LOCUS       NM_003222               2862 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens transcription factor AP-2 gamma (TFAP2C), mRNA.
ACCESSION   NM_003222
VERSION     NM_003222.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2862)
  AUTHORS   Yuan,L., Zhou,D., Li,W., Guan,J., Li,J. and Xu,B.
  TITLE     TFAP2C Activates CST1 Transcription to Facilitate Breast Cancer
            Progression and Suppress Ferroptosis
  JOURNAL   Biochem Genet 62 (5), 3858-3875 (2024)
   PUBMED   38243003
  REMARK    GeneRIF: TFAP2C Activates CST1 Transcription to Facilitate Breast
            Cancer Progression and Suppress Ferroptosis.
REFERENCE   2  (bases 1 to 2862)
  AUTHORS   Zhu,M., Meglicki,M., Lamba,A., Wang,P., Royer,C., Turner,K.,
            Jauhar,M.A., Jones,C., Child,T., Coward,K., Na,J. and
            Zernicka-Goetz,M.
  TITLE     Tead4 and Tfap2c generate bipotency and a bistable switch in
            totipotent embryos to promote robust lineage diversification
  JOURNAL   Nat Struct Mol Biol 31 (6), 964-976 (2024)
   PUBMED   38789684
  REMARK    GeneRIF: Tead4 and Tfap2c generate bipotency and a bistable switch
            in totipotent embryos to promote robust lineage diversification.
REFERENCE   3  (bases 1 to 2862)
  AUTHORS   Li,L., Lai,F., Liu,L., Lu,X., Hu,X., Liu,B., Lin,Z., Fan,Q.,
            Kong,F., Xu,Q. and Xie,W.
  TITLE     Lineage regulators TFAP2C and NR5A2 function as bipotency
            activators in totipotent embryos
  JOURNAL   Nat Struct Mol Biol 31 (6), 950-963 (2024)
   PUBMED   38243114
  REMARK    GeneRIF: Lineage regulators TFAP2C and NR5A2 function as bipotency
            activators in totipotent embryos.
REFERENCE   4  (bases 1 to 2862)
  AUTHORS   Kotomura,N., Shimono,Y. and Ishihara,S.
  TITLE     CYP19A1 Expression Is Controlled by mRNA Stability of the Upstream
            Transcription Factor AP-2gamma in Placental JEG3 Cells
  JOURNAL   Endocrinology 165 (6) (2024)
   PUBMED   38717933
  REMARK    GeneRIF: CYP19A1 Expression Is Controlled by mRNA Stability of the
            Upstream Transcription Factor AP-2gamma in Placental JEG3 Cells.
REFERENCE   5  (bases 1 to 2862)
  AUTHORS   Zeng,M., Wei,X., He,Y.L., Chen,J.X. and Lin,W.T.
  TITLE     TFAP2C inhibits cell autophagy to alleviate myocardial
            ischemia/reperfusion injury by regulating miR-23a-5p/SFRP5/Wnt5a
            axis
  JOURNAL   FASEB J 37 (6), e22959 (2023)
   PUBMED   37191968
  REMARK    GeneRIF: TFAP2C inhibits cell autophagy to alleviate myocardial
            ischemia/reperfusion injury by regulating miR-23a-5p/SFRP5/Wnt5a
            axis.
REFERENCE   6  (bases 1 to 2862)
  AUTHORS   Takahashi,H., Oyama,N., Itoh,Y., Ishida-Yamamoto,A., Kaneko,F. and
            Iizuka,H.
  TITLE     Transcriptional factor AP-2gamma increases human cystatin A gene
            transcription of keratinocytes
  JOURNAL   Biochem Biophys Res Commun 278 (3), 719-723 (2000)
   PUBMED   11095974
REFERENCE   7  (bases 1 to 2862)
  AUTHORS   McPherson,L.A., Baichwal,V.R. and Weigel,R.J.
  TITLE     Identification of ERF-1 as a member of the AP2 transcription factor
            family
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4342-4347 (1997)
   PUBMED   9113991
REFERENCE   8  (bases 1 to 2862)
  AUTHORS   Williamson,J.A., Bosher,J.M., Skinner,A., Sheer,D., Williams,T. and
            Hurst,H.C.
  TITLE     Chromosomal mapping of the human and mouse homologues of two new
            members of the AP-2 family of transcription factors
  JOURNAL   Genomics 35 (1), 262-264 (1996)
   PUBMED   8661133
REFERENCE   9  (bases 1 to 2862)
  AUTHORS   deConinck,E.C., McPherson,L.A. and Weigel,R.J.
  TITLE     Transcriptional regulation of estrogen receptor in breast
            carcinomas
  JOURNAL   Mol Cell Biol 15 (4), 2191-2196 (1995)
   PUBMED   7891714
REFERENCE   10 (bases 1 to 2862)
  AUTHORS   Bosher,J.M., Williams,T. and Hurst,H.C.
  TITLE     The developmentally regulated transcription factor AP-2 is involved
            in c-erbB-2 overexpression in human mammary carcinoma
  JOURNAL   Proc Natl Acad Sci U S A 92 (3), 744-747 (1995)
   PUBMED   7846046
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC051829.1 and BC035664.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003222.3.
            
            Summary: The protein encoded by this gene is a sequence-specific
            DNA-binding transcription factor involved in the activation of
            several developmental genes. The encoded protein can act as either
            a homodimer or heterodimer with other family members and is induced
            during retinoic acid-mediated differentiation. It plays a role in
            the development of the eyes, face, body wall, limbs, and neural
            tube. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051829.1, U85658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000201031.3/ ENSP00000201031.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               BC051829.1         5-120
            117-2238            BC035664.1         80-2201
            2239-2862           BC035664.1         2203-2826
FEATURES             Location/Qualifiers
     source          1..2862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.31"
     gene            1..2862
                     /gene="TFAP2C"
                     /gene_synonym="AP2-GAMMA; ERF1; hAP-2g; TFAP2G"
                     /note="transcription factor AP-2 gamma"
                     /db_xref="GeneID:7022"
                     /db_xref="HGNC:HGNC:11744"
                     /db_xref="MIM:601602"
     exon            1..287
                     /gene="TFAP2C"
                     /gene_synonym="AP2-GAMMA; ERF1; hAP-2g; TFAP2G"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1592
                     /gene="TFAP2C"
                     /gene_synonym="AP2-GAMMA; ERF1; hAP-2g; TFAP2G"
                     /note="estrogen receptor factor 1; transcription factor
                     ERF-1; activating enhancer-binding protein 2 gamma"
                     /codon_start=1
                     /product="transcription factor AP-2 gamma"
                     /protein_id="NP_003213.1"
                     /db_xref="CCDS:CCDS13454.1"
                     /db_xref="GeneID:7022"
                     /db_xref="HGNC:HGNC:11744"
                     /db_xref="MIM:601602"
                     /translation="MLWKITDNVKYEEDCEDRHDGSSNGNPRVPHLSSAGQHLYSPAP
                     PLSHTGVAEYQPPPYFPPPYQQLAYSQSADPYSHLGEAYAAAINPLHQPAPTGSQQQA
                     WPGRQSQEGAGLPSHHGRPAGLLPHLSGLEAGAVSARRDAYRRSDLLLPHAHALDAAG
                     LAENLGLHDMPHQMDEVQNVDDQHLLLHDQTVIRKGPISMTKNPLNLPCQKELVGAVM
                     NPTEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGR
                     SLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAEFPSKPVAEYL
                     TRPHLGGRNEMAARKNMLLAAQQLCKEFTELLSQDRTPHGTSRLAPVLETNIQNCLSH
                     FSLITHGFGSQAICAAVSALQNYIKEALIVIDKSYMNPGDQSPADSNKTLEKMEKHRK
                     "
     exon            288..773
                     /gene="TFAP2C"
                     /gene_synonym="AP2-GAMMA; ERF1; hAP-2g; TFAP2G"
                     /inference="alignment:Splign:2.1.0"
     exon            774..825
                     /gene="TFAP2C"
                     /gene_synonym="AP2-GAMMA; ERF1; hAP-2g; TFAP2G"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1042
                     /gene="TFAP2C"
                     /gene_synonym="AP2-GAMMA; ERF1; hAP-2g; TFAP2G"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1161
                     /gene="TFAP2C"
                     /gene_synonym="AP2-GAMMA; ERF1; hAP-2g; TFAP2G"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1306
                     /gene="TFAP2C"
                     /gene_synonym="AP2-GAMMA; ERF1; hAP-2g; TFAP2G"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..2862
                     /gene="TFAP2C"
                     /gene_synonym="AP2-GAMMA; ERF1; hAP-2g; TFAP2G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2834..2839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFAP2C"
                     /gene_synonym="AP2-GAMMA; ERF1; hAP-2g; TFAP2G"
                     /note="hexamer: AATAAA"
     polyA_site      2862
                     /gene="TFAP2C"
                     /gene_synonym="AP2-GAMMA; ERF1; hAP-2g; TFAP2G"
                     /note="major polyA site"
ORIGIN      
        1 aggacacact gttcgggcgc ggctttcccc gtccgcggag cggtcttgac actcgcggcg
       61 gcagcatcta cgctcgcaga gccgccgatg cgtgtccagt gacccggaca gcaaggcccg
      121 cgcgcggcgg gggcggcggc agacgcctgg tcaccgtgac cccgattttg gatttaccgc
      181 ttgggggctg gggggatcct ggatttaact ggcgactgtt ttgggggacg ccggacgcca
      241 tgttgtggaa aataaccgat aatgtcaagt acgaagagga ctgcgaggat cgccacgacg
      301 ggagcagcaa tgggaatccg cgggtccccc acctctcctc cgccgggcag cacctctaca
      361 gccccgcgcc acccctctcc cacactggag tcgccgaata tcagccgcca ccctactttc
      421 cccctcccta ccagcagctg gcctactccc agtcggccga cccctactcg catctggggg
      481 aagcgtacgc cgccgccatc aaccccctgc accagccggc gcccacaggc agccagcagc
      541 aggcctggcc cggccgccag agccaggagg gagcggggct gccctcgcac cacgggcgcc
      601 cggccggcct actgccccac ctctccgggc tggaggcggg cgcggtgagc gcccgcaggg
      661 atgcctaccg ccgctccgac ctgctgctgc cccacgcaca cgccctggat gccgcgggcc
      721 tggccgagaa cctggggctc cacgacatgc ctcaccagat ggacgaggtg cagaatgtcg
      781 acgaccagca cctgttgctg cacgatcaga cagtcattcg caaaggtccc atttccatga
      841 ccaagaaccc tctgaacctc ccctgtcaga aggagctggt gggggccgta atgaacccca
      901 ctgaggtctt ctgctcagtc cctggaagat tgtcgctcct cagctctacg tctaaataca
      961 aagtgacagt ggctgaagta cagaggcgac tgtccccacc tgaatgctta aatgcctcgt
     1021 tactgggagg tgttctcaga agagccaaat cgaaaaatgg aggccggtcc ttgcgggaga
     1081 agttggacaa gattgggttg aatcttccgg ccgggaggcg gaaagccgct catgtgactc
     1141 tcctgacatc cttagtagaa ggtgaagctg ttcatttggc tagggacttt gcctatgtct
     1201 gtgaagccga atttcctagt aaaccagtgg cagaatattt aaccagacct catcttggag
     1261 gacgaaatga gatggcagct aggaagaaca tgctattggc ggcccagcaa ctgtgtaaag
     1321 aattcacaga acttctcagc caagaccgga caccccatgg gaccagcagg ctcgccccag
     1381 tcttggagac gaacatacag aactgcttgt ctcatttcag cctgattacc cacgggtttg
     1441 gcagccaggc catctgtgcc gcggtgtctg ccctgcagaa ctacatcaaa gaagccctga
     1501 ttgtcataga caaatcctac atgaaccctg gagaccagag tccagctgat tctaacaaaa
     1561 ccctggagaa aatggagaaa cacaggaaat aaaattggaa cgaagaaagg ttaggagagt
     1621 agggaaggaa caggactgca aaaatccttc tccaccgcac agactgggaa cccctcctgg
     1681 cctgggggaa gagtttgtta cctaccttac tatttaaaga gccttcactg gttctgcatc
     1741 acccgcccct ggacttctta gttgtttctc tagcgctgag ctatctccta actttggacc
     1801 tattatcaga aggtgacaag tactggctct ttattcatta agcttttttt ttttgaaccc
     1861 cattctttcc ttctctgaaa gtggtgctat aagttttaga atcttttaaa tacattccct
     1921 gggccaacag acccacacac ttagccattg aaatgtcaaa ttgatgtgcc ctagatcaac
     1981 agatcaacaa tacctttttt ttcagtgtta aggtaatggt tggtttttgt gtccgctaaa
     2041 tatttacctt gaaaaaaaga aaagtgtgta tctagcttct tcagagatca agtcctctgg
     2101 taggaggcaa aggttctatc tgcttagcaa ctagttaata agtggtatct gacacactct
     2161 aaaccccgtg ttcaaacggg ggccttctgg ttttaggaaa cttgtagaaa cgaagcctgc
     2221 tgattgattt ttttctcctt tttttttttt ttttttttta actttgaaag ttaactcttc
     2281 aaatgggaga ctctttgaaa tgacatgttc ctttaaggta ctgaagcttt atttgcatat
     2341 ttatttcaga tgtttcgagt aaacttgaaa agggtaggca cgaagcaatt tgttgctgct
     2401 tgtcaccccc aagtccccgt ggaggttctg tattttaaga aacagtgcgt tgagtgtaca
     2461 gattttattt atgcgtaatt taatggggtc tgtaaatact ggtgcacttc ttacgacttt
     2521 tttgagacat gggatccaat tttaatatta acttttaatg gtgatggggt aatctataac
     2581 acatcataag gttttattca tatatataca gggtattaag aattaagagg atgctgggct
     2641 ctgttcttgg cttggaagat tctatttaat tgaaactctc tgttcagaaa gcaataactt
     2701 tgtctcgttc ctgttgggct gaaccctaag gtgagtgtgc agtacagtgt gtgtgggtga
     2761 aatggagatt tggaattgaa ctctctgcct gtaaatgttc cccaaataat tgttgtgtgt
     2821 atgatacgtg tataataaaa gtattcttgt tagaatctga aa
//
