LOCUS       NP_005644                502 aa            linear   PRI 27-APR-2025
DEFINITION  alpha-globin transcription factor CP2 isoform 1 [Homo sapiens].
ACCESSION   NP_005644
VERSION     NP_005644.2
DBSOURCE    REFSEQ: accession NM_005653.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 502)
  AUTHORS   Zieminski,R., Stupak,A., Kwiatek,M., Geca,T., Warowicka,A.,
            Hejne,K., Kwasniewska,A., Gozdzicka-Jozefiak,A. and Kwasniewski,W.
  TITLE     Analysis of the Expression of LSF Transcription Factor in the
            Regulation of Transcription and TSG101 during the Neoplastic
            Transformation of Endometrial Cells
  JOURNAL   Cells 13 (7), 580 (2024)
   PUBMED   38607019
  REMARK    GeneRIF: Analysis of the Expression of LSF Transcription Factor in
            the Regulation of Transcription and TSG101 during the Neoplastic
            Transformation of Endometrial Cells.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 502)
  AUTHORS   Schopf,J., Uhrig,S., Heilig,C.E., Lee,K.S., Walther,T.,
            Carazzato,A., Dobberkau,A.M., Weichenhan,D., Plass,C., Hartmann,M.,
            Diwan,G.D., Carrero,Z.I., Ball,C.R., Hohl,T., Kindler,T.,
            Rudolph-Hahnel,P., Helm,D., Schneider,M., Nilsson,A., Ora,I.,
            Imle,R., Banito,A., Russell,R.B., Jones,B.C., Lipka,D.B., Glimm,H.,
            Hubschmann,D., Hartmann,W., Frohling,S. and Scholl,C.
  TITLE     Multi-omic and functional analysis for classification and treatment
            of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions
  JOURNAL   Nat Commun 15 (1), 51 (2024)
   PUBMED   38168093
  REMARK    GeneRIF: Multi-omic and functional analysis for classification and
            treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 502)
  AUTHORS   Basu,A., Champagne,R.N., Patel,N.G., Nicholson,E.D. and Weiss,R.J.
  TITLE     TFCP2 is a transcriptional regulator of heparan sulfate assembly
            and melanoma cell growth
  JOURNAL   J Biol Chem 299 (6), 104713 (2023)
   PUBMED   37061003
  REMARK    GeneRIF: TFCP2 is a transcriptional regulator of heparan sulfate
            assembly and melanoma cell growth.
REFERENCE   4  (residues 1 to 502)
  AUTHORS   Ren,Y., YaneYang, Lu,Q., Wang,Q., Lu,G., Wei,Y. and Zhou,J.
  TITLE     Transcription factor cellular promoter 2 is required for upstream
            binding protein 1 -mediated angiogenesis
  JOURNAL   Gene Expr Patterns 48, 119308 (2023)
   PUBMED   36889372
  REMARK    GeneRIF: Transcription factor cellular promoter 2 is required for
            upstream binding protein 1 -mediated angiogenesis.
REFERENCE   5  (residues 1 to 502)
  AUTHORS   Yang,Z., Jia,X., Deng,Q., Luo,M., Hou,Y., Yue,J., Mei,J., Shan,N.
            and Wu,Z.
  TITLE     Human umbilical cord mesenchymal stem cell-derived extracellular
            vesicles loaded with TFCP2 activate Wnt/beta-catenin signaling to
            alleviate preeclampsia
  JOURNAL   Int Immunopharmacol 115, 109732 (2023)
   PUBMED   37724958
  REMARK    GeneRIF: Human umbilical cord mesenchymal stem cell-derived
            extracellular vesicles loaded with TFCP2 activate Wnt/beta-catenin
            signaling to alleviate preeclampsia.
REFERENCE   6  (residues 1 to 502)
  AUTHORS   Jane,S.M., Nienhuis,A.W. and Cunningham,J.M.
  TITLE     Hemoglobin switching in man and chicken is mediated by a
            heteromeric complex between the ubiquitous transcription factor CP2
            and a developmentally specific protein
  JOURNAL   EMBO J 14 (1), 97-105 (1995)
   PUBMED   7828600
  REMARK    Erratum:[EMBO J 1995 Feb 15;14(4):854]
REFERENCE   7  (residues 1 to 502)
  AUTHORS   Shirra,M.K., Zhu,Q., Huang,H.C., Pallas,D. and Hansen,U.
  TITLE     One exon of the human LSF gene includes conserved regions involved
            in novel DNA-binding and dimerization motifs
  JOURNAL   Mol Cell Biol 14 (8), 5076-5087 (1994)
   PUBMED   8035790
REFERENCE   8  (residues 1 to 502)
  AUTHORS   Swendeman,S.L., Spielholz,C., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Sheffery,M.
  TITLE     Characterization of the genomic structure, chromosomal location,
            promoter, and development expression of the alpha-globin
            transcription factor CP2
  JOURNAL   J Biol Chem 269 (15), 11663-11671 (1994)
   PUBMED   8157699
REFERENCE   9  (residues 1 to 502)
  AUTHORS   Yoon,J.B., Li,G. and Roeder,R.G.
  TITLE     Characterization of a family of related cellular transcription
            factors which can modulate human immunodeficiency virus type 1
            transcription in vitro
  JOURNAL   Mol Cell Biol 14 (3), 1776-1785 (1994)
   PUBMED   8114710
REFERENCE   10 (residues 1 to 502)
  AUTHORS   Lim,L.C., Swendeman,S.L. and Sheffery,M.
  TITLE     Molecular cloning of the alpha-globin transcription factor CP2
  JOURNAL   Mol Cell Biol 12 (2), 828-835 (1992)
   PUBMED   1732747
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX479302.1, BC003634.2,
            AC139768.14 and AC087884.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 10, 2002 this sequence version replaced NP_005644.1.
            
            Summary: This gene encodes a transcription factor that binds the
            alpha-globin promoter and activates transcription of the
            alpha-globin gene. The encoded protein regulates erythroid gene
            expression, plays a role in the transcriptional switch of globin
            gene promoters, and it activates many other cellular and viral gene
            promoters. The gene product interacts with certain inflammatory
            response factors, and polymorphisms of this gene may be involved in
            the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.9461.1,
                                           SRR1803617.190926.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257915.10/ ENSP00000257915.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12-q13.13"
     Protein         1..502
                     /product="alpha-globin transcription factor CP2 isoform 1"
                     /note="alpha-globin transcription factor CP2; SAA3
                     enhancer factor"
                     /calculated_mol_wt=57125
     Region          52..259
                     /region_name="CP2"
                     /note="CP2 transcription factor; pfam04516"
                     /db_xref="CDD:461338"
     Region          133..395
                     /region_name="DNA-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q12800.2)"
     Region          238..268
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q12800.2)"
     Region          294..325
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q12800.2)"
     Region          329..395
                     /region_name="SAM_TFCP2"
                     /note="SAM domain of TFCP2 transcription factors; cd09589"
                     /db_xref="CDD:188988"
     Site            353
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q12800.2)"
     CDS             1..502
                     /gene="TFCP2"
                     /gene_synonym="LBP1C; LSF; LSF1D; SEF; TFCP2C"
                     /coded_by="NM_005653.5:714..2222"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS8808.1"
                     /db_xref="GeneID:7024"
                     /db_xref="HGNC:HGNC:11748"
                     /db_xref="MIM:189889"
ORIGIN      
        1 mawalklpla deviesglvq dfdaslsgig qelgagaysm sdvlalpifk qeesslppdn
       61 enkilpfqyv lcaatspavk lhdetltyln qgqsyeirml dnrklgelpe ingklvksif
      121 rvvfhdrrlq ytehqqlegw rwnrpgdril didipmsvgi idpranptql ntveflwdpa
      181 krtsvfiqvh cisteftmrk hggekgvpfr vqidtfkene ngeytehlhs ascqikvfkp
      241 kgadrkqktd rekmekrtph ekekyqpsye ttiltecspw peityvnnsp spgfnsshss
      301 fslgegngsp nhqpeppppv tdnllptttp qeaqqwlhrn rfstftrlft nfsgadllkl
      361 trddviqicg padgirlfna lkgrmvrprl tiyvcqeslq lreqqqqqqq qqqkhedgds
      421 ngtffvyhai yleeltavel tekiaqlfsi spcqisqiyk qgptgihvli sdemiqnfqe
      481 eacfildtmk aetndsyhii lk
//
