LOCUS       NM_172238               2058 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens transcription factor AP-2 delta (TFAP2D), mRNA.
ACCESSION   NM_172238
VERSION     NM_172238.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2058)
  AUTHORS   Kolat,D., Zhao,L.Y., Kciuk,M., Pluciennik,E. and
            Kaluzinska-Kolat,Z.
  TITLE     AP-2delta Is the Most Relevant Target of AP-2 Family-Focused Cancer
            Therapy and Affects Genome Organization
  JOURNAL   Cells 11 (24), 4124 (2022)
   PUBMED   36552887
  REMARK    GeneRIF: AP-2delta Is the Most Relevant Target of AP-2
            Family-Focused Cancer Therapy and Affects Genome Organization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2058)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2058)
  AUTHORS   Fraune,C., Harms,L., Buscheck,F., Hoflmayer,D., Tsourlakis,M.C.,
            Clauditz,T.S., Simon,R., Moller,K., Luebke,A.M., Moller-Koop,C.,
            Steurer,S., Hube-Magg,C., Sauter,G., Weidemann,S., Lebok,P.,
            Dum,D., Kind,S., Minner,S., Izbicki,J.R., Schlomm,T., Huland,H.,
            Heinzer,H., Burandt,E., Haese,A., Graefen,M. and Schroeder,C.
  TITLE     Upregulation of the transcription factor TFAP2D is associated with
            aggressive tumor phenotype in prostate cancer lacking the
            TMPRSS2:ERG fusion
  JOURNAL   Mol Med 26 (1), 24 (2020)
   PUBMED   32143573
  REMARK    GeneRIF: Upregulation of the transcription factor TFAP2D is
            associated with aggressive tumor phenotype in prostate cancer
            lacking the TMPRSS2:ERG fusion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2058)
  AUTHORS   Hamdi,H.K., Reddy,S., Laz,N., Eltaher,R., Kandell,Z., Mahmud,T.,
            Alenazi,L., Haroun,B., Hassan,M. and Ragavendra,R.
  TITLE     A human specific Alu DNA cassette is found flanking the genes of
            transcription factor AP2
  JOURNAL   BMC Res Notes 12 (1), 222 (2019)
   PUBMED   30975199
  REMARK    GeneRIF: A polymorphic Alu in the flanking region of the TFAP2B and
            TFAP2D genes has been identified. The new insert was found in
            higher frequency in Europeans (0.4) and Asians (0.38) and lower
            frequency in Africans (0.25).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2058)
  AUTHORS   Scannell Bryan,M., Argos,M., Pierce,B., Tong,L., Rakibuz-Zaman,M.,
            Ahmed,A., Rahman,M., Islam,T., Yunus,M., Parvez,F., Roy,S.,
            Jasmine,F., Baron,J.A., Kibriya,M.G. and Ahsan,H.
  TITLE     Genome-wide association studies and heritability estimates of body
            mass index related phenotypes in Bangladeshi adults
  JOURNAL   PLoS One 9 (8), e105062 (2014)
   PUBMED   25133637
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2058)
  AUTHORS   Sun,L., Zhao,Y., Gu,S., Mao,Y., Ji,C. and Xin,X.
  TITLE     Regulation of the HMOX1 gene by the transcription factor AP-2delta
            with unique DNA binding site
  JOURNAL   Mol Med Rep 10 (1), 423-428 (2014)
   PUBMED   24789576
  REMARK    GeneRIF: Ap-2delta was identified as a new activating transcription
            factor of HMOX1.
REFERENCE   7  (bases 1 to 2058)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 2058)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   9  (bases 1 to 2058)
  AUTHORS   Wenke,A.K., Rothhammer,T., Moser,M. and Bosserhoff,A.K.
  TITLE     Regulation of integrin alpha10 expression in chondrocytes by the
            transcription factors AP-2epsilon and Ets-1
  JOURNAL   Biochem Biophys Res Commun 345 (1), 495-501 (2006)
   PUBMED   16684505
  REMARK    GeneRIF: Taken together, these results suggest that AP-2epsilon and
            Ets-1 are involved in the regulation of integrin alpha10
            transcription in chondrocytes.
REFERENCE   10 (bases 1 to 2058)
  AUTHORS   Cheng,C., Ying,K., Xu,M., Zhao,W., Zhou,Z., Huang,Y., Wang,W.,
            Xu,J., Zeng,L., Xie,Y. and Mao,Y.
  TITLE     Cloning and characterization of a novel human transcription factor
            AP-2 beta like gene (TFAP2BL1)
  JOURNAL   Int J Biochem Cell Biol 34 (1), 78-86 (2002)
   PUBMED   11733187
  REMARK    GeneRIF: cloning and characterization of a novel human
            transcription factor AP-2 like gene (TFAP2BL1), which is located on
            human chromosome 6p12.1-21.1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031224.1.
            
            On Nov 22, 2019 this sequence version replaced NM_172238.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY028376.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000008391.4/ ENSP00000008391.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-569               AL031224.1         117608-118176       c
            570-1067            AL031224.1         116089-116586       c
            1068-1128           AL031224.1         112552-112612       c
            1129-1294           AL031224.1         102681-102846       c
            1295-1413           AL031224.1         102390-102508       c
            1414-1555           AL031224.1         86454-86595         c
            1556-1669           AL031224.1         80378-80491         c
            1670-2058           AL031224.1         58669-59057         c
FEATURES             Location/Qualifiers
     source          1..2058
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..2058
                     /gene="TFAP2D"
                     /gene_synonym="AP-2delta; TFAP2BL1"
                     /note="transcription factor AP-2 delta"
                     /db_xref="GeneID:83741"
                     /db_xref="HGNC:HGNC:15581"
                     /db_xref="MIM:610161"
     exon            1..569
                     /gene="TFAP2D"
                     /gene_synonym="AP-2delta; TFAP2BL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             531..1889
                     /gene="TFAP2D"
                     /gene_synonym="AP-2delta; TFAP2BL1"
                     /note="transcription factor AP-2 beta (activating
                     enhancer-binding protein 2 beta)-like 1; AP-2 like;
                     activating enhancer binding protein 2 beta-like 1;
                     AP2-delta; transcription factor AP-2-beta-like 1;
                     activating enhancer-binding protein 2-delta; transcription
                     factor AP-2 delta (activating enhancer binding protein 2
                     delta)"
                     /codon_start=1
                     /product="transcription factor AP-2-delta"
                     /protein_id="NP_758438.2"
                     /db_xref="CCDS:CCDS4933.1"
                     /db_xref="GeneID:83741"
                     /db_xref="HGNC:HGNC:15581"
                     /db_xref="MIM:610161"
                     /translation="MSTTFPGLVHDAEIRHDGSNSYRLMQLGCLESVANSTVAYSSSS
                     PLTYSTTGTEFASPYFSTNHQYTPLHHQSFHYEFQHSHPAVTPDAYSLNSLHHSQQYY
                     QQIHHGEPTDFINLHNARALKSSCLDEQRRELGCLDAYRRHDLSLMSHGSQYGMHPDQ
                     RLLPGPSLGLAAAGADDLQGSVEAQCGLVLNGQGGVIRRGGTCVVNPTDLFCSVPGRL
                     SLLSSTSKYKVTIAEVKRRLSPPECLNASLLGGILRRAKSKNGGRCLREKLDRLGLNL
                     PAGRRKAANVTLLTSLVEGEALHLARDFGYTCETEFPAKAVGEHLARQHMEQKEQTAR
                     KKMILATKQICKEFQDLLSQDRSPLGSSRPTPILDLDIQRHLTHFSLITHGFGTPAIC
                     AALSTFQTVLSEMLNYLEKHTTHKNGGAADSGQGHANSEKAPLRKTSEAAVKEGKTEK
                     TD"
     exon            570..1067
                     /gene="TFAP2D"
                     /gene_synonym="AP-2delta; TFAP2BL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1128
                     /gene="TFAP2D"
                     /gene_synonym="AP-2delta; TFAP2BL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1294
                     /gene="TFAP2D"
                     /gene_synonym="AP-2delta; TFAP2BL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1413
                     /gene="TFAP2D"
                     /gene_synonym="AP-2delta; TFAP2BL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1555
                     /gene="TFAP2D"
                     /gene_synonym="AP-2delta; TFAP2BL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1669
                     /gene="TFAP2D"
                     /gene_synonym="AP-2delta; TFAP2BL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..2058
                     /gene="TFAP2D"
                     /gene_synonym="AP-2delta; TFAP2BL1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctagagct ctagcttcac aataaaatgt gtgcaaatac tctccacaga gataagtccc
       61 cacctcagtc ggtatagaaa agcatgataa aggttggaaa aaatggataa aaatgttgaa
      121 agaacctcca gttccttatt aggcgaagat acaatattta ttccttgtct cctgggataa
      181 atctcttctg cctattgtcc tcccagttct cagtgctgat gcttaatttt caaaacttct
      241 atattaccaa gggacctacg acatcagcca aagaaatact cagcaagtac aaaatctgtt
      301 ccagggagct gcttttgtgc agagggaaaa ttttgttcct acaggttttt aagtgggtac
      361 gaggcaagga gctatctgat ccgggcaaaa ccattacaat ttagatatct acctatagaa
      421 catttttttt ttcctttaaa aattggaaaa tacaagaagt ttggattttt ttttcccgat
      481 tctttttttg gagggggaaa ttgcatcgta agctttcgga gaaacccaac atgtcaacta
      541 cctttccggg actagtccac gatgccgaga tacgtcacga cggatcaaac agctaccgtt
      601 tgatgcagct tggctgtctg gagtcagtag ccaattccac tgtcgcctat tcctcctcct
      661 ctcctttaac ttactccacc accggcaccg agtttgcgtc cccctacttc tccactaacc
      721 accagtacac cccgctccac caccagtcct tccattacga gtttcagcac agccacccgg
      781 ccgtcacccc cgacgcctac tctctgaact ctctccacca ctcgcaacag tactaccagc
      841 agatccacca cggggagccc accgacttta ttaacctgca caatgcgcgg gcgctcaagt
      901 cgtcctgcct ggacgagcag aggcgggagc tgggctgcct cgatgcctac cgccgccatg
      961 acctgtccct catgagccat ggctctcagt atggaatgca cccagatcaa agactcctgc
     1021 cagggcccag cctggggctg gccgccgcgg gagcagacga cttgcagggc tctgtggagg
     1081 cccagtgtgg gcttgttctc aatggccaag gtggagtgat aagaagaggt ggcacctgtg
     1141 tggtcaaccc cacagactta ttttgctctg tccctggccg tttgtccctt cttagttcta
     1201 cttccaaata caaggtgacc attgctgagg taaagaggcg cctctcccca cctgagtgcc
     1261 tcaatgcttc actcttggga ggcattttga gaagagcaaa atcaaagaat gggggccgct
     1321 gcctgagaga gaaattggat aggcttggct taaacttacc agcaggaaga cggaaagcag
     1381 ctaatgtcac cctccttact tccttggttg aaggggaggc tttgcacttg gctcgggatt
     1441 ttggctacac ttgtgaaaca gagtttccag ccaaagcagt aggagaacat cttgccagac
     1501 aacatatgga acagaaagaa cagacagcaa gaaaaaagat gatcctggcg accaaacaaa
     1561 tctgtaaaga attccaagac ctcttgagcc aagatagatc accactggga tcctccagac
     1621 ccactccaat tctagacctt gacatccaga gacatttaac acatttcagt ttgatcactc
     1681 atggctttgg gactccggca atatgtgcag ctctaagcac tttccaaaca gttctcagtg
     1741 aaatgctgaa ctacttggaa aaacacacta ctcacaagaa cggcggagcg gcggattctg
     1801 gccaaggaca tgccaactcg gagaaagctc ccctgcggaa aacttcagag gctgccgtga
     1861 aagagggcaa aacagaaaag acagactagc tacatcaaac agaatctatt tccagagagt
     1921 cttgctgctg atattttttc taatatatat atcattgagg gtgactaatc ttcagtggac
     1981 caaatctcta cccttcccca accctccata aaaaaacaaa aatggaaatg aaaaatgaaa
     2041 caaaaaagga caaaacca
//
