LOCUS       NM_003225                492 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens trefoil factor 1 (TFF1), mRNA.
ACCESSION   NM_003225
VERSION     NM_003225.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 492)
  AUTHORS   Zhang,Y., Qiu,S., Liu,L. and Qiu,L.
  TITLE     The Transcription Factor RUNX1 Aggravates Hypoxia-Induced Human
            Retinal Microvascular Endothelial Cell Dysfunction by Negatively
            Regulating TFF1 Promoter
  JOURNAL   Ann Clin Lab Sci 53 (3), 427-437 (2023)
   PUBMED   37437926
  REMARK    GeneRIF: The Transcription Factor RUNX1 Aggravates Hypoxia-Induced
            Human Retinal Microvascular Endothelial Cell Dysfunction by
            Negatively Regulating TFF1 Promoter.
REFERENCE   2  (bases 1 to 492)
  AUTHORS   Zou,W., Zhang,Q., Sun,R., Li,X. and He,S.
  TITLE     Study on TFF1 and PALB2 gene variants associated with gastric
            carcinoma risk in the Chinese Han population
  JOURNAL   Cancer Epidemiol 83, 102333 (2023)
   PUBMED   36758349
  REMARK    GeneRIF: Study on TFF1 and PALB2 gene variants associated with
            gastric carcinoma risk in the Chinese Han population.
REFERENCE   3  (bases 1 to 492)
  AUTHORS   Eletto,D., Mentucci,F., Vllahu,M., Voli,A., Petrella,A.,
            Boccellato,F., Meyer,T.F., Porta,A. and Tosco,A.
  TITLE     IFNgamma-dependent silencing of TFF1 during Helicobacter pylori
            infection
  JOURNAL   Open Biol 12 (12), 220278 (2022)
   PUBMED   36514982
  REMARK    GeneRIF: IFNgamma-dependent silencing of TFF1 during Helicobacter
            pylori infection.
REFERENCE   4  (bases 1 to 492)
  AUTHORS   Shekarriz,R., Kochaki,N., Eslami-Jouibari,M., Omrani-Nava,V.,
            Ahmadi,M. and Alizadeh-Navaei,R.
  TITLE     TFF1 gene single nucleotide polymorphism (rs3761376) and colorectal
            cancer risk
  JOURNAL   Mol Biol Rep 49 (10), 10127-10131 (2022)
   PUBMED   36057754
  REMARK    GeneRIF: TFF1 gene single nucleotide polymorphism (rs3761376) and
            colorectal cancer risk.
REFERENCE   5  (bases 1 to 492)
  AUTHORS   Wang,Q., Jiang,Y., Du,M., Yang,L. and Yuan,Q.
  TITLE     Association of functional genetic variants in TFF1 and
            nephrolithiasis risk in a Chinese population
  JOURNAL   BMC Urol 22 (1), 127 (2022)
   PUBMED   35987613
  REMARK    GeneRIF: Association of functional genetic variants in TFF1 and
            nephrolithiasis risk in a Chinese population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 492)
  AUTHORS   Piggott,N.H., Henry,J.A., May,F.E. and Westley,B.R.
  TITLE     Antipeptide antibodies against the pNR-2 oestrogen-regulated
            protein of human breast cancer cells and detection of pNR-2
            expression in normal tissues by immunohistochemistry
  JOURNAL   J Pathol 163 (2), 95-104 (1991)
   PUBMED   1707960
REFERENCE   7  (bases 1 to 492)
  AUTHORS   Takahashi,H., Kida,N., Fujii,R., Tanaka,K., Ohta,M., Mori,K. and
            Hayashi,K.
  TITLE     Expression of the pS2 gene in human gastric cancer cells derived
            from poorly differentiated adenocarcinoma
  JOURNAL   FEBS Lett 261 (2), 283-286 (1990)
   PUBMED   2311759
REFERENCE   8  (bases 1 to 492)
  AUTHORS   Tomasetto,C., Rio,M.C., Gautier,C., Wolf,C., Hareuveni,M.,
            Chambon,P. and Lathe,R.
  TITLE     hSP, the domain-duplicated homolog of pS2 protein, is co-expressed
            with pS2 in stomach but not in breast carcinoma
  JOURNAL   EMBO J 9 (2), 407-414 (1990)
   PUBMED   2303034
REFERENCE   9  (bases 1 to 492)
  AUTHORS   Mori,K., Fujii,R., Kida,N., Takahashi,H., Ohkubo,S., Fujino,M.,
            Ohta,M. and Hayashi,K.
  TITLE     Complete primary structure of the human estrogen-responsive gene
            (pS2) product
  JOURNAL   J Biochem 107 (1), 73-76 (1990)
   PUBMED   2185238
REFERENCE   10 (bases 1 to 492)
  AUTHORS   Rio,M.C., Bellocq,J.P., Daniel,J.Y., Tomasetto,C., Lathe,R.,
            Chenard,M.P., Batzenschlager,A. and Chambon,P.
  TITLE     Breast cancer-associated pS2 protein: synthesis and secretion by
            normal stomach mucosa
  JOURNAL   Science 241 (4866), 705-708 (1988)
   PUBMED   3041593
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ083523.1, BC032811.1 and
            BU539534.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003225.2.
            
            Summary: Members of the trefoil family are characterized by having
            at least one copy of the trefoil motif, a 40-amino acid domain that
            contains three conserved disulfides. They are stable secretory
            proteins expressed in gastrointestinal mucosa. Their functions are
            not defined, but they may protect the mucosa from insults,
            stabilize the mucus layer, and affect healing of the epithelium.
            This gene, which is expressed in the gastric mucosa, has also been
            studied because of its expression in human tumors. This gene and
            two other related trefoil family member genes are found in a
            cluster on chromosome 21. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X00474.1, BM853943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291527.3/ ENSP00000291527.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               BQ083523.1         60-184
            126-465             BC032811.1         110-449
            466-492             BU539534.1         17-43               c
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..492
                     /gene="TFF1"
                     /gene_synonym="BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2"
                     /note="trefoil factor 1"
                     /db_xref="GeneID:7031"
                     /db_xref="HGNC:HGNC:11755"
                     /db_xref="MIM:113710"
     exon            1..125
                     /gene="TFF1"
                     /gene_synonym="BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..295
                     /gene="TFF1"
                     /gene_synonym="BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2"
                     /note="gastrointestinal trefoil protein pS2; breast cancer
                     estrogen-inducible sequence; polypeptide P1.A; breast
                     cancer estrogen-inducible protein"
                     /codon_start=1
                     /product="trefoil factor 1 precursor"
                     /protein_id="NP_003216.1"
                     /db_xref="CCDS:CCDS13685.1"
                     /db_xref="GeneID:7031"
                     /db_xref="HGNC:HGNC:11755"
                     /db_xref="MIM:113710"
                     /translation="MATMENKVICALVLVSMLALGTLAEAQTETCTVAPRERQNCGFP
                     GVTPSQCANKGCCFDDTVRGVPWCFYPNTIDVPPEEECEF"
     exon            126..278
                     /gene="TFF1"
                     /gene_synonym="BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2"
                     /inference="alignment:Splign:2.1.0"
     exon            279..492
                     /gene="TFF1"
                     /gene_synonym="BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      472..477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFF1"
                     /gene_synonym="BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2"
                     /note="hexamer: ATTAAA"
     polyA_site      492
                     /gene="TFF1"
                     /gene_synonym="BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2"
                     /note="major polyA site"
ORIGIN      
        1 atccctgact cggggtcgcc tttggagcag agaggaggca atggccacca tggagaacaa
       61 ggtgatctgc gccctggtcc tggtgtccat gctggccctc ggcaccctgg ccgaggccca
      121 gacagagacg tgtacagtgg ccccccgtga aagacagaat tgtggttttc ctggtgtcac
      181 gccctcccag tgtgcaaata agggctgctg tttcgacgac accgttcgtg gggtcccctg
      241 gtgcttctat cctaatacca tcgacgtccc tccagaagag gagtgtgaat tttagacact
      301 tctgcaggga tctgcctgca tcctgacgcg gtgccgtccc cagcacggtg attagtccca
      361 gagctcggct gccacctcca ccggacacct cagacacgct tctgcagctg tgcctcggct
      421 cacaacacag attgactgct ctgactttga ctactcaaaa ttggcctaaa aattaaaaga
      481 gatcgatatt aa
//
