..5224
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /note="transferrin receptor"
                     /db_xref="GeneID:7037"
                     /db_xref="HGNC:HGNC:11763"
                     /db_xref="MIM:190010"
     exon            1..260
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            261..319
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..2566
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transferrin receptor protein 1"
                     /codon_start=1
                     /product="transferrin receptor protein 1 isoform 1"
                     /protein_id="NP_003225.2"
                     /db_xref="CCDS:CCDS3312.1"
                     /db_xref="GeneID:7037"
                     /db_xref="HGNC:HGNC:11763"
                     /db_xref="MIM:190010"
                     /translation="MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDE
                     EENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLA
                     GTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQ
                     KDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGG
                     YVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNA
                     IGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPV
                     QTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGV
                     IKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIF
                     ASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEK
                     TMQNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYL
                     GTTMDTYKELIERIPELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRD
                     LNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVE
                     YHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRKQNNGAFNETLFRNQLALATW
                     TIQGAANALSGDVWDIDNEF"
     exon            320..521
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            522..717
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            718..867
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            868..970
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1084
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1183
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1323
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1481
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1601
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1687
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1751
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1819
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1878
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1960
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2182
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2323
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..5224
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5204..5209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /note="hexamer: AATAAA"
     polyA_site      5224
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /note="major polyA site"
ORIGIN      
        1 agagcgtcgg gatatcgggt ggcggctcgg gacggaggac gcgctagtgt gagtgcgggc
       61 ttctagaact acaccgaccc tcgtgtcctc ccttcatcct gcggggctgg ctggagcggc
      121 cgctccggtg ctgtccagca gccataggga gccgcacggg gagcgggaaa gcggtcgcgg
      181 ccccaggcgg ggcggccggg atggagcggg gccgcgagcc tgtggggaag gggctgtggc
      241 ggcgcctcga gcggctgcag gttcttctgt gtggcagttc agaatgatgg atcaagctag
      301 atcagcattc tctaacttgt ttggtggaga accattgtca tatacccggt tcagcctggc
      361 tcggcaagta gatggcgata acagtcatgt ggagatgaaa cttgctgtag atgaagaaga
      421 aaatgctgac aataacacaa aggccaatgt cacaaaacca aaaaggtgta gtggaagtat
      481 ctgctatggg actattgctg tgatcgtctt tttcttgatt ggatttatga ttggctactt
      541 gggctattgt aaaggggtag aaccaaaaac tgagtgtgag agactggcag gaaccgagtc
      601 tccagtgagg gaggagccag gagaggactt ccctgcagca cgtcgcttat attgggatga
      661 cctgaagaga aagttgtcgg agaaactgga cagcacagac ttcaccggca ccatcaagct
      721 gctgaatgaa aattcatatg tccctcgtga ggctggatct caaaaagatg aaaatcttgc
      781 gttgtatgtt gaaaatcaat ttcgtgaatt taaactcagc aaagtctggc gtgatcaaca
      841 ttttgttaag attcaggtca aagacagcgc tcaaaactcg gtgatcatag ttgataagaa
      901 cggtagactt gtttacctgg tggagaatcc tgggggttat gtggcgtata gtaaggctgc
      961 aacagttact ggtaaactgg tccatgctaa ttttggtact aaaaaagatt ttgaggattt
     1021 atacactcct gtgaatggat ctatagtgat tgtcagagca gggaaaatca cctttgcaga
     1081 aaaggttgca aatgctgaaa gcttaaatgc aattggtgtg ttgatataca tggaccagac
     1141 taaatttccc attgttaacg cagaactttc attctttgga catgctcatc tggggacagg
     1201 tgacccttac acacctggat tcccttcctt caatcacact cagtttccac catctcggtc
     1261 atcaggattg cctaatatac ctgtccagac aatctccaga gctgctgcag aaaagctgtt
     1321 tgggaatatg gaaggagact gtccctctga ctggaaaaca gactctacat gtaggatggt
     1381 aacctcagaa agcaagaatg tgaagctcac tgtgagcaat gtgctgaaag agataaaaat
     1441 tcttaacatc tttggagtta ttaaaggctt tgtagaacca gatcactatg ttgtagttgg
     1501 ggcccagaga gatgcatggg gccctggagc tgcaaaatcc ggtgtaggca cagctctcct
     1561 attgaaactt gcccagatgt tctcagatat ggtcttaaaa gatgggtttc agcccagcag
     1621 aagcattatc tttgccagtt ggagtgctgg agactttgga tcggttggtg ccactgaatg
     1681 gctagaggga tacctttcgt ccctgcattt aaaggctttc acttatatta atctggataa
     1741 agcggttctt ggtaccagca acttcaaggt ttctgccagc ccactgttgt atacgcttat
     1801 tgagaaaaca atgcaaaatg tgaagcatcc ggttactggg caatttctat atcaggacag
     1861 caactgggcc agcaaagttg agaaactcac tttagacaat gctgctttcc ctttccttgc
     1921 atattctgga atcccagcag tttctttctg tttttgcgag gacacagatt atccttattt
     1981 gggtaccacc atggacacct ataaggaact gattgagagg attcctgagt tgaacaaagt
     2041 ggcacgagca gctgcagagg tcgctggtca gttcgtgatt aaactaaccc atgatgttga
     2101 attgaacctg gactatgaga ggtacaacag ccaactgctt tcatttgtga gggatctgaa
     2161 ccaatacaga gcagacataa aggaaatggg cctgagttta cagtggctgt attctgctcg
     2221 tggagacttc ttccgtgcta cttccagact aacaacagat ttcgggaatg ctgagaaaac
     2281 agacagattt gtcatgaaga aactcaatga tcgtgtcatg agagtggagt atcacttcct
     2341 ctctccctac gtatctccaa aagagtctcc tttccgacat gtcttctggg gctccggctc
     2401 tcacacgctg ccagctttac tggagaactt gaaactgcgt aaacaaaata acggtgcttt
     2461 taatgaaacg ctgttcagaa accagttggc tctagctact tggactattc agggagctgc
     2521 aaatgccctc tctggtgacg tttgggacat tgacaatgag ttttaaatgt gatacccata
     2581 gcttccatga gaacagcagg gtagtctggt ttctagactt gtgctgatcg tgctaaattt
     2641 tcagtagggc tacaaaacct gatgttaaaa ttccatccca tcatcttggt actactagat
     2701 gtctttaggc agcagctttt aatacagggt agataacctg tacttcaagt taaagtgaat
     2761 aaccacttaa aaaatgtcca tgatggaata ttcccctatc tctagaattt taagtgcttt
     2821 gtaatgggaa ctgcctcttt cctgttgttg ttaatgaaaa tgtcagaaac cagttatgtg
     2881 aatgatctct ctgaatccta agggctggtc tctgctgaag gttgtaagtg gtcgcttact
     2941 ttgagtgatc ctccaacttc atttgatgct aaataggaga taccaggttg aaagaccttc
     3001 tccaaatgag atctaagcct ttccataagg aatgtagctg gtttcctcat tcctgaaaga
     3061 aacagttaac tttcagaaga gatgggcttg ttttcttgcc aatgaggtct gaaatggagg
     3121 tccttctgct ggataaaatg aggttcaact gttgattgca ggaataaggc cttaatatgt
     3181 taacctcagt gtcatttatg aaaagagggg accagaagcc aaagacttag tatattttct
     3241 tttcctctgt cccttccccc ataagcctcc atttagttct ttgttatttt tgtttcttcc
     3301 aaagcacatt gaaagagaac cagtttcagg tgtttagttg cagactcagt ttgtcagact
     3361 ttaaagaata atatgctgcc aaattttggc caaagtgtta atcttagggg agagctttct
     3421 gtccttttgg cactgagata tttattgttt atttatcagt gacagagttc actataaatg
     3481 gtgttttttt aatagaatat aattatcgga agcagtgcct tccataatta tgacagttat
     3541 actgtcggtt ttttttaaat aaaagcagca tctgctaata aaacccaaca gatactggaa
     3601 gttttgcatt tatggtcaac acttaagggt tttagaaaac agccgtcagc caaatgtaat
     3661 tgaataaagt tgaagctaag atttagagat gaattaaatt taattagggg ttgctaagaa
     3721 gcgagcactg accagataag aatgctggtt ttcctaaatg cagtgaattg tgaccaagtt
     3781 ataaatcaat gtcacttaaa ggctgtggta gtactcctgc aaaattttat agctcagttt
     3841 atccaaggtg taactctaat tcccattttg caaaatttcc agtacctttg tcacaatcct
     3901 aacacattat cgggagcagt gtcttccata atgtataaag aacaaggtag tttttaccta
     3961 ccacagtgtc tgtatcggag acagtgatct ccatatgtta cactaagggt gtaagtaatt
     4021 atcgggaaca gtgtttccca taattttctt catgcaatga catcttcaaa gcttgaagat
     4081 cgttagtatc taacatgtat cccaactcct ataattccct atcttttagt tttagttgca
     4141 gaaacatttt gtggtcatta agcattgggt gggtaaattc aaccactgta aaatgaaatt
     4201 actacaaaat ttgaaattta gcttgggttt ttgttacctt tatggtttct ccaggtcctc
     4261 tacttaatga gatagtagca tacatttata atgtttgcta ttgacaagtc attttaactt
     4321 tatcacatta tttgcatgtt acctcctata aacttagtgc ggacaagttt taatccagaa
     4381 ttgacctttt gacttaaagc agagggactt tgtatagaag gtttgggggc tgtggggaag
     4441 gagagtcccc tgaaggtctg acacgtctgc ctacccattc gtggtgatca attaaatgta
     4501 ggtatgaata agttcgaagc tccgtgagtg aaccatcatt ataaacgtga tgatcagctg
     4561 tttgtcatag ggcagttgga aacggcctcc tagggaaaag ttcatagggt ctcttcaggt
     4621 tcttagtgtc acttacctag atttacagcc tcacttgaat gtgtcactac tcacagtctc
     4681 tttaatcttc agttttatct ttaatctcct cttttatctt ggactgacat ttagcgtagc
     4741 taagtgaaaa ggtcatagct gagattcctg gttcgggtgt tacgcacacg tacttaaatg
     4801 aaagcatgtg gcatgttcat cgtataacac aatatgaata cagggcatgc attttgcagc
     4861 agtgagtctc ttcagaaaac ccttttctac agttagggtt gagttacttc ctatcaagcc
     4921 agtacgtgct aacaggctca atattcctga atgaaatatc agactagtga caagctcctg
     4981 gtcttgagat gtcttctcgt taaggagatg ggccttttgg aggtaaagga taaaatgaat
     5041 gagttctgtc atgattcact attctagaac ttgcatgacc tttactgtgt tagctctttg
     5101 aatgttcttg aaattttaga ctttctttgt aaacaaatga tatgtcctta tcattgtata
     5161 aaagctgtta tgtgcaacag tgtggagatt ccttgtctga tttaataaaa tacttaaaca
     5221 ctga
//
