LOCUS       NM_001063              20166 bp    mRNA    linear   PRI 29-NOV-2024
DEFINITION  Homo sapiens transferrin (TF), transcript variant 1, mRNA.
ACCESSION   NM_001063 NM_014111
VERSION     NM_001063.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 20166)
  AUTHORS   Wang,M., Zhang,D., Jiang,L., Ye,M., Nie,J. and Yin,J.
  TITLE     Association between serum transferrin saturation levels and heart
            failure in adults aged >/=40 years: a cross-sectional study based
            on NHANES (2017-2020.03)
  JOURNAL   Front Endocrinol (Lausanne) 15, 1419064 (2024)
   PUBMED   39280001
  REMARK    GeneRIF: Association between serum transferrin saturation levels
            and heart failure in adults aged >/=40 years: a cross-sectional
            study based on NHANES (2017-2020.03).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 20166)
  AUTHORS   Floegel,A., Intemann,T., Siani,A., Moreno,L.A., Molnar,D.,
            Veidebaum,T., Hadjigeorgiou,C., De Henauw,S., Hunsberger,M.,
            Eiben,G., Ahrens,W. and Wolters,M.
  CONSRTM   IDEFICS/I.Family consortia
  TITLE     Cohort-Based Reference Values for Serum Ferritin and Transferrin
            and Longitudinal Determinants of Iron Status in European Children
            Aged 3-15 Years
  JOURNAL   J Nutr 154 (2), 658-669 (2024)
   PUBMED   38048991
  REMARK    GeneRIF: Cohort-Based Reference Values for Serum Ferritin and
            Transferrin and Longitudinal Determinants of Iron Status in
            European Children Aged 3-15 Years.
REFERENCE   3  (bases 1 to 20166)
  AUTHORS   Tavakoli,F., Ghavimi,M.A., Fakhrzadeh,V., Abdolzadeh,D., Afshari,A.
            and Eslami,H.
  TITLE     Evaluation of salivary transferrin in patients with oral squamous
            cell carcinoma
  JOURNAL   Clin Exp Dent Res 10 (1), e809 (2024)
   PUBMED   37964689
  REMARK    GeneRIF: Evaluation of salivary transferrin in patients with oral
            squamous cell carcinoma.
REFERENCE   4  (bases 1 to 20166)
  AUTHORS   Barton,J.C., Barton,J.C. and Acton,R.T.
  TITLE     Height of non-Hispanic white adults with homeostatic iron regulator
            HFE genotypes p.C282Y/p.C282Y and wt/wt
  JOURNAL   Mol Genet Genomic Med 12 (1), e2321 (2024)
   PUBMED   37930135
  REMARK    GeneRIF: Height of non-Hispanic white adults with homeostatic iron
            regulator HFE genotypes p.C282Y/p.C282Y and wt/wt.
REFERENCE   5  (bases 1 to 20166)
  AUTHORS   Skarzynska,E., Mularczyk,K., Issat,T., Jakimiuk,A. and
            Lisowska-Myjak,B.
  TITLE     Meconium Transferrin and Ferritin as Markers of Homeostasis in the
            Developing Fetus
  JOURNAL   Int J Mol Sci 24 (21), 15937 (2023)
   PUBMED   37958917
  REMARK    GeneRIF: Meconium Transferrin and Ferritin as Markers of
            Homeostasis in the Developing Fetus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 20166)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   7  (bases 1 to 20166)
  AUTHORS   Hershberger,C.L., Larson,J.L., Arnold,B., Rosteck,P.R. Jr.,
            Williams,P., DeHoff,B., Dunn,P., O'Neal,K.L., Riemen,M.W.,
            Tice,P.A. et al.
  TITLE     A cloned gene for human transferrin
  JOURNAL   Ann N Y Acad Sci 646, 140-154 (1991)
   PUBMED   1809186
  REMARK    Review article
REFERENCE   8  (bases 1 to 20166)
  AUTHORS   Woodworth,R.C., Mason,A.B., Funk,W.D. and MacGillivray,R.T.
  TITLE     Expression and initial characterization of five site-directed
            mutants of the N-terminal half-molecule of human transferrin
  JOURNAL   Biochemistry 30 (45), 10824-10829 (1991)
   PUBMED   1932003
REFERENCE   9  (bases 1 to 20166)
  AUTHORS   Guillou,F., Zakin,M.M., Part,D., Boissier,F. and Schaeffer,E.
  TITLE     Sertoli cell-specific expression of the human transferrin gene.
            Comparison with the liver-specific expression
  JOURNAL   J Biol Chem 266 (15), 9876-9884 (1991)
   PUBMED   1851757
REFERENCE   10 (bases 1 to 20166)
  AUTHORS   Dautry-Varsat,A.
  TITLE     Receptor-mediated endocytosis: the intracellular journey of
            transferrin and its receptor
  JOURNAL   Biochimie 68 (3), 375-381 (1986)
   PUBMED   2874839
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC083905.20 and AC080128.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001063.3.
            
            Summary: This gene encodes a glycoprotein with an approximate
            molecular weight of 76.5 kDa. It is thought to have been created as
            a result of an ancient gene duplication event that led to
            generation of homologous C and N-terminal domains each of which
            binds one ion of ferric iron. The function of this protein is to
            transport iron from the intestine, reticuloendothelial system, and
            liver parenchymal cells to all proliferating cells in the body.
            This protein may also have a physiologic role as
            granulocyte/pollen-binding protein (GPBP) involved in the removal
            of certain organic matter and allergens from serum. [provided by
            RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.111522.1,
                                           SRR1660809.219437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402696.9/ ENSP00000385834.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC083905.20        13318-13408         c
            92-264              AC083905.20        11217-11389         c
            265-373             AC083905.20        6098-6206           c
            374-550             AC083905.20        5130-5306           c
            551-683             AC083905.20        4306-4438           c
            684-739             AC083905.20        3464-3519           c
            740-918             AC083905.20        2792-2970           c
            919-1096            AC083905.20        1855-2032           c
            1097-1251           AC083905.20        472-626             c
            1252-1345           AC080128.21        174763-174856       c
            1346-1378           AC080128.21        174131-174163       c
            1379-1534           AC080128.21        172605-172760       c
            1535-1670           AC080128.21        170874-171009       c
            1671-1735           AC080128.21        168466-168530       c
            1736-1920           AC080128.21        163421-163605       c
            1921-2110           AC080128.21        161800-161989       c
            2111-20166          AC080128.21        142397-160452       c
FEATURES             Location/Qualifiers
     source          1..20166
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..20166
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /note="transferrin"
                     /db_xref="GeneID:7018"
                     /db_xref="HGNC:HGNC:11740"
                     /db_xref="MIM:190000"
     exon            1..91
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2145
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; serotransferrin; siderophilin; beta-1
                     metal-binding globulin; epididymis secretory sperm binding
                     protein Li 71p"
                     /codon_start=1
                     /product="serotransferrin isoform 1 precursor"
                     /protein_id="NP_001054.2"
                     /db_xref="CCDS:CCDS3080.1"
                     /db_xref="GeneID:7018"
                     /db_xref="HGNC:HGNC:11740"
                     /db_xref="MIM:190000"
                     /translation="MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDH
                     MKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAE
                     FYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPE
                     PRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGA
                     GDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMG
                     GKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYL
                     GYEYVTAIRNLREGTCPEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAET
                     TEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDTPEAGYFAIAV
                     VKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSK
                     KDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNP
                     DPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKILRQQQ
                     HLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLR
                     KCSTSSLLEACTFRRP"
     exon            92..264
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            265..373
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..550
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..683
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..739
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            740..918
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1096
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1251
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1345
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1378
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1534
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1670
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1735
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1920
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2110
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..20166
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2288..2293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /note="hexamer: AATAAA"
     polyA_site      2321
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /note="major polyA site"
     regulatory      2511..2516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2531
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
     regulatory      11384..11389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /note="hexamer: AGTAAA"
     polyA_site      11404
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
     regulatory      20141..20146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
                     /note="hexamer: AATAAA"
     polyA_site      20166
                     /gene="TF"
                     /gene_synonym="HEL-S-71p; PRO1557; PRO2086; TFQTL1"
ORIGIN      
        1 acagaagcga gtccgactgt gctcgctgct cagcgccgca cccggaagat gaggctcgcc
       61 gtgggagccc tgctggtctg cgccgtcctg gggctgtgtc tggctgtccc tgataaaact
      121 gtgagatggt gtgcagtgtc ggagcatgag gccactaagt gccagagttt ccgcgaccat
      181 atgaaaagcg tcattccatc cgatggtccc agtgttgctt gtgtgaagaa agcctcctac
      241 cttgattgca tcagggccat tgcggcaaac gaagcggatg ctgtgacact ggatgcaggt
      301 ttggtgtatg atgcttacct ggctcccaat aacctgaagc ctgtggtggc agagttctat
      361 gggtcaaaag aggatccaca gactttctat tatgctgttg ctgtggtgaa gaaggatagt
      421 ggcttccaga tgaaccagct tcgaggcaag aagtcctgcc acacgggtct aggcaggtcc
      481 gctgggtgga acatccccat aggcttactt tactgtgact tacctgagcc acgtaaacct
      541 cttgagaaag cagtggccaa tttcttctcg ggcagctgtg ccccttgtgc ggatgggacg
      601 gacttccccc agctgtgtca actgtgtcca gggtgtggct gctccaccct taaccaatac
      661 ttcggctact cgggagcctt caagtgtctg aaggatggtg ctggggatgt ggcctttgtc
      721 aagcactcga ctatatttga gaacttggca aacaaggctg acagggacca gtatgagctg
      781 ctttgcctgg acaacacccg gaagccggta gatgaataca aggactgcca cttggcccag
      841 gtcccttctc ataccgtcgt ggcccgaagt atgggcggca aggaggactt gatctgggag
      901 cttctcaacc aggcccagga acattttggc aaagacaaat caaaagaatt ccaactattc
      961 agctctcctc atgggaagga cctgctgttt aaggactctg cccacgggtt tttaaaagtc
     1021 ccccccagga tggatgccaa gatgtacctg ggctatgagt atgtcactgc catccggaat
     1081 ctacgggaag gcacatgccc agaagcccca acagatgaat gcaagcctgt gaagtggtgt
     1141 gcgctgagcc accacgagag gctcaagtgt gatgagtgga gtgttaacag tgtagggaaa
     1201 atagagtgtg tatcagcaga gaccaccgaa gactgcatcg ccaagatcat gaatggagaa
     1261 gctgatgcca tgagcttgga tggagggttt gtctacatag cgggcaagtg tggtctggtg
     1321 cctgtcttgg cagaaaacta caataagagc gataattgtg aggatacacc agaggcaggg
     1381 tattttgcta tagcagtggt gaagaaatca gcttctgacc tcacctggga caatctgaaa
     1441 ggcaagaagt cctgccatac ggcagttggc agaaccgctg gctggaacat ccccatgggc
     1501 ctgctctaca ataagatcaa ccactgcaga tttgatgaat ttttcagtga aggttgtgcc
     1561 cctgggtcta agaaagactc cagtctctgt aagctgtgta tgggctcagg cctaaacctg
     1621 tgtgaaccca acaacaaaga gggatactac ggctacacag gcgctttcag gtgtctggtt
     1681 gagaagggag atgtggcctt tgtgaaacac cagactgtcc cacagaacac tgggggaaaa
     1741 aaccctgatc catgggctaa gaatctgaat gaaaaagact atgagttgct gtgccttgat
     1801 ggtaccagga aacctgtgga ggagtatgcg aactgccacc tggccagagc cccgaatcac
     1861 gctgtggtca cacggaaaga taaggaagct tgcgtccaca agatattacg tcaacagcag
     1921 cacctatttg gaagcaacgt aactgactgc tcgggcaact tttgtttgtt ccggtcggaa
     1981 accaaggacc ttctgttcag agatgacaca gtatgtttgg ccaaacttca tgacagaaac
     2041 acatatgaaa aatacttagg agaagaatat gtcaaggctg ttggtaacct gagaaaatgc
     2101 tccacctcat cactcctgga agcctgcact ttccgtagac cttaaaatct cagaggtagg
     2161 gctgccacca aggtgaagat gggaacgcag atgatccatg agtttgccct ggtttcactg
     2221 gcccaagtgg tttgtgctaa ccacgtctgt cttcacagct ctgtgttgcc atgtgtgctg
     2281 aacaaaaaat aaaaattatt attgatttta tatttcaaaa actccattct ttcctaaata
     2341 ttttcaacaa aggatttctt tatgcattct gcctaaatac ctatgcaact gagcccttcc
     2401 ttctcagctc aagattcgtc tggtctttcc ctacagcttt gtgtgtgcca tggccacatc
     2461 tcctgggtac agttcaagga gacatctttt ctaaaagggt ctgcgtgatc attaaaatat
     2521 aatcaaatgt atactggtgt gtgtgtgcac gtgcgcgtgc gtgtgtcatg ctaaggaagg
     2581 ggcaagaagg aggatgcaga gtgagttaca gagatcaagt actcaagtga gtacagaaag
     2641 actacagaag acttaccttt atttggtatt ttaaatgaat tccatcaggc tgaggtcctg
     2701 attctaacta gctgaaaaaa gtgaaacact gacatctttt ttgctgaaaa gcattccctg
     2761 agcttgatgc cacagcagtt actgccctgt ctcctgccct tctcagccca gcttcctgta
     2821 aggtggaggc tgacttttct gtctcactta ttattggctg aacatacaga atttggtctt
     2881 ctgcttcacc aacttacctg aatgtaccct ggcaaaagtc accgtctacc tgccaactgt
     2941 taaaccaatt caggtcttcc attcctgagc ccatttcctg cagttgataa agttgaccac
     3001 tccctcctcc ttggaactct tttcctcagt ttctctgaca tggcaggtct ctgctttgat
     3061 tcctacctct ctctgttcat ttgtagtctt cactgtgggc tcatcctact ggcctggaaa
     3121 ccttagggaa atcttcctgg ggttttctct tgatctggtc agtgctcctc tcactttgca
     3181 ggccctcctt cagtgatgct catgactcct aggcatctgt atctatagct gtgaccccag
     3241 cctccagcag tatccctgca cttatacatc ctactaccta cctgtgggtc tatactcgag
     3301 tcttgcagca gtcagaaacc caacaaatca aaaattgaag tgatcatcct gttcttctct
     3361 ctcttgcttc cctaaaccaa ctgttgttat agtatattcc atatcagctg aagacctggt
     3421 catctaccca atcacataag ccataaatag aggggtgaaa tttcagttcg ccattttccc
     3481 tcacactaca tccagcgtca ccaagttctg ttgattttgc tttctaaata acttcagttg
     3541 gctcctttct tttcctgact cctaacacag cctcatctta tactcaaata cagaagtgca
     3601 gataaggggt atctggacac aacattccac acctctctca actgtctagt attcaagaaa
     3661 ataggactct gggtccactt tgcagtccag acctgatatg gaccgtttta cacacagccc
     3721 tgctttcctc tgagcctatc aacgatctgc cttatttaat attaacctaa acttacccca
     3781 aatcctataa ctctgccttt tcctttgttt ggtgagatac cccatggctc ccctgggacg
     3841 cagtctgtct cattgcaatg gatcaataaa cctaatttta ttacactaca ggtatattcc
     3901 tggaagtctt agacaactgg gctaaaacaa aaatattcaa catccattct taattattaa
     3961 attagttact aaaataggat agacagatgt tatttggcca taattttata tacatgtaaa
     4021 caaaagctaa tacataccta atgatgaaga aacagaagca ttcctactaa agttaggaac
     4081 atgaaaaaaa ttgattacta tctatcttat tttacagtgt tttagaacag gtggccaatc
     4141 caattataca agaaaaataa gttataatat ttaaagaaat gccaaaatta cttttatttg
     4201 taagtgatta tacacctagg aaatccatga gaaccaaata ataataaagt attatggcca
     4261 ggcgcagtgg ttcatgccta taatcccagc attttgggag gctgaggtgg gtggatcacc
     4321 tgaggtcagg agttcaagac cagcctggcc aacatggcga aaccccatct cttctaaaaa
     4381 tacaaaaatt agcctggttt ggtggcacac acctgtagtc ccagctactc aggaggctga
     4441 agcatgagaa gtgcttgatc ctgggaggca gaggttgcag tgagccaagg tcgcaccaga
     4501 gcactccagc ctagtgacag agcaagactc tgtctggaaa ataataaaaa taataataat
     4561 aggcagggcg tggtggctca cacctgtaat ctcagcactt tgggaggcca agtcgggcgg
     4621 atcacctgag gtcaggagtt cgagaccagc ttgacaacat ggagaaactc catctctact
     4681 taaaataaaa attagccggg cgtagtggtg catgcctgta atcccagcta ctcgggaggc
     4741 tgaggcggga gaattgcttg aacctgggag gcagaagttg tggtgagccg agatcgcacc
     4801 attgcactcc agtctagaca acaagagcaa aactctgtct caaaataata aaaataataa
     4861 taataataaa taaagtggta aaagtggtaa gataaaattc agtaaagtga aaggaaatat
     4921 taaaataaaa aataactttc ttttatacaa ataatagtga gttaggacaa taataattaa
     4981 caagaataaa taaaatgtat catttagtaa attaataaaa gctacattta aaccacactt
     5041 atcaaagtaa aaaataatgt aaagaagaca tattgctttg gataggaaga ctcagtattg
     5101 taaagatgtc aattctccct aaattaatca atatacaatt ttttaacttg acaaaatgat
     5161 actaatcctc aactaaaaaa caaaagtgag acagataaga aaaattctga tgagagtgga
     5221 agagctcttc cagctgttaa aatgtaatga taagctcctg aaccttggcc ttagcaatga
     5281 ttttttggct atcacatcaa aagcccaggc cacaaaagca aaaataaata aatgggacta
     5341 catcaagctg aaaagcttct gcatagcaaa gacaacaagc aacaaaatga aatggcaacc
     5401 tatggattgg aaaaaatatt tgcaaactat atatctaata agatacaaca aattgataaa
     5461 gaactcatac aactcaatag caggaaaaca aatgatccca gttaaaaatg ggcaaaaacc
     5521 tgaaaagaca tttctccaag aagaaaaatg gccaagatgg atatgaaaag gtgttcaaca
     5581 tcactaatca taagggaaat gtgaattgaa accattatga gacactagat aataatagga
     5641 tgactattat caaaaagtca aaagatatta atcataaacg tggataaggg tgaagagaac
     5701 agaaaacctt tgtgcattgt tggtgagaat gtacagccat tgtggaaaac agtatggagg
     5761 tttctaaata aactgaaaat agggctacat atgacccaac aatccctctt taggggatat
     5821 acacaaataa aatgagatag ccaccttgta gagataaatg tgatcccacg ttcattgcag
     5881 cattgcagcc aatataggga agcaacctaa atgcctgttg aagaatgaat ggataaagaa
     5941 actgtataca cacacacaca cacacaatgg aatattattc agccctaaaa agaatatctt
     6001 gccatttgcc acaacatgga tgaaactgga ggatattaag tgaaataagg cagatacaga
     6061 aagaaaaata ttacacgatt tcactcacat ggggaatcta aagaaaacac tcaaatacag
     6121 gtatacagag ataacaaaac ctgaggtgga ggagggtgga gagatgtagg tcagaggata
     6181 caaagcagca gataggaggg ctaggcgcag tggctcactc ctgtaatccc aggactttgg
     6241 gaggcagagg tgggcagatt gcttgagtcc aggagtttga gaccagccta ggcaacatga
     6301 caaaacccca tctctgcaaa aaaaaaaaaa aaaacaaaaa aaaccccaaa aaaccaaaac
     6361 aacaacaaac aaacaagcaa acaaaacaca cacacacaaa aaaaattagc gaggagtgct
     6421 ggtgcccacc tgtagtccca gctactcagg aggatggatt gagcctggga ggtcgaggct
     6481 gcagtgagca gtgatttgat cgtgccactg cactccagcc tggggacagg agaccccgtc
     6541 tcaaacaaaa caaaaccaag tagcagatat gcatgatgaa caagcctaga gatctaatgt
     6601 acaacataag gaccacagta taggtaataa attctacttt atttgggatt cctccttcac
     6661 tgtagtaatc tttttttaac tatgtatgta tctcataaca tgttgtatac cttaaatata
     6721 ttcaacgaag cttattttaa aaaatgaaat gtataatgat gactggaaag ggtggtagtc
     6781 acatggaaat aatgaagcag aataaaagtt ccagatatta aatgcaaatg agaatttatt
     6841 acatgataaa gctggcatta tactcggggg ggacagatag gctactcact gaagtgttta
     6901 gaagcagagt agctgaaaat tttggcgcag aagaaaatct cgtggacctc caacttaccg
     6961 gttaaagtaa aaactttcga aacgtataaa ggtttaaata taaaattaaa atcgtaaaaa
     7021 caattactat gttaacatat ttcttatata gtacttagat tttccaacat tccacaaacc
     7081 tagtagcaat taaggaaaat attaatttca gatcatataa aattcagaag tcctgtaaga
     7141 caaaaataga caaataaaat gtgaagattt ttaagaaaga acaaagggct aatctatatt
     7201 ttgaaatcag tataaaaaga cgaacagaat ttgagatgtg agcgcggaca gctctgctgg
     7261 gccctccagg ccctccgccc ggtagaaccc ggagccctgg ccgcggctgc cccaccgggc
     7321 ccatttcttg aagcagcggc gaaccacttt tcctccccga cctgccggct gcagggtctc
     7381 cccgcccaac cctgccaggc tcagacgaag cttctgctga gccgcctgga cgcagcgccc
     7441 ctgggtggcg gcaggtatag cagggcggga agcagggagg cggccccaac gccgcggagg
     7501 ccaccagcgg gtgcagaggg ccaggaaagc tggtctgcgc gcggctcagc tgcctccgta
     7561 ggccatggag ccgagcagat ccgggtcttc gggtggccgc aatgtcccaa gtggacgaca
     7621 cccacctagt cccgaggaca accgacaaag tccttaatgg gcccagaagg tgaggggagt
     7681 ccggcaatga ggggtggtag ggttagcggc catcgcccag ctcgtcttcc ttctaccaga
     7741 cgctggtgct ggaaaagaga agtgtaagaa taacttgcgc cattaggccc atcggaaagg
     7801 cccaccaccc tttaggaaga ttactggctg tttatagaag gcccgtgtat atcctatgaa
     7861 gaagctgctc tcaacttccc ccccagcctt ttaaaagaaa acatttgcta catcgagccg
     7921 ttctaggtgt aaagaggttg tgacttatga tagagttaga aaatcacaca tcttgtaaat
     7981 tcccatttgt taaaaaaata ataataataa taataataat aataataata ataggacata
     8041 aatggcttct ggagatgact ttttgcaatg aagttgttag accacctctg gaagtgacag
     8101 caggagccac acatccacgt ttattaagtg agttagagca ggagtcccca acccctggat
     8161 ctaggttgca cgctccttat gagactctaa taatgcctga tgatctgagg tggaacagtt
     8221 tcatcctgaa accatgcccc taccttccat ggaaaaattg ccttccgtga aaccattccc
     8281 tggtgccaaa gaggttgggg accactgggt tagaggacat ggggcagaag acctgagaag
     8341 gaagagagga cagttctgtg ccacactggt catatttaga agacattttc atattccaac
     8401 cattgttctg tgtgtgcatt ttatttctca cgactgtata tgtagttaac aatactattt
     8461 tttagggagg tgggggggtc agccccccgc ctggccagcc gccccgtccg ggagggaggt
     8521 gggggggtca gccccccgcc cggccagccg ccccgtctgg gaggtgaggg gcgcctctgc
     8581 ccggccgccc ctactgggaa gtgaggagcc cctctgccag gccagccgcc ccgtccggga
     8641 gggaggtggg ggggtcagcc ccccgcccgg ccagccgccc tgtccgggag ggaggtgggg
     8701 gggtcagccc tccgcccggc cagccgcccc gtctgggagg tgaggggcgc ctctgcccgg
     8761 ccgcccctac tgggaagtga ggagcccctc tgcccggcca gccgccccgt ccgggaggga
     8821 ggtggggggg tcggcccccc gcccgaccag ccgccccatc cgggagggag gtgggggggt
     8881 cagccccccg cccggccagc cgccctgtcc gggagggagg tgggggtgtc agccccacgc
     8941 ccggccagcc gcctcgtccg ggagggaggt gggggggtca gccccccgcc cggccagccg
     9001 ccccgtccgg gagggaggtg gggggggtca gcccccctgc ccggccagtg gccccgtccg
     9061 ggaggtgagg ggcgcctctg cccggctgcc cctactggga agtgaggagc ccctctgccc
     9121 ggccagccgc ccgtccggga gggagagtgg ggggtcagcc cccccccgcc cggccagccg
     9181 ccctgtccgg gaggtgaggg gcgcctctgc ccagccacca cccggtctgg gaggtgtgcc
     9241 caacagctca ttgagaacgg gccaggatga caatggcggc cttgtggaat agaaaggcgg
     9301 gaaaggcggg gaaaagattg agaaatcgga tggttgccgt gtctgtgtag aaagaagtag
     9361 acatgggaga cttttcattt tgttctgcac taagaaaaat tcctctgtct tgggatcctg
     9421 ttgatctgtg accttacccc caaccctgtg ctctctgaaa catgtgctgt gtccactcag
     9481 ggttaaatgg attaagggcg gtgcaagatg tgctttgtta aacagatgct tgaaggcagc
     9541 atgctcgtta agagtcatcg ccaatcccta atctcaagta atcagggaca caaacactgc
     9601 ggaaggccgc agggtcctct gcctaggaaa accagagacc tttgttcact tgtttatctg
     9661 ctgaccttcc ctccactatt gtcccatgac cctgccaaat ccccctctgt gagaaacacc
     9721 caagaattat caataaaaaa ataaattaaa aaaaaaaaaa aaaaacaata ctattttttg
     9781 aactatctac cctttctaga tgttctgaaa tgcctatgtt aaaattagag atagtaaaat
     9841 aacacatttt gtaaatcttt ttgttaaaat tcatatgtaa tgttgttttg gttggggggg
     9901 gtggccaaac cacctgttaa taatacacat tgtgtttgtg cactggttca ggggaggaga
     9961 gaggaaagga agtgtaagag ctctatgcca atgtgcttat agtgaggcaa ggttaaccat
    10021 tgtctcatgc ctgggcattt tgttttactt atctgggtat attgtggatc taaaggacaa
    10081 atgagtcctg actttacatc tagtctttct agatgttaaa gaggttgcta gtgtatgaca
    10141 aaagtagtta gtaaactaat atattttgta catttcgttt taagattccc aggaaagaca
    10201 gtcttctgaa aatttgagca ttattgccca gtgggttgat ggagatggga aggtgtaggc
    10261 cagaatgttc atacttggaa gactcagtca taactgtttt tacatgtgtt cactttattc
    10321 aagacttctg tgcatatagt ggacgaatta acttcttacc tgaaacatct tatctatgta
    10381 gatgttcaga attgcctgat gtatgttaag tgtagaggta gtaaaatatc accttgtaaa
    10441 tatctttttg ctaaaattct tgggaagtac tgtcttttgg aagtggaatt gtgaagccac
    10501 ctctgtaagc agtatagtac tgtctatact tgttcaatgg tttagaaatg ggagggaaga
    10561 aattgccaaa ggtaatatgc tagtgtgttc atacttggac atttcacttg ccatttttct
    10621 gtctgttttg tgcattttgt tttgctgtgt atgtagagta cataatggac aaatgagtcc
    10681 taattttgca acatttggtc tctagatgtt taagaagttg ccagtgtatg acaaagtatc
    10741 tagtaaaatt agcacatttt gcacactttg tattgaaatt cataggaaag cttgtcttct
    10801 gtaaatgatt tttgggtatg aatttgttca gccatctcta agcgttacac atgcctgtac
    10861 ctgtccactg gattgaagac agagagaagg gagtgaggaa ggactggttc aaggtcaaaa
    10921 ttgtcatatt tagaagatac ctccgattat agccactgat acatgtgcaa ttttatttta
    10981 cagtgctatg tacacagtgg aaagttatat gaaatatctg gtctctctag atagttagaa
    11041 atgcttgatg tatttaaaag tagaaatagt ataataacac tttttgtaaa tagcttttaa
    11101 aaactgatgg gaaatactgt gtttgcaagt gggattgtta aatcacctct gtgaacagtg
    11161 ttacttgttc attcagttga ggaaggtgag agggaagaaa ttacaaaaga tgttttgcta
    11221 ttgtgtacta gaaaatttca gtttatccat tgccttatat gttaaatgca ttgcaagtaa
    11281 ctttgctata ctacatattg tgttatatac tggaaaaatg agtcctaatt ttaaaatatc
    11341 cactctctag atactaaaga ggttgccaat gtatgacaaa aatagtaaag taacacattt
    11401 tgtacacttt gtgttaacgt ttataaaaag actatcttct gaaaacgact tttggaagtg
    11461 aaatgataac atcaacccta agtgacacat gggcccatat ccaccaggtt ggtggtgcag
    11521 aggagctgga agaaatgaag gattctagat cagaatattc ctatttagaa gacagtttaa
    11581 gataaaccat gtgtgtagtt tattcaaccc tactgatgca agagaatagg gtctggaggc
    11641 aggaaacata aagcagattc atgcagactt cctagaaata aatgaaatgg aaacacatca
    11701 gctatgacag gacatatact ctccaacaga gtaaatgact ttgtaacttt atttcatcct
    11761 ctccatttac atagggcgta catcaagtaa atgactaggg tgtatactaa gtaaatgact
    11821 ttgtaacttt atttcatcct cttcatttac ataaggcata taccaagtaa ccaatggaaa
    11881 ccttgagagg gtatttaaac ccgagaaaat tctgtaactg ggctcttgag cccctaagca
    11941 caggccttct cccaccctgt ggagcgtact ttcatttcat aaatctctgc ttttgttgtt
    12001 tcattctttc cttgctttgt gtgttttgtc caattcttgg ttcaatatgc ccagaacctg
    12061 gacaccctcc actggtaaca tattttggca aggcagccag gaggtaagcc caaagtttgg
    12121 gatttttcat cttttctttt ccactccata caggggaatc tctccctctg tctctttttc
    12181 ctttccaact cgggaccctt ggtgggcagc gcctaaacac ggaggcaacc gcaggtttct
    12241 gggtggggcc atcctgaagg acttttttct atcttttctg gttgtggtcc ctgattccta
    12301 tgtgtggcgc agctcagggc aaacttgcag ctcagggtga acttgcatgt gtttcaggcg
    12361 acggaaaccc tacttgactg gctaaggaca aaagaagcct actcagcttc catttcctat
    12421 cattacagtt catggctatc atgctagtgg aacaggaagc atgggataat gtggccttat
    12481 caaattataa ggatgctaaa cgccagtgat tacacccagg aaccaaagga cagctcacaa
    12541 ttgcctctgg agggaaaata tgcaaagcgg cactggtgcc cacgtaaggt cagagatgcc
    12601 tgacactctt aagactggac cccaaagggg gattccccag gggatcctcc agacttcaac
    12661 ctctccaaag gggatgccct tggcagcagt tctaaggact agtactaagc cctccttaga
    12721 attttctctt gcagttgcaa tactgtttgg ccccaatatg gtttggattc tggcatttgc
    12781 tgttgaatgg gaaagcggga tgcagttgca tgtatccagg ctttggtgct gctgttctaa
    12841 gcaggggcag gcctagttat tatgtgatgt tctcctttgg tgctgtttga ccccagtgtt
    12901 ctttcgagtc tggggaggtt tggcctttaa aaatcaaact gccatggaaa ttgctttacc
    12961 tgaaataata gttcacagcc ttcattggat tgcttattgg gtacacaaag taaaattggc
    13021 aagcttgtat tgctatctca tggttagggt tccaaggtaa aagctattga atcttcattt
    13081 gtgtgtgtgt atacacatgt ctagatgtgt ttatttgcac atttgttata tgttgtgttt
    13141 tggcatataa gtaaaagagc actcataaat taagtaaata agtcgaagca attttcaagt
    13201 tcacatgact taagtataac tttcctaaac aggctagttt taaaattatt ggtgaagtaa
    13261 aaatagaaat gccttcagaa ttgtcagcat atatttttgt ctgggtttta tatttgtctc
    13321 tgctagatat tttgaggtgt tagggtttgg catagaaggt tataaaacta taaacccagc
    13381 caaaacaaaa cgatctcgtt tgcgtttttt tttttttttt tttttttttt tttgacaaat
    13441 gagcataatt taatgttagc taaatcttct gggttactgg caaaaatacg tatgtattaa
    13501 ctttgaggct cttacttagg tttaagtgca cacctggcta ttcaaaatgt ggttaacagg
    13561 gaaataactg actttaaaag atagtgtcta acatttcggt ttacagaggt aatctagata
    13621 aactgttaaa agtgaaacaa ttgagtacag tgaatgggac aaatgtttta gataagcttt
    13681 ttgtgtaaag tcttaaaatc atttttgatg ctcatttaag atctgggcca tttccaatta
    13741 gaaaggttgt gatatgggga aatatgtttc taaaattgtg gaattgttct taactataaa
    13801 ttcccatatc tgatagttca ggatttctag ctttttagcg tttcactaaa gttttaggtt
    13861 actaaggata agaattctag ttaacacata attctgtata caaaacatgc cagaaagttt
    13921 gtgttattag tgagaaaaag aataatttag aagttatcta aaagttagtt caaattacag
    13981 atttgaaaag gttacttatg aaacaatgta gtaaggaacc agtaagtaga ggagaacgat
    14041 atggaaaaag tttagataat aaaatattct ttaaaacctg atagagaatt ggagatattt
    14101 ggctaattaa cattttcata gtgaaagctg ttagtcttga taaaagtaaa ataagcattg
    14161 taaagaaatg catcggcagt ttggcaattc ctttttacta tagttaagca tgaagccgga
    14221 tttggtgtgg agccaaattt cacatacatg cttgcattgc ttcacactgt ttactgtttt
    14281 gtgtggatag tgctggcact ggagtactta ttggttatgt gcctatagtg tatttcttga
    14341 ttgcacagga tgtatggtga tattggtgaa cttaaggata ctgaattgtg tatcaggaac
    14401 aaaatattca ttatgtgggt tttggggggc cctaggtaaa cactgtagcc tccagggtag
    14461 attgagaagg aaaaatttag ggttgggttc ctatttgttt ttgcttctaa ttttcatttg
    14521 tttgccattt attctcctct ggctttgctt gtgtatgcac atataaaatc atatatattt
    14581 tttttaaatt tctagtggaa ggcttttatt tggttctgtg aatagttatt ttgttcccta
    14641 tgcatttcta gcaagtcatc atttgttcca tttatctgga attcctaggc tacctttgtc
    14701 aggctggcag gaattgatgg agcacaccag ctttttaacc ttgaactaac tcaaattctg
    14761 tttatgatac tttaagtgtg ttgagtatat tttcataaac agaatttgag tcatatttct
    14821 ctgtctgccc attttctcca aaattcgtaa actatttgtg aatattctta attcatggca
    14881 atgtgtttgt ttgcatatag tcaagcaggg ttcctagggc tgctttggga gacagaaccc
    14941 agaaacctgg catactggca aaagggtaag aatttcttac cagccagact ctggtctctg
    15001 tctctctgtg caaactgcat aaatgaatag taaaagtcac tgtttatctc ctctgtaaag
    15061 ttttgattaa tataaaaaaa gaattctgag gccgatctta agctgtagtg aatctggtgt
    15121 gctttgtgtc tttctgtatt gttttgtcat aaagaggggt accttagaat aaaatgtgtg
    15181 cttaggaccc catagacctg ctgttcaaga cacaccagca gactggtcag tcatgtcttt
    15241 gggagcttga ccttgtaacc atgtggccat gctttctctt ttcacagtgg cagcctgggt
    15301 ttagggttca attcctggct tagggaatga gtcctttatc ttctgtctgt gtatttatat
    15361 gtgttgtgtg tgtactataa aagagcatta attaattagc ttaataataa taagagctta
    15421 aatcaaatat tttatcagaa aagtaaaaaa tgtaatgcct tctatttact tcatgtaact
    15481 taagtaatct ttgggaaata aagacagttt taaagattat tggtaaaata aaaatatctt
    15541 caaaatgtaa atatttagtc taaattatgc aggtcagata ttagatttgc aaaatgcttt
    15601 aaggtcataa accgcttctt tgacttttaa aaattgctca atttattttg gagcattaga
    15661 ttctagataa ggcctgggga caaatagaat tagccatgtc ccctagctat gcaaagaagg
    15721 ttataaagaa aggagatttt atataagaaa ggatcttata tcgtaaattc gtgtcctaaa
    15781 gtaaaataag cggttgttaa aaaagaggga tgtttaggac aagttagaaa gtcaaagcat
    15841 gtcgtagatg gtctgtgtaa gtcatgaaat aatttacaaa agagaattta tgcaagaaat
    15901 atacaattta acggtgatta gacctcctaa atgcttcata aaatgccact atgactctta
    15961 actctacaac ttgcctgctt tacagctcgg taaggcctga gacacgtgga gtcagatgct
    16021 ggagtcagac cttaagtgta cttctctctg ggtcctagac tccacaacta atatataatt
    16081 aaaatcctta acttaccaaa gttttcacca aaagtaaaac tcgctaagag ttaacattgt
    16141 aacatgtaag tgagactact gaagcaacag ttttacatgc aagttacgta agaaaagtga
    16201 atgcattttc agtgaaagat tataacaagg catgggaatg tagatttttt tttctgtcta
    16261 aagggttaaa ggattgtttt aagttaggat aaagctaaaa gtttgaatga gttgtggaag
    16321 atttataaaa attaatattg taaaaaatta tgtgtgtgaa catattgact aaatttaaag
    16381 gggtattttc tggtttttcc ataaattgaa catcaaaata aaagcacaaa cagggttttc
    16441 ttaaagcacc gatctgctct ttaacaaaca tttgtaaagg attataaaag gtttatgaga
    16501 atctcacctt atggtcaaac ggattaagat tggaaagata tgtctacaag gttttcttaa
    16561 aaattggggt tgacattaat agcacactaa tgcaagggtg aaatttggct ttctctcttg
    16621 aacaagattt tcatgcagta ttaaaagata atgaaagatc tttgtttgcc ttttgaataa
    16681 actacccccc caccaaaaaa aaggaaggga aagacaagag acagattgtt tgtaaagtaa
    16741 gtcttccatc tatcaacatg gaaaggtttt tgccttttaa aacatttttg agtcatcatt
    16801 ttgctaaatg aatgactatg gtaacctgga attccatttc ataatgtcaa gtgttttaaa
    16861 tctttaacat atttaatagg cttcccaaaa tcaaatttca gcttcaaaat tgtcttttct
    16921 aacctctaac tttgagatgc tgcagagggc ccctgaagca tccaaaagag aggtaaacag
    16981 aattatttga catgtttaat tacatgggaa gcattgtcaa aaagaaaaaa atttaatctt
    17041 cttcaggtta tattttagtg aataatatta atatatgttc caaaattgta tgagatttct
    17101 aaaattccaa tatgtctgag tatatgctat caatcataat tatgattatt atgttattgt
    17161 agaccacaga aataaccaaa tttccttgtc aattgtgttt ttaactataa ctatttaaag
    17221 tcatttccac agttaattgc ttaatgctga tgcagtttct gaaaacttca caagcatgca
    17281 aagtcctaga atatggtgtc ttttaggaga ttcatgaaag attggaaagg accctaaaaa
    17341 gcactcttga atacaggttt ctaataagtt tagaattata tcatttgaac tgggtaagaa
    17401 ttcctggaac tttaatgaaa agactgactg agttctaaaa ctgctaaccc aagtagaaca
    17461 aaaattaatt aaataccaag aaaatacttt gccagatttt catgctaaat cagctgatac
    17521 tgaaactgtt tagatataaa atttgaataa actccatcat ttaaatcaaa ttacctatga
    17581 taacccatca gttatcagtg ttatgcacct aatttgggga aacaactggt attcaagagg
    17641 atatgagtct aatgttaatt aagcatgaac tcatggagaa ccaggatggc caccttgtcc
    17701 ttcctaagtc gttaaagctt ttgttagtaa aatttctgca ttacatgact cgtcacggaa
    17761 aagataaaat gatccaaatt gaatatattg atgtggtgac ttataaattg ctaaaatagt
    17821 ttataaccaa tgtttggtcc catattcctg ggaaaacaat caaagcttca ggtacatcca
    17881 gtcacctgat aggccattta aacattttat agagggattt tattcaattg ttattttcag
    17941 tgcatgtttt ctggttgtat aaaagctttc ccatgcaaga gggctgatgt tataacacta
    18001 agttattatg ccaccaagta ttttcacaag gtaaagaaag ctttttatgg ttcactgagg
    18061 acaatcaact ccttcacaac ctagaaactg aagattgtat cttctgaaaa cattggataa
    18121 agactgtcct tgccatccac actacagcaa aacttctgga ctttgaactt tgggttcatg
    18181 atctcacaac tgagaagagt ccctccacac tcttggaact gtacacccat tggaaccctt
    18241 aaggtaaagc taaccaggga agtttctctc ccgaagaaga tggcatcctt gatgtgaaca
    18301 gcttttccca agatcatgaa tcaagacttc tctattatca tgagactctt atctttgaat
    18361 attttttcct tgcttttgcc tctatgaaga atagaagtgg aaaaaggatc tgttgtgtac
    18421 aattatgggt tatactttta tttgtgaaga attttgcagc cagctttagg tcctttttcc
    18481 atgatttgga ataaaagagg caaatgtatc cctcataata ggctccatag cagtttactg
    18541 taaaggctat ggttacataa tagactaaat tatcttaaga aagttatgct aaataataga
    18601 gttggctaaa cagaagagta tctgtgcagc tgctggcact catggcctat ggagaaaaca
    18661 tcaggtatta tagagattca gttgtagcaa attaatgaag agactgctta gttaagtgag
    18721 tagactcttt agctcattgt ttaatctatt tgagtttagg aggtttggtt tatggtgacc
    18781 ctggataagg agcatactta ctctcaactc ttggtattat cctcctgata gtcataataa
    18841 tagtctccct ggtgtgctgt attctctcaa cggttttaaa tgtttgcatg ctgccacctc
    18901 tagaatgtca aatggcctct cttcaactgg aatgacaaga gctgaaagaa attgcagcca
    18961 tgaggacact gtaacctacg aatgatgtgc tgagtccaaa agcccaaagt gttggtaact
    19021 gagagtggtg ctaagtaagg ccctaagttt tggtcacact ctcacttaag tgagaacctg
    19081 accaaaaaag tggaattttt tttttttttt ttttttttga gatggagtct cactctgtca
    19141 cccgggctgg agtgcagtgg cacgatctcg gctcactgca agctccactt cccgggttca
    19201 cgccattttt ctgtctcagc ctcccgagta gctgggacta caggcacctg ccaccacgcc
    19261 cggctaattt ttttgtattt ttagtggaga cggggtttca ccatgttagc caggatggtc
    19321 tcgatctcct aacctcatga tctgcccacc tcggcctccc aaagtgctgg gataacaggc
    19381 gtgagccact gcacctggcc aaaaagggga atttttttta aacaaaatta tgggaggtca
    19441 tttttttgta ctgagcccat gcgccaggcc ccaacagacc aaactaaacc aaaacggagt
    19501 cacgtatgcc aagaccttaa ggaaacacat agatcctaga acagaccaca ggccaggttt
    19561 tgtttttctc ctacaaatct ctataacaaa cattcctgac agcatagata tccaccccct
    19621 gagttcccat taaatctttt aaccaaatta atttcctctc gccaaaagac catcaagctt
    19681 cagatgatca tgcaacaaaa gtttcatcca gttccaccac ccctggccat caaggagcta
    19741 ccctgccttc actagaaaga gcagagcagg acttctgtga tcctcaatag gtagggacta
    19801 ggcctcaagc caacatgaag cagttacaaa agaaagacca tcggcccctc cacctcccat
    19861 aaagatttat ggggatccca tctctggagg gaaatgaggc agaagaatag ggtctgtagg
    19921 caaggaatat aaggcagatg catgctcact tcctagaact aaatcaaatg gaaacacttc
    19981 agctatgatg ggaaatgtct tctgtattta catagggcat acactgagta accaatggaa
    20041 acctctagag ggtatttaaa ccccagaaaa ttctgtaacc gggctattga gcccctatgc
    20101 tcaagccctc tgccaccctg tggagtgtac ttttgttttc aataaacctc tgcttttgtt
    20161 gcttca
//
