LOCUS       NP_009042                410 aa            linear   PRI 27-APR-2025
DEFINITION  transcription factor Dp-1 [Homo sapiens].
ACCESSION   NP_009042
VERSION     NP_009042.1
DBSOURCE    REFSEQ: accession NM_007111.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 410)
  AUTHORS   Zhao,R., Song,N., Ning,X., Chen,X. and Ma,R.
  TITLE     ZNF146 regulates cell cycle progression via TFDP1 and DEPDC1B in
            ovarian cancer cells
  JOURNAL   Reproduction 168 (1), e230484 (2024)
   PUBMED   38614125
  REMARK    GeneRIF: ZNF146 regulates cell cycle progression via TFDP1 and
            DEPDC1B in ovarian cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 410)
  AUTHORS   Wu,M. and Ye,M.
  TITLE     Transcription factor Dp-1 knockdown downregulates thymidine kinase
            1 expression to protect against proliferation and
            epithelial-mesenchymal transition in cervical cancer
  JOURNAL   Funct Integr Genomics 23 (4), 301 (2023)
   PUBMED   37715794
  REMARK    GeneRIF: Transcription factor Dp-1 knockdown downregulates
            thymidine kinase 1 expression to protect against proliferation and
            epithelial-mesenchymal transition in cervical cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 410)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 410)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   5  (residues 1 to 410)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (residues 1 to 410)
  AUTHORS   Zhang,Y., Venkatraj,V.S., Fischer,S.G., Warburton,D. and
            Chellappan,S.P.
  TITLE     Genomic cloning and chromosomal assignment of the E2F dimerization
            partner TFDP gene family
  JOURNAL   Genomics 39 (1), 95-98 (1997)
   PUBMED   9027491
REFERENCE   7  (residues 1 to 410)
  AUTHORS   Hijmans,E.M., Voorhoeve,P.M., Beijersbergen,R.L., van 't Veer,L.J.
            and Bernards,R.
  TITLE     E2F-5, a new E2F family member that interacts with p130 in vivo
  JOURNAL   Mol Cell Biol 15 (6), 3082-3089 (1995)
   PUBMED   7760804
REFERENCE   8  (residues 1 to 410)
  AUTHORS   Wu,C.L., Zukerberg,L.R., Ngwu,C., Harlow,E. and Lees,J.A.
  TITLE     In vivo association of E2F and DP family proteins
  JOURNAL   Mol Cell Biol 15 (5), 2536-2546 (1995)
   PUBMED   7739537
REFERENCE   9  (residues 1 to 410)
  AUTHORS   Ginsberg,D., Vairo,G., Chittenden,T., Xiao,Z.X., Xu,G.,
            Wydner,K.L., DeCaprio,J.A., Lawrence,J.B. and Livingston,D.M.
  TITLE     E2F-4, a new member of the E2F transcription factor family,
            interacts with p107
  JOURNAL   Genes Dev 8 (22), 2665-2679 (1994)
   PUBMED   7958924
REFERENCE   10 (residues 1 to 410)
  AUTHORS   Hiebert,S.W., Chellappan,S.P., Horowitz,J.M. and Nevins,J.R.
  TITLE     The interaction of RB with E2F coincides with an inhibition of the
            transcriptional activity of E2F
  JOURNAL   Genes Dev 6 (2), 177-185 (1992)
   PUBMED   1531329
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC011685.2 and AL442125.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of a family of transcription
            factors that heterodimerize with E2F proteins to enhance their
            DNA-binding activity and promote transcription from E2F target
            genes. The encoded protein functions as part of this complex to
            control the transcriptional activity of numerous genes involved in
            cell cycle progression from G1 to S phase. Alternative splicing
            results in multiple transcript variants. Pseudogenes of this gene
            are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan
            2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.394999.1,
                                           SRR1163658.95258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375370.10/ ENSP00000364519.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..410
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     Protein         1..410
                     /product="transcription factor Dp-1"
                     /note="E2F dimerization partner 1; DRTF1-polypeptide 1;
                     E2F-related transcription factor; down-regulated in liver
                     cancer stem cells"
                     /calculated_mol_wt=44939
     Site            3
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q14186.1)"
     Site            23
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q14186.1)"
     Region          73..116
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14186.1)"
     Region          105..127
                     /region_name="Interaction with CEBPA.
                     /evidence=ECO:0000269|PubMed:20176812"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14186.1)"
     Region          112..193
                     /region_name="E2F_TDP"
                     /note="E2F/DP family winged-helix DNA-binding domain;
                     pfam02319"
                     /db_xref="CDD:460530"
     Region          161..195
                     /region_name="DEF box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14186.1)"
     Site            order(198,202,205..206,208..209,212..213,215..216,
                     219..220,223,226..227,230,233..234,236..237,239..241,244,
                     255..266,268,279..287,289,291,293,299..300,302)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          198..244
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:271217"
     Region          200..338
                     /region_name="DP"
                     /note="Transcription factor DP; pfam08781"
                     /db_xref="CDD:462601"
     Region          204..277
                     /region_name="Dimerization. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14186.1)"
     Region          211..327
                     /region_name="Enhances binding of RB protein to E2F"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14186.1)"
     Region          214..246
                     /region_name="DCB1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14186.1)"
     Site            order(222,225..226,229,262,271,273,288..295,302)
                     /site_type="other"
                     /note="RbC binding site [polypeptide binding]"
                     /db_xref="CDD:271217"
     Region          259..315
                     /region_name="DCB2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14186.1)"
     Region          370..410
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14186.1)"
     CDS             1..410
                     /gene="TFDP1"
                     /gene_synonym="DILC; Dp-1; DP1; DRTF1"
                     /coded_by="NM_007111.5:201..1433"
                     /db_xref="CCDS:CCDS9538.1"
                     /db_xref="GeneID:7027"
                     /db_xref="HGNC:HGNC:11749"
                     /db_xref="MIM:189902"
ORIGIN      
        1 makdagliea ngelkvfidq nlspgkgvvs lvavhpstvn plgkqllpkt fgqsnvniaq
       61 qvvigtpqrp aasntlvvgs phtpsthfas qnqpsdsspw sagkrnrkge kngkglrhfs
      121 mkvcekvqrk gttsynevad elvaefsaad nhilpnesay dqknirrrvy dalnvlmamn
      181 iiskekkeik wiglptnsaq ecqnleverq rrlerikqkq sqlqelilqq iafknlvqrn
      241 rhaeqqasrp pppnsvihlp fiivntskkt vidcsisndk feylfnfdnt feihddievl
      301 krmgmacgle sgscsaedlk marslvpkal epyvtemaqg tvggvfitta gstsngtrfs
      361 asdltngadg mlatssngsq ysgsrvetpv syvgeddeed ddfnendedd
//
