LOCUS       NM_007111               2639 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transcription factor Dp-1 (TFDP1), transcript variant
            1, mRNA.
ACCESSION   NM_007111
VERSION     NM_007111.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2639)
  AUTHORS   Zhao,R., Song,N., Ning,X., Chen,X. and Ma,R.
  TITLE     ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in
            ovarian cancer cells
  JOURNAL   Reproduction 168 (1), e230484 (2024)
   PUBMED   38614125
  REMARK    GeneRIF: ZNF146 regulates cell cycle progression via TFDP1 and
            DEPDC1B in ovarian cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2639)
  AUTHORS   Wu,M. and Ye,M.
  TITLE     Transcription factor Dp-1 knockdown downregulates thymidine kinase
            1 expression to protect against proliferation and
            epithelial-mesenchymal transition in cervical cancer
  JOURNAL   Funct Integr Genomics 23 (4), 301 (2023)
   PUBMED   37715794
  REMARK    GeneRIF: Transcription factor Dp-1 knockdown downregulates
            thymidine kinase 1 expression to protect against proliferation and
            epithelial-mesenchymal transition in cervical cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2639)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2639)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   5  (bases 1 to 2639)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2639)
  AUTHORS   Zhang,Y., Venkatraj,V.S., Fischer,S.G., Warburton,D. and
            Chellappan,S.P.
  TITLE     Genomic cloning and chromosomal assignment of the E2F dimerization
            partner TFDP gene family
  JOURNAL   Genomics 39 (1), 95-98 (1997)
   PUBMED   9027491
REFERENCE   7  (bases 1 to 2639)
  AUTHORS   Hijmans,E.M., Voorhoeve,P.M., Beijersbergen,R.L., van 't Veer,L.J.
            and Bernards,R.
  TITLE     E2F-5, a new E2F family member that interacts with p130 in vivo
  JOURNAL   Mol Cell Biol 15 (6), 3082-3089 (1995)
   PUBMED   7760804
REFERENCE   8  (bases 1 to 2639)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
REFERENCE   9  (bases 1 to 2639)
  AUTHORS   Ginsberg,D., Vairo,G., Chittenden,T., Xiao,Z.X., Xu,G.,
            Wydner,K.L., DeCaprio,J.A., Lawrence,J.B. and Livingston,D.M.
  TITLE     E2F-4, a new member of the E2F transcription factor family,
            interacts with p107
  JOURNAL   Genes Dev 8 (22), 2665-2679 (1994)
   PUBMED   7958924
REFERENCE   10 (bases 1 to 2639)
  AUTHORS   Hiebert,S.W., Chellappan,S.P., Horowitz,J.M. and Nevins,J.R.
  TITLE     The interaction of RB with E2F coincides with an inhibition of the
            transcriptional activity of E2F
  JOURNAL   Genes Dev 6 (2), 177-185 (1992)
   PUBMED   1531329
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC011685.2 and AL442125.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007111.4.
            
            Summary: This gene encodes a member of a family of transcription
            factors that heterodimerize with E2F proteins to enhance their
            DNA-binding activity and promote transcription from E2F target
            genes. The encoded protein functions as part of this complex to
            control the transcriptional activity of numerous genes involved in
            cell cycle progression from G1 to S phase. Alternative splicing
            results in multiple transcript variants. Pseudogenes of this gene
            are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan
            2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.394999.1,
                                           SRR1163658.95258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375370.10/ ENSP00000364519.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1658              BC011685.2         13-1670
            1659-2639           AL442125.13        176205-177185
FEATURES             Location/Qualifiers
     source          1..2639
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..2639
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /note="transcription factor Dp-1"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
     exon            1..136
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..212
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1433
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /note="E2F dimerization partner 1; DRTF1-polypeptide 1;
                     E2F-related transcription factor; down-regulated in liver
                     cancer stem cells"
                     /codon_start=1
                     /product="transcription factor Dp-1"
                     /protein_id="NP_009042.1"
                     /db_xref="CCDS:CCDS9538.1"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
                     /translation="MAKDAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGK
                     QLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQNQPSDSSPWSA
                     GKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAY
                     DQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQ
                     KQSQLQELILQQIAFKNLVQRNRHAEQQASRPPPPNSVIHLPFIIVNTSKKTVIDCSI
                     SNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKMARSLVPKALEPYV
                     TEMAQGTVGGVFITTAGSTSNGTRFSASDLTNGADGMLATSSNGSQYSGSRVETPVSY
                     VGEDDEEDDDFNENDEDD"
     exon            213..279
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..386
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..508
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..674
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..818
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..887
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1039
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1206
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1285
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..2639
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1965..1970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /note="hexamer: AATAAA"
     polyA_site      1984
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
     regulatory      2611..2616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /note="hexamer: AATAAA"
     polyA_site      2639
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /note="major polyA site"
ORIGIN      
        1 actcggccca gggcagggac cccgccacgg ccgggaccgc ccggcccggc cccagcccgc
       61 gcctctccgc gccgccccgc gctccgcacc gcgccctctc cgcgtccccg cccgcgcggc
      121 cggaccgggc agccagaaaa atcatttttc ttctctggga aggtgaacat ttgtagcatt
      181 gatttcccgg atctggtaac atggcaaaag atgccggtct aattgaagcc aacggagaac
      241 tcaaggtctt catagaccag aaccttagtc ccgggaaagg cgtggtgtcc ctcgtggccg
      301 ttcacccctc caccgtcaac ccgctcggga agcagctctt gccaaaaacc tttggacagt
      361 ccaatgtcaa cattgcccag caagtggtaa ttggtacgcc tcagagaccg gcagcgtcaa
      421 acaccctggt ggtaggaagc ccacacaccc ccagcactca ctttgcctct cagaaccagc
      481 cttccgactc ctcaccttgg tctgccggga agcgcaacag gaaaggagag aagaatggca
      541 agggcctacg gcatttctcc atgaaggtct gcgagaaggt gcagaggaaa gggaccactt
      601 cctacaacga agtggcagac gagctggttg cggagttcag tgctgccgac aaccacatct
      661 taccaaacga gtcagcttat gaccagaaaa acataagacg gcgcgtctac gatgccttaa
      721 acgtgctaat ggccatgaac atcatctcca aggagaagaa ggagatcaag tggattggtc
      781 tgcccaccaa ctcggctcag gaatgtcaga acttagaggt ggaaagacag aggagacttg
      841 aaagaataaa acagaaacag tctcaacttc aagaacttat tctacagcaa attgccttca
      901 agaacctggt gcagagaaac cggcatgcgg agcagcaggc cagccggcca ccgccaccca
      961 actcagtcat ccacctgccc ttcatcatcg tcaacaccag caagaagacg gtcatcgact
     1021 gcagcatctc caatgacaaa tttgagtatc tgtttaattt tgacaacaca tttgaaatcc
     1081 acgatgacat agaagtgctg aagcggatgg gcatggcttg cgggctggag tcggggagct
     1141 gctctgccga agaccttaaa atggccagaa gtctggtccc caaggctctg gagccatacg
     1201 tgacagaaat ggctcaggga actgttggag gcgtgttcat cacgacggca ggttccacgt
     1261 ctaacggcac aaggttctct gccagtgacc tgaccaacgg tgcagatggg atgctggcca
     1321 caagctccaa tgggtctcag tacagcggct ccagggtgga gactccggtg tcctacgtcg
     1381 gggaggacga cgaggaggac gatgacttca acgagaatga cgaggacgac tgacgtcctc
     1441 cccacttcag attcggcttc aggaaaacgt ttagcgaaaa gaaacttttt ttttaatgtg
     1501 ggttttctgt ttccttttgg cctactccca agaagatatt ggtaagctat tgaatttaga
     1561 tatgcacctc tgataagcaa ggattgtttc ccgtaggatt aggacgtgct gtggatgtgt
     1621 gttttgatac cagtgtgctg atgcagagcg tttatttact tgttaggatt ttgtgttttc
     1681 atttgctatt tttctttaag tgcagagttc atttttgccc ctgaaaagtt tttgctgagt
     1741 ttgctgaaga aattgtattt caaccacatc catgaaaata aaacacctcc tgttgtggat
     1801 ggtgagcccc tgatgccgct tatttgccgt gagtttggac ggcacccctg ctggcggata
     1861 gcaagactct gtggagtttg ttcagtggta cggtgtccaa gcaaacagca gaatgcaact
     1921 ttctaaacag ccccaagcaa acagcagaat tcaacttttt aaacaataaa caccatcaac
     1981 cttattgact ttattgtccc ttaaattata ttgactgttg tgattccatc aagtttgtac
     2041 actcttttct ctccctgttt tgcagcaaca aattgcgaag tgcttttgtt tgtttgtttt
     2101 cgtttggtta aagcttattg ccatgctggt gcggctatgg agactgtctg gaaggcttgg
     2161 aatggtttat tgcttatggt aaaatttgcc tgatttctta caggcagcgt ttggaaacct
     2221 tttattatat agttgtttac atacttataa gtctatcatt taaagacatg tactgaaaca
     2281 aatgtatttg tttcataagc atcttcctgt aatctattat aaaattgaaa ttaaatatag
     2341 agaatgtttt aacaattttt taactcaaaa tttgtcaatc atttttaata gttctttttt
     2401 tataaaaaga aaaaggaatt taaggacagg cagtagtctc ttttaaaatt tattcacaaa
     2461 acccattaac tgcacagttg ctattagctg cctgttctaa aacgatagtc tttttattga
     2521 aacacaaata aacttttctg taatatttta tggtatataa agagacttta attgtttgac
     2581 ttgtttaact tggcactgtt agtttttatt aataaaacgc gcatgggcat tttaaacaa
//
