LOCUS       NM_012252               6646 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transcription factor EC (TFEC), transcript variant 1,
            mRNA.
ACCESSION   NM_012252
VERSION     NM_012252.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6646)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6646)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 6646)
  AUTHORS   Haq,R. and Fisher,D.E.
  TITLE     Biology and clinical relevance of the micropthalmia family of
            transcription factors in human cancer
  JOURNAL   J Clin Oncol 29 (25), 3474-3482 (2011)
   PUBMED   21670463
REFERENCE   4  (bases 1 to 6646)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   5  (bases 1 to 6646)
  AUTHORS   Kuiper,R.P., Schepens,M., Thijssen,J., Schoenmakers,E.F. and van
            Kessel,A.G.
  TITLE     Regulation of the MiTF/TFE bHLH-LZ transcription factors through
            restricted spatial expression and alternative splicing of
            functional domains
  JOURNAL   Nucleic Acids Res 32 (8), 2315-2322 (2004)
   PUBMED   15118077
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6646)
  AUTHORS   Mansky,K.C., Sulzbacher,S., Purdom,G., Nelsen,L., Hume,D.A.,
            Rehli,M. and Ostrowski,M.C.
  TITLE     The microphthalmia transcription factor and the related
            helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to
            activate the tartrate-resistant acid phosphatase promoter
  JOURNAL   J Leukoc Biol 71 (2), 304-310 (2002)
   PUBMED   11818452
REFERENCE   7  (bases 1 to 6646)
  AUTHORS   Chung,M.C., Kim,H.K. and Kawamoto,S.
  TITLE     TFEC can function as a transcriptional activator of the nonmuscle
            myosin II heavy chain-A gene in transfected cells
  JOURNAL   Biochemistry 40 (30), 8887-8897 (2001)
   PUBMED   11467950
  REMARK    GeneRIF: Two alternatively spliced TFEC isoforms have been found to
            be sequence-specific transcriptional activators of the nonmuscle
            myosin II heavy chain-A gene in transfected cells.
REFERENCE   8  (bases 1 to 6646)
  AUTHORS   Yasumoto,K. and Shibahara,S.
  TITLE     Molecular cloning of cDNA encoding a human TFEC isoform, a newly
            identified transcriptional regulator
  JOURNAL   Biochim Biophys Acta 1353 (1), 23-31 (1997)
   PUBMED   9256061
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313546.1 and AC096551.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_012252.3.
            
            Summary: This gene encodes a member of the micropthalmia (MiT)
            family of basic helix-loop-helix leucine zipper transcription
            factors. MiT transcription factors regulate the expression of
            target genes by binding to E-box recognition sequences as homo- or
            heterodimers, and play roles in multiple cellular processes
            including survival, growth and differentiation. The encoded protein
            is a transcriptional activator of the nonmuscle myosin II heavy
            chain-A gene, and may also co-regulate target genes in osteoclasts
            as a heterodimer with micropthalmia-associated transcription
            factor. Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Sep
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D43945.1, AK313546.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265440.12/ ENSP00000265440.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1247              AK313546.1         3-1249
            1248-6646           AC096551.1         120310-125708       c
FEATURES             Location/Qualifiers
     source          1..6646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.2"
     gene            1..6646
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /note="transcription factor EC"
                     /db_xref="GeneID:22797"
                     /db_xref="HGNC:HGNC:11754"
                     /db_xref="MIM:604732"
     exon            1..131
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /inference="alignment:Splign:2.1.0"
     exon            132..383
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1247
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /note="isoform a is encoded by transcript variant 1; class
                     E basic helix-loop-helix protein 34"
                     /codon_start=1
                     /product="transcription factor EC isoform a"
                     /protein_id="NP_036384.1"
                     /db_xref="CCDS:CCDS5762.1"
                     /db_xref="GeneID:22797"
                     /db_xref="HGNC:HGNC:11754"
                     /db_xref="MIM:604732"
                     /translation="MTLDHQIINPTLKWSQPAVPSGGPLVQHAHTTLDSDAGLTENPL
                     TKLLAIGKEDDNAQWHMEDVIEDIIGMESSFKEEGADSPLLMQRTLSGSILDVYSGEQ
                     GISPINMGLTSASCPSSLPMKREITETDTRALAKERQKKDNHNLIERRRRYNINYRIK
                     ELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLL
                     RIQELEIQARTHGLPTLASLGTVDLGAHVTKQQSHPEQNSVDYCQQLTVSQGPSPELC
                     DQAIAFSDPLSYFTDLSFSAALKEEQRLDGMLLDDTISPFGTDPLLSATSPAVSKESS
                     RRSSFSSDDGDEL"
     exon            384..470
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /inference="alignment:Splign:2.1.0"
     exon            471..585
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /inference="alignment:Splign:2.1.0"
     exon            586..642
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /inference="alignment:Splign:2.1.0"
     exon            643..718
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /inference="alignment:Splign:2.1.0"
     exon            719..866
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /inference="alignment:Splign:2.1.0"
     exon            867..6646
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1824..1829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /note="hexamer: AATAAA"
     regulatory      1842..1847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /note="hexamer: TATAAA"
     polyA_site      1851
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /note="major polyA site"
     polyA_site      1864
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
     regulatory      6624..6629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /note="hexamer: AATGAA"
     polyA_site      6646
                     /gene="TFEC"
                     /gene_synonym="bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L;
                     TFECL"
                     /note="major polyA site"
ORIGIN      
        1 attcattact cacggctaga tcgtttactt tggttgtccc ttctggcatg gtgcatatgt
       61 tatgggaaga gggattataa tttggtgctg tttgtagaga tgacaacact gataaaatcc
      121 actcattgct ggtcccagca cacctggaaa gttctgcaag gcctcagcta cagaaagccc
      181 agagacagaa agtaaactct ttcatgaccc ttgatcatca gatcatcaat ccaactctta
      241 aatggtcaca acctgcagtg ccaagtggtg ggcctcttgt gcagcatgca cacacaactc
      301 tggacagtga tgctggcctc acagaaaacc cactcaccaa gttactagct attgggaaag
      361 aagatgacaa tgcacaatgg catatggagg acgttattga ggatataatc ggtatggaat
      421 caagttttaa agaggaagga gcagactctc ctctgctaat gcaaagaaca ttatctggaa
      481 gtattttgga tgtgtatagc ggtgaacaag gaatttcacc aattaacatg gggcttacaa
      541 gtgcttcttg tccaagtagt ctaccaatga aaagagaaat tacagaaact gacactagag
      601 ctttagcaaa agagagacaa aaaaaggaca accacaacct cattgaaaga agaagaaggt
      661 ataatattaa ttaccgaatc aaggagcttg gcactcttat tccaaagtct aatgatcctg
      721 atatgcgctg gaacaaagga accattctaa aagcatcagt ggagtacatc aagtggctac
      781 aaaaagaaca acagagagcc cgagaattgg aacacagaca gaagaaatta gagcaggcta
      841 acaggcgact tctacttcgg attcaggaac tagaaattca ggctcgtact catggtctgc
      901 caaccctggc ttcacttggc acggttgatt taggtgctca tgtcaccaaa cagcagagcc
      961 atcctgagca gaattcagta gactattgcc aacaactgac tgtgtctcag gggccaagcc
     1021 ctgagctctg tgatcaagct atagcctttt ctgatccttt gtcatacttc acagatttat
     1081 catttagtgc tgcattgaaa gaggaacaaa gattggatgg catgctattg gatgacacaa
     1141 tctctccatt tggaacagat cctctgctat ctgccacttc ccctgcagtt tccaaagaaa
     1201 gcagtaggag aagtagcttt agctcagatg atggtgatga attataagaa ataaacagac
     1261 ccaattcatc aactggaaag caattctatg ctggtgctat gcaattatgc tctgtgtttc
     1321 atatgttgct ttggcttatt ttttttctta aaggaatgtg ttgttcatga aaaactgata
     1381 gaagcaacag aagaattcgc aggaagaaaa atcatagtgt taatgaatta ttgagggcga
     1441 aaaaaaggtg ttttcttctt tgactacgga gtccaaatcc acttaaattc tgttttcctg
     1501 aaaagaggta cagcataaga aatagctctt tattgatgtt ttaaaagcag caacttggtg
     1561 gtgtactact ggaactaatg actgcaaagt gttaaacgac tgaaatatac aaacagtctc
     1621 ttagttactc atttccatct tctcttcaac tttcacatca gtcttccgga atcaagatca
     1681 acatatcagg tggtcattgc ctttctccat tgtctagtag acatgtctaa agttcaaact
     1741 ttataggata aataaatgta taatagatta tctgtcactt gtggttgaaa ggcaaatcta
     1801 caataaatgt gagaattttc cacaataaaa tatggataac ttataaaaac attggttact
     1861 aaaattagat cctcatttta ttgtagttgg ttcaattaca ctaattctaa aagcatccat
     1921 gcatatttat atctccagtc tctgttcagg aaaaggaaca tattgaatat tttcctcagg
     1981 aatatggacc agaattgtat cccttcacac aaacatacac atacacatat gcacatcatt
     2041 caggtagtat atgttctttt gttttcttca tgcttctgac tgcatcagaa tcacattcca
     2101 aattctcttt tcttatgaag aagagatgtc agatcatcaa ttttagtaaa taaaatataa
     2161 aatgtccccc tgcaaggaca gttttcaggt acttaaaact tttcatcagt attggacaga
     2221 aatcaattag ttgttgattt ggtttttctc caaatggata aaatattgaa aattgaattg
     2281 ccaattgaca aaataattat tacaacaaac tatttcttat tattttcagt tctgagagga
     2341 acgtaaggtt ctatttctat aaacacttag agtgtcctat gatctttggt tgcactgtta
     2401 gcatttatta taagcactta taactatgat gcttcattta gatttttatc tcttgcgctt
     2461 gttttaggtt aggaaattaa gttaccaagc acgttgctct gtgctggacc tccaagagtg
     2521 atcatccgat caatgagtat tcatggaggc atactcagaa ctgcagtgag tcctgagaaa
     2581 atgtagaaga gttgaaaaag atatggtctt actcctaagg tagttaatga gaatgcatga
     2641 aaaacaaaaa caaaagatag aagacatata gaataaaaaa tctaagcata aactgtaaat
     2701 acagaaggtc agagaaaatg aaaatgactg acaaacttta tgggaacagc agaatttgac
     2761 ttctctttga aaggcattaa ttgagtgaaa gtgagggcat ataaaggaat aataccaacc
     2821 aaatgataaa agtgagaata ataggggaag tatctttata ggactttaat tagaaagatc
     2881 tggatgccct agaagatgtc tgttggggag ttctgaagca taagactgac aacaggttgt
     2941 gaaggccctt agaaaactat ggtgaaataa tatagtatta atataataga aacaaatctt
     3001 tttagtagca gggaggatgc taaaaactaa aatatatatt actaatgagt gagatgtaat
     3061 ctttcatgaa tattaagctt tgggataaat tttgaaagga tcttttagtt gcttctcaca
     3121 tggaaaatat gtcactatga aatgtgagac cctaatgctg ataaaagtag aaaaatagta
     3181 aatcattatg gtataataat tatctcaggc ttagcttgta tcatttgctc agaatttgga
     3241 gaattaaaat aattttattg tttgacatgg aaaaataatt actaacttct gggtacagtc
     3301 attaaagcct gatagataaa ttcatctgaa atatgccatg tgaaacagct attagataca
     3361 tcttctcaat aattttcaag acgatattac atacttttaa ttttataaca aaattccact
     3421 tcattatctg agttgataat ttgattaaat gttaaaaatt atagataagg aatatatttt
     3481 ggagttcata gaaaacacac cactttatta gatagagact ggcttcagtt ctcattttat
     3541 ctgctcttct catttcttca tattttgagt agacttgcac tgatgatgtc attactcagt
     3601 cattattttc tgttctgtta aggtacaact actgggcctt gaaatctatc cttcacaatc
     3661 ttggctgaga taaggacttg gcacaggatg atagagcctg gacacaagag atctggagag
     3721 ggaactgcta tttgctgcta cattcagatt atgagatgtc agggaactgt aaaaagggta
     3781 atgaattttt aaagagagta aagagttatg ctgtgtcccg gtcaactgaa atacattaaa
     3841 aattaattag atggtagttc ttaacttttt aaggcagata ccttgagaat ctagtgagtt
     3901 atagaccctc tccctagaaa agtatagaac tgtttatatg gacaataatt cacatgcatt
     3961 cagagatctt agggatctcc tgaatgtttt cttggatccc aagtgaaaaa ttcctgaatc
     4021 aggtctctta ggtgtgcggt taatgtcatg tataacaatg gggggaccct tacttatcta
     4081 aatataatta tcccaatcct aataatgatg aggttgcata ggaaagtaat agtgtaccaa
     4141 actttagatt attcactaaa aaagttgttc atttatgaag tagtcgttta tcaaacatgt
     4201 cctccccact cagcaaacta tgccttctat ttattatata tgggtcagtt tcactataat
     4261 tactgagtgt tataaacatc tgaccataac attttgaaat gatgcaaata aatttccaaa
     4321 caaaaatagt gtgaatttaa aagcaaatta tttgagtatc taagaaacaa gatagacttc
     4381 tagaaaaatt tgactctcta gaatatttct tgcagaaatg agatttttca taatagtaaa
     4441 agaggcatat gtttatcaaa caatgctgtc acaaaaagca tcaactgtaa tgggactatt
     4501 aatgcataat tattgattta ttcattcaat taatatacaa ttatcccttt tcatttaaag
     4561 atttaattca taattacaat tataataaaa cttcctttaa agtaagatac aataatttta
     4621 ttgtttttca ttcttttttc aacaaaatat cccatccaat cattttttat attattaaat
     4681 attggctgct ttttcttgga ttcacattaa acagcccttt ccaacttcca attgtcttaa
     4741 aataatgatg acctcctgtg agtagataca gctctttaca atttttttct ttagtgcctt
     4801 ttcttcttga atttttccta tatcaaatgg agaatatatg tacagatggt attttctcag
     4861 tttataggca tatcagtgac catggctttc tttatatagg tttttaaaaa agccctaaat
     4921 aataaatagc cagatgagct ggggacattg agaaatagcc ttcctcttcc tttttcaact
     4981 catttttttc ccacctacat gactgtaaat caaatattta atagctctta cttaaaaaaa
     5041 cagatacaaa gaatgtcttg atttggtgtg ctcatttacc ataatgtcat gaggggaatt
     5101 agatttcaca actttaaaag gaatatattt ttattttatt ttgaaaaact gagtcatata
     5161 ggaattttct tatacttcaa ggcatcatgg aaacactttt ttcctgtttg gatattgtgg
     5221 aatttaaacg ttcaaataaa taaatggcat aactaagtgt tccaaatttt tttacaatgt
     5281 ctttgaccct attcaaacac tttaggtatt tactgaccgt ctgatgtgta agatgtggaa
     5341 taaaactgga atcaattaat tatttcactg tgttatcagc gcaagatcaa ccatctgggt
     5401 ttcttaaaga cacccgaagg attgaatttt gtttcagtat tgataatggc atagtctcta
     5461 tgtgctacat ggaattacat catttatccc tccagtgccc tatatgttga taagtatgtc
     5521 agtttgactt agtatacata tatacagaga tttcattaca tttacctaat aaatacaaaa
     5581 tacatttcga gtgttactga tctcctatgt tacatgagcc tcctgtaatc attgtgcatt
     5641 gatgttccaa tgttttattg tttgtatgaa ttttaatttg aaaacaagga aacaatccaa
     5701 aagcagaaaa aatagctttt cttaaaattt tcagtgctac attttccctc tgaggtccat
     5761 agagatttga atgtatagga gattatccga aaacagctat tttgattaaa aaatatatct
     5821 cccaggattc aaccaactta atgatgaagt actattgtct actgctttat acataaaagg
     5881 gaacttttta tctgcttgta aagggatttt tatgtgtatt tctgcataat cagatgactt
     5941 ctattgtgtt ttctactgat gaaattctct gtaaaatgtc tttttcttac attatccaac
     6001 aggcataaag aataacagta aagacttttg tgtttgtaat actacctctt ttatccctgc
     6061 actactgttt tattgcaaaa attctatatt gtcactgtat tttttccata gaatataaat
     6121 tttgttcttg tgctaaagct ggtagtttat gtagcagaca aaatatacaa ataaaagaag
     6181 agactgattt tgctgaaaga attatatata atcaagaagt tacatattgt tctttaaata
     6241 tgatactgaa ttttaaaagc aaacgaaatt caagaatctt atctaacagc atagcagttg
     6301 cttatggcat acaaggctaa aattaattca gctatttaat cttaataatt attatgtagt
     6361 taaaaatctt tgactttaat agtgttttac atatacaaat agctgaagta acattcctat
     6421 aattttaatc tgacattggt tagatcaaga aaacattgtt aataagactg tagaatttgt
     6481 aattattgct atttttcatt tttaataaca aagtaatgtg tcttattttc taagaaaatg
     6541 gagaactttg gtgtacttta atacatacaa aaatctttgt aaaaatacct taaaatgtac
     6601 caatattttc tttgcatata ttaaatgaaa gactataatt atgaaa
//
