LOCUS       NM_022366               1784 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transcription factor B2, mitochondrial (TFB2M), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_022366
VERSION     NM_022366.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1784)
  AUTHORS   Wu,W., Zhou,S., Liu,T. and Liang,D.
  TITLE     Mitochondrial transcription factor B2 overexpression increases M2
            macrophage infiltration via cytosolic mitochondrial DNA-stimulated
            Interleukin-6 secretion in ovarian cancer
  JOURNAL   Bioengineered 13 (5), 12211-12223 (2022)
   PUBMED   35577351
  REMARK    GeneRIF: Mitochondrial transcription factor B2 overexpression
            increases M2 macrophage infiltration via cytosolic mitochondrial
            DNA-stimulated Interleukin-6 secretion in ovarian cancer.
REFERENCE   2  (bases 1 to 1784)
  AUTHORS   Inatomi,T., Matsuda,S., Ishiuchi,T., Do,Y., Nakayama,M., Abe,S.,
            Kasho,K., Wanrooij,S., Nakada,K., Ichiyanagi,K., Sasaki,H.,
            Yasukawa,T. and Kang,D.
  TITLE     TFB2M and POLRMT are essential for mammalian mitochondrial DNA
            replication
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1869 (1), 119167 (2022)
   PUBMED   34744028
  REMARK    GeneRIF: TFB2M and POLRMT are essential for mammalian mitochondrial
            DNA replication.
REFERENCE   3  (bases 1 to 1784)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1784)
  AUTHORS   Bostwick,A.M., Moya,G.E., Senti,M.L., Basu,U., Shen,J., Patel,S.S.
            and Dittenhafer-Reed,K.E.
  TITLE     Phosphorylation of mitochondrial transcription factor B2 controls
            mitochondrial DNA binding and transcription
  JOURNAL   Biochem Biophys Res Commun 528 (3), 580-585 (2020)
   PUBMED   32505352
  REMARK    GeneRIF: Phosphorylation of mitochondrial transcription factor B2
            controls mitochondrial DNA binding and transcription.
REFERENCE   5  (bases 1 to 1784)
  AUTHORS   Geng,X., Geng,Z., Li,H., Zhang,Y., Li,J. and Chang,H.
  TITLE     Over-expression of TFB2M facilitates cell growth and metastasis via
            activating ROS-Akt-NF-kappaB signalling in hepatocellular carcinoma
  JOURNAL   Liver Int 40 (7), 1756-1769 (2020)
   PUBMED   32174027
  REMARK    GeneRIF: Over-expression of TFB2M facilitates cell growth and
            metastasis via activating ROS-Akt-NF-kappaB signalling in
            hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 1784)
  AUTHORS   Gleyzer,N., Vercauteren,K. and Scarpulla,R.C.
  TITLE     Control of mitochondrial transcription specificity factors (TFB1M
            and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and
            PGC-1 family coactivators
  JOURNAL   Mol Cell Biol 25 (4), 1354-1366 (2005)
   PUBMED   15684387
REFERENCE   7  (bases 1 to 1784)
  AUTHORS   Gaspari,M., Falkenberg,M., Larsson,N.G. and Gustafsson,C.M.
  TITLE     The mitochondrial RNA polymerase contributes critically to promoter
            specificity in mammalian cells
  JOURNAL   EMBO J 23 (23), 4606-4614 (2004)
   PUBMED   15526033
REFERENCE   8  (bases 1 to 1784)
  AUTHORS   McCulloch,V. and Shadel,G.S.
  TITLE     Human mitochondrial transcription factor B1 interacts with the
            C-terminal activation region of h-mtTFA and stimulates
            transcription independently of its RNA methyltransferase activity
  JOURNAL   Mol Cell Biol 23 (16), 5816-5824 (2003)
   PUBMED   12897151
REFERENCE   9  (bases 1 to 1784)
  AUTHORS   Rantanen,A., Gaspari,M., Falkenberg,M., Gustafsson,C.M. and
            Larsson,N.G.
  TITLE     Characterization of the mouse genes for mitochondrial transcription
            factors B1 and B2
  JOURNAL   Mamm Genome 14 (1), 1-6 (2003)
   PUBMED   12532263
REFERENCE   10 (bases 1 to 1784)
  AUTHORS   Falkenberg,M., Gaspari,M., Rantanen,A., Trifunovic,A., Larsson,N.G.
            and Gustafsson,C.M.
  TITLE     Mitochondrial transcription factors B1 and B2 activate
            transcription of human mtDNA
  JOURNAL   Nat Genet 31 (3), 289-294 (2002)
   PUBMED   12068295
  REMARK    GeneRIF: This transcription factor activates transcription of human
            mitochondrial DNA.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA038232.1, AK026835.1 and CK725134.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022366.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1178097.1,
                                           SRR1660805.64358.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000366514.5/
                                                  ENSP00000355471.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DA038232.1         3-9
            8-1781              AK026835.1         9-1782
            1782-1784           CK725134.1         14-16               c
FEATURES             Location/Qualifiers
     source          1..1784
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..1784
                     /gene="TFB2M"
                     /gene_synonym="h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2"
                     /note="transcription factor B2, mitochondrial"
                     /db_xref="GeneID:64216"
                     /db_xref="HGNC:HGNC:18559"
                     /db_xref="MIM:607055"
     exon            1..436
                     /gene="TFB2M"
                     /gene_synonym="h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1314
                     /gene="TFB2M"
                     /gene_synonym="h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2"
                     /note="HCV NS5A-transactivated protein 5; mitochondrial
                     12S rRNA dimethylase 2; mitochondrial transcription factor
                     B2; hepatitis C virus NS5A-transactivated protein 5;
                     S-adenosylmethionine-6-N', N'-adenosyl(rRNA)
                     dimethyltransferase 2"
                     /codon_start=1
                     /product="dimethyladenosine transferase 2, mitochondrial"
                     /protein_id="NP_071761.1"
                     /db_xref="CCDS:CCDS1627.1"
                     /db_xref="GeneID:64216"
                     /db_xref="HGNC:HGNC:18559"
                     /db_xref="MIM:607055"
                     /translation="MWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGL
                     SDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLAQIYLGKPSRPPHLLLEC
                     NPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGG
                     VIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIY
                     KFGRIEVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYTR
                     KGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLTPMNYNIFFHLLKHCFGRRSAT
                     VIDHLRSLTPLDARDILMQIGKQEDEKVVNMHPQDFKTLFETIERSKDCAYKWLYDET
                     LEDR"
     exon            437..525
                     /gene="TFB2M"
                     /gene_synonym="h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..679
                     /gene="TFB2M"
                     /gene_synonym="h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..828
                     /gene="TFB2M"
                     /gene_synonym="h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            829..918
                     /gene="TFB2M"
                     /gene_synonym="h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..981
                     /gene="TFB2M"
                     /gene_synonym="h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1142
                     /gene="TFB2M"
                     /gene_synonym="h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1784
                     /gene="TFB2M"
                     /gene_synonym="h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFB2M"
                     /gene_synonym="h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2"
                     /note="hexamer: ATTAAA"
     polyA_site      1784
                     /gene="TFB2M"
                     /gene_synonym="h-mtTFB; h-mtTFB2; Hkp1; hTFB2M; mtTFB2"
                     /note="major polyA site"
ORIGIN      
        1 agtgtttact tccgcttgac ctggcccgga cgccagaaaa tgttccacgt gggataccct
       61 gcgtggggtt cactgtagta gctgcactag gtgattcttg gagcgggcct gagagacaag
      121 gacatgtgga tcccagtggt cgggcttcct cggcggctga ggctctccgc cttggcgggc
      181 gctggtcgct tttgcatttt agggtctgaa gcggcgacgc gaaagcattt gccggcgagg
      241 aaccactgtg ggctctctga ctcctctccg cagctgtggc ccgaaccgga tttcaggaat
      301 ccgccaagga aggcgtctaa ggccagctta gactttaagc gttacgtaac cgatcggaga
      361 ttggctgaga ccctggcgca aatctatttg ggaaaaccaa gtagacctcc acacctactg
      421 ctggagtgca atccaggtcc tggaatcctg actcaggcat tacttgaagc tggtgccaaa
      481 gtggttgcgc tcgaaagtga caaaactttt attccacatt tggagtcctt aggaaaaaat
      541 ctggatggaa aactacgagt gattcactgt gacttcttta aactagatcc tagaagtggt
      601 ggagtaataa aaccacctgc tatgtcttct cgagggctct ttaagaattt gggaatagaa
      661 gcagttcctt ggacagcaga catcccttta aaagtagttg gaatgttccc aagtagaggt
      721 gagaaaaggg cactttggaa actcgcatat gacttgtatt cctgtacttc tatatataaa
      781 tttggacgaa tagaagtaaa tatgtttatt ggtgaaaaag aattccagaa actaatggca
      841 gatcccggaa atccagactt gtatcatgta ttaagtgtta tctggcaatt agcttgtgag
      901 attaaggttc tgcacatgga gccttggtca tcatttgata tatacacccg gaaagggccg
      961 ctggaaaacc caaagcgtag ggaattatta gaccaattac aacaaaagct gtatcttatt
     1021 caaatgattc ctcgtcaaaa tttatttacc aagaacttaa cacctatgaa ctataatata
     1081 ttttttcact tgttaaagca ctgttttggg aggcgcagcg ccactgtaat agaccactta
     1141 cgttcattga ctccacttga tgcgagagat atattgatgc aaataggaaa acaggaggat
     1201 gagaaagtag ttaacatgca ccctcaagac ttcaaaacac tttttgaaac tatagagcgt
     1261 tccaaagatt gtgcttataa atggctgtat gatgaaaccc tggaagatag gtagcaacta
     1321 gactgtcgtt tttggtggag cggttcattt atttggaaac tatgacatga aaaccaaatt
     1381 tgaaaactca catcctttca gcagaaggta actgttcttg tcttgcacaa gccaggcaga
     1441 tcatttctcc taagctgata tcattggctt attggatgaa acagtgtctg ctattttatt
     1501 cacaattgaa taaaatgaaa acttcaatta attgtggatt tgatcagatt gaattcgttt
     1561 tgtttcagat tcctatttaa atatttcact tgtactgttg ctgatttttg catcttcttg
     1621 aagagcaaga gtctgtacat tattaagctt agaaagtaag caaaactgat ttactggttt
     1681 gcctttcagt ttgttgaaat gtattgtcaa gtactgtaca atgaaattgt ttaaatttta
     1741 atatgattta agctttttag aaattaaaat attttaaata agaa
//
