LOCUS       NM_207459               1935 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens testis expressed 19 (TEX19), mRNA.
ACCESSION   NM_207459
VERSION     NM_207459.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Alzahrani,F.A., Hawsawi,Y.M., Altayeb,H.N., Alsiwiehri,N.O.,
            Alzahrani,O.R., Alatwi,H.E., Al-Amer,O.M., Alomar,S. and Mansour,L.
  TITLE     In silico modeling of the interaction between TEX19 and LIRE1, and
            analysis of TEX19 gene missense SNPs
  JOURNAL   Mol Genet Genomic Med 9 (7), e1707 (2021)
   PUBMED   34036740
  REMARK    GeneRIF: In silico modeling of the interaction between TEX19 and
            LIRE1, and analysis of TEX19 gene missense SNPs.
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1935)
  AUTHORS   Xu,Z., Tang,H., Zhang,T., Sun,M., Han,Q., Xu,J., Wei,M. and Yu,Z.
  TITLE     TEX19 promotes ovarian carcinoma progression and is a potential
            target for epitope vaccine immunotherapy
  JOURNAL   Life Sci 241, 117171 (2020)
   PUBMED   31843525
  REMARK    GeneRIF: High TEX19 expression is associated with ovarian carcinoma
            progression.
REFERENCE   5  (bases 1 to 1935)
  AUTHORS   MacLennan,M., Garcia-Canadas,M., Reichmann,J., Khazina,E.,
            Wagner,G., Playfoot,C.J., Salvador-Palomeque,C., Mann,A.R.,
            Peressini,P., Sanchez,L., Dobie,K., Read,D., Hung,C.C.,
            Eskeland,R., Meehan,R.R., Weichenrieder,O., Garcia-Perez,J.L. and
            Adams,I.R.
  TITLE     Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in
            mouse embryonic stem cells
  JOURNAL   Elife 6, e26152 (2017)
   PUBMED   28806172
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1935)
  AUTHORS   Planells-Palop,V., Hazazi,A., Feichtinger,J., Jezkova,J.,
            Thallinger,G., Alsiwiehri,N.O., Almutairi,M., Parry,L.,
            Wakeman,J.A. and McFarlane,R.J.
  TITLE     Human germ/stem cell-specific gene TEX19 influences cancer cell
            proliferation and cancer prognosis
  JOURNAL   Mol Cancer 16 (1), 84 (2017)
   PUBMED   28446200
  REMARK    GeneRIF: TEX19 is required to drive cell proliferation in a range
            of cancer cell types, possibly mediated via an oncogenic transcript
            regulation mechanism. TEX19 expression is linked to a poor
            prognosis for some cancers and collectively these findings indicate
            that not only can TEX19 expression serve as a novel cancer
            biomarker
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1935)
  AUTHORS   Zhong,J., Chen,Y., Liao,X., Li,J., Wang,H., Wu,C., Zou,X., Yang,G.,
            Shi,J., Luo,L., Liu,L., Deng,J. and Tang,A.
  TITLE     Testis expressed 19 is a novel cancer-testis antigen expressed in
            bladder cancer
  JOURNAL   Tumour Biol 37 (6), 7757-7765 (2016)
   PUBMED   26695143
  REMARK    GeneRIF: TEX19 expression in normal tissue is restricted to human
            testis. TEX19 mRNA expression was detected in 60 % of bladder
            cancer samples, whereas 58.20 % were positive for TEXT19 protein
            expression. Compared to low-grade tumors, TEX19 exhibited increased
            expression in high-grade tumors, from 53.69 to 77.14 %,
            respectively. TEX19 was also expressed in all six bladder cancer
            cell lines.
REFERENCE   8  (bases 1 to 1935)
  AUTHORS   Tarabay,Y., Kieffer,E., Teletin,M., Celebi,C., Van Montfoort,A.,
            Zamudio,N., Achour,M., El Ramy,R., Gazdag,E., Tropel,P., Mark,M.,
            Bourc'his,D. and Viville,S.
  TITLE     The mammalian-specific Tex19.1 gene plays an essential role in
            spermatogenesis and placenta-supported development
  JOURNAL   Hum Reprod 28 (8), 2201-2214 (2013)
   PUBMED   23674551
REFERENCE   9  (bases 1 to 1935)
  AUTHORS   Kuntz,S., Kieffer,E., Bianchetti,L., Lamoureux,N., Fuhrmann,G. and
            Viville,S.
  TITLE     Tex19, a mammalian-specific protein with a restricted expression in
            pluripotent stem cells and germ line
  JOURNAL   Stem Cells 26 (3), 734-744 (2008)
   PUBMED   18096721
  REMARK    GeneRIF: Tex19 is a mammalian-specific protein duplicated in mouse
            and rat, renamed Tex19.1 and Tex19.2, whereas only one form is
            found in human.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036191.1 and BC057820.1.
            
            On Nov 22, 2018 this sequence version replaced NM_207459.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036191.1, BC057820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333437.5/ ENSP00000331500.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1871              BC036191.1         1-1871
            1872-1935           BC057820.1         1873-1936
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1935
                     /gene="TEX19"
                     /note="testis expressed 19"
                     /db_xref="GeneID:400629"
                     /db_xref="HGNC:HGNC:33802"
                     /db_xref="MIM:615647"
     exon            1..39
                     /gene="TEX19"
                     /inference="alignment:Splign:2.1.0"
     exon            40..1935
                     /gene="TEX19"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..805
                     /gene="TEX19"
                     /note="testis-expressed sequence 19 protein"
                     /codon_start=1
                     /product="testis-expressed protein 19"
                     /protein_id="NP_997342.1"
                     /db_xref="CCDS:CCDS11809.1"
                     /db_xref="GeneID:400629"
                     /db_xref="HGNC:HGNC:33802"
                     /db_xref="MIM:615647"
                     /translation="MCPPVSMRYEEEGMSYLYASWMYQLQHGDQLSICFTCFKAAFLD
                     FKDLLESEDWEEDNWDPELMEHTEAESEQEGSSGMELSWGQSPGQPVQGGSEAWGPGT
                     LAAAPEGLEDAGLDPHFVPTELWPQEAVPLGLGLEDADWTQGLPWRFEELLTCSHWPS
                     FFPS"
     regulatory      1917..1922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX19"
                     /note="hexamer: CATAAA"
     polyA_site      1935
                     /gene="TEX19"
                     /note="major polyA site"
ORIGIN      
        1 ctttccctgg gtgcccacat gaacagagac accaggatgc tctcctgaga ccacagcaac
       61 tgcagaagct gaagacattt ccagaagttc aagcttccac cctctgcagg tccccactga
      121 gctgggaccc aggtcatcca ccccacccca aatccctgga taggaaaccc ctttctcctc
      181 ctgctccttg tccccttcat ccctgccgcc cagcatccta ctggcctcag cacctgtggc
      241 cagaccgtcc aagatcctct gaaggcccag ctcttgctgt ccaccccggc agtaggcagg
      301 cagcctggcc atgtgccctc cggtcagcat gcggtatgag gaagagggca tgtcctacct
      361 ctacgcctcc tggatgtatc agcttcaaca tggagatcag ctaagcattt gcttcacctg
      421 cttcaaggct gcctttctag actttaaaga cttgctggag tcagaggact gggaagaaga
      481 caactgggac cctgagctga tggagcacac tgaggcagag tcagagcagg aggggtcctc
      541 agggatggag ctgagctggg ggcagagccc aggacagcct gtgcaggggg gctctgaggc
      601 atgggggcca gggaccctgg cagcagcccc agaagggttg gaagatgcag gtctggaccc
      661 ccactttgtc cccactgaac tatggcctca ggaggctgtg cccctgggcc tgggccttga
      721 ggatgctgac tggacccagg gtcttccctg gagatttgag gagcttctta cctgctcaca
      781 ctggccaagc ttctttcctt catagcaggg gtttctcaaa gtggacctgc ccccagggga
      841 gcccgtggtg ttgaagctgg gcattacctg ggcagtggac cctgccgagg ctgaggccta
      901 gttactggcc ctgcagcttg tctccatggt gggctgctat gataccatct acctacagaa
      961 gatgacccca gacagggccc tgaggacccc agggcagcac tggaaattgc tgctggagcc
     1021 tggtgaagtg tgggtggtga gactccaaga tgcaccccaa gagcaggacc tgcactggtg
     1081 gatgctgagc attctagaaa catcgttaac aggacacagg gcagagctgg tccctgcagc
     1141 ctcagccctg cagaagagga ttcaccatag tctcttattc accctggacc aacagggaga
     1201 gcaagaaggg agactcagcc tgtaagccac agtcctccag ccaagaacag gatctcagca
     1261 cccctgagac acagagcagg ggtcctgagg aaagcctggc tgttgcagga gcctcggcca
     1321 tgggggagct gccctgtttc cagcctcagt ccagggcccc agaactgaga gactaaggct
     1381 catgtagctg ccattgtcct gggcacacca ggacatcaga gactgggaag ggccagcaat
     1441 tgctgttcca caacagccag gggagcagtt ggcaaaggaa acatggggag caactttagg
     1501 ggctgggaga tagggcctgt tgtggcctca gagggaagca ttacaaatat tcataacctg
     1561 gaaacaagtt cttaccagtt gattgtcaca tagttctgga tgtgttggcc tgaatggctg
     1621 ttgtgctgct tgtgacatgg ggggcagggc acagaacttg tgcctatttc accttggcca
     1681 tggggaggga cattgcttgt aaaacacatg ctctgcagaa cacaccagaa tctgtggtga
     1741 cctggatgtg ttctcgactt tgccaggaca atctcagggg tgccacaaga ccctgtcagc
     1801 agcactagga tctctggtct acagtggagg gagagctggt tttaaatgtt ggccgttgat
     1861 gcaatttaac catttaattc ctgttgctct atatgttgtt tttaatttta aaaagtcata
     1921 aaagctttca aacaa
//
