LOCUS       NM_001395496            2911 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens testis expressed 9 (TEX9), transcript variant 20,
            mRNA.
ACCESSION   NM_001395496 XM_017022160
VERSION     NM_001395496.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2911)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2911)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2911)
  AUTHORS   Xu,F., Zhang,S., Liu,Z., Gu,J., Li,Y., Wang,L., Mao,W., Zhu,Q.,
            Shou,H., Ge,D. and Lu,C.
  TITLE     TEX9 and eIF3b functionally synergize to promote the progression of
            esophageal squamous cell carcinoma
  JOURNAL   BMC Cancer 19 (1), 875 (2019)
   PUBMED   31481019
  REMARK    GeneRIF: Testis-expressed protein 9 (TEX9) expression is positively
            associated with eukaryotic translation initiation factor 3 subunit
            b (eIF3b) expression in esophageal squamous cell carcinoma (ESCC).
            TEX9 expression is positively correlated with tumor-node-metastasis
            stage in ESCC. eIF3b binding to TEX9 mRNA functionally synergizes
            to promote the proliferation and migration, and inhibit the
            apoptosis of ESCC cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2911)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 2911)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   6  (bases 1 to 2911)
  AUTHORS   Goldstein,J.I., Jarskog,L.F., Hilliard,C., Alfirevic,A., Duncan,L.,
            Fourches,D., Huang,H., Lek,M., Neale,B.M., Ripke,S., Shianna,K.,
            Szatkiewicz,J.P., Tropsha,A., van den Oord,E.J., Cascorbi,I.,
            Dettling,M., Gazit,E., Goff,D.C., Holden,A.L., Kelly,D.L.,
            Malhotra,A.K., Nielsen,J., Pirmohamed,M., Rujescu,D., Werge,T.,
            Levy,D.L., Josiassen,R.C., Kennedy,J.L., Lieberman,J.A., Daly,M.J.
            and Sullivan,P.F.
  TITLE     Clozapine-induced agranulocytosis is associated with rare HLA-DQB1
            and HLA-B alleles
  JOURNAL   Nat Commun 5, 4757 (2014)
   PUBMED   25187353
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2911)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   8  (bases 1 to 2911)
  AUTHORS   Brandler,W.M., Morris,A.P., Evans,D.M., Scerri,T.S., Kemp,J.P.,
            Timpson,N.J., St Pourcain,B., Smith,G.D., Ring,S.M., Stein,J.,
            Monaco,A.P., Talcott,J.B., Fisher,S.E., Webber,C. and Paracchini,S.
  TITLE     Common variants in left/right asymmetry genes and pathways are
            associated with relative hand skill
  JOURNAL   PLoS Genet 9 (9), e1003751 (2013)
   PUBMED   24068947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068726.5 and AC084782.2.
            
            On Jul 13, 2021 this sequence version replaced XM_017022160.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2488854.1,
                                           SRR14038195.2382541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000696102.1/ ENSP00000512397.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC068726.5         173380-173431
            53-144              AC068726.5         173533-173624
            145-208             AC068726.5         181395-181458
            209-288             AC084782.2         98686-98765
            289-337             AC084782.2         103206-103254
            338-420             AC084782.2         104052-104134
            421-596             AC084782.2         105977-106152
            597-679             AC084782.2         108899-108981
            680-853             AC084782.2         109395-109568
            854-988             AC084782.2         127036-127170
            989-1123            AC084782.2         142339-142473
            1124-2911           AC084782.2         143101-144888
FEATURES             Location/Qualifiers
     source          1..2911
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..2911
                     /gene="TEX9"
                     /note="testis expressed 9"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
     exon            1..52
                     /gene="TEX9"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1201
                     /gene="TEX9"
                     /note="isoform 1 is encoded by transcript variant 20;
                     testis-expressed sequence 9 protein; testis-expressed
                     protein 9"
                     /codon_start=1
                     /product="testis-expressed protein 9 isoform 1"
                     /protein_id="NP_001382425.1"
                     /db_xref="CCDS:CCDS10157.1"
                     /db_xref="GeneID:374618"
                     /db_xref="HGNC:HGNC:29585"
                     /db_xref="MIM:620935"
                     /translation="MAGRSLCLTRSSVPGTPFPPPVQQPSTPGPDLLALEEEYKRLNA
                     ELQAKTADVVQQAKEIIRDRQEVRSRPVSTQMKSCDDEDDYSLRGLLPSEGIVHLHSE
                     TKPKTKNIDPVNKVQNKLHSANKGRKTNSSVKLKYSDVQTADDVAIPEDFSDFSLAKT
                     ISKIEGQLEEEGLPEYIDDIFSGVSNDIGTEAQIRFLKAKLHVMQEELDNVVCECNKK
                     EDEIQNLKSQVKNFEEDFMRQQRTINMQQSQVEKYKTLFEEANKKYDGLQQQLSSVER
                     ELENKRRLQKQAASSQSATEVRLNRALEEAEKYKLELSKLRQNNKDIANEEHKKIEVL
                     KSENKKLEKQKGELMIGFKKQLKLIDVLKRQKMHIEAAKMLSFTEEEFMKALEWGNS"
     exon            53..144
                     /gene="TEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            145..208
                     /gene="TEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            209..288
                     /gene="TEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            289..337
                     /gene="TEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            338..420
                     /gene="TEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            421..596
                     /gene="TEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            597..679
                     /gene="TEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            680..853
                     /gene="TEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            854..988
                     /gene="TEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1123
                     /gene="TEX9"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..2911
                     /gene="TEX9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1418..1423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX9"
                     /note="hexamer: AATAAA"
     polyA_site      1440
                     /gene="TEX9"
                     /note="major polyA site"
     regulatory      1686..1691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX9"
                     /note="hexamer: ATTAAA"
     polyA_site      1707
                     /gene="TEX9"
     regulatory      2853..2858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX9"
                     /note="hexamer: AATAAA"
     regulatory      2878..2883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX9"
                     /note="hexamer: AATAAA"
     polyA_site      2896
                     /gene="TEX9"
     polyA_site      2911
                     /gene="TEX9"
                     /note="major polyA site"
ORIGIN      
        1 ggtaaccgcg tcgcagtcgc cgaagatggc ggggcgaagt ctgtgtctca cgagaagcag
       61 cgttccaggg actccgttcc cgccacccgt tcagcaaccc tctacacctg gacccgacct
      121 cctcgccttg gaggaagaat ataagcgttt aaatgcagaa ttgcaggcaa aaacagctga
      181 cgtggttcaa caagctaagg aaataataag agatcggcaa gaagtacgat ctaggcctgt
      241 ttcaacacaa atgaaatcat gtgatgacga agatgattac agtttaagag gtctgttacc
      301 atctgaaggg atagttcatc ttcattcaga aactaagcca aagaccaaaa acattgatcc
      361 tgtaaacaag gttcaaaaca aattacactc tgcaaataaa ggaaggaaaa caaattcaag
      421 tgttaaattg aaatactctg atgtccaaac tgccgacgat gttgccattc cagaggattt
      481 ctcagacttt tcccttgcaa aaacaattag caaaattgaa gggcaactgg aggaagaagg
      541 cttacctgaa tatatagatg atattttttc tggtgttagt aatgacattg gaacagaagc
      601 acagatcaga tttctaaagg ccaaactcca tgttatgcag gaggaattgg ataatgttgt
      661 atgtgaatgc aataaaaagg aggatgaaat tcagaattta aagtctcaag taaaaaattt
      721 tgaagaagat tttatgagac agcagcgaac aattaatatg caacagtctc aagtagaaaa
      781 atacaaaact cttttcgaag aagcaaacaa aaagtatgat ggattacagc aacagttgtc
      841 ttcagtagaa agggaattag aaaataaaag aagactgcaa aaacaggctg caagtagtca
      901 aagtgccaca gaggttcgct tgaatagagc tctagaagaa gcagaaaagt ataaactgga
      961 gttaagtaaa ttaaggcaaa ataacaagga catagcaaat gaagaacaca aaaaaattga
     1021 agtgttaaaa tcagaaaaca agaagctaga aaaacaaaaa ggagaattaa tgatagggtt
     1081 caagaaacag ttaaaattaa ttgatgtttt aaaaaggcaa aagatgcata ttgaagctgc
     1141 caagatgcta tctttcactg aggaggaatt tatgaaagca cttgaatggg gaaattcata
     1201 agtgatctac ttcagttagt ctctatgaca gtatgtgatg gatacccatt ttacttattg
     1261 tagtggtttg aattattttt attcttcata agtaatatat ttgattatga aagcaaaata
     1321 atttcaaaga attccctttt tagatttagg agattagcta ttagctcttt ttgagttgtt
     1381 ttttaagttc ttagcgtgac aattaagcac atcagataat aaaattcttg actcttttca
     1441 tttataattc tcctccctta cagtagacca aaaaagatgc tttaaaagaa aattccaaat
     1501 atttatttcc ctggctaaat caagtaagta aagttcgtaa acacagacag aaggcagttc
     1561 actttggggt agagttctgt attagtcaag gtaaatatac tgtcttgagg atggggatgc
     1621 aaacagtgct ctgtagtgtt gtagaaatcg gattttgaaa ttatcagtac aaaaataaca
     1681 gcttgattaa aattaatttg tatctgataa ttgtttacaa gttatgaaat tcagtgatga
     1741 tttacaaaat ccaaacagac aatggatacc taatgccact gaactgtaaa acaaaagtta
     1801 tgctgacatc tagtggtaac atgcaaaaaa tctatgcttt acccaatttt gatgatatca
     1861 tttctcttca caaatttcac tcctttgttg atatactttc ctgaactctt caccaagcag
     1921 atcaatatca tcctcttttt taaatactcc ctacgagaaa aatactttgt gggttacttt
     1981 tgaataccag aatatttcac taaatgcttt taagactgac agacataaga ttagtaaagt
     2041 tatctccaag gtaatgaaat ctattcaaca gattaatgaa actttaaaaa aatcaatact
     2101 tttcaaaaaa taagacttta catatatatt gaatattcct agactgaccc aattttctga
     2161 tttatcagct ctagtgtagg agcttttcat aggaatctga gctcttctac aagttctact
     2221 gcttggatta cctagatagg aaggcacttc atctatactg taccctaccc ttttctttaa
     2281 atagctctat aatatgatat aatggtgagc ttcagtagat tcatgcatgg gattagttct
     2341 tcatgcctca gttctatggc taatcagcaa acagtcaatc ttgcagaaaa gaatccaggt
     2401 ttggagttaa gccatttaag caaacccttt ggaattcttc actgttctat ttttcttttc
     2461 ccctacagta tactgcaaaa ggctctttaa aacaaaatta aatatttact taaattgcaa
     2521 tctaaagaat aaagaatttt agggataact gaagtcattt ggcaccatta ggacctaaag
     2581 gataaaggtc atttttggat atcaagttta ttaatccctc ctgctgcctc cacaattatt
     2641 tcctctacaa aaatatcaaa tcccaaagaa agacattcct acaatttata atttagttta
     2701 tgaaatgtat taattacata tggattttat cattaataca tcattttgta ttccttaatc
     2761 ctttctaacc aattagacta tcaagtcctg tggccaggca gtaattacct atatatcttt
     2821 ttccttcctt agcaccagag tgaatataat aaaataaata tgcacttgat tctactgaat
     2881 aaaatatgaa atggcatttc tatagctgaa a
//
