LOCUS       NM_003221               5631 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens transcription factor AP-2 beta (TFAP2B), mRNA.
ACCESSION   NM_003221
VERSION     NM_003221.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5631)
  AUTHORS   Zhang,H., Raymundo,J.R., Daly,K.E., Zhu,W., Senapati,B., Zhong,H.,
            Ahilan,A.R. and Marneros,A.G.
  TITLE     AP-2alpha/AP-2beta Transcription Factors Are Key Regulators of
            Epidermal Homeostasis
  JOURNAL   J Invest Dermatol 144 (7), 1505-1521 (2024)
   PUBMED   38237728
  REMARK    GeneRIF: AP-2alpha/AP-2beta Transcription Factors Are Key
            Regulators of Epidermal Homeostasis.
REFERENCE   2  (bases 1 to 5631)
  AUTHORS   Lv,Z., Shi,Y., Wu,H., Cao,K., Liu,X. and Wang,C.
  TITLE     Novel Circular RNA CircUBAP2 Drives Tumor Progression by Regulating
            the miR-143/TFAP2B Axis in Prostate Cancer
  JOURNAL   Protein Pept Lett 31 (1), 61-73 (2024)
   PUBMED   37962045
  REMARK    GeneRIF: Novel Circular RNA CircUBAP2 Drives Tumor Progression by
            Regulating the miR-143/TFAP2B Axis in Prostate Cancer.
REFERENCE   3  (bases 1 to 5631)
  AUTHORS   Kawaguchi,A., Akiba,J., Ogasawara,S., Kondo,R., Naito,Y.,
            Kusano,H., Sanada,S., Muto,I., Nakama,T. and Yano,H.
  TITLE     Transcription factor activating enhancer-binding protein 2B
            expression correlates with invasiveness and prognosis of
            extramammary Paget's disease
  JOURNAL   Pathol Res Pract 242, 154309 (2023)
   PUBMED   36689838
  REMARK    GeneRIF: Transcription factor activating enhancer-binding protein
            2B expression correlates with invasiveness and prognosis of
            extramammary Paget's disease.
REFERENCE   4  (bases 1 to 5631)
  AUTHORS   Cui,G., Gao,Z., Chang,S., Narwade,N., Chen,Y., Poudel,B.,
            Lei,K.M.K., Zhang,W., Li,G., Poon,T.C.W. and Cheung,E.
  TITLE     TRIM37 Augments AP-2gamma Transcriptional Activity and Cellular
            Localization via K63-linked Ubiquitination to Drive Breast Cancer
            Progression
  JOURNAL   Int J Biol Sci 18 (11), 4316-4328 (2022)
   PUBMED   35864973
  REMARK    GeneRIF: TRIM37 Augments AP-2gamma Transcriptional Activity and
            Cellular Localization via K63-linked Ubiquitination to Drive Breast
            Cancer Progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5631)
  AUTHORS   Satoda,M., Zhao,F., Diaz,G.A., Burn,J., Goodship,J., Davidson,H.R.,
            Pierpont,M.E. and Gelb,B.D.
  TITLE     Mutations in TFAP2B cause Char syndrome, a familial form of patent
            ductus arteriosus
  JOURNAL   Nat Genet 25 (1), 42-46 (2000)
   PUBMED   10802654
REFERENCE   6  (bases 1 to 5631)
  AUTHORS   Williamson,J.A., Bosher,J.M., Skinner,A., Sheer,D., Williams,T. and
            Hurst,H.C.
  TITLE     Chromosomal mapping of the human and mouse homologues of two new
            members of the AP-2 family of transcription factors
  JOURNAL   Genomics 35 (1), 262-264 (1996)
   PUBMED   8661133
REFERENCE   7  (bases 1 to 5631)
  AUTHORS   Duan,C. and Clemmons,D.R.
  TITLE     Transcription factor AP-2 regulates human insulin-like growth
            factor binding protein-5 gene expression
  JOURNAL   J Biol Chem 270 (42), 24844-24851 (1995)
   PUBMED   7559606
REFERENCE   8  (bases 1 to 5631)
  AUTHORS   Moser,M., Imhof,A., Pscherer,A., Bauer,R., Amselgruber,W.,
            Sinowatz,F., Hofstadter,F., Schule,R. and Buettner,R.
  TITLE     Cloning and characterization of a second AP-2 transcription factor:
            AP-2 beta
  JOURNAL   Development 121 (9), 2779-2788 (1995)
   PUBMED   7555706
REFERENCE   9  (bases 1 to 5631)
  AUTHORS   Gaubatz,S., Imhof,A., Dosch,R., Werner,O., Mitchell,P., Buettner,R.
            and Eilers,M.
  TITLE     Transcriptional activation by Myc is under negative control by the
            transcription factor AP-2
  JOURNAL   EMBO J 14 (7), 1508-1519 (1995)
   PUBMED   7729426
REFERENCE   10 (bases 1 to 5631)
  AUTHORS   Gelb,B.D.
  TITLE     Char Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301285
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC037225.1, AL049693.16 and
            BU738725.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003221.3.
            
            Summary: This gene encodes a member of the AP-2 family of
            transcription factors. AP-2 proteins form homo- or hetero-dimers
            with other AP-2 family members and bind specific DNA sequences.
            They are thought to stimulate cell proliferation and suppress
            terminal differentiation of specific cell types during embryonic
            development. Specific AP-2 family members differ in their
            expression patterns and binding affinity for different promoters.
            This protein functions as both a transcriptional activator and
            repressor. Mutations in this gene result in autosomal dominant Char
            syndrome, suggesting that this gene functions in the
            differentiation of neural crest cell derivatives. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.160614.1, BC037225.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393655.4/ ENSP00000377265.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1539              BC037225.1         2-1540
            1540-5225           AL049693.16        11928-15613
            5226-5625           BU738725.1         18-417              c
            5626-5631           AL049693.16        16014-16019
FEATURES             Location/Qualifiers
     source          1..5631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..5631
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
                     /note="transcription factor AP-2 beta"
                     /db_xref="GeneID:7021"
                     /db_xref="HGNC:HGNC:11743"
                     /db_xref="MIM:601601"
     exon            1..102
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1404
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
                     /note="activating enhancer binding protein 2 beta;
                     AP2-beta"
                     /codon_start=1
                     /product="transcription factor AP-2-beta"
                     /protein_id="NP_003212.2"
                     /db_xref="CCDS:CCDS4934.2"
                     /db_xref="GeneID:7021"
                     /db_xref="HGNC:HGNC:11743"
                     /db_xref="MIM:601601"
                     /translation="MHSPPRDQAAIMLWKLVENVKYEDIYEDRHDGVPSHSSRLSQLG
                     SVSQGPYSSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDPYSHVNDPYSLNPLHQPQ
                     QHPWGQRQRQEVGSEAGSLLPQPRAALPQLSGLDPRRDYHSVRRPDVLLHSAHHGLDA
                     GMGDSLSLHGLGHPGMEDVQSVEDANNSGMNLLDQSVIKKVPVPPKSVTSLMMNKDGF
                     LGGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAK
                     SKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYICETEFPAK
                     AVSEYLNRQHTDPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRPSPILEPGIQ
                     SCLTHFSLITHGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTTNRHTSGEGPGSK
                     TGDKEEKHRK"
     exon            103..561
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..622
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
                     /inference="alignment:Splign:2.1.0"
     exon            623..842
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..961
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1103
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..5631
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1722..1727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
                     /note="hexamer: AATAAA"
     polyA_site      1744
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
                     /note="major polyA site"
     regulatory      5602..5607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
                     /note="hexamer: AATAAA"
     polyA_site      5631
                     /gene="TFAP2B"
                     /gene_synonym="AP-2B; AP-2beta; AP2-B; PDA2"
ORIGIN      
        1 agacatctgc tcctcacatg aatgcactca cctcctagag accaggctgc catcatgctc
       61 tggaagcttg tggagaatgt caagtacgaa gatatctatg aggaccggca cgatggtgtc
      121 ccgagccaca gctcgcggct ctcccagctg ggctcggtgt cccaaggacc ctactcgagc
      181 gccccgccgc tgtcccacac cccgtcgtcg gacttccagc cgccctactt cccacccccc
      241 taccagccgc tcccctacca ccagagccag gacccctact cccacgtcaa cgacccctac
      301 tccctgaacc cactgcacca gccccagcaa catccctggg ggcaacggca gcggcaagaa
      361 gtgggttcgg aagccggctc tctcctgccc cagcctcggg ccgccttgcc ccagctctcg
      421 ggccttgacc cccggaggga ctaccactcg gtccgccggc cggacgtgct gctgcattcg
      481 gcgcaccacg gcctggacgc gggcatgggt gacagcctct cgctgcacgg cctcggccat
      541 cccggaatgg aagacgtcca gtcagttgaa gatgccaata acagcggcat gaatctattg
      601 gaccagtctg tcattaaaaa agttccagtt cctcccaaat cggtgacttc tctaatgatg
      661 aataaagacg gcttcctggg aggcatgtct gtcaacaccg gcgaggtgtt ttgctccgtc
      721 ccaggccgtt tgtctctgct cagttcaact tcgaagtaca aagtaactgt gggagaagtt
      781 cagagacggc tgtcgccccc tgaatgcctc aatgcatctc tcctcggcgg agtcctcaga
      841 agagccaaat cgaaaaatgg ggggagatct ttgcgagaaa ggctagaaaa aatcggtttg
      901 aatttacccg cgggcaggcg caaagcagca aatgtcacgt tactcacctc cctggtggaa
      961 ggagaagctg ttcacttagc tagggatttt gggtacattt gcgaaacgga gtttcccgcc
     1021 aaagccgtct ctgagtattt gaaccggcag cacacagacc cgagtgacct gcactcccga
     1081 aagaatatgc tgttggccac caagcaactt tgtaaagaat ttacggatct actggcgcag
     1141 gaccggacac cgatagggaa cagccgaccc agccccatcc tggagccggg gatccagagc
     1201 tgcctcacgc acttcagcct catcacgcac ggcttcggcg ccccggccat ttgcgccgcg
     1261 ctcacggccc tgcagaacta tctcaccgag gcgctcaaag gcatggacaa gatgttcttg
     1321 aacaacacca ccactaacag gcacacgtct ggggaaggcc caggtagtaa aactggcgac
     1381 aaggaggaga aacacaggaa atgaaaaatt tttaaaaaaa gaaggaaaaa tgttttaaat
     1441 acaaaaggaa aaacagacaa aaatttaatt ttagctttaa aatattggat tggctttgga
     1501 agaattatat taggtagaat acacatacaa tcaaaatttt aaaaaaaaaa gctaaataac
     1561 ttaaaaaaaa actgaggcgt acaacggagc aacaatatcg gttctcagtg tctatttcaa
     1621 gatacatttg gagacaaccg tccggatttt ccacttcggt tctttcgagt ttagtaatac
     1681 tgataataaa agaaaaccat gatttcccct tccctttgga aaataaacat aagactaaac
     1741 atgagaaaaa cgctaactta ttggaagaaa atcggagaaa cgttggtgtc aatgctttga
     1801 gagctggttg actgagacgc acgaactttt taattttaaa tatattttta ggaaactctc
     1861 gcagtccccg ccctccatct cacctcaccc gtctcccaac cacccttttc catgttaccc
     1921 tcccttcctc acattgttac gggaatcttc tgggatgaaa atgagtgtgg ttggcccttt
     1981 tgcgttgttt cagtcctctc ggtacctccc cgcccagccc tgcgatctta actcaccggg
     2041 cccggctccc cggccgcttg cataattagg gagggcgagg gcggggcggg aggcctgtgg
     2101 agaccaggcg gaggctgcaa tttttggtgc cggccggcag agcaggttct ggcggctgag
     2161 gaaaatccgg accaataagt tgattcaaac atcatcagtt cctttcagaa atgttactag
     2221 ctcccagcct tgccagcatc tgcatagaga gaatctcaca tttattatat ttgtgtcatc
     2281 tactaatttt atgaactata gtaaaaaaaa aaaaacacac acacacacaa tatgaatacg
     2341 ttgattagta tgtaattcct tcggaggggt atgtaccatt tcattctctt ctgttttcca
     2401 aagctttgcc cgcatggttt atgagcttct tcaaagagga cttgggcttc ctacacaatc
     2461 tataaggtac agagaaaaaa aaatccgatc cctttttaat caaagcctgt gtgtcagaat
     2521 tctgcaggtg cacttcttta aagaagctca aagggaataa tttagaaagt ggccaatatg
     2581 atggaagcag ctttgaatct acatgctaac attcctcaac actccaattc cggtggaggt
     2641 ggcaggggag ggggtctgca aaatgaattt taagggaaaa gagtaaggat tcttagagcc
     2701 ctatattcta atagtattgc cctgcattta aaattgattt gatttccctg ggttctttgg
     2761 tgattgctgt ttaagcaagg aaagaagcag ctttacgagt ggacgtgggg aggagggcgg
     2821 cacaagcacc cacatttctg taacaattgc tttcttacaa gatgctttat gaatgaggca
     2881 tttttccctc ccagacgtgc acttgttttg gcatataatg gcaaaataat gcaaagtgaa
     2941 gggagatgta tttcagcttt gatttttacc gtctggatac atcgggacta ttcccagtgg
     3001 ataaagtttc atgcatttaa tatttctcac ttctggcagc ccagctcctt tcttgggctc
     3061 catcttagca ttatcatgaa ataagatctg gaatccattg tctgcacctc cgcaaaagca
     3121 gtgagaaatt atcccgggat aagggtgaat gagagaggtc tctaaatata gtgttgatac
     3181 actcacctat ttaacaaagt agacgagatc tttgcaatac cccttaaaga taacgacata
     3241 gatgttgttc tgcaggattt atagttagga cccactcaat tctccaggac tcccggtttt
     3301 gcccccctcc cgctttgcct tggtgggggt ggggattggg ggagtgggga ttgcgttggg
     3361 gttttaggaa tctgctgaga gctttgccca tttttattaa aagaggaaag ggaagttagg
     3421 aagctcgtct caggtcacca aaagggccca agcaactgtt agggccacac tgcagcccat
     3481 ctccaacccc tagcttcgtt tagcacttct gatcttcatg gcccagccct agaactgttg
     3541 agaggaatgc aatggccaag agctagacgt tacggagagt gtagtcactc tcttttccca
     3601 gctcagaggc ctgcgccttc gtccgagagc tcggccgatc gcattagatg tgttctgatt
     3661 gcacaaggcc aggagagacc acactgaaaa cgatcgtctc ctttccttgc agggcaacgc
     3721 gccccacgcg tgtgacgtgc gagagacgcg atggacgcgc cttgctctta ctgtgcaggt
     3781 cctgagagcg tgtgggccac aggcgcccag tcgtgttgag gacatagaat cagccgctgg
     3841 aggggctgcc gactgcgcgg gcccttcccg ctctcggtct caccctaagg gctaaggcga
     3901 ccgagaaagc cccattctcc agtaggtaat ggggcggcgc ccggtgggct gcaggtgggg
     3961 agggctccca gcgccgccag cggccacccg gggcgccggc tcctggaggg agagtggcct
     4021 agaaatatcc aaggaatccg aagcttcccc tcctccacct ctgccagtac ggaaacaccc
     4081 caccgtcaca atcctaaagc ggggagatgg gatgggaatt gtcttacttg gcaaggcagg
     4141 gtaccttcat tgccagacgc cctcatttgt gtgttcctcc ttgctccagc gagatagaac
     4201 cttttgcgcc cccaaccccg tttcgtggag tgagcccact accccttctc cctccctcac
     4261 ttctcctttc atgtaggacc cccgccccct tgctttcctt agccaggccc gctacattta
     4321 tctgataatt gagttattaa aagatttggt ttccttgggc ctataaatca ataaacagta
     4381 ggattaacgc aatagtttgc cttttaagtc aagggagacg tttaaggcaa gcccctttga
     4441 gctttgtttt caaaccaaac aggtgagttg cagctctccc cccggcccct gcactcttca
     4501 gacatttggt ccctgcccac tcctaaacgc tcagtcccaa aacaaaatag cgaaagacag
     4561 gaggagtcag gatgtggcag tgctgccttc acactttcca cttcgcaagt tcttttaaag
     4621 gttccaaaga tctccagacc attctctgcc aaaccctgcc gcctcctgca cgtattgcag
     4681 gtctctgggg agcaagaaat gtcctgtttg ggtgaggatt ccgtcaccta aaaagatctt
     4741 taacttctcc cccaaagtgg gaaggtaact ttctccccct tttccccacc accttcactc
     4801 ctacaccccc aattaccttg cattttcttt ccttccttct ggcctccaca cccatagctt
     4861 tcctccatcc ccacttaaag aaccgaagag gcttttaaag acctggctgc tttgttttcc
     4921 ttggccaagg aagccacttt ctctcaagca attatttcat atcctacgaa aactttggtc
     4981 gaatggaaaa ctcgaaacct cgagcttatc tacacactgt tcctctgcta caatgctttc
     5041 ctagttaaga gtgtttatag agaatttgtc atcacatctg atatcctgta cttgtaatac
     5101 attatgtgga aaggaaataa ccttaaaccg tctgatgttg cctcaagagc ccaaacggcg
     5161 tttccccacc tttgacgatg tatgtgaaat tactggctta aaaaaaaaag tatcaatttt
     5221 tttttaacgg aatgaacact atccttcttt aaatgccaaa atcgactcca cctttgagtt
     5281 ggtctctaat tctctaacat tgtttttgcc acacaatcaa gaaatatcaa tctattgact
     5341 cttcacgaga agagctctgg agggtattca tgttaagttt gtatatattt atttatgctt
     5401 aatttaatgg gaatgtgtaa atatggcgag caagtagttt gggattattt atctgtgaat
     5461 ctatacctct gtgaatgggt ggttaaaaaa cctcttgacc ctagatagaa tcctatctga
     5521 atttttctgt tctttataaa caagctgtta tggtaatggg tagaaattgg tttattgtcc
     5581 agtgttaatc tgatttacat aaataaaaag attgttgtgt tttcatcttc a
//
