LOCUS       NM_016521               1693 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transcription factor Dp family member 3 (TFDP3), mRNA.
ACCESSION   NM_016521
VERSION     NM_016521.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1693)
  AUTHORS   Jiao,Y., Ding,L., Chu,M., Wang,T., Kang,J., Zhao,X., Li,H.,
            Chen,X., Gao,Z., Gao,L. and Wang,Y.
  TITLE     Effects of cancer-testis antigen, TFDP3, on cell cycle regulation
            and its mechanism in L-02 and HepG2 cell lines in vitro
  JOURNAL   PLoS One 12 (8), e0182781 (2017)
   PUBMED   28797103
  REMARK    GeneRIF: TFDP3 can bind to E2F1 molecule to form E2F/TFDP3 complex;
            and the localizations of TFDP3 and E2F1 molecules and the
            co-localization were different in different phases of cell cycle in
            the nucleus and cytoplasm, which indicated that the E2F/TFDP3
            complex involved in the process of regulating the cell cycle.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1693)
  AUTHORS   Yin,K., Liu,Y., Chu,M. and Wang,Y.
  TITLE     TFDP3 Regulates Epithelial-Mesenchymal Transition in Breast Cancer
  JOURNAL   PLoS One 12 (1), e0170573 (2017)
   PUBMED   28114432
  REMARK    GeneRIF: data highlight that TFDP3 is expressed in breast cancer,
            that it is a member of the cancer-testis antigen family and that it
            functions as a regulator in epithelial-mesenchymal transition
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1693)
  AUTHORS   Chu,M., Yin,K., Dong,Y., Wang,P., Xue,Y., Zhou,P., Wang,Y. and
            Wang,Y.
  TITLE     TFDP3 confers chemoresistance in minimal residual disease within
            childhood T-cell acute lymphoblastic leukemia
  JOURNAL   Oncotarget 8 (1), 1405-1415 (2017)
   PUBMED   27902457
  REMARK    GeneRIF: Authors established a preclinical model of resistance to
            induction therapy to examine the functional relevance of TFDP3 to
            chemoresistance in MRD derived from Jurkat/E6-1.
REFERENCE   4  (bases 1 to 1693)
  AUTHORS   Ma,Y., Xin,Y., Li,R., Wang,Z., Yue,Q., Xiao,F. and Hao,X.
  TITLE     TFDP3 was expressed in coordination with E2F1 to inhibit
            E2F1-mediated apoptosis in prostate cancer
  JOURNAL   Gene 537 (2), 253-259 (2014)
   PUBMED   24406621
  REMARK    GeneRIF: TFDP3 was highly expressed in cancer tissues including
            prostate cancer tissues.TFDP3 was expressed in coordination with
            E2F1 in most prostate cancer tissues.
REFERENCE   5  (bases 1 to 1693)
  AUTHORS   Sun,H.X., Xu,Y., Yang,X.R., Wang,W.M., Bai,H., Shi,R.Y.,
            Nayar,S.K., Devbhandari,R.P., He,Y.Z., Zhu,Q.F., Sun,Y.F., Hu,B.,
            Khan,M., Anders,R.A. and Fan,J.
  TITLE     Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma
            growth through the transcription factor dimerization partner 3/ E2F
            transcription factor 1-dependent apoptotic pathway
  JOURNAL   Hepatology 57 (3), 1088-1097 (2013)
   PUBMED   23212661
  REMARK    GeneRIF: Data gathered from cell lines, tumorigenicity studies, and
            primary hepatocellular carcinoma samples demonstrate a negative
            role of HIF-2alpha in tumors, which is mediated by the TFDP3/E2F1
            pathway.
            Erratum:[Hepatology. 2018 Feb;67(2):808. doi: 10.1002/hep.29735..
            PMID: 31265144]
REFERENCE   6  (bases 1 to 1693)
  AUTHORS   Ingram,L., Munro,S., Coutts,A.S. and La Thangue,N.B.
  TITLE     E2F-1 regulation by an unusual DNA damage-responsive DP partner
            subunit
  JOURNAL   Cell Death Differ 18 (1), 122-132 (2011)
   PUBMED   20559320
  REMARK    GeneRIF: DP-4 downregulating E2F-1 activity and contributes to a
            new pRb-independent mechanism for regulating cell cycle
            progression.
REFERENCE   7  (bases 1 to 1693)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 1693)
  AUTHORS   Tian,C., Lv,D., Qiao,H., Zhang,J., Yin,Y.H., Qian,X.P., Wang,Y.P.,
            Zhang,Y. and Chen,W.F.
  TITLE     TFDP3 inhibits E2F1-induced, p53-mediated apoptosis
  JOURNAL   Biochem Biophys Res Commun 361 (1), 20-25 (2007)
   PUBMED   17632080
REFERENCE   9  (bases 1 to 1693)
  AUTHORS   Qiao,H., Di Stefano,L., Tian,C., Li,Y.Y., Yin,Y.H., Qian,X.P.,
            Pang,X.W., Li,Y., McNutt,M.A., Helin,K., Zhang,Y. and Chen,W.F.
  TITLE     Human TFDP3, a novel DP protein, inhibits DNA binding and
            transactivation by E2F
  JOURNAL   J Biol Chem 282 (1), 454-466 (2007)
   PUBMED   17062573
  REMARK    GeneRIF: TFDP3, a novel DP protein, inhibits DNA binding and
            transactivation by E2F
REFERENCE   10 (bases 1 to 1693)
  AUTHORS   Milton,A., Luoto,K., Ingram,L., Munro,S., Logan,N., Graham,A.L.,
            Brummelkamp,T.R., Hijmans,E.M., Bernards,R. and La Thangue,N.B.
  TITLE     A functionally distinct member of the DP family of E2F subunits
  JOURNAL   Oncogene 25 (22), 3212-3218 (2006)
   PUBMED   16418725
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z77249.2 and AF219119.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_016521.2.
            
            Summary: This gene encodes a member of the DP family of
            transcription factors. These factors heterodimerize with E2F
            proteins to enhance their DNA-binding activity and promote
            transcription from E2F target genes. This protein functions as a
            negative regulator and inhibits the DNA binding and transcriptional
            activities of E2F factors.[provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR5189667.263057.1, AF219119.2
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310125.5/ ENSP00000385461.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 Z77249.2           105559-105564       c
            7-1686              AF219119.2         1-1680
            1687-1693           Z77249.2           103872-103878       c
FEATURES             Location/Qualifiers
     source          1..1693
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     gene            1..1693
                     /gene="TFDP3"
                     /gene_synonym="CT30; DP4; HCA661"
                     /note="transcription factor Dp family member 3"
                     /db_xref="GeneID:51270"
                     /db_xref="HGNC:HGNC:24603"
                     /db_xref="MIM:300772"
     exon            1..1693
                     /gene="TFDP3"
                     /gene_synonym="CT30; DP4; HCA661"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1313
                     /gene="TFDP3"
                     /gene_synonym="CT30; DP4; HCA661"
                     /note="E2F-like protein; cancer/testis antigen 30;
                     hepatocellular carcinoma-associated antigen 661"
                     /codon_start=1
                     /product="transcription factor Dp family member 3"
                     /protein_id="NP_057605.3"
                     /db_xref="CCDS:CCDS14636.2"
                     /db_xref="GeneID:51270"
                     /db_xref="HGNC:HGNC:24603"
                     /db_xref="MIM:300772"
                     /translation="MAKYVSLTEANEELKVLMDENQTSRPVAVHTSTVNPLGKQLLPK
                     TFGQSSVNIDQQVVIGMPQRPAASNIPVVGSPNPPSTHFASQNQHSYSSPPWAGQHNR
                     KGEKNGMGLCRLSMKVWETVQRKGTTSCQEVVGELVAKFRAASNHASPNESAYDVKNI
                     KRRTYDALNVLMAMNIISREKKKIKWIGLTTNSAQNCQNLRVERQKRLERIKQKQSEL
                     QQLILQQIAFKNLVLRNQYVEEQVSQRPLPNSVIHVPFIIISSSKKTVINCSISDDKS
                     EYLFKFNSSFEIHDDTEVLMWMGMTFGLESGSCSAEDLKMARNLVPKALEPYVTEMAQ
                     GTFGGVFTTAGSRSNGTWLSASDLTNIAIGMLATSSGGSQYSGSRVETPAVEEEEEED
                     NNDDDLSENDEDD"
     regulatory      1664..1669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFDP3"
                     /gene_synonym="CT30; DP4; HCA661"
                     /note="hexamer: AATAAA"
     polyA_site      1693
                     /gene="TFDP3"
                     /gene_synonym="CT30; DP4; HCA661"
                     /note="major polyA site"
ORIGIN      
        1 gcacctcacg gcagccctac actcggcctg gaagaattgt ttttcttctc tggaaaggtg
       61 aacatttata gcatttattt cccaaatctg ttaacatggc aaaatatgtc agtctcactg
      121 aagctaacga agaactcaag gtcttaatgg acgagaacca gaccagccgc cccgtggccg
      181 ttcacacctc caccgtgaac ccgctcggga agcagctctt gccgaaaacc tttggacagt
      241 ccagtgtcaa cattgaccag caagtggtaa ttggtatgcc tcagagacca gcagcatcaa
      301 acatccctgt ggtaggaagc ccaaacccac ccagcactca ctttgcctct cagaaccagc
      361 attcctactc ctcacctcct tgggccgggc agcacaacag gaaaggagag aagaatggca
      421 tgggcctgtg ccgtctttcc atgaaggtct gggagacggt gcagaggaaa gggaccactt
      481 cctgccagga agtggtgggc gagctggtcg ccaagttcag agctgccagc aaccacgcct
      541 caccaaacga gtcagcttat gacgtgaaaa acataaaacg gcgcacctac gatgccttaa
      601 acgtgctgat ggccatgaat atcatctcca gggagaaaaa gaagatcaag tggattggtc
      661 tgaccaccaa ctcggctcag aactgtcaga acttacgggt ggaaagacag aagagacttg
      721 aaagaataaa gcagaaacag tctgaacttc aacaacttat tctacagcaa attgctttca
      781 agaacctggt gctgagaaac cagtatgtgg aggagcaggt cagccagcgg ccgctgccca
      841 actcagtcat ccacgtgccc ttcatcatca tcagcagtag caagaagacc gtcatcaact
      901 gcagcatctc cgacgacaaa tcagaatatc tgtttaagtt taacagctcc tttgaaatcc
      961 acgatgacac agaagtgctg atgtggatgg gcatgacttt tgggctagag tccgggagct
     1021 gctctgccga agaccttaaa atggccagaa atttggtccc aaaggctctg gagccgtacg
     1081 tgacagaaat ggctcaggga acttttggag gtgtgttcac gacggcaggt tccaggtcta
     1141 atggcacgtg gctttctgcc agtgacctga ccaacattgc gattgggatg ctggccacaa
     1201 gctccggtgg atctcagtac agtggctcca gggtggagac cccagcagtc gaggaggaag
     1261 aggaggagga caacaacgat gacgacctca gtgagaatga cgaggatgac tgacgtcctc
     1321 tcgccttaag attcagcttc aggaaaacat ttagggaaaa gaaacttttt tttttttttt
     1381 aatgtgaggt tttctgtttc ttttttgcct actcccaaga agatattggt aagctataga
     1441 atttagatat gcacctctga taagcaagga ttgtttcccg tatgattaag acgtgctgtt
     1501 gatgtgtgtt ttgataccag tgtgctgaca cagaatcttt atttactttt taggattttg
     1561 tgttttcatt ttctattttt ctttaaatgc agagttcatt gttgcccctt aacagttttt
     1621 cctgagttta ctgaagaaat tgtacttcat ccacatccat gaaaataaaa tgctctcctt
     1681 ttgtgcacag tga
//
