LOCUS       NM_005653               3807 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens transcription factor CP2 (TFCP2), transcript variant
            1, mRNA.
ACCESSION   NM_005653
VERSION     NM_005653.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3807)
  AUTHORS   Zieminski,R., Stupak,A., Kwiatek,M., Geca,T., Warowicka,A.,
            Hejne,K., Kwasniewska,A., Gozdzicka-Jozefiak,A. and Kwasniewski,W.
  TITLE     Analysis of the Expression of LSF Transcription Factor in the
            Regulation of Transcription and TSG101 during the Neoplastic
            Transformation of Endometrial Cells
  JOURNAL   Cells 13 (7), 580 (2024)
   PUBMED   38607019
  REMARK    GeneRIF: Analysis of the Expression of LSF Transcription Factor in
            the Regulation of Transcription and TSG101 during the Neoplastic
            Transformation of Endometrial Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3807)
  AUTHORS   Schopf,J., Uhrig,S., Heilig,C.E., Lee,K.S., Walther,T.,
            Carazzato,A., Dobberkau,A.M., Weichenhan,D., Plass,C., Hartmann,M.,
            Diwan,G.D., Carrero,Z.I., Ball,C.R., Hohl,T., Kindler,T.,
            Rudolph-Hahnel,P., Helm,D., Schneider,M., Nilsson,A., Ora,I.,
            Imle,R., Banito,A., Russell,R.B., Jones,B.C., Lipka,D.B., Glimm,H.,
            Hubschmann,D., Hartmann,W., Frohling,S. and Scholl,C.
  TITLE     Multi-omic and functional analysis for classification and treatment
            of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions
  JOURNAL   Nat Commun 15 (1), 51 (2024)
   PUBMED   38168093
  REMARK    GeneRIF: Multi-omic and functional analysis for classification and
            treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3807)
  AUTHORS   Basu,A., Champagne,R.N., Patel,N.G., Nicholson,E.D. and Weiss,R.J.
  TITLE     TFCP2 is a transcriptional regulator of heparan sulfate assembly
            and melanoma cell growth
  JOURNAL   J Biol Chem 299 (6), 104713 (2023)
   PUBMED   37061003
  REMARK    GeneRIF: TFCP2 is a transcriptional regulator of heparan sulfate
            assembly and melanoma cell growth.
REFERENCE   4  (bases 1 to 3807)
  AUTHORS   Ren,Y., YaneYang, Lu,Q., Wang,Q., Lu,G., Wei,Y. and Zhou,J.
  TITLE     Transcription factor cellular promoter 2 is required for upstream
            binding protein 1 -mediated angiogenesis
  JOURNAL   Gene Expr Patterns 48, 119308 (2023)
   PUBMED   36889372
  REMARK    GeneRIF: Transcription factor cellular promoter 2 is required for
            upstream binding protein 1 -mediated angiogenesis.
REFERENCE   5  (bases 1 to 3807)
  AUTHORS   Yang,Z., Jia,X., Deng,Q., Luo,M., Hou,Y., Yue,J., Mei,J., Shan,N.
            and Wu,Z.
  TITLE     Human umbilical cord mesenchymal stem cell-derived extracellular
            vesicles loaded with TFCP2 activate Wnt/beta-catenin signaling to
            alleviate preeclampsia
  JOURNAL   Int Immunopharmacol 115, 109732 (2023)
   PUBMED   37724958
  REMARK    GeneRIF: Human umbilical cord mesenchymal stem cell-derived
            extracellular vesicles loaded with TFCP2 activate Wnt/beta-catenin
            signaling to alleviate preeclampsia.
REFERENCE   6  (bases 1 to 3807)
  AUTHORS   Jane,S.M., Nienhuis,A.W. and Cunningham,J.M.
  TITLE     Hemoglobin switching in man and chicken is mediated by a
            heteromeric complex between the ubiquitous transcription factor CP2
            and a developmentally specific protein
  JOURNAL   EMBO J 14 (1), 97-105 (1995)
   PUBMED   7828600
  REMARK    Erratum:[EMBO J 1995 Feb 15;14(4):854]
REFERENCE   7  (bases 1 to 3807)
  AUTHORS   Shirra,M.K., Zhu,Q., Huang,H.C., Pallas,D. and Hansen,U.
  TITLE     One exon of the human LSF gene includes conserved regions involved
            in novel DNA-binding and dimerization motifs
  JOURNAL   Mol Cell Biol 14 (8), 5076-5087 (1994)
   PUBMED   8035790
REFERENCE   8  (bases 1 to 3807)
  AUTHORS   Swendeman,S.L., Spielholz,C., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Sheffery,M.
  TITLE     Characterization of the genomic structure, chromosomal location,
            promoter, and development expression of the alpha-globin
            transcription factor CP2
  JOURNAL   J Biol Chem 269 (15), 11663-11671 (1994)
   PUBMED   8157699
REFERENCE   9  (bases 1 to 3807)
  AUTHORS   Yoon,J.B., Li,G. and Roeder,R.G.
  TITLE     Characterization of a family of related cellular transcription
            factors which can modulate human immunodeficiency virus type 1
            transcription in vitro
  JOURNAL   Mol Cell Biol 14 (3), 1776-1785 (1994)
   PUBMED   8114710
REFERENCE   10 (bases 1 to 3807)
  AUTHORS   Lim,L.C., Swendeman,S.L. and Sheffery,M.
  TITLE     Molecular cloning of the alpha-globin transcription factor CP2
  JOURNAL   Mol Cell Biol 12 (2), 828-835 (1992)
   PUBMED   1732747
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX479302.1, BC003634.2,
            AC139768.14 and AC087884.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005653.4.
            
            Summary: This gene encodes a transcription factor that binds the
            alpha-globin promoter and activates transcription of the
            alpha-globin gene. The encoded protein regulates erythroid gene
            expression, plays a role in the transcriptional switch of globin
            gene promoters, and it activates many other cellular and viral gene
            promoters. The gene product interacts with certain inflammatory
            response factors, and polymorphisms of this gene may be involved in
            the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.9461.1,
                                           SRR1803617.190926.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257915.10/ ENSP00000257915.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               BX479302.1         12-456
            446-568             BC003634.2         192-314
            569-569             AC139768.14        73389-73389
            570-2626            BC003634.2         316-2372
            2627-3807           AC087884.18        74633-75813
FEATURES             Location/Qualifiers
     source          1..3807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12-q13.13"
     gene            1..3807
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /note="transcription factor CP2"
                     /db_xref="GeneID:7024"
                     /db_xref="HGNC:HGNC:11748"
                     /db_xref="MIM:189889"
     exon            1..835
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             714..2222
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-globin transcription factor CP2; SAA3 enhancer
                     factor"
                     /codon_start=1
                     /product="alpha-globin transcription factor CP2 isoform 1"
                     /protein_id="NP_005644.2"
                     /db_xref="CCDS:CCDS8808.1"
                     /db_xref="GeneID:7024"
                     /db_xref="HGNC:HGNC:11748"
                     /db_xref="MIM:189889"
                     /translation="MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVL
                     ALPIFKQEESSLPPDNENKILPFQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDN
                     RKLGELPEINGKLVKSIFRVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGI
                     IDPRANPTQLNTVEFLWDPAKRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTFKE
                     NENGEYTEHLHSASCQIKVFKPKGADRKQKTDREKMEKRTPHEKEKYQPSYETTILTE
                     CSPWPEITYVNNSPSPGFNSSHSSFSLGEGNGSPNHQPEPPPPVTDNLLPTTTPQEAQ
                     QWLHRNRFSTFTRLFTNFSGADLLKLTRDDVIQICGPADGIRLFNALKGRMVRPRLTI
                     YVCQESLQLREQQQQQQQQQQKHEDGDSNGTFFVYHAIYLEELTAVELTEKIAQLFSI
                     SPCQISQIYKQGPTGIHVLISDEMIQNFQEEACFILDTMKAETNDSYHIILK"
     exon            836..987
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1064
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1170
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1277
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1430
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1541
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1630
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1679
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1773
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1864
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1989
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2132
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2184
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..3807
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2600..2605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /note="hexamer: TATAAA"
     polyA_site      2626
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /note="major polyA site"
     regulatory      3680..3685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /note="hexamer: ATTAAA"
     polyA_site      3707
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
     polyA_site      3778
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
ORIGIN      
        1 gttcgccggg caggcgagga aagaggacgc catgattggt tggcgctggg gcggcggacg
       61 gtggaagggc ctggcgagtc taggttttac gcctgtgctg gactttctcc ttccatgttt
      121 ccaggccgtg gggggctaca gagggcgaga agtcggctca gcggaaacct ggatttggtt
      181 ctaagccgtg gggttgagaa ggggtgaccg gaagtgatcg tgggactgac cggaagcgag
      241 gcctggaggg gaaagagaga gcgagacctg ggagggaggg ggcctccagc agaaaggggc
      301 gggggaaaag gtgcaaaagc agcgtgggag cgccgggctg gcttcctgcg gctgctgctg
      361 gtctgactgg gaagcagcaa gccaccacta cgaactctca agaggagtgg gagtgcggga
      421 gtccagagct gcctctggga agtctgcagt agttgagcaa aggggtcctc acgttcctga
      481 gagctgggca ggggggattt tggaacctgg ggcagccaag aacgagcagc caagggtacg
      541 ggagattagt tgtgcacaga gcagtgctgg tcgggcttgg gggtggctgg tgggcactgc
      601 gtgggaaacc ttggtttgta gttttcttgg tttgcgttac tcctgttggg tagaattacc
      661 ctccgcgcct ttgtacaaga cacggtgtct cctggggcaa ggaaggagcc aggatggcct
      721 gggctctgaa gctgcctctg gccgacgaag tgattgaatc cgggttggtg caggactttg
      781 atgctagcct gtccgggatc ggccaggaac tgggtgctgg tgcctatagc atgagtgatg
      841 tccttgcatt gcccattttt aagcaagaag agtcgagttt gcctcctgat aatgagaata
      901 aaatcctgcc ttttcaatat gtgctttgtg ctgctacctc tccagcagtg aaactccatg
      961 atgaaaccct aacgtatctc aatcaaggac agtcttatga aattcgaatg ctagacaata
     1021 ggaaacttgg agaacttcca gaaattaatg gcaaattggt gaagagtata ttccgtgtgg
     1081 tgttccatga cagaaggctt cagtacactg agcatcagca gctagagggc tggaggtgga
     1141 accgacctgg agacagaatt cttgacatag atatcccgat gtctgtgggt ataatcgatc
     1201 ctagggctaa tccaactcaa ctaaatacag tggagttcct gtgggaccct gcaaagagga
     1261 catctgtgtt tattcaggtg cactgtatta gcacagagtt cactatgagg aaacatggtg
     1321 gagaaaaggg ggtgccattc cgagtacaaa tagatacctt caaggagaat gaaaacgggg
     1381 aatatactga gcacttacac tcggccagct gccagatcaa agttttcaag cccaaaggtg
     1441 cagacagaaa gcaaaaaacg gatagggaaa aaatggagaa acgaacacct catgaaaagg
     1501 agaaatatca gccttcctat gagacaacca tactcacaga gtgttctcca tggcccgaga
     1561 tcacgtatgt caataactcc ccatcacctg gcttcaacag ttcccatagc agtttttctc
     1621 ttggggaagg aaatggttca ccaaaccacc agccagagcc accccctcca gtcacagata
     1681 acctcttacc aacaaccaca cctcaggaag ctcagcagtg gttgcatcga aatcgttttt
     1741 ctacattcac aaggcttttc acaaacttct caggggcaga tttattgaaa ttaactagag
     1801 atgatgtgat ccaaatctgt ggccctgcag atggaatcag actttttaat gcattaaaag
     1861 gccggatggt gcgtccaagg ttaaccattt atgtttgtca ggaatcactg cagttgaggg
     1921 agcagcaaca acagcagcag caacagcagc agaagcatga ggatggagac tcaaatggta
     1981 ctttcttcgt ttaccatgct atctatctag aagaactaac agctgttgaa ttgacagaaa
     2041 aaattgctca gcttttcagc atttcccctt gccagatcag ccagatttac aagcaggggc
     2101 caacaggaat tcatgtgctc atcagtgatg agatgataca gaactttcag gaagaagcat
     2161 gttttattct ggacacaatg aaagcagaaa ccaatgatag ctatcatatc atactgaagt
     2221 aggagtgcgg cgtttcgtgc ccagtggctg ctccttcctt cacctctgaa aacggccctc
     2281 ttgaaggggg atatgaatgg agatttgaag gtctgcaaga acctgactcg tctgactgtg
     2341 tgtggaggag tccaggccat ggaggcagaa tcctggccct ctgtgttggc ccaagctctt
     2401 gtggtacaca cagattactg cccaatatgc agttctgcag ctgttttagt taaatttctg
     2461 gaccttgttg ttgttaaata tcagtagaaa ctctacataa tttagagtgt atgtagggca
     2521 taatgatgat gggaattgtg tgatgtttaa caggaagatc ttaaattttg tgatatggag
     2581 ccctgtaatt tttttcttat ataaaaatgg gtatctatat tcataagact aggtcttcaa
     2641 tctctttgta ctggtctcaa atgtactggt atctctgctt tttgccacag tttgtccctg
     2701 aaaactttat cagtgaggag aaatacagaa ttttcctttt ggttcccctg taataccaca
     2761 actaatagta ttttcagcta acatttattg accaggcagt gtgataaatt ttttgaatga
     2821 ccatcttgtt taacccccta atcacactat ctgaagtagg tgctatagtg acccccaacc
     2881 gaagatgagg aaatggagac acacagtggc taagtagctt gctaggtgcc aggagctggc
     2941 aggcagtgat gctgaaatcc aaaccaggca atctggccct ccttattcac cctctcatac
     3001 caccagtgct acccattata acctgtgttc acttcgctta ttactgtggc ccttctggtg
     3061 actacaacat aacactgagt atgaactgag gaattaacca ctgaaagaga caaagcacac
     3121 ctaaataatg atgaacaaat caagacctac aagaaatgaa cacatagatg ctttttaagt
     3181 gtcattagtt atcggaatca aagaatttga ggtggtgaca actggggatt atctgtaact
     3241 ccccaaattt actgttcttg aatgacattc tcaaactatt tattaatgag ttagtctcat
     3301 ccctgctttc tgtttcctct ctctgcatct tctcttggca taggaagtta ttttactcat
     3361 gctatgtttt ttaatagaag ctttacaaaa aaagatgcat tcccttcctg ttcacactct
     3421 taccatgttt ttgttcttcc ttaagaatga ttgtgtgtgt gtgtgtgtgt gtgtgtaagt
     3481 gtgtaagtgt aacatcatgg gttttctttc ttcacttgta aagttttatc tagaaatact
     3541 tttacaggtt atgttgaggt acacaaagat aatgttctaa gattgtgtat tggatttgga
     3601 tttgtgtgtg tgtgtgtgtg tgtgtgtgtt taaagcattt gataaggttt aaatgttttt
     3661 tatacagaga tttttgttca ttaaactcaa tctgcatcat ggtctaattt ctcttggttt
     3721 gaaacaaatt gaaaactttg aaaccaaaaa attaagtcaa tgacttgttt aaaactgacc
     3781 tgagcaactt gttatattac accaaaa
//
