LOCUS       NM_001128148            5012 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens transferrin receptor (TFRC), transcript variant 2,
            mRNA.
ACCESSION   NM_001128148
VERSION     NM_001128148.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5012)
  AUTHORS   Xing,P., Zhou,M., Sun,J., Wang,D., Huang,W. and An,P.
  TITLE     NAT10-mediated ac4C acetylation of TFRC promotes sepsis-induced
            pulmonary injury through regulating ferroptosis
  JOURNAL   Mol Med 30 (1), 140 (2024)
   PUBMED   39251905
  REMARK    GeneRIF: NAT10-mediated ac[4]C acetylation of TFRC promotes
            sepsis-induced pulmonary injury through regulating ferroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5012)
  AUTHORS   Ji,W., Zhang,W., Zhang,X. and Ke,Y.
  TITLE     TRIM33 enhances the ubiquitination of TFRC to enhance the
            susceptibility of liver cancer cells to ferroptosis
  JOURNAL   Cell Signal 121, 111268 (2024)
   PUBMED   38909931
  REMARK    GeneRIF: TRIM33 enhances the ubiquitination of TFRC to enhance the
            susceptibility of liver cancer cells to ferroptosis.
REFERENCE   3  (bases 1 to 5012)
  AUTHORS   Shang,X., Wang,H., Gu,J., Zhao,X., Zhang,J., Sun,B. and Zhu,X.
  TITLE     Ferroptosis-related gene transferrin receptor protein 1 expression
            correlates with the prognosis and tumor immune microenvironment in
            cervical cancer
  JOURNAL   PeerJ 12, e17842 (2024)
   PUBMED   39131609
  REMARK    GeneRIF: Ferroptosis-related gene transferrin receptor protein 1
            expression correlates with the prognosis and tumor immune
            microenvironment in cervical cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5012)
  AUTHORS   Qin,J., Li,Z., Su,L., Wen,X., Tang,X., Huang,M. and Wu,J.
  TITLE     Expression of transferrin receptor/TFRC protein in bladder cancer
            cell T24 and its role in inducing iron death in bladder cancer
  JOURNAL   Int J Biol Macromol 274 (Pt 1), 133323 (2024)
   PUBMED   38908617
  REMARK    GeneRIF: Expression of transferrin receptor/TFRC protein in bladder
            cancer cell T24 and its role in inducing iron death in bladder
            cancer.
REFERENCE   5  (bases 1 to 5012)
  AUTHORS   Pacella,I., Pinzon Grimaldos,A., Rossi,A., Tucci,G., Zagaglioni,M.,
            Potenza,E., Pinna,V., Rotella,I., Cammarata,I., Cancila,V.,
            Belmonte,B., Tripodo,C., Pietropaolo,G., Di Censo,C., Sciume,G.,
            Licursi,V., Peruzzi,G., Antonucci,Y., Campello,S., Guerrieri,F.,
            Iebba,V., Prota,R., Di Chiara,M., Terrin,G., De Peppo,V.,
            Grazi,G.L., Barnaba,V. and Piconese,S.
  TITLE     Iron capture through CD71 drives perinatal and tumor-associated
            Treg expansion
  JOURNAL   JCI Insight 9 (15), e167967 (2024)
   PUBMED   38954474
  REMARK    GeneRIF: Iron capture through CD71 drives perinatal and
            tumor-associated Treg expansion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5012)
  AUTHORS   Chicz,R.M., Urban,R.G., Lane,W.S., Gorga,J.C., Stern,L.J.,
            Vignali,D.A. and Strominger,J.L.
  TITLE     Predominant naturally processed peptides bound to HLA-DR1 are
            derived from MHC-related molecules and are heterogeneous in size
  JOURNAL   Nature 358 (6389), 764-768 (1992)
   PUBMED   1380674
REFERENCE   7  (bases 1 to 5012)
  AUTHORS   Hayes,G.R., Enns,C.A. and Lucas,J.J.
  TITLE     Identification of the O-linked glycosylation site of the human
            transferrin receptor
  JOURNAL   Glycobiology 2 (4), 355-359 (1992)
   PUBMED   1421757
REFERENCE   8  (bases 1 to 5012)
  AUTHORS   Do,S.I. and Cummings,R.D.
  TITLE     Presence of O-linked oligosaccharide on a threonine residue in the
            human transferrin receptor
  JOURNAL   Glycobiology 2 (4), 345-353 (1992)
   PUBMED   1421756
REFERENCE   9  (bases 1 to 5012)
  AUTHORS   Baynes,R.D., Shih,Y.J., Hudson,B.G. and Cook,J.D.
  TITLE     Characterization of transferrin receptor released by K562
            erythroleukemia cells
  JOURNAL   Proc Soc Exp Biol Med 197 (4), 416-423 (1991)
   PUBMED   1871153
REFERENCE   10 (bases 1 to 5012)
  AUTHORS   Shih,Y.J., Baynes,R.D., Hudson,B.G., Flowers,C.H., Skikne,B.S. and
            Cook,J.D.
  TITLE     Serum transferrin receptor is a truncated form of tissue receptor
  JOURNAL   J Biol Chem 265 (31), 19077-19081 (1990)
   PUBMED   2229063
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF994006.1, BC001188.1,
            X01060.1 and BX537966.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001128148.2.
            
            Summary: This gene encodes a cell surface receptor necessary for
            cellular iron uptake by the process of receptor-mediated
            endocytosis. This receptor is required for erythropoiesis and
            neurologic development. Multiple alternatively spliced variants
            have been identified. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.18761.1,
                                           SRR1660809.22598.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360110.9/ ENSP00000353224.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-549               CF994006.1         100-648
            550-4190            BC001188.1         535-4175
            4191-4327           X01060.1           4381-4517
            4328-4926           BC001188.1         4313-4911
            4927-5011           BX537966.1         4724-4808
            5012-5012           BC001188.1         4997-4997
FEATURES             Location/Qualifiers
     source          1..5012
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..5012
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /note="transferrin receptor"
                     /db_xref="GeneID:7037"
                     /db_xref="HGNC:HGNC:11763"
                     /db_xref="MIM:190010"
     exon            1..48
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            49..107
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2354
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /note="isoform 1 is encoded by transcript variant 2;
                     transferrin receptor protein 1"
                     /codon_start=1
                     /product="transferrin receptor protein 1 isoform 1"
                     /protein_id="NP_001121620.1"
                     /db_xref="CCDS:CCDS3312.1"
                     /db_xref="GeneID:7037"
                     /db_xref="HGNC:HGNC:11763"
                     /db_xref="MIM:190010"
                     /translation="MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDE
                     EENADNNTKANVTKPKRCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLA
                     GTESPVREEPGEDFPAARRLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQ
                     KDENLALYVENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGG
                     YVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNA
                     IGVLIYMDQTKFPIVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPV
                     QTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGV
                     IKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIF
                     ASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEK
                     TMQNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYL
                     GTTMDTYKELIERIPELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRD
                     LNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVE
                     YHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRKQNNGAFNETLFRNQLALATW
                     TIQGAANALSGDVWDIDNEF"
     exon            108..309
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            310..505
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            506..655
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            656..758
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            759..872
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            873..971
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1111
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1269
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1389
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1475
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1539
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1607
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1666
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1748
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1970
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2111
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..5012
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4992..4997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /note="hexamer: AATAAA"
     polyA_site      5012
                     /gene="TFRC"
                     /gene_synonym="CD71; IMD46; p90; T9; TFR; TFR1; TR; TRFR"
                     /note="major polyA site"
ORIGIN      
        1 agagcgtcgg gatatcgggt ggcggctcgg gacggaggac gcgctagtgt tcttctgtgt
       61 ggcagttcag aatgatggat caagctagat cagcattctc taacttgttt ggtggagaac
      121 cattgtcata tacccggttc agcctggctc ggcaagtaga tggcgataac agtcatgtgg
      181 agatgaaact tgctgtagat gaagaagaaa atgctgacaa taacacaaag gccaatgtca
      241 caaaaccaaa aaggtgtagt ggaagtatct gctatgggac tattgctgtg atcgtctttt
      301 tcttgattgg atttatgatt ggctacttgg gctattgtaa aggggtagaa ccaaaaactg
      361 agtgtgagag actggcagga accgagtctc cagtgaggga ggagccagga gaggacttcc
      421 ctgcagcacg tcgcttatat tgggatgacc tgaagagaaa gttgtcggag aaactggaca
      481 gcacagactt caccggcacc atcaagctgc tgaatgaaaa ttcatatgtc cctcgtgagg
      541 ctggatctca aaaagatgaa aatcttgcgt tgtatgttga aaatcaattt cgtgaattta
      601 aactcagcaa agtctggcgt gatcaacatt ttgttaagat tcaggtcaaa gacagcgctc
      661 aaaactcggt gatcatagtt gataagaacg gtagacttgt ttacctggtg gagaatcctg
      721 ggggttatgt ggcgtatagt aaggctgcaa cagttactgg taaactggtc catgctaatt
      781 ttggtactaa aaaagatttt gaggatttat acactcctgt gaatggatct atagtgattg
      841 tcagagcagg gaaaatcacc tttgcagaaa aggttgcaaa tgctgaaagc ttaaatgcaa
      901 ttggtgtgtt gatatacatg gaccagacta aatttcccat tgttaacgca gaactttcat
      961 tctttggaca tgctcatctg gggacaggtg acccttacac acctggattc ccttccttca
     1021 atcacactca gtttccacca tctcggtcat caggattgcc taatatacct gtccagacaa
     1081 tctccagagc tgctgcagaa aagctgtttg ggaatatgga aggagactgt ccctctgact
     1141 ggaaaacaga ctctacatgt aggatggtaa cctcagaaag caagaatgtg aagctcactg
     1201 tgagcaatgt gctgaaagag ataaaaattc ttaacatctt tggagttatt aaaggctttg
     1261 tagaaccaga tcactatgtt gtagttgggg cccagagaga tgcatggggc cctggagctg
     1321 caaaatccgg tgtaggcaca gctctcctat tgaaacttgc ccagatgttc tcagatatgg
     1381 tcttaaaaga tgggtttcag cccagcagaa gcattatctt tgccagttgg agtgctggag
     1441 actttggatc ggttggtgcc actgaatggc tagagggata cctttcgtcc ctgcatttaa
     1501 aggctttcac ttatattaat ctggataaag cggttcttgg taccagcaac ttcaaggttt
     1561 ctgccagccc actgttgtat acgcttattg agaaaacaat gcaaaatgtg aagcatccgg
     1621 ttactgggca atttctatat caggacagca actgggccag caaagttgag aaactcactt
     1681 tagacaatgc tgctttccct ttccttgcat attctggaat cccagcagtt tctttctgtt
     1741 tttgcgagga cacagattat ccttatttgg gtaccaccat ggacacctat aaggaactga
     1801 ttgagaggat tcctgagttg aacaaagtgg cacgagcagc tgcagaggtc gctggtcagt
     1861 tcgtgattaa actaacccat gatgttgaat tgaacctgga ctatgagagg tacaacagcc
     1921 aactgctttc atttgtgagg gatctgaacc aatacagagc agacataaag gaaatgggcc
     1981 tgagtttaca gtggctgtat tctgctcgtg gagacttctt ccgtgctact tccagactaa
     2041 caacagattt cgggaatgct gagaaaacag acagatttgt catgaagaaa ctcaatgatc
     2101 gtgtcatgag agtggagtat cacttcctct ctccctacgt atctccaaaa gagtctcctt
     2161 tccgacatgt cttctggggc tccggctctc acacgctgcc agctttactg gagaacttga
     2221 aactgcgtaa acaaaataac ggtgctttta atgaaacgct gttcagaaac cagttggctc
     2281 tagctacttg gactattcag ggagctgcaa atgccctctc tggtgacgtt tgggacattg
     2341 acaatgagtt ttaaatgtga tacccatagc ttccatgaga acagcagggt agtctggttt
     2401 ctagacttgt gctgatcgtg ctaaattttc agtagggcta caaaacctga tgttaaaatt
     2461 ccatcccatc atcttggtac tactagatgt ctttaggcag cagcttttaa tacagggtag
     2521 ataacctgta cttcaagtta aagtgaataa ccacttaaaa aatgtccatg atggaatatt
     2581 cccctatctc tagaatttta agtgctttgt aatgggaact gcctctttcc tgttgttgtt
     2641 aatgaaaatg tcagaaacca gttatgtgaa tgatctctct gaatcctaag ggctggtctc
     2701 tgctgaaggt tgtaagtggt cgcttacttt gagtgatcct ccaacttcat ttgatgctaa
     2761 ataggagata ccaggttgaa agaccttctc caaatgagat ctaagccttt ccataaggaa
     2821 tgtagctggt ttcctcattc ctgaaagaaa cagttaactt tcagaagaga tgggcttgtt
     2881 ttcttgccaa tgaggtctga aatggaggtc cttctgctgg ataaaatgag gttcaactgt
     2941 tgattgcagg aataaggcct taatatgtta acctcagtgt catttatgaa aagaggggac
     3001 cagaagccaa agacttagta tattttcttt tcctctgtcc cttcccccat aagcctccat
     3061 ttagttcttt gttatttttg tttcttccaa agcacattga aagagaacca gtttcaggtg
     3121 tttagttgca gactcagttt gtcagacttt aaagaataat atgctgccaa attttggcca
     3181 aagtgttaat cttaggggag agctttctgt ccttttggca ctgagatatt tattgtttat
     3241 ttatcagtga cagagttcac tataaatggt gtttttttaa tagaatataa ttatcggaag
     3301 cagtgccttc cataattatg acagttatac tgtcggtttt ttttaaataa aagcagcatc
     3361 tgctaataaa acccaacaga tactggaagt tttgcattta tggtcaacac ttaagggttt
     3421 tagaaaacag ccgtcagcca aatgtaattg aataaagttg aagctaagat ttagagatga
     3481 attaaattta attaggggtt gctaagaagc gagcactgac cagataagaa tgctggtttt
     3541 cctaaatgca gtgaattgtg accaagttat aaatcaatgt cacttaaagg ctgtggtagt
     3601 actcctgcaa aattttatag ctcagtttat ccaaggtgta actctaattc ccattttgca
     3661 aaatttccag tacctttgtc acaatcctaa cacattatcg ggagcagtgt cttccataat
     3721 gtataaagaa caaggtagtt tttacctacc acagtgtctg tatcggagac agtgatctcc
     3781 atatgttaca ctaagggtgt aagtaattat cgggaacagt gtttcccata attttcttca
     3841 tgcaatgaca tcttcaaagc ttgaagatcg ttagtatcta acatgtatcc caactcctat
     3901 aattccctat cttttagttt tagttgcaga aacattttgt ggtcattaag cattgggtgg
     3961 gtaaattcaa ccactgtaaa atgaaattac tacaaaattt gaaatttagc ttgggttttt
     4021 gttaccttta tggtttctcc aggtcctcta cttaatgaga tagtagcata catttataat
     4081 gtttgctatt gacaagtcat tttaacttta tcacattatt tgcatgttac ctcctataaa
     4141 cttagtgcgg acaagtttta atccagaatt gaccttttga cttaaagcag agggactttg
     4201 tatagaaggt ttgggggctg tggggaagga gagtcccctg aaggtctgac acgtctgcct
     4261 acccattcgt ggtgatcaat taaatgtagg tatgaataag ttcgaagctc cgtgagtgaa
     4321 ccatcattat aaacgtgatg atcagctgtt tgtcataggg cagttggaaa cggcctccta
     4381 gggaaaagtt catagggtct cttcaggttc ttagtgtcac ttacctagat ttacagcctc
     4441 acttgaatgt gtcactactc acagtctctt taatcttcag ttttatcttt aatctcctct
     4501 tttatcttgg actgacattt agcgtagcta agtgaaaagg tcatagctga gattcctggt
     4561 tcgggtgtta cgcacacgta cttaaatgaa agcatgtggc atgttcatcg tataacacaa
     4621 tatgaataca gggcatgcat tttgcagcag tgagtctctt cagaaaaccc ttttctacag
     4681 ttagggttga gttacttcct atcaagccag tacgtgctaa caggctcaat attcctgaat
     4741 gaaatatcag actagtgaca agctcctggt cttgagatgt cttctcgtta aggagatggg
     4801 ccttttggag gtaaaggata aaatgaatga gttctgtcat gattcactat tctagaactt
     4861 gcatgacctt tactgtgtta gctctttgaa tgttcttgaa attttagact ttctttgtaa
     4921 acaaatgata tgtccttatc attgtataaa agctgttatg tgcaacagtg tggagattcc
     4981 ttgtctgatt taataaaata cttaaacact ga
//
