LOCUS       NM_001288732            5244 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens testis expressed 2 (TEX2), transcript variant 2, mRNA.
ACCESSION   NM_001288732 XM_005257505
VERSION     NM_001288732.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5244)
  AUTHORS   Kuhlwilm,M. and Boeckx,C.
  TITLE     A catalog of single nucleotide changes distinguishing modern humans
            from archaic hominins
  JOURNAL   Sci Rep 9 (1), 8463 (2019)
   PUBMED   31186485
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5244)
  AUTHORS   Hariri,H., Ugrankar,R., Liu,Y. and Henne,W.M.
  TITLE     Inter-organelle ER-endolysosomal contact sites in metabolism and
            disease across evolution
  JOURNAL   Commun Integr Biol 9 (3), e1156278 (2016)
   PUBMED   27489577
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5244)
  AUTHORS   Lee,I. and Hong,W.
  TITLE     Diverse membrane-associated proteins contain a novel SMP domain
  JOURNAL   FASEB J 20 (2), 202-206 (2006)
   PUBMED   16449791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036672.1, AL834251.2, BC040521.1, AA825291.1 and AC025362.12.
            
            On Jun 2, 2019 this sequence version replaced NM_001288732.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            acceptor splice site at an internal coding exon compared to variant
            1. The resulting shorter isoform (2) lacks a 7 aa protein segment
            compared to isoform 1. Variants 2 and 3 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040522.1, AL832371.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000584379.6/ ENSP00000463001.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2019              BC036672.1         35-2053
            2020-2511           AL834251.2         1994-2485
            2512-5036           BC040521.1         2500-5024
            5037-5038           AA825291.1         10-11               c
            5039-5244           AC025362.12        105738-105943       c
FEATURES             Location/Qualifiers
     source          1..5244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..5244
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /note="testis expressed 2"
                     /db_xref="GeneID:55852"
                     /db_xref="HGNC:HGNC:30884"
                     /db_xref="MIM:619929"
     exon            1..93
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /inference="alignment:Splign:2.1.0"
     exon            94..1762
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..3502
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /note="isoform 2 is encoded by transcript variant 2;
                     testis expressed sequence 2; transmembrane protein 96;
                     testis-expressed protein 2; testis-expressed sequence 2
                     protein"
                     /codon_start=1
                     /product="testis-expressed protein 2 isoform 2"
                     /protein_id="NP_001275661.1"
                     /db_xref="CCDS:CCDS74131.1"
                     /db_xref="GeneID:55852"
                     /db_xref="HGNC:HGNC:30884"
                     /db_xref="MIM:619929"
                     /translation="MTSLYGRHAEKTTDMPKPSAPKVHVQRSVSRDTIAIHFSASGEE
                     EEEEEEEFREYFEEGLDDQSIVTGLEAKEDLYLEPQVGHDPAGPAASPVLADGLSVSQ
                     APAILPVSKNTVKLLESPVPAAQVLSTVPLAVSPGSSSSGPLASSPSVSSLSEQKTSS
                     SSPLSSPSKSPILSSSASTSTLSSAKPFMSLVKSLSTEVEPKESPHPARHRHLMKTLV
                     KSLSTDTSRQESDTVSYKPPDSKLNLHLFKQFTQPRNTGGDSKTAPSSPLTSPSDTRS
                     FFKVPEMEAKIEDTKRRLSEVIYEPFQLLSKIIGEESGSHRPKALSSSASELSNLSSL
                     NGHLESNNNYSIKEEECDSEGDGYGSDSNIPRSDHPKSTGEPTREIELKSSQGSSLKD
                     LGLKTSSLVLEKCSLSALVSKEDEEFCELYTEDFDLETEGESKVDKLSDIPLKPEVLA
                     EDGVVLDSEDEVDSAVQHPELPVKTLGFFIMCVYVYLILPLPHYVSGLFLGIGLGFMT
                     AVCVIWFFTPPSAHKYHKLHKNLRHWNTRSLDIKEPEILKGWMNEIYNYDPETYHATL
                     THSVFVRLEGGTLRLSKPNKNISRRASYNEPKPEVTYISQKIYDLSDSKIYLVPKTLA
                     RKRIWNKKYPICIELGQQDDFMSKAQTDKETSEEKPPAEGSEDPKKPPRPQEGTRSSQ
                     RDQILYLFGRTGREKEEWFRRFILASKLKSEIKKSSGVSGGKPGLLPAHSRHNSPSGH
                     LTHSRSSSKGSVEEIMSQPKQKELAGSVRQKMLLDYSVYMGRCVPQESRSPQRSPLQS
                     AESSPTAGKKLPEVPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDLVSKKIQMKLSKI
                     KLPYFMNELTLTELDMGVAVPKILQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNL
                     TKLGKEPLVEALKVGEIGKEGCRPRAFCLADSDEESSSAGSSEEDDAPEPSGGDKQLL
                     PGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQEC
                     RGTLAVNIPPPPTDRVWYGFRKPPHVELKARPKLGEREVTLVHVTDWIEKKLEQEFQK
                     VFVMPNMDDVYITIMHSAMDPRSTSCLLKDPPVEAADQP"
     exon            1763..1963
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2294
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2542
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2689
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2789
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2922
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..3048
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3258
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3379
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..5244
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4765..4770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /note="hexamer: ATTAAA"
     polyA_site      4800
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /note="major polyA site"
     regulatory      5011..5016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /note="hexamer: AATAAA"
     polyA_site      5036
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /note="major polyA site"
     regulatory      5085..5090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
                     /note="hexamer: AATAAA"
     polyA_site      5109
                     /gene="TEX2"
                     /gene_synonym="HT008; TMEM96"
ORIGIN      
        1 aggaccgcgg ccggtgcccc agccgaagcc ggagtcgcgc ggccgggagc acgggcgccg
       61 gcatagtaca atgaggcagc cagcggatct tggagcctga gcccttgtga agccggcaat
      121 gacaagtctg tatggtcgcc atgccgagaa aaccactgac atgccaaaac catcagcccc
      181 taaagtgcac gtgcagaggt ccgtgtcccg agataccatc gccattcact tctcggcatc
      241 cggcgaggag gaggaggaag aggaggagga gttcagggag tactttgagg aggggctgga
      301 tgaccaaagc attgtaacag ggctggaagc caaggaagac ctctatcttg aaccccaagt
      361 tggccatgac cccgccggcc ctgctgcctc gcctgtcctg gcagatggac tgtccgtgtc
      421 ccaggcccct gccattttgc ccgtctccaa gaacactgta aagctgttgg agtcccctgt
      481 tccagcagca caagtattaa gtacagtgcc attggctgtg tccccagggt cgtcttcgtc
      541 ggggccctta gctagctctc ccagtgtgtc atccctttct gagcagaaaa ccagttcttc
      601 ctccccattg tcctctcctt ctaagtctcc catcctctca tccagtgcct caacctccac
      661 cctttccagt gcaaaaccct tcatgagcct tgtgaagtcc ctgtcgaccg aggtggagcc
      721 aaaagaatcc ccacaccccg caaggcacag gcacttgatg aagacattag tcaagtctct
      781 gtccacggac acttcccggc aggagtcgga tacagtgtcc tataagccac ctgattccaa
      841 actgaactta cacctgttca agcagttcac acagccccga aacacaggtg gagattccaa
      901 aactgcacct tcttccccac tgacttctcc ctctgatact cgttcctttt ttaaagtgcc
      961 cgaaatggag gctaaaattg aagatactaa acgacgcctt tcagaagtca tctatgagcc
     1021 ttttcagctc cttagtaaaa ttatagggga agaaagtggc agccataggc ccaaagcctt
     1081 atcttcaagt gcttcagaac tctccaatct gtccagcttg aatgggcact tggaaagcaa
     1141 taacaactac agcatcaagg aggaggagtg tgattctgag ggggatggct acggaagtga
     1201 ttccaacatc cccagaagtg accacccaaa gtccactggt gagcccacaa gagagataga
     1261 actgaaaagt tcccagggga gcagtctgaa ggatttaggc ctgaagacaa gttctctagt
     1321 tctggagaaa tgttctttgt ctgccttagt gagcaaagaa gatgaagagt tttgtgaact
     1381 gtacactgag gacttcgatt tggaaacgga gggggagagt aaagttgata agctctcaga
     1441 tattcctctc aagccagagg tgctcgcgga agatggtgtg gtccttgaca gtgaggacga
     1501 ggtggactcg gccgtgcagc acccggaatt gccagtgaag acgttgggct tctttataat
     1561 gtgtgtctat gtgtacctca tcctccccct cccccactat gtgagtggac tctttctggg
     1621 aattggcctt ggattcatga ctgcagtttg cgtgatttgg ttttttacac caccaagtgc
     1681 tcataaatat cacaagttac acaaaaatct gcgacactgg aacacaagat ctctggatat
     1741 caaagaacct gaaatactga agggatggat gaatgagatt tacaactatg atccagaaac
     1801 ctaccatgcg actttgacac attcagtctt tgttcgactt gagggtggaa ccttaagact
     1861 ttcaaagccc aataaaaata tatccaggag ggccagctac aatgaaccca agccagaggt
     1921 cacctacatc agccagaaaa tctatgacct ctcagacagc aagatttatc ttgtacctaa
     1981 aactttggct cgaaagcgaa tctggaataa aaagtacccc atttgtatcg agcttggtca
     2041 gcaagatgac tttatgtcta aagctcagac tgataaggag acttcagaag agaagccgcc
     2101 agctgaggga agtgaggacc ctaagaagcc accccgccct caggagggaa caagatctag
     2161 ccagcgagat cagatactct atctctttgg gagaactggc cgagaaaaag aggaatggtt
     2221 taggagattt attctggcat ctaagctaaa gtcggaaatc aagaagtcat cgggtgtctc
     2281 tggaggtaaa ccagggcttt tgcctgcaca cagcagacac aacagtccgt ccgggcacct
     2341 gacccacagc cgcagcagca gcaaaggcag tgtggaggag atcatgtcac agccaaagca
     2401 gaaggagctg gcaggcagcg tgcggcagaa gatgcttctc gactacagcg tgtacatggg
     2461 caggtgtgtc ccccaggaaa gccgaagccc ccagaggagc cccctgcaga gtgcggagag
     2521 cagccccaca gctgggaaga agttgccaga ggttccaccc tctgaggagg aagaacagga
     2581 agcctgggtg aatgccttgc ttggaagaat attttgggac ttcttaggag agaaatactg
     2641 gtctgatctg gtgtctaaga agatccaaat gaaactcagc aaaataaagc tcccctactt
     2701 tatgaatgag ctcactctga cggaacttga catgggcgtg gctgtgccaa aaatcctcca
     2761 ggccttcaag ccttacgttg atcaccaagg actctggatt gatttggaaa tgtcctacaa
     2821 tgggtccttt ctgatgactc tcgagaccaa aatgaatttg accaaactag gtaaagagcc
     2881 tcttgttgaa gccctgaagg ttggagaaat tggcaaagaa ggttgcaggc cccgggcatt
     2941 ctgtctggcg gacagcgatg aggaatcctc cagcgctggc tcctccgagg aagacgatgc
     3001 cccagagccc agcgggggag acaaacagct cctcccaggg gctgaagggt acgttggagg
     3061 tcatcgaaca agtaagatta tgaggtttgt tgataaaatt accaagtcaa aatatttcca
     3121 aaaagcaaca gagacagagt ttattaaaaa gaagatcgaa gaagtctcca acacacccct
     3181 gctgctcact gttgaagtac aagaatgtag aggaaccttg gcggtcaaca ttccaccacc
     3241 cccgactgac cgagtatggt atggtttccg aaagccacca catgtggagc tgaaagctcg
     3301 gccaaaactt ggagagagag aagtgacttt agttcatgtg acagactgga tagagaagaa
     3361 actggagcaa gagtttcaga aagtttttgt catgccaaac atggatgatg tttatatcac
     3421 tataatgcac tcagccatgg accctcgctc tacttcctgc ctcctgaaag acccacctgt
     3481 ggaggctgct gatcagccat gatgggtgat gtcagatgtt ccccatattg tgacatcgag
     3541 ctggatgtgt ggggttcttg gccgccatct gtactgtagc actggcctct gtgccacagc
     3601 tactgtttct taaaggactg cttctgccct ctgcctgcca gtgcccattc cactgtgagg
     3661 tgtcattccc tgcatctagt gacaactgtc tggattgcct gctgcaaagc tttgatttgg
     3721 caaaggagac catggaagaa tcatggtgga tccagaagtt atacgtgacc cacaccatgg
     3781 cttttaaaag tctacccatg tttgtggcag caaatgagca cagtaagagc aaagctgaac
     3841 aacttgcctc ctctactcct ccaaagcttt tcttcaggca gccggtgcac agtggacttt
     3901 ttcacttcta tactttgtat gcggccttcc acacttccag agaatgtcag tgtgcaatgt
     3961 gtctggaggg tggggagagg aattctgtga gccttttcat ttcggtgaca gaagagatgg
     4021 gcagagcaac ttattttcca cattaaattg tgcatttggg aagcaagtag ccatagtaca
     4081 cacacaacac gctatcagct tgggtaagga cagtgggatt tatgtgaaca tcaggcaaag
     4141 ccatgagatc aaaccatccc aagcctttca ccaatgaggt acaaccacct gggggctagc
     4201 taatcttgaa tgttttcctg agacaggagc gtatgtgaaa acatcaaaca ctgcacatga
     4261 caggatgggt cctctcatac agatgggatg gggttagaaa gccagagcca gtttttccat
     4321 ctggcgtttc ctgtgtcctc caggtttata tgggaatcga aacagtttgt taatctgatt
     4381 gggagagttc catgggcaga tttcccttcc tgaaggccaa aacggagaac tgctctcttt
     4441 aattatttca agagtcaaga ccaaaagttt gctcagcatc acactacatc tcaaaattaa
     4501 tgttgccaac ttaattttgt gcatttgtgt cagaatgttt agtttacaag gttgggggct
     4561 ctctttgctt cgagaagtaa acctaatacc atttttttat tgtttaaagc tgcattcaac
     4621 gtcaaaatta ccttgggtaa cttttgataa cttacatgtg tggacaaagc taatagtggt
     4681 tttttaaaca gcaccttgcc tgaacatgac tttaaagaaa ttaatatatt gaaaacatgt
     4741 ttgaaccctt attttaattg caccattaaa acatttgact taaattgttt gaccattcca
     4801 gttggtgtac tgttctgatt tttcgttgtg taggccgatc tgcctgtcag agtccacgtg
     4861 tcctggtcac tggtctttat aattgttgtg caataactaa aggctaagga ctagatgcac
     4921 tatcgtgtaa agagattaca catgactgta ccatgttgca cttaatcaaa tagtatgtgg
     4981 ggatttaaaa tcgcttgcat tgtttcacaa aataaatatc tcaatgtcaa atactagata
     5041 agcatctaag tcatttctac ggaatcctgt tcagataggg gcacaataaa atgagtacag
     5101 agcaccgggg ccctcacctg gcaatcgcag ctttcattta ctgcgttgat cactgcccag
     5161 tcctaaggct acaaagccat cctcactaca tccttcaaac tatgtgccat tatcttcagc
     5221 ccacatttaa agaatccagt gaaa
//
