LOCUS       NM_012143               3539 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens tuftelin interacting protein 11 (TFIP11), transcript
            variant 2, mRNA.
ACCESSION   NM_012143
VERSION     NM_012143.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3539)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3539)
  AUTHORS   Chen,J., Wu,M., Yang,Y., Ruan,C., Luo,Y., Song,L., Wu,T., Huang,J.,
            Yang,B. and Liu,T.
  TITLE     TFIP11 promotes replication fork reversal to preserve genome
            stability
  JOURNAL   Nat Commun 15 (1), 1262 (2024)
   PUBMED   38341452
  REMARK    GeneRIF: TFIP11 promotes replication fork reversal to preserve
            genome stability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3539)
  AUTHORS   Duchemin,A., O'Grady,T., Hanache,S., Mereau,A., Thiry,M.,
            Wacheul,L., Michaux,C., Perpete,E., Hervouet,E., Peixoto,P.,
            Ernst,F.G.M., Audic,Y., Dequiedt,F., Lafontaine,D.L.J. and
            Mottet,D.
  TITLE     DHX15-independent roles for TFIP11 in U6 snRNA modification,
            U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity
  JOURNAL   Nat Commun 12 (1), 6648 (2021)
   PUBMED   34789764
  REMARK    GeneRIF: DHX15-independent roles for TFIP11 in U6 snRNA
            modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing
            fidelity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3539)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3539)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3539)
  AUTHORS   Wang,H.J., Tannukit,S., Wen,X., Shapiro,J.L., Snead,M.L. and
            Paine,M.L.
  TITLE     Using the yeast two-hybrid assay to discover protein partners for
            the leucine-rich amelogenin peptide and for tuftelin-interacting
            protein 11
  JOURNAL   Eur J Oral Sci 114 Suppl 1, 276-9 (2006)
   PUBMED   16674698
REFERENCE   7  (bases 1 to 3539)
  AUTHORS   Wen,X., Lei,Y.P., Zhou,Y.L., Okamoto,C.T., Snead,M.L. and
            Paine,M.L.
  TITLE     Structural organization and cellular localization of
            tuftelin-interacting protein 11 (TFIP11)
  JOURNAL   Cell Mol Life Sci 62 (9), 1038-1046 (2005)
   PUBMED   15868102
  REMARK    GeneRIF: TFIP11 is a novel splicing factor and transfected
            TFIP11-GFP fusion protein was found to locate in a novel subnuclear
            TFIP body.
REFERENCE   8  (bases 1 to 3539)
  AUTHORS   Jurica,M.S. and Moore,M.J.
  TITLE     Pre-mRNA splicing: awash in a sea of proteins
  JOURNAL   Mol Cell 12 (1), 5-14 (2003)
   PUBMED   12887888
  REMARK    Review article
REFERENCE   9  (bases 1 to 3539)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 3539)
  AUTHORS   Paine,C.T., Paine,M.L., Luo,W., Okamoto,C.T., Lyngstadaas,S.P. and
            Snead,M.L.
  TITLE     A tuftelin-interacting protein (TIP39) localizes to the apical
            secretory pole of mouse ameloblasts
  JOURNAL   J Biol Chem 275 (29), 22284-22292 (2000)
   PUBMED   10806191
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC411331.1, AL050258.1 and
            AI468631.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012143.3.
            
            Summary: This gene encodes a protein component of the spliceosome
            that promotes the release of the lariat-intron during late-stage
            splicing through the recruitment of a pre-mRNA splicing factor
            called DEAH-box helicase 15. The encoded protein contains a G-patch
            domain, a hallmark of RNA-processing proteins, that binds DEAH-box
            helicase 15. This protein contains an atypical nuclear localization
            sequence as well as a nuclear speckle-targeting sequence, enabling
            it to localize to distinct speckled regions within the cell
            nucleus. Polymorphisms in this gene are associated with dental
            caries suggesting a role in amelogenesis. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Nov
            2016].
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR,
            compared to variant1. Variants 1-6 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL050258.1, SRR1803617.25500.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407690.6/ ENSP00000384421.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DC411331.1         34-35
            3-3538              AL050258.1         14-3549
            3539-3539           AI468631.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..3539
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.1"
     gene            1..3539
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /note="tuftelin interacting protein 11"
                     /db_xref="GeneID:24144"
                     /db_xref="HGNC:HGNC:17165"
                     /db_xref="MIM:612747"
     exon            1..80
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            81..157
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            158..243
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            244..461
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..2766
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /note="isoform 1 is encoded by transcript variant 2;
                     septin and tuftelin-interacting protein 1; sip1/tuftelin
                     interacting protein"
                     /codon_start=1
                     /product="tuftelin-interacting protein 11 isoform 1"
                     /protein_id="NP_036275.1"
                     /db_xref="CCDS:CCDS13838.1"
                     /db_xref="GeneID:24144"
                     /db_xref="HGNC:HGNC:17165"
                     /db_xref="MIM:612747"
                     /translation="MSLSHLYRDGEGRIDDDDDERENFEITDWDLQNEFNPNRQRHWQ
                     TKEEATYGVWAERDSDDERPSFGGKRARDYSAPVNFISAGLKKGAAEEAELEDSDDEE
                     KPVKQDDFPKDFGPRKLKTGGNFKPSQKGFAGGTKSFMDFGSWERHTKGIGQKLLQKM
                     GYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAYGSERTTQSMQDFPVVDSEEEAEEEF
                     QKELSQWRKDPSGSKKKPKYSYKTVEELKAKGRISKKLTAPQKELSQVKVIDMTGREQ
                     KVYYSYSQISHKHNVPDDGLPLQSQQLPQSGKEAKAPGFALPELEHNLQLLIDLTEQE
                     IIQNDRQLQYERDMVVNLFHELEKMTEVLDHEERVISNLSKVLEMVEECERRMQPDCS
                     NPLTLDECARIFETLQDKYYEEYRMSDRVDLAVAIVYPLMKEYFKEWDPLKDCTYGTE
                     IISKWKSLLENDQLLSHGGQDLSADAFHRLIWEVWMPFVRNIVTQWQPRNCDPMVDFL
                     DSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTVPIHSWIHPWLPLMQARLEPL
                     YSPIRSKLSSALQKWHPSDSSAKLILQPWKDVFTPGSWEAFMVKNIVPKLGMCLGELV
                     INPHQQHMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVLCSWLSNSPNYEEITKW
                     YLGWKSMFSDQVLAHPSVKDKFNEALDIMNRAVSSNVGAYMQPGARENIAYLTHTERR
                     KDFQYEAMQERREAENMAQRGIGVAASSVPMNFKDLIETKAEEHNIVFMPVIGKRHEG
                     KQLYTFGRIVIYIDRGVVFVQGEKTWVPTSLQSLIDMAK"
     exon            462..615
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            616..772
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            773..900
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1053
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1581
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1688
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1857
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2101
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2244
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2410
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..3539
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2822..2827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /note="hexamer: AATAAA"
     polyA_site      2852
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /note="major polyA site"
     regulatory      3514..3519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /note="hexamer: AATAAA"
     regulatory      3523..3528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
                     /note="hexamer: AATAAG"
     polyA_site      3535
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
     polyA_site      3539
                     /gene="TFIP11"
                     /gene_synonym="bK445C9.6; NTR1; Spp382; STIP; STIP-1;
                     TIP39"
ORIGIN      
        1 gcttccgggt tctggtgtag gagcggcgtc ttctcgcgcg gatggtgaag ctgaatttgg
       61 tacgctggac cctcggacag acagcaagag agagacaagc ccgaggcctg acttctagca
      121 ctcctgagtt tgagccctat gagcagtgga acctagggac caccaaggat ccagatataa
      181 ttctttcctc agtaatagaa aaaagaatct gggatctaag aagataccta ctcattttct
      241 aagtgactgg ccatgtcatt gtcccactta taccgggatg gggaaggccg cattgatgat
      301 gatgatgacg agcgggagaa ctttgagatc actgactggg atctccagaa tgagttcaac
      361 cccaaccgac agcgccactg gcagaccaag gaagaagcca cctacggggt gtgggcagag
      421 cgagactcgg atgatgagag gcccagcttt ggaggcaaac gggcccgtga ctactctgcg
      481 ccagtcaact tcatcagcgc agggctcaag aaaggggcag cggaggaggc agagttggaa
      541 gattctgatg acgaagagaa acctgttaag caggacgact ttcctaagga ttttggacca
      601 aggaagctaa aaacgggtgg caattttaag cccagccaga aaggttttgc aggaggaacc
      661 aaatctttca tggacttcgg cagctgggaa agacacacaa aaggaattgg acagaagctt
      721 cttcagaaga tgggctacgt ccctggacgg ggcctcggga agaatgcaca aggtatcatt
      781 aacccaattg aagccaagca gagaaaggga aaaggtgctg tgggggctta tggatccgag
      841 cgcaccactc agtccatgca agacttccct gtggttgact cagaggaaga agctgaagag
      901 gagtttcaga aggagctgag ccagtggagg aaagacccaa gtggaagcaa gaagaagccc
      961 aaatactctt acaagaccgt ggaagagttg aaggccaagg gcaggattag caagaagctc
     1021 actgctcccc agaaggaact ttctcaagtc aaggtcatag acatgacagg ccgggagcag
     1081 aaggtctact acagctacag tcagatcagc cacaagcaca acgttcccga tgatgggctg
     1141 ccgctacagt cccaacagct gccacagtct ggcaaagagg ccaaggcccc cggcttcgcg
     1201 ctgcccgagc tggagcacaa cctgcagctg ctcatcgacc tcacggagca ggagatcatc
     1261 cagaatgacc ggcagctaca gtatgagcgg gacatggtgg tcaacctctt ccacgagctg
     1321 gagaagatga ccgaggtcct ggaccacgag gagcgggtca tctcgaacct cagcaaggtc
     1381 ctggagatgg tggaggagtg cgagcggcgg atgcagcccg actgcagcaa ccccctcacc
     1441 ctggacgagt gtgcccgcat cttcgaaacc ctgcaggaca agtactatga ggagtacagg
     1501 atgtccgacc gtgtggacct tgctgtggcc atcgtctatc cactcatgaa ggagtacttc
     1561 aaggagtggg atcccctcaa agactgcact tatggcaccg agatcatctc taagtggaaa
     1621 agcctcctag agaatgacca gctcttgtcc catggcggac aggacctctc agcagatgcc
     1681 tttcacaggt tgatatggga agtctggatg ccttttgttc gaaatattgt cacccagtgg
     1741 cagccaagga actgtgaccc gatggtggac tttttggata gttgggtgca cattattcct
     1801 gtgtggatct tagataacat actggaccaa ctcatcttcc ccaagctgca aaaggaggtg
     1861 gaaaactgga acccgctcac agacactgtt cccatccact cttggatcca cccatggctg
     1921 ccccttatgc aggcacggct ggagccactc tattccccca tccgtagtaa gctgtccagc
     1981 gccctgcaga agtggcaccc cagcgactcc tctgccaagc tcatcctcca gccctggaag
     2041 gatgtcttca ctcctggctc ctgggaagca ttcatggtca aaaacatagt gcccaagctg
     2101 gggatgtgtc ttggtgagct agtcattaac ccccaccagc agcacatgga tgcattctat
     2161 tgggtgattg actgggaagg gatgatctct gtctctagcc tggtgggact tcttgaaaag
     2221 cacttcttcc ccaagtggct tcaggtgctg tgctcttggc tcagtaacag cccaaattat
     2281 gaggagatca ccaagtggta cctgggttgg aagtcgatgt tctcagacca agtgctggca
     2341 catccatctg tcaaggacaa atttaatgag gcacttgata tcatgaaccg ggcggtgtcc
     2401 tccaacgttg gtgcctacat gcagccagga gcacgggaga acattgccta tctcacccac
     2461 acggagcgga ggaaggactt ccagtacgag gccatgcagg agaggcggga ggctgagaac
     2521 atggctcaga ggggcattgg cgtggccgct agctctgtgc ccatgaactt taaggacctc
     2581 attgagacca aggctgagga gcacaacatt gtcttcatgc ccgtcattgg gaagcgacac
     2641 gaagggaagc agctctacac ctttggccgc attgtgatct acatcgaccg gggagtggtc
     2701 tttgtccagg gcgagaagac gtgggtgccc acctcactgc agagcctgat cgacatggcc
     2761 aagtgaactg tggcaggtcc agaaccagtc agagacttgc ccctaagagg gatgtactgt
     2821 aaataaacag tatttttaga tcaccttcaa aagggtaact tctttactca ggagctactc
     2881 cacatcaggc caggtcatga gggaaggatg taaaatggga caatgccacg tagggcagga
     2941 atctttatac caagtcctca tgtggggtat cgtcctcaaa acaggacagc caagttgatg
     3001 ttctttcctg gcaaaggagt tctctgtagt tcctccatag cagccttccc tttagtctct
     3061 ggtggcagct tctacctcag ccaacactga gtacctcaca acgagttcag tcagtagcag
     3121 aaggatcttc tctcttgttc ctgatgattt caaggtcctc acagtcctga taatctggtt
     3181 cttcccgaaa ctcccaaata tctatggaga gctgttctag cttttgcaca gggaaccagt
     3241 ggacagaggt atcattaaat atgtccatgt attgtgaagt ctgaggaaac tcaagctcct
     3301 ccagtccttt taaaatctga gcagaaaaat tcaagtataa aaacttcaga tagtcacagt
     3361 aatccccact cttctgggat aaatttccac tttacttgtc atccccactt tactttttaa
     3421 aaaaataaca aatagggtat tttgatttaa atgcttttgc acaatgaatt gggcgcccca
     3481 aggacagtgg atatcatgga ctgtgatact aagaataaag gaaataagga aaaaactaa
//
