LOCUS       NM_013342               1180 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens TCF3 fusion partner (TFPT), transcript variant 1,
            mRNA.
ACCESSION   NM_013342
VERSION     NM_013342.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1180)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1180)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1180)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1180)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1180)
  AUTHORS   Zhang,S., Zhou,B., Wang,L., Li,P., Bennett,B.D., Snyder,R.,
            Garantziotis,S., Fargo,D.C., Cox,A.D., Chen,L. and Hu,G.
  TITLE     INO80 is required for oncogenic transcription and tumor growth in
            non-small cell lung cancer
  JOURNAL   Oncogene 36 (10), 1430-1439 (2017)
   PUBMED   27641337
REFERENCE   6  (bases 1 to 1180)
  AUTHORS   Jiang,F., Ai,J., Xiao,W. and Wang,Z.
  TITLE     FB1, an E2A fusion partner in childhood leukemia, interacts with
            U19/EAF2 and inhibits its transcriptional activity
  JOURNAL   Cancer Lett 253 (2), 265-272 (2007)
   PUBMED   17395368
  REMARK    GeneRIF: FB1 is an important binding partner and a functional
            regulator of U19/EAF2, EAF1, and/or ELL.
REFERENCE   7  (bases 1 to 1180)
  AUTHORS   Franchini,C., Fontana,F., Minuzzo,M., Babbio,F. and Privitera,E.
  TITLE     Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner)
            appears p53 independent, cell type restricted and cell density
            influenced
  JOURNAL   Apoptosis 11 (12), 2217-2224 (2006)
   PUBMED   17041757
  REMARK    GeneRIF: Although p53 is a main regulator of apoptosis in mammalian
            cells, the Tfpt induced apoptosis appears p53-independent.
REFERENCE   8  (bases 1 to 1180)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
REFERENCE   9  (bases 1 to 1180)
  AUTHORS   Irie,Y., Yamagata,K., Gan,Y., Miyamoto,K., Do,E., Kuo,C.H.,
            Taira,E. and Miki,N.
  TITLE     Molecular cloning and characterization of Amida, a novel protein
            which interacts with a neuron-specific immediate early gene product
            arc, contains novel nuclear localization signals, and causes cell
            death in cultured cells
  JOURNAL   J Biol Chem 275 (4), 2647-2653 (2000)
   PUBMED   10644725
REFERENCE   10 (bases 1 to 1180)
  AUTHORS   Brambillasca,F., Mosna,G., Colombo,M., Rivolta,A., Caslini,C.,
            Minuzzo,M., Giudici,G., Mizzi,L., Biondi,A. and Privitera,E.
  TITLE     Identification of a novel molecular partner of the E2A gene in
            childhood leukemia
  JOURNAL   Leukemia 13 (3), 369-375 (1999)
   PUBMED   10086727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI820344.1, AF052052.1 and BQ027375.1.
            
            On Aug 11, 2020 this sequence version replaced NM_013342.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004281.1, SRR14038192.2418437.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMN03267751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391759.6/ ENSP00000375639.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               BI820344.1         19-429
            412-1177            AF052052.1         303-1068
            1178-1180           BQ027375.1         26-28               c
FEATURES             Location/Qualifiers
     source          1..1180
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1180
                     /gene="TFPT"
                     /gene_synonym="amida; FB1; INO80F"
                     /note="TCF3 fusion partner"
                     /db_xref="GeneID:29844"
                     /db_xref="HGNC:HGNC:13630"
                     /db_xref="MIM:609519"
     exon            1..411
                     /gene="TFPT"
                     /gene_synonym="amida; FB1; INO80F"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..1150
                     /gene="TFPT"
                     /gene_synonym="amida; FB1; INO80F"
                     /note="isoform 1 is encoded by transcript variant 1;
                     amida, partner of the E2A; INO80 complex subunit F; TCF3
                     (E2A) fusion partner (in childhood Leukemia)"
                     /codon_start=1
                     /product="TCF3 fusion partner isoform 1"
                     /protein_id="NP_037474.1"
                     /db_xref="CCDS:CCDS12878.1"
                     /db_xref="GeneID:29844"
                     /db_xref="HGNC:HGNC:13630"
                     /db_xref="MIM:609519"
                     /translation="MELEQREGTMAAVGFEEFSAPPGSELALPPLFGGHILESELETE
                     VEFVSGGLGGSGLRERDEEEEAARGRRRRQRELNRRKYQALGRRCREIEQVNERVLNR
                     LHQVQRITRRLQQERRFLMRVLDSYGDDYRASQFTIVLEDEGSQGTDAPTPGNAENEP
                     PEKETLSPPRRTPAPPEPGSPAPGEGPSGRKRRRVPRDGRRAGNALTPELAPVQIKVE
                     EDFGFEADEALDSSWVSRGPDKLLPYPTLASPASD"
     exon            412..670
                     /gene="TFPT"
                     /gene_synonym="amida; FB1; INO80F"
                     /inference="alignment:Splign:2.1.0"
     exon            671..741
                     /gene="TFPT"
                     /gene_synonym="amida; FB1; INO80F"
                     /inference="alignment:Splign:2.1.0"
     exon            742..811
                     /gene="TFPT"
                     /gene_synonym="amida; FB1; INO80F"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1030
                     /gene="TFPT"
                     /gene_synonym="amida; FB1; INO80F"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1180
                     /gene="TFPT"
                     /gene_synonym="amida; FB1; INO80F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1160..1165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFPT"
                     /gene_synonym="amida; FB1; INO80F"
                     /note="hexamer: AATAAA"
     polyA_site      1180
                     /gene="TFPT"
                     /gene_synonym="amida; FB1; INO80F"
                     /note="major polyA site"
ORIGIN      
        1 attagcacct ggcactaggc ggagagaggc ggtaagccgc gaggaggaaa gggactcacg
       61 tcccgctgtg gaccgatcct gctaagcaga gaatcgctgt ggccggacga cggggcgtcg
      121 agacaagaag aaagacgttg gcaactcaga ggactggttg cggcgttaga caagaaagca
      181 aggcctttaa gcagggattc ggggtggacg tgggggtggg ccgaagcgaa gccggaaaca
      241 ggaaactaca actcccacaa ggcctagggc cacgtcccgc cgtcctcggc tgctgagcct
      301 gatgggacaa gtagttttgc gaacggctta acctacagat tgaagaggtc ggaagctctg
      361 aggcccgggg cttccggagg tcgcggagat ggaattggag cagagagaag ggaccatggc
      421 agccgtgggc tttgaggagt tctcagcgcc gccaggctca gagttggcgt tgcctcccct
      481 atttggtggc cacatcctgg agagcgagct ggagacggaa gtggagtttg tgtcaggtgg
      541 tctgggcggc tcagggctcc gggagcgaga tgaagaggaa gaggcagccc ggggtcggcg
      601 gcggcgccag cgggaattaa atcgcagaaa gtaccaggca ctaggtcggc gctgccggga
      661 gatcgagcag gtgaacgagc gggtcctgaa caggctccat caggtgcaga ggataactcg
      721 gaggctgcag caggaacgga ggttcctcat gagagtgctg gactcctacg gggatgacta
      781 ccgggccagc cagttcacca ttgtgctgga ggatgagggc agccagggca cggatgcccc
      841 caccccaggc aatgcggaga atgagcctcc agagaaagag acactgtccc cgcccagaag
      901 gactcctgca cccccagaac ccggcagccc agcccccggt gaggggccca gtgggcggaa
      961 gaggcggcga gtgccacggg atggacgccg agcaggaaat gcgctgactc cagagctggc
     1021 cccggtgcag attaaggttg aggaagactt tggctttgaa gcagatgagg ccctggattc
     1081 cagttgggtt tctcggggtc cagacaaact gctgccctac ccgaccctgg ccagcccagc
     1141 ctctgactga cgcatgccca ataaactgac cccacactca
//
