LOCUS       NM_003223               2163 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transcription factor AP-4 (TFAP4), mRNA.
ACCESSION   NM_003223
VERSION     NM_003223.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2163)
  AUTHORS   Zheng,H., Wu,D., Chen,H., Bai,J. and Fang,Y.
  TITLE     Downregulation of miR-144 blocked the proliferation and invasion of
            nerve cells in Hirschsprung disease by regulating Transcription
            Factor AP 4 (TFAP4)
  JOURNAL   Pediatr Surg Int 39 (1), 251 (2023)
   PUBMED   37610449
  REMARK    GeneRIF: Downregulation of miR-144 blocked the proliferation and
            invasion of nerve cells in Hirschsprung disease by regulating
            Transcription Factor AP 4 (TFAP4).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2163)
  AUTHORS   Potts,M.A., Mizutani,S., Garnham,A.L., Li Wai Suen,C.S.N.,
            Kueh,A.J., Tai,L., Pal,M., Strasser,A. and Herold,M.J.
  TITLE     Deletion of the transcriptional regulator TFAP4 accelerates
            c-MYC-driven lymphomagenesis
  JOURNAL   Cell Death Differ 30 (6), 1447-1456 (2023)
   PUBMED   36894688
  REMARK    GeneRIF: Deletion of the transcriptional regulator TFAP4
            accelerates c-MYC-driven lymphomagenesis.
REFERENCE   3  (bases 1 to 2163)
  AUTHORS   Shen,Q., Xu,Z., Sun,G., Wang,H. and Zhang,L.
  TITLE     TFAP4 Activates IGF2BP1 and Promotes Progression of Non-Small Cell
            Lung Cancer by Stabilizing TK1 Expression through m6A Modification
  JOURNAL   Mol Cancer Res 20 (12), 1763-1775 (2022)
   PUBMED   36074102
  REMARK    GeneRIF: TFAP4 Activates IGF2BP1 and Promotes Progression of
            Non-Small Cell Lung Cancer by Stabilizing TK1 Expression through
            m6A Modification.
REFERENCE   4  (bases 1 to 2163)
  AUTHORS   Guo,J., Fang,X., Liu,G., Zhou,J., Zeng,L. and Yu,B.
  TITLE     Tribbles Pseudokinase 2 Promotes the Proliferation, Migration, and
            Invasion of Osteosarcoma through Modulating AP4/p21 Pathway
  JOURNAL   Ann Clin Lab Sci 52 (3), 406-415 (2022)
   PUBMED   35777810
  REMARK    GeneRIF: Tribbles Pseudokinase 2 Promotes the Proliferation,
            Migration, and Invasion of Osteosarcoma through Modulating AP4/p21
            Pathway.
REFERENCE   5  (bases 1 to 2163)
  AUTHORS   Wang,W., Wu,J., Dai,X. and Cheng,K.
  TITLE     Inhibitory effect of CC chemokine ligand 23 (CCL23)/ transcription
            factor activating enhancer binding protein 4 (TFAP4) on cell
            proliferation, invasion and angiogenesis in hepatocellular
            carcinoma
  JOURNAL   Bioengineered 13 (1), 1626-1636 (2022)
   PUBMED   35001801
  REMARK    GeneRIF: Inhibitory effect of CC chemokine ligand 23 (CCL23)/
            transcription factor activating enhancer binding protein 4 (TFAP4)
            on cell proliferation, invasion and angiogenesis in hepatocellular
            carcinoma.
REFERENCE   6  (bases 1 to 2163)
  AUTHORS   Petersenn,S., Rasch,A.C., Heyens,M. and Schulte,H.M.
  TITLE     Structure and regulation of the human growth hormone-releasing
            hormone receptor gene
  JOURNAL   Mol Endocrinol 12 (2), 233-247 (1998)
   PUBMED   9482665
REFERENCE   7  (bases 1 to 2163)
  AUTHORS   Lewis,T.B., Wood,S., Michaelis,E.K., DuPont,B.R. and Leach,R.J.
  TITLE     Localization of a gene for a glutamate binding subunit of a NMDA
            receptor (GRINA) to 8q24
  JOURNAL   Genomics 32 (1), 131-133 (1996)
   PUBMED   8786101
REFERENCE   8  (bases 1 to 2163)
  AUTHORS   Ou,S.H., Garcia-Martinez,L.F., Paulssen,E.J. and Gaynor,R.B.
  TITLE     Role of flanking E box motifs in human immunodeficiency virus type
            1 TATA element function
  JOURNAL   J Virol 68 (11), 7188-7199 (1994)
   PUBMED   7933101
REFERENCE   9  (bases 1 to 2163)
  AUTHORS   Hu,Y.F., Luscher,B., Admon,A., Mermod,N. and Tjian,R.
  TITLE     Transcription factor AP-4 contains multiple dimerization domains
            that regulate dimer specificity
  JOURNAL   Genes Dev 4 (10), 1741-1752 (1990)
   PUBMED   2123466
REFERENCE   10 (bases 1 to 2163)
  AUTHORS   Mermod,N., Williams,T.J. and Tjian,R.
  TITLE     Enhancer binding factors AP-4 and AP-1 act in concert to activate
            SV40 late transcription in vitro
  JOURNAL   Nature 332 (6164), 557-561 (1988)
   PUBMED   2833704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009171.6, DA449763.1, S73885.1 and BU159415.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003223.2.
            
            Summary: Transcription factors of the basic helix-loop-helix-zipper
            (bHLH-ZIP) family contain a basic domain, which is used for DNA
            binding, and HLH and ZIP domains, which are used for
            oligomerization. Transcription factor AP4 activates both viral and
            cellular genes by binding to the symmetrical DNA sequence CAGCTG
            (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed
            2123466]).[supplied by OMIM, Jul 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S73885.1, SRR11853566.9864.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000204517.11/ ENSP00000204517.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC009171.6         148387-148409       c
            24-61               DA449763.1         76-113
            62-78               S73885.1           45-61
            79-786              BU159415.1         9-716
            787-802             AC009171.6         137165-137180       c
            803-943             AC009171.6         135841-135981       c
            944-1099            AC009171.6         135476-135631       c
            1100-2138           AC009171.6         132597-133635       c
            2139-2163           S73885.1           2118-2142
FEATURES             Location/Qualifiers
     source          1..2163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2163
                     /gene="TFAP4"
                     /gene_synonym="AP-4; bHLHc41"
                     /note="transcription factor AP-4"
                     /db_xref="GeneID:7023"
                     /db_xref="HGNC:HGNC:11745"
                     /db_xref="MIM:600743"
     exon            1..366
                     /gene="TFAP4"
                     /gene_synonym="AP-4; bHLHc41"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1294
                     /gene="TFAP4"
                     /gene_synonym="AP-4; bHLHc41"
                     /note="activating enhancer-binding protein 4; class C
                     basic helix-loop-helix protein 41; transcription factor
                     AP-4 (activating enhancer binding protein 4)"
                     /codon_start=1
                     /product="transcription factor AP-4"
                     /protein_id="NP_003214.1"
                     /db_xref="CCDS:CCDS10510.1"
                     /db_xref="GeneID:7023"
                     /db_xref="HGNC:HGNC:11745"
                     /db_xref="MIM:600743"
                     /translation="MEYFMVPTQKVPSLQHFRKTEKEVIGGLCSLANIPLTPETQRDQ
                     ERRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQE
                     KTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGIGSPDIWEDEKAEDLRREMIELRQ
                     QLDKERSVRMMLEEQVRSLEAHMYPEKLKVIAQQVQLQQQQEQVRLLHQEKLEREQQQ
                     LRTQLLPPPAPTHHPTVIVPAPPPPPSHHINVVTMGPSSVINSVSTSRQNLDTIVQAI
                     QHIEGTQEKQELEEEQRRAVIVKPVRSCPEAPTSDTASDSEASDSDAMDQSREEPSGD
                     GELP"
     exon            367..532
                     /gene="TFAP4"
                     /gene_synonym="AP-4; bHLHc41"
                     /inference="alignment:Splign:2.1.0"
     exon            533..631
                     /gene="TFAP4"
                     /gene_synonym="AP-4; bHLHc41"
                     /inference="alignment:Splign:2.1.0"
     exon            632..802
                     /gene="TFAP4"
                     /gene_synonym="AP-4; bHLHc41"
                     /inference="alignment:Splign:2.1.0"
     exon            803..943
                     /gene="TFAP4"
                     /gene_synonym="AP-4; bHLHc41"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1099
                     /gene="TFAP4"
                     /gene_synonym="AP-4; bHLHc41"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..2163
                     /gene="TFAP4"
                     /gene_synonym="AP-4; bHLHc41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2139..2144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFAP4"
                     /gene_synonym="AP-4; bHLHc41"
                     /note="hexamer: AATAAA"
     polyA_site      2163
                     /gene="TFAP4"
                     /gene_synonym="AP-4; bHLHc41"
                     /note="major polyA site"
ORIGIN      
        1 agacatctga tcagctgcaa acacacacac acacacacac acacacacac acacacacac
       61 acacacacat acacacgccc ggggaggcag gccggagaga cctccctccc gcccctcccg
      121 cccgcctccc tcccctcgcc gccgccgccg ccgccagcat ctgggaccgg ccgattctgc
      181 acctccgtcc ggcgctgccc tttgattcgg atttccatct tgcattctcc ggctgatcgc
      241 gggacctggc tcgtgcagag gaggggggcc gatcgctatg gagtatttca tggtgcccac
      301 tcagaaggtg ccctctttgc aacatttcag gaaaacagag aaagaagtga taggagggct
      361 ctgtagcctt gccaacattc cactaacccc cgagactcag cgggaccagg agcggcggat
      421 tcggcgggag atcgccaaca gcaacgagcg gagacgcatg cagagcatca acgcgggatt
      481 ccagtccctc aagaccctca tcccccacac agacggagag aagctcagca aggcagccat
      541 tctccagcag acagccgagt acatcttctc cctggagcag gagaagacca ggctcttgca
      601 gcagaacaca cagctcaagc gcttcatcca ggagctgagc ggctcgtccc ccaagcgacg
      661 gcgggcagag gacaaggacg aaggcatagg ctccccggac atctgggagg acgagaaggc
      721 ggaggacctg cggcgggaga tgattgagct gcggcagcag ctggacaagg agcgctcggt
      781 gcgcatgatg ctggaggagc aggtgcgctc gctggaggcc cacatgtacc cggaaaagct
      841 caaggtgatt gcgcagcagg tgcagctgca gcagcagcag gaacaggtga ggctgctgca
      901 ccaggagaag ctggagcggg aacagcagca gctgcggacc cagcttctgc cccctccggc
      961 ccccacccac caccccacgg tgatcgtgcc agcaccgcct cctcctccct cccaccacat
     1021 caatgtcgtc accatgggcc cctcctcggt catcaactct gtttccacat cccggcaaaa
     1081 tctggacacc atcgtgcagg caatccagca catcgagggc acccaggaaa agcaggagct
     1141 ggaggaggag cagcggcgag ctgtcatcgt gaagcctgtc cgcagctgcc cggaggcccc
     1201 cacctctgac accgcctccg actccgaggc ctcagacagt gacgccatgg accagagccg
     1261 ggaggagccg tcgggggacg gggagcttcc ctgactaccc ccccagccct cctctccctt
     1321 ctgggggctg gagggagccg gggcagccac agggagagac atgggcgaat gagtgagaaa
     1381 tttttacaaa attacgatgt catttgggtc tcttttatga cctctttttc aatactgtaa
     1441 atcgaccttt gaacgaagcc actcaacccg aggtcccggg gctggggtgt cgcagagcgt
     1501 gtgggagcat cggcacccca gggcggggcc tcggccccgg gggctggagg aagctgacac
     1561 ggagatgcct ggcctctctc tgccaaaaag cattttttcc tttaaatatg ttttttaaga
     1621 acagggaaaa ttaaacaaaa ccccaggtta tttcttccct gcccagagcc agcctgggat
     1681 tgtcagcctt caatcccctt tccttcctct ttttgggttt tcttctttct cctttaagca
     1741 cttacatggt tgggggtaag actaggctgg ggcattctgg gggcccggag gtctccgttg
     1801 cttcttggtt ggggtttgct gctgctgtgc ccccctcccc cttccccatc tcggcactag
     1861 aattcgccac tctcccaccc cccagccccc acctctgcct ccaggtctca tcttccaccc
     1921 caaaaatgtc tgtctctctc tttttgtttt gtttgttgtt ggttttttat ttctttttgg
     1981 tttgctttct gtttttgttt tgtttttctt ttttttcttt cttttttttt tttttttaca
     2041 attttgaggt cttcgtgttc aaggagaagc tattatattt tgttaagaaa gtggggagaa
     2101 aaaaaccaag aggccaccgt gcctttgtaa agaaacaaaa taaagtttgt actttgtttt
     2161 tta
//
