LOCUS       NM_003226                867 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens trefoil factor 3 (TFF3), mRNA.
ACCESSION   NM_003226
VERSION     NM_003226.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 867)
  AUTHORS   Weste,J., Houben,T., Harder,S., Schluter,H., Lucke,E., Schreiber,J.
            and Hoffmann,W.
  TITLE     Different Molecular Forms of TFF3 in the Human Respiratory Tract:
            Heterodimerization with IgG Fc Binding Protein (FCGBP) and
            Proteolytic Cleavage in Bronchial Secretions
  JOURNAL   Int J Mol Sci 23 (23), 15359 (2022)
   PUBMED   36499686
  REMARK    GeneRIF: Different Molecular Forms of TFF3 in the Human Respiratory
            Tract: Heterodimerization with IgG Fc Binding Protein (FCGBP) and
            Proteolytic Cleavage in Bronchial Secretions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 867)
  AUTHORS   Hasan,M.M., Gazi,M.A., Das,S., Fahim,S.M., Hossaini,F., Khan,A.R.,
            Ferdous,J., Alam,M.A., Mahfuz,M. and Ahmed,T.
  TITLE     Gut biomolecules (I-FABP, TFF3 and lipocalin-2) are associated with
            linear growth and biomarkers of environmental enteric dysfunction
            (EED) in Bangladeshi children
  JOURNAL   Sci Rep 12 (1), 13905 (2022)
   PUBMED   35974137
  REMARK    GeneRIF: Gut biomolecules (I-FABP, TFF3 and lipocalin-2) are
            associated with linear growth and biomarkers of environmental
            enteric dysfunction (EED) in Bangladeshi children.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 867)
  AUTHORS   Cheng,F., Wang,X., Chiou,Y.S., He,C., Guo,H., Tan,Y.Q., Basappa,B.,
            Zhu,T., Pandey,V. and Lobie,P.E.
  TITLE     Trefoil factor 3 promotes pancreatic carcinoma progression via WNT
            pathway activation mediated by enhanced WNT ligand expression
  JOURNAL   Cell Death Dis 13 (3), 265 (2022)
   PUBMED   35332126
  REMARK    GeneRIF: Trefoil factor 3 promotes pancreatic carcinoma progression
            via WNT pathway activation mediated by enhanced WNT ligand
            expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 867)
  AUTHORS   Wang,X. and Qin,H.
  TITLE     TFF3 promotes pituitary tumor cell migration and angiogenesis via
            VEGFA
  JOURNAL   Acta Neurobiol Exp (Wars) 82 (2), 237-243 (2022)
   PUBMED   35833823
  REMARK    GeneRIF: TFF3 promotes pituitary tumor cell migration and
            angiogenesis via VEGFA.
REFERENCE   5  (bases 1 to 867)
  AUTHORS   Chinery,R., Williamson,J. and Poulsom,R.
  TITLE     The gene encoding human intestinal trefoil factor (TFF3) is located
            on chromosome 21q22.3 clustered with other members of the trefoil
            peptide family
  JOURNAL   Genomics 32 (2), 281-284 (1996)
   PUBMED   8833157
REFERENCE   6  (bases 1 to 867)
  AUTHORS   Schmitt,H., Wundrack,I., Beck,S., Gott,P., Welter,C., Shizuya,H.,
            Simon,M.I. and Blin,N.
  TITLE     A third P-domain peptide gene (TFF3), human intestinal trefoil
            factor, maps to 21q22.3
  JOURNAL   Cytogenet Cell Genet 72 (4), 299-302 (1996)
   PUBMED   8641134
REFERENCE   7  (bases 1 to 867)
  AUTHORS   Seib,T., Dooley,S. and Welter,C.
  TITLE     Characterization of the genomic structure and the promoter region
            of the human intestinal trefoil factor
  JOURNAL   Biochem Biophys Res Commun 214 (1), 195-199 (1995)
   PUBMED   7669039
REFERENCE   8  (bases 1 to 867)
  AUTHORS   Thim,L., Woldike,H.F., Nielsen,P.F., Christensen,M.,
            Lynch-Devaney,K. and Podolsky,D.K.
  TITLE     Characterization of human and rat intestinal trefoil factor
            produced in yeast
  JOURNAL   Biochemistry 34 (14), 4757-4764 (1995)
   PUBMED   7718582
REFERENCE   9  (bases 1 to 867)
  AUTHORS   Hauser,F., Poulsom,R., Chinery,R., Rogers,L.A., Hanby,A.M.,
            Wright,N.A. and Hoffmann,W.
  TITLE     hP1.B, a human P-domain peptide homologous with rat intestinal
            trefoil factor, is expressed also in the ulcer-associated cell
            lineage and the uterus
  JOURNAL   Proc Natl Acad Sci U S A 90 (15), 6961-6965 (1993)
   PUBMED   8346203
REFERENCE   10 (bases 1 to 867)
  AUTHORS   Podolsky,D.K., Lynch-Devaney,K., Stow,J.L., Oates,P., Murgue,B.,
            DeBeaumont,M., Sands,B.E. and Mahida,Y.R.
  TITLE     Identification of human intestinal trefoil factor. Goblet
            cell-specific expression of a peptide targeted for apical secretion
  JOURNAL   J Biol Chem 268 (9), 6694-6702 (1993)
   PUBMED   8454642
  REMARK    Erratum:[J Biol Chem. 1993 Jun 5;268(16):12230.. PMID: 8505343]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001623.1.
            
            On Jun 26, 2020 this sequence version replaced NM_003226.3.
            
            Summary: Members of the trefoil family are characterized by having
            at least one copy of the trefoil motif, a 40-amino acid domain that
            contains three conserved disulfides. They are stable secretory
            proteins expressed in gastrointestinal mucosa. Their functions are
            not defined, but they may protect the mucosa from insults,
            stabilize the mucus layer and affect healing of the epithelium.
            This gene is expressed in goblet cells of the intestines and colon.
            This gene and two other related trefoil family member genes are
            found in a cluster on chromosome 21. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017859.1, BM738740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518498.3/ ENSP00000430690.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AP001623.1         45667-45783         c
            118-264             AP001623.1         43859-44005         c
            265-867             AP001623.1         42041-42643         c
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..867
                     /gene="TFF3"
                     /gene_synonym="ITF; P1B; TFI"
                     /note="trefoil factor 3"
                     /db_xref="GeneID:7033"
                     /db_xref="HGNC:HGNC:11757"
                     /db_xref="MIM:600633"
     exon            1..117
                     /gene="TFF3"
                     /gene_synonym="ITF; P1B; TFI"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..278
                     /gene="TFF3"
                     /gene_synonym="ITF; P1B; TFI"
                     /note="polypeptide P1.B; trefoil factor 3 (intestinal)"
                     /codon_start=1
                     /product="trefoil factor 3 precursor"
                     /protein_id="NP_003217.4"
                     /db_xref="CCDS:CCDS33565.3"
                     /db_xref="GeneID:7033"
                     /db_xref="HGNC:HGNC:11757"
                     /db_xref="MIM:600633"
                     /translation="MAARALCMLGLVLALLSSSSAEEYVGLSANQCAVPAKDRVDCGY
                     PHVTPKECNNRGCCFDSRIPGVPWCFKPLQEAECTF"
     exon            118..264
                     /gene="TFF3"
                     /gene_synonym="ITF; P1B; TFI"
                     /inference="alignment:Splign:2.1.0"
     exon            265..867
                     /gene="TFF3"
                     /gene_synonym="ITF; P1B; TFI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      437..442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFF3"
                     /gene_synonym="ITF; P1B; TFI"
                     /note="hexamer: AATAAA"
     polyA_site      481
                     /gene="TFF3"
                     /gene_synonym="ITF; P1B; TFI"
                     /note="major polyA site"
     regulatory      843..848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFF3"
                     /gene_synonym="ITF; P1B; TFI"
                     /note="hexamer: AGTAAA"
     polyA_site      867
                     /gene="TFF3"
                     /gene_synonym="ITF; P1B; TFI"
ORIGIN      
        1 gagtcctgag ctgcgtcccg gagcccacgg tggtcatggc tgccagagcg ctctgcatgc
       61 tggggctggt cctggccttg ctgtcctcca gctctgctga ggagtacgtg ggcctgtctg
      121 caaaccagtg tgccgtgcca gccaaggaca gggtggactg cggctacccc catgtcaccc
      181 ccaaggagtg caacaaccgg ggctgctgct ttgactccag gatccctgga gtgccttggt
      241 gtttcaagcc cctgcaggaa gcagaatgca ccttctgagg cacctccagc tgcccccggc
      301 cgggggatgc gaggctcgga gcacccttgc ccggctgtga ttgctgccag gcactgttca
      361 tctcagcttt tctgtccctt tgctcccggc aagcgcttct gctgaaagtt catatctgga
      421 gcctgatgtc ttaacgaata aaggtcccat gctccacccg aggacagttc ttcgtgcctg
      481 agactttctg aggttgtgct ttatttctgc tgcgtcgtgg gagagggcgg gagggtgtca
      541 ggggagagtc tgcccaggcc tcaagggcag gaaaagactc cctaaggagc tgcagtgcat
      601 gcaaggatat tttgaatcca gactggcacc cacgtcacag gaaagcctag gaacactgta
      661 agtgccgctt cctcgggaaa gcagaaaaaa tacatttcag gtagaagttt tcaaaaatca
      721 caagtctttc ttggtgaaga cagcaagcca ataaaactgt cttccaaagt ggtcctttat
      781 ttcacaacca ctctcgctac tgttcaatac ttgtactatt cctgggtttt gtttctttgt
      841 acagtaaaca ttatgaacaa acaggca
//
