LOCUS       NM_001313965            4810 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens transferrin receptor (TFRC), transcript variant 3,
            mRNA.
ACCESSION   NM_001313965
VERSION     NM_001313965.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4810)
  AUTHORS   Xing,P., Zhou,M., Sun,J., Wang,D., Huang,W. and An,P.
  TITLE     NAT10-mediated ac4C acetylation of TFRC promotes sepsis-induced
            pulmonary injury through regulating ferroptosis
  JOURNAL   Mol Med 30 (1), 140 (2024)
   PUBMED   39251905
  REMARK    GeneRIF: NAT10-mediated ac[4]C acetylation of TFRC promotes
            sepsis-induced pulmonary injury through regulating ferroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4810)
  AUTHORS   Ji,W., Zhang,W., Zhang,X. and Ke,Y.
  TITLE     TRIM33 enhances the ubiquitination of TFRC to enhance the
            susceptibility of liver cancer cells to ferroptosis
  JOURNAL   Cell Signal 121, 111268 (2024)
   PUBMED   38909931
  REMARK    GeneRIF: TRIM33 enhances the ubiquitination of TFRC to enhance the
            susceptibility of liver cancer cells to ferroptosis.
REFERENCE   3  (bases 1 to 4810)
  AUTHORS   Shang,X., Wang,H., Gu,J., Zhao,X., Zhang,J., Sun,B. and Zhu,X.
  TITLE     Ferroptosis-related gene transferrin receptor protein 1 expression
            correlates with the prognosis and tumor immune microenvironment in
            cervical cancer
  JOURNAL   PeerJ 12, e17842 (2024)
   PUBMED   39131609
  REMARK    GeneRIF: Ferroptosis-related gene transferrin receptor protein 1
            expression correlates with the prognosis and tumor immune
            microenvironment in cervical cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4810)
  AUTHORS   Qin,J., Li,Z., Su,L., Wen,X., Tang,X., Huang,M. and Wu,J.
  TITLE     Expression of transferrin receptor/TFRC protein in bladder cancer
            cell T24 and its role in inducing iron death in bladder cancer
  JOURNAL   Int J Biol Macromol 274 (Pt 1), 133323 (2024)
   PUBMED   38908617
  REMARK    GeneRIF: Expression of transferrin receptor/TFRC protein in bladder
            cancer cell T24 and its role in inducing iron death in bladder
            cancer.
REFERENCE   5  (bases 1 to 4810)
  AUTHORS   Pacella,I., Pinzon Grimaldos,A., Rossi,A., Tucci,G., Zagaglioni,M.,
            Potenza,E., Pinna,V., Rotella,I., Cammarata,I., Cancila,V.,
            Belmonte,B., Tripodo,C., Pietropaolo,G., Di Censo,C., Sciume,G.,
            Licursi,V., Peruzzi,G., Antonucci,Y., Campello,S., Guerrieri,F.,
            Iebba,V., Prota,R., Di Chiara,M., Terrin,G., De Peppo,V.,
            Grazi,G.L., Barnaba,V. and Piconese,S.
  TITLE     Iron capture through CD71 drives perinatal and tumor-associated
            Treg expansion
  JOURNAL   JCI Insight 9 (15), e167967 (2024)
   PUBMED   38954474
  REMARK    GeneRIF: Iron capture through CD71 drives perinatal and
            tumor-associated Treg expansion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4810)
  AUTHORS   Chicz,R.M., Urban,R.G., Lane,W.S., Gorga,J.C., Stern,L.J.,
            Vignali,D.A. and Strominger,J.L.
  TITLE     Predominant naturally processed peptides bound to HLA-DR1 are
            derived from MHC-related molecules and are heterogeneous in size
  JOURNAL   Nature 358 (6389), 764-768 (1992)
   PUBMED   1380674
REFERENCE   7  (bases 1 to 4810)
  AUTHORS   Hayes,G.R., Enns,C.A. and Lucas,J.J.
  TITLE     Identification of the O-linked glycosylation site of the human
            transferrin receptor
  JOURNAL   Glycobiology 2 (4), 355-359 (1992)
   PUBMED   1421757
REFERENCE   8  (bases 1 to 4810)
  AUTHORS   Do,S.I. and Cummings,R.D.
  TITLE     Presence of O-linked oligosaccharide on a threonine residue in the
            human transferrin receptor
  JOURNAL   Glycobiology 2 (4), 345-353 (1992)
   PUBMED   1421756
REFERENCE   9  (bases 1 to 4810)
  AUTHORS   Baynes,R.D., Shih,Y.J., Hudson,B.G. and Cook,J.D.
  TITLE     Characterization of transferrin receptor released by K562
            erythroleukemia cells
  JOURNAL   Proc Soc Exp Biol Med 197 (4), 416-423 (1991)
   PUBMED   1871153
REFERENCE   10 (bases 1 to 4810)
  AUTHORS   Shih,Y.J., Baynes,R.D., Hudson,B.G., Flowers,C.H., Skikne,B.S. and
            Cook,J.D.
  TITLE     Serum transferrin receptor is a truncated form of tissue receptor
  JOURNAL   J Biol Chem 265 (31), 19077-19081 (1990)
   PUBMED   2229063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX537966.1, AC024937.21 and
            BC001188.1.
            
            On May 31, 2019 this sequence version replaced NM_001313965.1.
            
            Summary: This gene encodes a cell surface receptor necessary for
            cellular iron uptake by the process of receptor-mediated
            endocytosis. This receptor is required for erythropoiesis and
            neurologic development. Multiple alternatively spliced variants
            have been identified. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (3) lacks an alternate 5' exon and
            initiates translation at a downstream start codon, compared to
            variant 1. The encoded isoform (2) has a shorter N-terminus
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537966.1, SRR18074969.979664.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1721              BX537966.1         2-1722
            1722-1722           AC024937.21        109769-109769       c
            1723-3459           BX537966.1         1724-3460
            3460-3461           AC024937.21        105276-105277       c
            3462-3988           BX537966.1         3461-3987
            3989-3989           AC024937.21        104748-104748       c
            3990-4809           BX537966.1         3989-4808
            4810-4810           BC001188.1         4997-4997
FEATURES             Location/Qualifiers
     source          1..4810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..4810
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /note="transferrin receptor"
                     /db_xref="GeneID:7037"
                     /db_xref="HGNC:HGNC:11763"
                     /db_xref="MIM:190010"
     exon            1..48
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            49..107
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            108..303
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2152
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /note="isoform 2 is encoded by transcript variant 3;
                     transferrin receptor protein 1"
                     /codon_start=1
                     /product="transferrin receptor protein 1 isoform 2"
                     /protein_id="NP_001300894.1"
                     /db_xref="CCDS:CCDS82891.1"
                     /db_xref="GeneID:7037"
                     /db_xref="HGNC:HGNC:11763"
                     /db_xref="MIM:190010"
                     /translation="MIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAARRLYWD
                     DLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWR
                     DQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKK
                     DFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFG
                     HAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDW
                     KTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPG
                     AAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSS
                     LHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASK
                     VEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARA
                     AAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARG
                     DFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSG
                     SHTLPALLENLKLRKQNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF"
     exon            304..453
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            454..556
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            557..670
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            671..769
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            770..909
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1067
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1187
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1273
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1337
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1405
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1464
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1546
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1768
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1909
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..4810
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4790..4795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /note="hexamer: AATAAA"
     polyA_site      4810
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /note="major polyA site"
ORIGIN      
        1 agagcgtcgg gatatcgggt ggcggctcgg gacggaggac gcgctagtgt tcttctgtgt
       61 ggcagttcag aatgatggat caagctagat cagcattctc taacttggat ttatgattgg
      121 ctacttgggc tattgtaaag gggtagaacc aaaaactgag tgtgagagac tggcaggaac
      181 cgagtctcca gtgagggagg agccaggaga ggacttccct gcagcacgtc gcttatattg
      241 ggatgacctg aagagaaagt tgtcggagaa actggacagc acagacttca ccggcaccat
      301 caagctgctg aatgaaaatt catatgtccc tcgtgaggct ggatctcaaa aagatgaaaa
      361 tcttgcgttg tatgttgaaa atcaatttcg tgaatttaaa ctcagcaaag tctggcgtga
      421 tcaacatttt gttaagattc aggtcaaaga cagcgctcaa aactcggtga tcatagttga
      481 taagaacggt agacttgttt acctggtgga gaatcctggg ggttatgtgg cgtatagtaa
      541 ggctgcaaca gttactggta aactggtcca tgctaatttt ggtactaaaa aagattttga
      601 ggatttatac actcctgtga atggatctat agtgattgtc agagcaggga aaatcacctt
      661 tgcagaaaag gttgcaaatg ctgaaagctt aaatgcaatt ggtgtgttga tatacatgga
      721 ccagactaaa tttcccattg ttaacgcaga actttcattc tttggacatg ctcatctggg
      781 gacaggtgac ccttacacac ctggattccc ttccttcaat cacactcagt ttccaccatc
      841 tcggtcatca ggattgccta atatacctgt ccagacaatc tccagagctg ctgcagaaaa
      901 gctgtttggg aatatggaag gagactgtcc ctctgactgg aaaacagact ctacatgtag
      961 gatggtaacc tcagaaagca agaatgtgaa gctcactgtg agcaatgtgc tgaaagagat
     1021 aaaaattctt aacatctttg gagttattaa aggctttgta gaaccagatc actatgttgt
     1081 agttggggcc cagagagatg catggggccc tggagctgca aaatccggtg taggcacagc
     1141 tctcctattg aaacttgccc agatgttctc agatatggtc ttaaaagatg ggtttcagcc
     1201 cagcagaagc attatctttg ccagttggag tgctggagac tttggatcgg ttggtgccac
     1261 tgaatggcta gagggatacc tttcgtccct gcatttaaag gctttcactt atattaatct
     1321 ggataaagcg gttcttggta ccagcaactt caaggtttct gccagcccac tgttgtatac
     1381 gcttattgag aaaacaatgc aaaatgtgaa gcatccggtt actgggcaat ttctatatca
     1441 ggacagcaac tgggccagca aagttgagaa actcacttta gacaatgctg ctttcccttt
     1501 ccttgcatat tctggaatcc cagcagtttc tttctgtttt tgcgaggaca cagattatcc
     1561 ttatttgggt accaccatgg acacctataa ggaactgatt gagaggattc ctgagttgaa
     1621 caaagtggca cgagcagctg cagaggtcgc tggtcagttc gtgattaaac taacccatga
     1681 tgttgaattg aacctggact atgagaggta caacagccaa ctgctttcat ttgtgaggga
     1741 tctgaaccaa tacagagcag acataaagga aatgggcctg agtttacagt ggctgtattc
     1801 tgctcgtgga gacttcttcc gtgctacttc cagactaaca acagatttcg ggaatgctga
     1861 gaaaacagac agatttgtca tgaagaaact caatgatcgt gtcatgagag tggagtatca
     1921 cttcctctct ccctacgtat ctccaaaaga gtctcctttc cgacatgtct tctggggctc
     1981 cggctctcac acgctgccag ctttactgga gaacttgaaa ctgcgtaaac aaaataacgg
     2041 tgcttttaat gaaacgctgt tcagaaacca gttggctcta gctacttgga ctattcaggg
     2101 agctgcaaat gccctctctg gtgacgtttg ggacattgac aatgagtttt aaatgtgata
     2161 cccatagctt ccatgagaac agcagggtag tctggtttct agacttgtgc tgatcgtgct
     2221 aaattttcag tagggctaca aaacctgatg ttaaaattcc atcccatcat cttggtacta
     2281 ctagatgtct ttaggcagca gcttttaata cagggtagat aacctgtact tcaagttaaa
     2341 gtgaataacc acttaaaaaa tgtccatgat ggaatattcc cctatctcta gaattttaag
     2401 tgctttgtaa tgggaactgc ctctttcctg ttgttgttaa tgaaaatgtc agaaaccagt
     2461 tatgtgaatg atctctctga atcctaaggg ctggtctctg ctgaaggttg taagtggtcg
     2521 cttactttga gtgatcctcc aacttcattt gatgctaaat aggagatacc aggttgaaag
     2581 accttctcca aatgagatct aagcctttcc ataaggaatg tagctggttt cctcattcct
     2641 gaaagaaaca gttaactttc agaagagatg ggcttgtttt cttgccaatg aggtctgaaa
     2701 tggaggtcct tctgctggat aaaatgaggt tcaactgttg attgcaggaa taaggcctta
     2761 atatgttaac ctcagtgtca tttatgaaaa gaggggacca gaagccaaag acttagtata
     2821 ttttcttttc ctctgtccct tcccccataa gcctccattt agttctttgt tatttttgtt
     2881 tcttccaaag cacattgaaa gagaaccagt ttcaggtgtt tagttgcaga ctcagtttgt
     2941 cagactttaa agaataatat gctgccaaat tttggccaaa gtgttaatct taggggagag
     3001 ctttctgtcc ttttggcact gagatattta ttgtttattt atcagtgaca gagttcacta
     3061 taaatggtgt ttttttaata gaatataatt atcggaagca gtgccttcca taattatgac
     3121 agttatactg tcggtttttt ttaaataaaa gcagcatctg ctaataaaac ccaacagata
     3181 ctggaagttt tgcatttatg gtcaacactt aagggtttta gaaaacagcc gtcagccaaa
     3241 tgtaattgaa taaagttgaa gctaagattt agagatgaat taaatttaat taggggttgc
     3301 taagaagcga gcactgacca gataagaatg ctggttttcc taaatgcagt gaattgtgac
     3361 caagttataa atcaatgtca cttaaaggct gtggtagtac tcctgcaaaa ttttatagct
     3421 cagtttatcc aaggtgtaac tctaattccc attttgcaaa atttccagta cctttgtcac
     3481 aatcctaaca cattatcggg agcagtgtct tccataatgt ataaagaaca aggtagtttt
     3541 tacctaccac agtgtctgta tcggagacag tgatctccat atgttacact aagggtgtaa
     3601 gtaattatcg ggaacagtgt ttcccataat tttcttcatg caatgacatc ttcaaagctt
     3661 gaagatcgtt agtatctaac atgtatccca actcctataa ttccctatct tttagtttta
     3721 gttgcagaaa cattttgtgg tcattaagca ttgggtgggt aaattcaacc actgtaaaat
     3781 gaaattacta caaaatttga aatttagctt gggtttttgt tacctttatg gtttctccag
     3841 gtcctctact taatgagata gtagcataca tttataatgt ttgctattga caagtcattt
     3901 taactttatc acattatttg catgttacct cctataaact tagtgcggac aagttttaat
     3961 ccagaattga ccttttgact taaagcagag ggactttgta tagaaggttt gggggctgtg
     4021 gggaaggaga gtcccctgaa ggtctgacac gtctgcctac ccattcgtgg tgatcaatta
     4081 aatgtaggta tgaataagtt cgaagctccg tgagtgaacc atcattataa acgtgatgat
     4141 cagctgtttg tcatagggca gttggaaacg gcctcctagg gaaaagttca tagggtctct
     4201 tcaggttctt agtgtcactt acctagattt acagcctcac ttgaatgtgt cactactcac
     4261 agtctcttta atcttcagtt ttatctttaa tctcctcttt tatcttggac tgacatttag
     4321 cgtagctaag tgaaaaggtc atagctgaga ttcctggttc gggtgttacg cacacgtact
     4381 taaatgaaag catgtggcat gttcatcgta taacacaata tgaatacagg gcatgcattt
     4441 tgcagcagtg agtctcttca gaaaaccctt ttctacagtt agggttgagt tacttcctat
     4501 caagccagta cgtgctaaca ggctcaatat tcctgaatga aatatcagac tagtgacaag
     4561 ctcctggtct tgagatgtct tctcgttaag gagatgggcc ttttggaggt aaaggataaa
     4621 atgaatgagt tctgtcatga ttcactattc tagaacttgc atgaccttta ctgtgttagc
     4681 tctttgaatg ttcttgaaat tttagacttt ctttgtaaac aaatgatatg tccttatcat
     4741 tgtataaaag ctgttatgtg caacagtgtg gagattcctt gtctgattta ataaaatact
     4801 taaacactga
//
