LOCUS       NM_015926               1320 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens testis expressed 264, ER-phagy receptor (TEX264),
            transcript variant 1, mRNA.
ACCESSION   NM_015926
VERSION     NM_015926.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Lascaux,P., Hoslett,G., Tribble,S., Trugenberger,C., Anticevic,I.,
            Otten,C., Torrecilla,I., Koukouravas,S., Zhao,Y., Yang,H.,
            Aljarbou,F., Ruggiano,A., Song,W., Peron,C., Deangeli,G.,
            Domingo,E., Bancroft,J., Carrique,L., Johnson,E., Vendrell,I.,
            Fischer,R., Ng,A.W.T., Ngeow,J., D'Angiolella,V., Raimundo,N.,
            Maughan,T., Popovic,M., Milosevic,I. and Ramadan,K.
  TITLE     TEX264 drives selective autophagy of DNA lesions to promote DNA
            repair and cell survival
  JOURNAL   Cell 187 (20), 5698-5718 (2024)
   PUBMED   39265577
  REMARK    GeneRIF: TEX264 drives selective autophagy of DNA lesions to
            promote DNA repair and cell survival.
REFERENCE   2  (bases 1 to 1320)
  AUTHORS   Tu,Y.X.I., Sydor,A.M., Coyaud,E., Laurent,E.M.N., Dyer,D.,
            Mellouk,N., St-Germain,J., Vernon,R.M., Forman-Kay,J.D., Li,T.,
            Hua,R., Zhao,K., Ridgway,N.D., Kim,P.K., Raught,B. and Brumell,J.H.
  TITLE     Global Proximity Interactome of the Human Macroautophagy Pathway
  JOURNAL   Autophagy 18 (5), 1174-1186 (2022)
   PUBMED   34524948
REFERENCE   3  (bases 1 to 1320)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1320)
  AUTHORS   Fielden,J., Wiseman,K., Torrecilla,I., Li,S., Hume,S., Chiang,S.C.,
            Ruggiano,A., Narayan Singh,A., Freire,R., Hassanieh,S., Domingo,E.,
            Vendrell,I., Fischer,R., Kessler,B.M., Maughan,T.S.,
            El-Khamisy,S.F. and Ramadan,K.
  TITLE     TEX264 coordinates p97- and SPRTN-mediated resolution of
            topoisomerase 1-DNA adducts
  JOURNAL   Nat Commun 11 (1), 1274 (2020)
   PUBMED   32152270
  REMARK    GeneRIF: TEX264 recognises both unmodified and SUMO1-modifed TOP1
            and initiates TOP1cc repair by recruiting p97 and SPRTN.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1320)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1320)
  AUTHORS   Chino,H., Hatta,T., Natsume,T. and Mizushima,N.
  TITLE     Intrinsically Disordered Protein TEX264 Mediates ER-phagy
  JOURNAL   Mol Cell 74 (5), 909-921 (2019)
   PUBMED   31006538
  REMARK    GeneRIF: A long intrinsically disordered region of TEX264 is
            required for its ER-phagy receptor function to bridge the gap
            between the ER and autophagosomal membranes independently of its
            amino acid sequence. These results suggest that TEX264 is a major
            ER-phagy receptor.
REFERENCE   7  (bases 1 to 1320)
  AUTHORS   An,H., Ordureau,A., Paulo,J.A., Shoemaker,C.J., Denic,V. and
            Harper,J.W.
  TITLE     TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting
            Protein Critical for ER Remodeling during Nutrient Stress
  JOURNAL   Mol Cell 74 (5), 891-908 (2019)
   PUBMED   31006537
  REMARK    GeneRIF: TEX264, an endoplasmic reticulum (ER)resident protein,
            remodels subdomainsof the ER into ring-like structures
            inassociation with ATG8 proteins uponnutrient stress, which then
            fuse withlysosomes for ER turnover.
REFERENCE   8  (bases 1 to 1320)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 1320)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG772477.1, AY358972.1 and AA463493.1.
            
            On Jun 2, 2019 this sequence version replaced NM_015926.5.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1, 2, 4, 5, and 7 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.54796.1,
                                           SRR5189658.65290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341333.10/ ENSP00000340969.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BG772477.1         83-106
            25-1236             AY358972.1         1-1212
            1237-1320           AA463493.1         7-90                c
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..1320
                     /gene="TEX264"
                     /gene_synonym="ZSIG11"
                     /note="testis expressed 264, ER-phagy receptor"
                     /db_xref="GeneID:51368"
                     /db_xref="HGNC:HGNC:30247"
                     /db_xref="MIM:620608"
     exon            1..37
                     /gene="TEX264"
                     /gene_synonym="ZSIG11"
                     /inference="alignment:Splign:2.1.0"
     exon            38..329
                     /gene="TEX264"
                     /gene_synonym="ZSIG11"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1013
                     /gene="TEX264"
                     /gene_synonym="ZSIG11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testis expressed gene 264; testis-expressed sequence 264
                     protein; testis-expressed protein 264"
                     /codon_start=1
                     /product="testis-expressed protein 264 isoform 1"
                     /protein_id="NP_057010.1"
                     /db_xref="CCDS:CCDS2833.1"
                     /db_xref="GeneID:51368"
                     /db_xref="HGNC:HGNC:30247"
                     /db_xref="MIM:620608"
                     /translation="MSDLLLLGLIGGLTLLLLLTLLAFAGYSGLLAGVEVSAGSPPIR
                     NVTVAYKFHMGLYGETGRLFTESCSISPKLRSIAVYYDNPHMVPPDKCRCAVGSILSE
                     GEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIK
                     ERKLCAYPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGA
                     DTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGDTRSEHSYSESGASGSSFEEL
                     DLEGEGPLGESRLDPGTEPLGTTKWLWEPTAPEKGKE"
     exon            330..551
                     /gene="TEX264"
                     /gene_synonym="ZSIG11"
                     /inference="alignment:Splign:2.1.0"
     exon            552..720
                     /gene="TEX264"
                     /gene_synonym="ZSIG11"
                     /inference="alignment:Splign:2.1.0"
     exon            721..1320
                     /gene="TEX264"
                     /gene_synonym="ZSIG11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1288..1293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX264"
                     /gene_synonym="ZSIG11"
                     /note="hexamer: AATAAA"
     polyA_site      1320
                     /gene="TEX264"
                     /gene_synonym="ZSIG11"
                     /note="major polyA site"
ORIGIN      
        1 ctgcgcggat cggcgtccgc agcgggcggc tgctgagctg ccttgaggtg cagtgttggg
       61 gatccagagc catgtcggac ctgctactac tgggcctgat tgggggcctg actctcttac
      121 tgctgctgac gctgctggcc tttgccgggt actcagggct actggctggg gtggaagtga
      181 gtgctgggtc accccccatc cgcaacgtca ctgtggccta caagttccac atggggctct
      241 atggtgagac tgggcggctt ttcactgaga gctgcagcat ctctcccaag ctccgctcca
      301 tcgctgtcta ctatgacaac ccccacatgg tgccccctga taagtgccga tgtgccgtgg
      361 gcagcatcct gagtgaaggt gaggaatcgc cctcccctga gctcatcgac ctctaccaga
      421 aatttggctt caaggtgttc tccttcccgg cacccagcca tgtggtgaca gccaccttcc
      481 cctacaccac cattctgtcc atctggctgg ctacccgccg tgtccatcct gccttggaca
      541 cctacatcaa ggagcggaag ctgtgtgcct atcctcggct ggagatctac caggaagacc
      601 agatccattt catgtgccca ctggcacggc agggagactt ctatgtgcct gagatgaagg
      661 agacagagtg gaaatggcgg gggcttgtgg aggccattga cacccaggtg gatggcacag
      721 gagctgacac aatgagtgac acgagttctg taagcttgga agtgagccct ggcagccggg
      781 agacttcagc tgccacactg tcacctgggg cgagcagccg tggctgggat gacggtgaca
      841 cccgcagcga gcacagctac agcgagtcag gtgccagcgg ctcctctttt gaggagctgg
      901 acttggaggg cgaggggccc ttaggggagt cacggctgga ccctgggact gagcccctgg
      961 ggactaccaa gtggctctgg gagcccactg cccctgagaa gggcaaggag taacccatgg
     1021 cctgcaccct cctgcagtgc agttgctgag gaactgagca gactctccag cagactctcc
     1081 agccctcttc ctccttcctc tgggggagga ggggttcctg agggacctga cttcccctgc
     1141 tccaggcctc ttgctaagcc ttctcctcac tgccctttag gctcccaggg ccagaggagc
     1201 cagggactat tttctgcacc agcccccagg gctgccaccc ctgttgtgtc tttttttcag
     1261 actcacagtg gagcttccag gacccagaat aaagccaatg atttacttgt ttcacctgga
//
