LOCUS       NM_005423                603 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens trefoil factor 2 (TFF2), mRNA.
ACCESSION   NM_005423
VERSION     NM_005423.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 603)
  AUTHORS   Ghanemi,A., Yoshioka,M. and St-Amand,J.
  TITLE     Diet Impact on Obesity beyond Calories and Trefoil Factor Family 2
            (TFF2) as an Illustration: Metabolic Implications and Potential
            Applications
  JOURNAL   Biomolecules 11 (12), 1830 (2021)
   PUBMED   34944474
  REMARK    GeneRIF: Diet Impact on Obesity beyond Calories and Trefoil Factor
            Family 2 (TFF2) as an Illustration: Metabolic Implications and
            Potential Applications.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 603)
  AUTHORS   Adewale,B., Heintz,J.R., Pastore,C.F., Rossi,H.L., Hung,L.Y.,
            Rahman,N., Bethony,J., Diemert,D., Babatunde,J.A. and Herbert,D.R.
  TITLE     Parasitic helminth infections in humans modulate Trefoil Factor
            levels in a manner dependent on the species of parasite and age of
            the host
  JOURNAL   PLoS Negl Trop Dis 15 (10), e0009550 (2021)
   PUBMED   34662329
  REMARK    GeneRIF: Parasitic helminth infections in humans modulate Trefoil
            Factor levels in a manner dependent on the species of parasite and
            age of the host.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 603)
  AUTHORS   Samson,M.H., Abildgaard,A.M., Espelund,U., Rasmussen,T.R.,
            Folkersen,B., Frystyk,J. and Nexo,E.
  TITLE     Circulating trefoil factors in relation to lung cancer, age and
            lung function: a cross-sectional study in patients referred for
            suspected lung cancer
  JOURNAL   Scand J Clin Lab Invest 81 (6), 446-450 (2021)
   PUBMED   34242119
  REMARK    GeneRIF: Circulating trefoil factors in relation to lung cancer,
            age and lung function: a cross-sectional study in patients referred
            for suspected lung cancer.
REFERENCE   4  (bases 1 to 603)
  AUTHORS   Wada,Y., Nakajima,S., Kushima,R., Takemura,S., Mori,N.,
            Hasegawa,H., Nakayama,T., Mukaisho,K.I., Yoshida,A., Umano,S.,
            Yamamoto,K., Sugihara,H. and Murakami,K.
  TITLE     Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing
            metaplasias in autoimmune gastritis: a case series of 22 Japanese
            patients
  JOURNAL   Virchows Arch 479 (1), 169-178 (2021)
   PUBMED   33515301
  REMARK    GeneRIF: Pyloric, pseudopyloric, and spasmolytic
            polypeptide-expressing metaplasias in autoimmune gastritis: a case
            series of 22 Japanese patients.
REFERENCE   5  (bases 1 to 603)
  AUTHORS   Takako,K., Hoang,L., Terinte,C., Pesci,A., Aviel-Ronen,S.,
            Alvarado-Cabrero,I., Oliva,E., Park,K.J., Soslow,R.A. and
            Stolnicu,S.
  TITLE     Trefoil Factor 2 (TFF2) as a Surrogate Marker for Endocervical
            Gastric-type Carcinoma
  JOURNAL   Int J Gynecol Pathol 40 (1), 65-72 (2021)
   PUBMED   32897966
  REMARK    GeneRIF: Trefoil Factor 2 (TFF2) as a Surrogate Marker for
            Endocervical Gastric-type Carcinoma.
REFERENCE   6  (bases 1 to 603)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   7  (bases 1 to 603)
  AUTHORS   Bhogal,N., Donnelly,D. and Findlay,J.B.
  TITLE     The ligand binding site of the neurokinin 2 receptor. Site-directed
            mutagenesis and identification of neurokinin A binding residues in
            the human neurokinin 2 receptor
  JOURNAL   J Biol Chem 269 (44), 27269-27274 (1994)
   PUBMED   7961636
REFERENCE   8  (bases 1 to 603)
  AUTHORS   Hanby,A.M., Poulsom,R., Singh,S., Elia,G., Jeffery,R.E. and
            Wright,N.A.
  TITLE     Spasmolytic polypeptide is a major antral peptide: distribution of
            the trefoil peptides human spasmolytic polypeptide and pS2 in the
            stomach
  JOURNAL   Gastroenterology 105 (4), 1110-1116 (1993)
   PUBMED   8405856
REFERENCE   9  (bases 1 to 603)
  AUTHORS   Tomasetto,C., Rockel,N., Mattei,M.G., Fujita,R. and Rio,M.C.
  TITLE     The gene encoding the human spasmolytic protein (SML1/hSP) is in
            21q 22.3, physically linked to the homologous breast cancer marker
            gene BCEI/pS2
  JOURNAL   Genomics 13 (4), 1328-1330 (1992)
   PUBMED   1505966
REFERENCE   10 (bases 1 to 603)
  AUTHORS   Tomasetto,C., Rio,M.C., Gautier,C., Wolf,C., Hareuveni,M.,
            Chambon,P. and Lathe,R.
  TITLE     hSP, the domain-duplicated homolog of pS2 protein, is co-expressed
            with pS2 in stomach but not in breast carcinoma
  JOURNAL   EMBO J 9 (2), 407-414 (1990)
   PUBMED   2303034
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA307808.1, BC032820.1 and
            BM853946.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005423.4.
            
            Summary: Members of the trefoil family are characterized by having
            at least one copy of the trefoil motif, a 40-amino acid domain that
            contains three conserved disulfides. They are stable secretory
            proteins expressed in gastrointestinal mucosa. Their functions are
            not defined, but they may protect the mucosa from insults,
            stabilize the mucus layer and affect healing of the epithelium. The
            encoded protein inhibits gastric acid secretion. This gene and two
            other related trefoil family member genes are found in a cluster on
            chromosome 21. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP341913.1, BM853946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2153946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291526.5/ ENSP00000291526.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AA307808.1         106-360
            256-599             BC032820.1         240-583
            600-603             BM853946.1         602-605
FEATURES             Location/Qualifiers
     source          1..603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..603
                     /gene="TFF2"
                     /gene_synonym="SML1; SP"
                     /note="trefoil factor 2"
                     /db_xref="GeneID:7032"
                     /db_xref="HGNC:HGNC:11756"
                     /db_xref="MIM:182590"
     exon            1..116
                     /gene="TFF2"
                     /gene_synonym="SML1; SP"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..427
                     /gene="TFF2"
                     /gene_synonym="SML1; SP"
                     /note="spasmolysin; spasmolytic polypeptide; spasmolytic
                     protein 1"
                     /codon_start=1
                     /product="trefoil factor 2 precursor"
                     /protein_id="NP_005414.1"
                     /db_xref="CCDS:CCDS13684.1"
                     /db_xref="GeneID:7032"
                     /db_xref="HGNC:HGNC:11756"
                     /db_xref="MIM:182590"
                     /translation="MGRRDAQLLAALLVLGLCALAGSEKPSPCQCSRLSPHNRTNCGF
                     PGITSDQCFDNGCCFDSSVTGVPWCFHPLPKQESDQCVMEVSDRRNCGYPGISPEECA
                     SRKCCFSNFIFEVPWCFFPKSVEDCHY"
     exon            117..266
                     /gene="TFF2"
                     /gene_synonym="SML1; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            267..413
                     /gene="TFF2"
                     /gene_synonym="SML1; SP"
                     /inference="alignment:Splign:2.1.0"
     exon            414..603
                     /gene="TFF2"
                     /gene_synonym="SML1; SP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      579..584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFF2"
                     /gene_synonym="SML1; SP"
                     /note="hexamer: AATAAA"
     polyA_site      603
                     /gene="TFF2"
                     /gene_synonym="SML1; SP"
                     /note="major polyA site"
ORIGIN      
        1 attctgcaag ccaccctggg gtgcagctga gctagacatg ggacggcgag acgcccagct
       61 cctggcagcg ctcctcgtcc tggggctatg tgccctggcg gggagtgaga aaccctcccc
      121 ctgccagtgc tccaggctga gcccccataa caggacgaac tgcggcttcc ctggaatcac
      181 cagtgaccag tgttttgaca atggatgctg tttcgactcc agtgtcactg gggtcccctg
      241 gtgtttccac cccctcccaa agcaagagtc ggatcagtgc gtcatggagg tctcagaccg
      301 aagaaactgt ggctacccgg gcatcagccc cgaggaatgc gcctctcgga agtgctgctt
      361 ctccaacttc atctttgaag tgccctggtg cttcttcccg aagtctgtgg aagactgcca
      421 ttactaagag aggctggttc cagaggatgc atctggctca ccgggtgttc cgaaaccaaa
      481 gaagaaactt cgccttatca gcttcatact tcatgaaatc ctgggttttc ttaaccatct
      541 tttcctcatt ttcaatggtt taacatataa tttctttaaa taaaaccctt aaaatctgct
      601 aaa
//
