LOCUS       NM_032126                992 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens testis expressed 35 (TEX35), transcript variant 1,
            mRNA.
ACCESSION   NM_032126
VERSION     NM_032126.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 992)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 992)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 992)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 992)
  AUTHORS   Tang,A., Yu,Z., Gui,Y., Guo,X., Long,Y. and Cai,Z.
  TITLE     Identification and characteristics of a novel testis-specific gene,
            Tsc24, in human and mice
  JOURNAL   Biol Pharm Bull 29 (11), 2187-2191 (2006)
   PUBMED   17077512
REFERENCE   5  (bases 1 to 992)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136694.1, AL552172.3 and AW628627.1.
            
            On Nov 24, 2018 this sequence version replaced NM_032126.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.142172.1, AL136694.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319416.7/ ENSP00000323795.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AL136694.1         37-155
            120-135             AL552172.3         74-89
            136-886             AL136694.1         172-922
            887-992             AW628627.1         8-113               c
FEATURES             Location/Qualifiers
     source          1..992
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..992
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /note="testis expressed 35"
                     /db_xref="GeneID:84066"
                     /db_xref="HGNC:HGNC:25366"
     exon            1..119
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..782
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Testis-Specific Conserved gene 24kDa; testis-expressed
                     sequence 35 protein; testis-expressed protein 35"
                     /codon_start=1
                     /product="testis-expressed protein 35 isoform 1"
                     /protein_id="NP_115502.2"
                     /db_xref="CCDS:CCDS1323.1"
                     /db_xref="GeneID:84066"
                     /db_xref="HGNC:HGNC:25366"
                     /translation="MSAKRAELKKTHLSKNYKAVCLELKPEPTKTFDYKAVKQEGRFT
                     KAGVTQDLKNELREVREELKEKMEEIKQIKDLMDKDFDKLHEFVEIMKEMQKDMDEKM
                     DILINTQKNYKLPLRRAPKEQQELRLMGKTHREPQLRPKKMDGASGVNGAPCALHKKT
                     MAPQKTKQGSLDPLHHCGTCCEKCLLCALKNNYNRGNIPSEASGLYKGGEEPVTTQPS
                     VGHAVPAPKSQTEGR"
     exon            120..170
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /inference="alignment:Splign:2.1.0"
     exon            171..239
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /inference="alignment:Splign:2.1.0"
     exon            240..296
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /inference="alignment:Splign:2.1.0"
     exon            297..356
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /inference="alignment:Splign:2.1.0"
     exon            357..421
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /inference="alignment:Splign:2.1.0"
     exon            422..623
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /inference="alignment:Splign:2.1.0"
     exon            624..666
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /inference="alignment:Splign:2.1.0"
     exon            667..992
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      972..977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /note="hexamer: AATAAA"
     polyA_site      992
                     /gene="TEX35"
                     /gene_synonym="C1orf49; TSC24"
                     /note="major polyA site"
ORIGIN      
        1 gacctgtaag ttgcctagga cagtggcctg gtcccagggg ctgttgtggg gagttgaaga
       61 acaccctggc ctcctccatc atgtcggcca agagggcaga attgaagaaa acacatctga
      121 gcaagaacta caaggcagtt tgcctggaat tgaagccaga gccgaccaaa acatttgatt
      181 acaaagcagt taaacaagaa gggcggttta ccaaagcagg agtgacacag gacctaaaga
      241 atgaactcag ggaagtgaga gaagagctca aggagaaaat ggaggagata aaacagataa
      301 aggatctaat ggacaaggat tttgataaac ttcacgaatt tgtggaaatt atgaaggaaa
      361 tgcagaaaga tatggatgag aagatggaca ttttaataaa tacacagaag aactataagc
      421 ttccccttag aagagcacca aaggagcagc aggaactcag gctgatggga aagactcaca
      481 gagaaccaca gctcaggccc aagaaaatgg atggagccag tggagtcaat ggagcaccct
      541 gtgctcttca caagaagacg atggcaccac aaaaaacaaa acagggctca ctggatcccc
      601 ttcatcactg tgggacctgc tgcgagaaat gtttgttgtg tgctctaaag aacaactaca
      661 atcgggggaa cattccttca gaggcctcag gcctttacaa aggtggagag gagccagtga
      721 ccacccaacc ttctgtgggc cacgctgtgc ctgccccaaa gtcccagact gagggaaggt
      781 gaagcttaac tgccagcttg aaatgagagt aaagaagata cagagcaaac agtgtttcag
      841 aaactgtcct gccctgggtg tgattctttg gcttcaattt gaaggacgag gaatgatggg
      901 atttcatatt ttatttcaca ccagttcctc cttgtttcat ctctttgcta agctggctgc
      961 ttctaccatc taataaataa ttggccaagt tc
//
