LOCUS       NM_001178139            9880 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens transcription factor Dp-2 (TFDP2), transcript variant
            3, mRNA.
ACCESSION   NM_001178139
VERSION     NM_001178139.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9880)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 9880)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 9880)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 9880)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   5  (bases 1 to 9880)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 9880)
  AUTHORS   Zhang,Y., Venkatraj,V.S., Fischer,S.G., Warburton,D. and
            Chellappan,S.P.
  TITLE     Genomic cloning and chromosomal assignment of the E2F dimerization
            partner TFDP gene family
  JOURNAL   Genomics 39 (1), 95-98 (1997)
   PUBMED   9027491
REFERENCE   7  (bases 1 to 9880)
  AUTHORS   Loiseau,L., Pasteau,S. and Brun,G.
  TITLE     Molecular cloning and expression pattern of the DP members of the
            chicken E2F transcription factor
  JOURNAL   Gene Expr 6 (5), 259-273 (1997)
   PUBMED   9368098
REFERENCE   8  (bases 1 to 9880)
  AUTHORS   Rogers,K.T., Higgins,P.D., Milla,M.M., Phillips,R.S. and
            Horowitz,J.M.
  TITLE     DP-2, a heterodimeric partner of E2F: identification and
            characterization of DP-2 proteins expressed in vivo
  JOURNAL   Proc Natl Acad Sci U S A 93 (15), 7594-7599 (1996)
   PUBMED   8755520
  REMARK    GeneRIF: This study demonstrates translation from an internal
            methionine.
REFERENCE   9  (bases 1 to 9880)
  AUTHORS   Zhang,Y. and Chellappan,S.P.
  TITLE     Cloning and characterization of human DP2, a novel dimerization
            partner of E2F
  JOURNAL   Oncogene 10 (11), 2085-2093 (1995)
   PUBMED   7784053
REFERENCE   10 (bases 1 to 9880)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA321332.1, BC013993.2,
            AK314786.1, AC133435.2, AC128648.5, AC112504.6 and BC040991.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001178139.1.
            
            Summary: The gene is a member of the transcription factor DP
            family. The encoded protein forms heterodimers with the E2F
            transcription factors resulting in transcriptional activation of
            cell cycle regulated genes. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.3415059.1,
                                           SRR14038197.2490750.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000489671.6/ ENSP00000420616.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                DA321332.1         1-84
            85-144              BC013993.2         1-60
            145-306             AK314786.1         1-162
            307-449             AK314786.1         164-306
            450-450             AC133435.2         24830-24830
            451-732             AK314786.1         308-589
            733-733             AC128648.5         35505-35505         c
            734-1060            AK314786.1         591-917
            1061-1149           AK314786.1         919-1007
            1150-1150           AC128648.5         10565-10565         c
            1151-1377           AK314786.1         1009-1235
            1378-1378           AC112504.6         1748-1748
            1379-1510           AK314786.1         1237-1368
            1511-1511           AC112504.6         8538-8538
            1512-1795           AK314786.1         1370-1653
            1796-9467           AC112504.6         9037-16708
            9468-9880           BC040991.2         1878-2290
FEATURES             Location/Qualifiers
     source          1..9880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..9880
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /note="transcription factor Dp-2"
                     /db_xref="GeneID:7029"
                     /db_xref="HGNC:HGNC:11751"
                     /db_xref="MIM:602160"
     exon            1..362
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     exon            363..469
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..1795
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /note="isoform 2 is encoded by transcript variant 3;
                     transcription factor Dp-2 (E2F dimerization partner 2)"
                     /codon_start=1
                     /product="transcription factor Dp-2 isoform 2"
                     /protein_id="NP_001171610.1"
                     /db_xref="CCDS:CCDS54650.1"
                     /db_xref="GeneID:7029"
                     /db_xref="HGNC:HGNC:11751"
                     /db_xref="MIM:602160"
                     /translation="MTAKNVGLTSTNAEVRGFIDQNLSPTKGNISFVAFPVSNTNSPT
                     KILPKTLGPINVNVGPQMIISTPQRLTSSGSVLIGSPYTPAPAMVTQTHIAEATGWVP
                     GDRKRARKFIDSDFSESKRSKKGDKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVS
                     EFTNSNNHLAADSAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQ
                     NLEIEKQRRIERIKQKRAQLQELLLQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPF
                     IIINTSRKTVIDCSISSDKFEYLFNFDNTFEIHDDIEVLKRMGMSFGLESGKCSLEDL
                     KLAKSLVPKALEGYITDISTGPSWLNQGLLLNSTQSVSNLDLTTGATLPQSSVNQGLC
                     LDAEVALATGQFLAPNSHQSSSAASHCSESRGETPCSFNDEDEEDDEEDSSSPE"
     exon            470..536
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     exon            537..640
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..762
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     exon            763..810
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..973
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1117
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1186
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1338
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1505
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1611
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..9880
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1791..1796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /note="hexamer: AATAAA"
     polyA_site      1820
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /note="major polyA site"
     regulatory      9840..9845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /note="hexamer: AATGAA"
     regulatory      9862..9867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /note="hexamer: AATAAA"
     polyA_site      9863
                     /gene="TFDP2"
                     /gene_synonym="DP2"
     polyA_site      9880
                     /gene="TFDP2"
                     /gene_synonym="DP2"
                     /note="major polyA site"
ORIGIN      
        1 gcgcactgtg ctgctccgcc gccaaagctc gcgcggggga agcggggctg tagctgggca
       61 gggagagggc ggacgaaatc ggtagcgatc tcggctgcgg cgctgccgca gctgcccggc
      121 ccgcggggcg cgccctgacc cttcatcttt gggcaggctc gagggcgcgc gcacggttgg
      181 cgttctgggg cctcaaactc ctgggccttg accgggcagg ccgcgtctcc ccgggtgtga
      241 gtccaccggg acccggccgc cgcctaagcg cgggcgccac agaagcggcg gcgcccgaag
      301 acgcgctcct ggctcggccc gacagcctcg cttggccgcc agttcttctg cagccgaagg
      361 cggttgttct tttaaagaat tattgaagac gaaggttttt ttctttttat ttttttaatg
      421 gctttacaga atcttaaata gaatacagtt tgacatgacg gcaaaaaatg ttggtttgac
      481 ttccacaaat gcagaagtaa gaggatttat agatcagaat ctcagtccaa caaaaggcaa
      541 catttcattt gttgcatttc cagtttccaa taccaactca cctacaaaga ttttaccaaa
      601 aaccttagga ccaataaatg tgaatgttgg accccaaatg attataagca caccacagag
      661 actaaccagt tcaggaagtg ttctgattgg gagtccatat acccctgcac cagcaatggt
      721 tactcagaca cacatagcag aagctactgg ctgggtccct ggtgatagaa aacgggctag
      781 aaaatttata gactctgatt tttcagaaag taaacgaagc aaaaaaggag ataaaaatgg
      841 gaaaggcttg agacactttt caatgaaagt gtgtgagaaa gttcaacgaa aaggtacaac
      901 atcgtacaat gaagtcgctg atgagctggt gtcagagttc accaattcaa ataaccattt
      961 ggctgctgat tcggcttatg atcagaagaa cattaggcga agagtttatg atgctttaaa
     1021 tgtgctaatg gcaatgaaca taatttcaaa ggaaaaaaaa gaaatcaagt ggattggcct
     1081 gcctaccaat tctgctcagg aatgtcagaa tctggagata gagaagcaga ggcggataga
     1141 acggataaag cagaagcggg cccagctgca agaacttctc ctacagcaaa tcgctttcaa
     1201 aaacctggta cagagaaatc gacaaaatga gcagcaaaac cagggcccgc cggctctgaa
     1261 ctctaccatt cagctgccat tcataatcat caatacaagc agaaaaacag tcatagattg
     1321 cagcatctcc agtgacaagt ttgagtatct tttcaatttt gacaacacct ttgagatcca
     1381 tgatgacata gaagtactaa agcggatggg aatgtcgttt ggcctggagt caggcaaatg
     1441 ctctctggag gatctgaaac ttgcgaaatc cctggtgcca aaggctttag aaggttatat
     1501 cacagatatc tccacaggac cttcttggtt aaatcaggga ctacttctga actctaccca
     1561 atcagtttca aatttagacc tgaccactgg tgccacctta ccccagtcaa gtgtaaacca
     1621 agggttatgc ttggatgcag aagtggcctt agcaactggg cagttcctgg ccccaaacag
     1681 tcaccagtcc agcagtgcgg cctctcactg ctccgagtcc cgaggcgaga ccccctgttc
     1741 gttcaatgat gaagatgagg aagatgatga ggaggattcc tcctccccag aataaagaca
     1801 agagaaagcc tacgtttcaa tatgtgatgc tcatgtgtgt ttgtagtgtg agctcttgtt
     1861 tttgaaatga ttgcttcagt ctttgccttt gtttgcactg tgtgttcagt gaaaactaga
     1921 gaaacacaat aagcaaatca catgaaggct gagatgattg agatgaaagt taacatagtg
     1981 tgaatgaaag tctggccaac agagcagtag atgatataac aaagaaagca tgctttctga
     2041 ggagatagtg gggataatcc ctgaagagtt ggcagtgtga gtgcaactca tttatcttct
     2101 gtgaggtggg atttttgtgt tcctcacacc catgtaatta ttcttagaat tgagattgct
     2161 acacggagca gtccttgacg atcgtgtttc tgacgtttct cttccttgcc tggactgcct
     2221 ttgacaaggc agaaatgaac atgaaaagtc cccaggagag gggagctgtg tagtgaggga
     2281 tactgagggc agtcctgtgg ctgaggggca cagattgaac tgctgaacta gttggaggtc
     2341 tagatgaggt gctttacgca tcagctgcct tagacagctt ctagaaagga gcgagcgcta
     2401 cttcttaagt acttaagtga catttagata atttatagta aaactgaaat tattattagc
     2461 caatgcattg gtgcatagaa tttactaggg ctacttctgg aagccaaaat agaatagcat
     2521 ttccatgtgc attaaatact ttgccagcac tgcctttgcc agcatcctaa atctggagtt
     2581 ttacaaagaa ggaaactgta tctttaggtt aatcaaagct atgcatttca tatagctttt
     2641 tcatttaaaa caagacaaag aaacaaattc ctatgaccaa attgcttgcc tacagttccc
     2701 tgcagtaatt gtatgatctc acccagtgtg caatttgtga aaatgaacca aatgtcatta
     2761 cttttgtctt aaagaaaagt ctatttcaag aatatgaaca gcagtgtttc cttgtacatg
     2821 tcaccttttt tcacattttc attaatcaga atgaccttat tgagcctact cctggggtca
     2881 attgcatttc aaactaatcc aatatttagt gtttcacaga aacactagaa aacgttgaac
     2941 actcctactg cctggatata tggtagtgca gttatgttgt ttatggctca agatgtcatt
     3001 agaaatactg cagtggtgta ttcacagctg ctccttctct gaatgaaaga gtgtagggac
     3061 acctgccacc atggccagac cctgactgaa tttcacatta aggctttgga aaggagcaaa
     3121 taataatggg agaattaact ccaaaacttt gacctgaatc atgtggattt gtcccaagat
     3181 tatgctagat gcaccaagca tggcccaaat tggttctttt ttaaatccca tgggggaagt
     3241 gcaggctcct tcctgtggtg cctctttata gcctcaccac catgctaaca ctgagcatgg
     3301 tgaggaggag gaagctttgg ctagctaaac atgtttaata aggccataaa aactgagaaa
     3361 gaaaaacatt caactttagc tgaagctcct ttgatacaaa agtttcattc tgtcagaaat
     3421 aagccatagt acagactcag agatagaggc agtttctaga gaactcggtc ttatcgtggg
     3481 ttctggagca cacctctcag accagtcagg aacactgggg aggtgacagc aggtccccag
     3541 gggcctgcag ggaatctttc agctgcacgg attgggattt ccctccaaac caaactgtcc
     3601 tttaaggggc agcctcctct tttactaact ccaccctttc tcatctctgg gacccagcag
     3661 ggacctggag aggccaacag ccactgctac ctttgtagtc ttcaaaatat tgaactgcag
     3721 gtcccaagat gcatttcagg atttaagaca ggtgcactaa tgataaccat tccttcacca
     3781 agtagcaaca ttcttgccag agttcttggg aaacctgttt ttttctctac tctccatctc
     3841 tgctgctctc atgctttaaa ttgataaaat atgggctcaa aaaaagaaag ccgccaaaga
     3901 ctcttatcct tattggtgcc ccatcattgg ccaccccagc cataggtgtg tgctgttggt
     3961 gggaaatggt ctccttcctc agcgttgtgt ttgggttact ggtgaggcca gctcacagag
     4021 tgacatcatg gtcaccagta catgtcgctg gagtaaaatc ttgcctttag aaactaggtt
     4081 gagctgttca gaaaggtcaa ttctcttctg tattccccct caacatttat ctgggtctaa
     4141 agctcagcac tgagtcacaa tttcacacaa gatcaaagtg aggcagtgtt aggaaaccat
     4201 gggctgggtg cagtgcctct cgcctgtaat cgtagcactt tgggaggccg aggcgggcac
     4261 attgcttgag ctcaggagtt caagaccagc ctgggcaaca tgacaaaacc ctgtctctac
     4321 aaaaatacaa aaattagctg ggtgtggtgg ggcatgcctg tagtcctggc tactcaagag
     4381 gctgaggtgg gaggattgct tgagcgcagg aggcggaggt tgtagagcca agatcacacc
     4441 actgcactcc agcctgggtg acagagcaag accctgtctc aaaaaaaaaa aaaaaaaaaa
     4501 tggaagttgt ggtcacaatg cccaggcttc tttgttatag tggcacgctg ggttacttgc
     4561 cacacacaga tcactcctcc cagggctgct ggcacacact gattgtgggg agttcaagag
     4621 gccttttccc cttgagggtg tggctgtccc cctttcaggc gtgtggcgtc attcatggag
     4681 gaagtgctgg ctctacttag cacacgcaca gtggcactag gacctgcgtg cctggccctc
     4741 agtgggtagg gcggtgctgc ctaggcacac agcagcgctt acgggcccca ggtgcctact
     4801 aggctgcctt cctcttcccc gctgtcagtc tgtgtcctcc acgtgcttat ttcctgtggt
     4861 gagagcagtt gtggtgtttg tataccttgt gccttatgat caaggtgggc cttggaggag
     4921 ggcgggaaag gagcgaccaa catggcggtc ctccacccct cagcgacacc caccgcccga
     4981 gaaactacag acaatggcca caagtttggc gtccttcaat ttaattcttt aaagaagtgc
     5041 tgggaagaaa aagctatgtg gtttctacca ttttagcagg ataaagagga taactccttc
     5101 cattagcaaa ttttacagtt gttaacagta ctctgccata tttgaaaaat aatgccagag
     5161 tcagtccttg aaaacaaggt agctcctatc agaattcaaa tggaaatttt tttttttttt
     5221 tttttttttt ttgagactga gtctcgctct gttgcccagg ctggagtgca gtggtgatct
     5281 cggctcactg caagctccgc ctcccgggtt cacgccattc tcctgcctca gctgggacca
     5341 tgcctggcta attttttttg tatttttagt agagacgggg tttcaccgtg ttagccagga
     5401 tggtctcgat ctcctgacct tatgatccac ccctctcggc ctcccaaagt gctgggatta
     5461 caggcgtgag ccaccgcacc cggcctcaaa tggaaatatt tcacagagga gtggttcagt
     5521 ttagccctgc aagacatcta taacttgact gtttgctaaa ccacaactct ttttggctac
     5581 ttgggtcata gagacagcag agttgctcca agtataaatg tgacttaggc tccctccagc
     5641 acacagtgtg tatgttggag ggagtgtgga ttagcagaga atgagaacta cctcagctat
     5701 tcctgccata accacactga gagagggggg cacggtgggg agcctattta gctttttttt
     5761 ttttttgaga cggagtcttg ctctgtcgcc aggctggagt gtagtggcgc aatcccggct
     5821 cactgcaacc tctgcctccc gggttcaagc gattctcctg cctcagcctc ccaagtagct
     5881 gggattatag gcgcatgccg ccacacccga ctaatttttt gtatttttag tagagtcagg
     5941 gtttcaccgt gttgcccagg ctggtgtcga actcctgacc tcaggtgatc tgcccacctc
     6001 agcctcccga agtgctggga ttacaggtgt gagccaccgc acccggctct atttagcttt
     6061 ttaaaaatta tttcctttca agggcccttt aatatctatc aagctccctc ccctaacaaa
     6121 atgggctgtc cctgcccaac aagtctgaaa tagaccttaa aactgtgctg ccttagtggt
     6181 aagtaagggg tgggggttgg acagtgaatc ttaagatttc atccttcatt cagtaagcat
     6241 ttgagtacct actgtgagca ggcattgggg cggagcagcg agagccctgc cgatgttggg
     6301 ttctcctcct attggggaaa cttgatcaca gatggaacac gtgcagattg attgatgagt
     6361 gctgtggaga aagcagcagc gtagcgggac cgtttgggaa aggctacttt ggctgggggt
     6421 ggctgggaaa ggcccctctg ggaaagagac agttttactg agtcagatgg tggaaagaca
     6481 gatgtctcta tactttctta acaagccact ctgtcccata acatgcactt ggaatctctc
     6541 ctaagttcca gaggccccac tgttccagtt tcaagccttc attttggagt ctgtttggga
     6601 acttttaaga cttcaaagca aagttagcta ccagcaattt ctgtaaacca agagaagatt
     6661 gtcacaaaga ttcactactt tccaactgaa tctatgcagt agaaaaatca ttagaaaata
     6721 caaaaattag ccgggcgtgg tggcacatgc ctgtagtccc agctactcgg gaggctgagg
     6781 caggagaatc acttgaaccc aggaggcgga ggttgcagtg agccaagatc ccgccactgc
     6841 actccagccc aggtgacaga gcaggactct gtctcaaaaa aagaaaaaag aaagaaagaa
     6901 aaatgattag aaattgagaa ctattttacg tgtttctaag ttgttggcta catcaaagag
     6961 atcatctgta ttctgcatat gggctggctt tggtgaagct gatgactgga cttctaagaa
     7021 ccgttttccc aaatgggttc ccatattcat gcacccaaag caatggtccc caagcactga
     7081 tgaaaactaa tatgcatttc ccaaagaccc acactatgta tcaggagcct gcaccatgcc
     7141 atttgaatga ccctcagcaa tgtgcctccc tgccctcaaa ttcccagttg ataacagtgt
     7201 ttgattaaat ttccactcaa gccaaacatg gttactaaga agagaaaaac ctgatgtttg
     7261 cataatattt tttttcccct cgagatggag tcttgctctg ttgcccaggc tggagtgcag
     7321 tggcatgatc tcagccactg caacctctgc ctcccgggtt caagcgattc ttctgcctca
     7381 gcctcccaag tagttgggat tacagacatg tgccaccacg cctggctaat ttttgtattt
     7441 ttagtagaga cagggtttca ccatgttgac cacactggtc ttgaacttct aaccatgtga
     7501 tctgcctgcc tcggcctccc aaagtgctgg gattacaggc ttgagccacc acgcccagcc
     7561 taagatttta tgattaaaaa aaattcaagc tcaataccca cataaattat aacgtttctc
     7621 aggaagtagt cccttaacca aaacgtctct gagaagtgat gcttaggtaa tctctgggat
     7681 ccgattttcc cacatgtctc actccacagt atgctaaaga agaaaaagtg agtgggcaca
     7741 acactttgac cctctggcta agccctggga gtccctgaca ggtccagaaa cttctctgac
     7801 acccattcac cagggtgctg agataggaga aagtgctcat ttataatgtg tattctgtgc
     7861 agctgttctc agacaagacc ggatcttgtc atcttacctt ttgctttaca aaaaaggcct
     7921 gttgaagtca atgctgtctt gccccttgct gtttcagcag gttagacttt ggtcttcact
     7981 gcttatagct gcattggagg ccaacgtagc tgatgctcag ggtcaggcct cgccccttcg
     8041 ccgcaggtct caggatcggg gataacatcg ctcccaccct gctcatttag agatgggaaa
     8101 caagcaagag cttgacttgc ctcccatccc tcagcctgtc tgtggcagag cctgcaccaa
     8161 aacccagagc ttcttccctc cgtgagggcc acgctgtcac cacagtcctc ccagatgggt
     8221 tttggattag catcagtcct gtgtcaccaa gtgccaaaca gctgaggggt agaagtggga
     8281 ctcctttccc gagccccagc atgaggctgt ggtgtcaggt ttaggcctct ctcaagtcag
     8341 aaaaccccgg gctgagacct ccacagacaa gggctcccca tgctggccat tggcaggggc
     8401 ccaagaagtt cagtgaccaa ctggtccttc cacaccacac cagctggtgc tgcccatgtc
     8461 tgtcgaatca taacggaaaa ttccccagat cacgtttgga tttaaaaact catcccttgt
     8521 cgtgcttcaa tgcatgccat ttgtcactta ccatacttca ccatggccga gcttcatgtc
     8581 acatggcctg gcgattgtgc ttgttcacac tggggccagg attttcatac taaaacgtca
     8641 ctgacaatgg ggctactttt ctcctgaata gctcctctgg gcttgttgca gttctagttt
     8701 tcccagtagt tccatggcag gttcaacctc tcagtgtcct gaaaaatgga accacccact
     8761 aaccatatgc actggctgcc caggtggctg cactccgggg atcacgtttc agtactgagt
     8821 tccttcacgc acttggttca ccaccatcac tcttgagttt tggacaaaag aggtgggtat
     8881 gccaggcaca gtggctcacg cctgtgatcc cagcactttg ggaggccgag gcgggcggat
     8941 cacctgaggt cgggagttcg aaaccagcct gaccaacatg gagaaaccct gtctctacta
     9001 aaaatataaa attagccggg tgtggtggcg catgcctgta atcccagcta ctcgggaggc
     9061 tgaggcagga gaatctcttg aacccaggag gcaaaagttg caatgagctg agatcgtgcc
     9121 atttgcactc cagcctgggc aacaagagcg aaattccatc tcaaaaaaaa aaggtgggta
     9181 aagggccatg agcccaaacc actaggttgt tcaccttttc atctgaaaat gctttactct
     9241 gactatgtgc tattgggttt tatttccaga aaatatagtt ctcctttttt ctgcatgaag
     9301 gatacatcgt ggtgccacat gctttaagca atttaaacaa gagagataag aggaaaatgc
     9361 aaccaccaca tctgacttgc ccaatgtaga ctttccttta ttagattgaa gtacacaacc
     9421 taatatgata tattattttg tagtatctca gactttgtaa ataaatgcca ttatttttat
     9481 atggaaattt tatagaagag ctatttctgt atacgtaatt actcctgatt ttctgaaatt
     9541 gcttctggta gataacagac aagtcctaag cagtgttcca ctaagggtgg ttccaggcct
     9601 gcctgccgtg gagttgactg ggggaatttt acagttttgc gatcctagga tgcgtcccag
     9661 acgctcagtc agaagtgctg gaggtggggc ctgggaagct gtatttgtaa tgaactctgg
     9721 tgttttttgt ccattaaagt gtatctttgt ccatcctata agattaaagg aaagaaaaag
     9781 catctcaaat gagtgtaagt tgttcttgag aaaaaaatgt atcagacttt tatgatttga
     9841 atgaaatgta ttatagaaaa aaataaacac tttaaaataa
//
