LOCUS       NM_031275               1144 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens testis expressed 12 (TEX12), mRNA.
ACCESSION   NM_031275
VERSION     NM_031275.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1144)
  AUTHORS   Bui,M.D., Luong,T.L.A., Tran,H.D., Duong,T.T.H., Nguyen,T.N.,
            Nguyen,D.T., Nguyen,T.D. and Nong,V.H.
  TITLE     A Novel Frameshift Microdeletion of the TEX12 Gene Caused
            Infertility in Two Brothers with Nonobstructive Azoospermia
  JOURNAL   Reprod Sci 30 (9), 2876-2881 (2023)
   PUBMED   37012491
  REMARK    GeneRIF: A Novel Frameshift Microdeletion of the TEX12 Gene Caused
            Infertility in Two Brothers with Nonobstructive Azoospermia.
REFERENCE   2  (bases 1 to 1144)
  AUTHORS   Sandhu,S., Sou,I.F., Hunter,J.E., Salmon,L., Wilson,C.L.,
            Perkins,N.D., Hunter,N., Davies,O.R. and McClurg,U.L.
  TITLE     Centrosome dysfunction associated with somatic expression of the
            synaptonemal complex protein TEX12
  JOURNAL   Commun Biol 4 (1), 1371 (2021)
   PUBMED   34880391
  REMARK    GeneRIF: Centrosome dysfunction associated with somatic expression
            of the synaptonemal complex protein TEX12.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1144)
  AUTHORS   Dunce,J.M., Salmon,L.J. and Davies,O.R.
  TITLE     Structural basis of meiotic chromosome synaptic elongation through
            hierarchical fibrous assembly of SYCE2-TEX12
  JOURNAL   Nat Struct Mol Biol 28 (8), 681-693 (2021)
   PUBMED   34373646
  REMARK    GeneRIF: Structural basis of meiotic chromosome synaptic elongation
            through hierarchical fibrous assembly of SYCE2-TEX12.
REFERENCE   4  (bases 1 to 1144)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1144)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1144)
  AUTHORS   Matteini,A.M., Li,J., Lange,E.M., Tanaka,T., Lange,L.A.,
            Tracy,R.P., Wang,Y., Biggs,M.L., Arking,D.E., Fallin,M.D.,
            Chakravarti,A., Psaty,B.M., Bandinelli,S., Ferrucci,L., Reiner,A.P.
            and Walston,J.D.
  TITLE     Novel gene variants predict serum levels of the cytokines IL-18 and
            IL-1ra in older adults
  JOURNAL   Cytokine 65 (1), 10-16 (2014)
   PUBMED   24182552
REFERENCE   7  (bases 1 to 1144)
  AUTHORS   Davies,O.R., Maman,J.D. and Pellegrini,L.
  TITLE     Structural analysis of the human SYCE2-TEX12 complex provides
            molecular insights into synaptonemal complex assembly
  JOURNAL   Open Biol 2 (7), 120099 (2012)
   PUBMED   22870393
  REMARK    GeneRIF: a model of chromosome synapsis driven by growth of
            SYCE2-TEX12 higher-order structures within the CE of the SC.
REFERENCE   8  (bases 1 to 1144)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1144)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 1144)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC029506.1 and AF285600.1.
            
            On Mar 22, 2007 this sequence version replaced NM_031275.3.
            
            Summary: This gene is similar to a mouse gene that is expressed in
            the testis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029506.1, BI561514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280358.5/ ENSP00000280358.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               BC029506.1         1-167
            168-535             AF285600.1         74-441
            536-1144            BC029506.1         536-1144
FEATURES             Location/Qualifiers
     source          1..1144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     gene            1..1144
                     /gene="TEX12"
                     /note="testis expressed 12"
                     /db_xref="GeneID:56158"
                     /db_xref="HGNC:HGNC:11734"
                     /db_xref="MIM:605791"
     exon            1..116
                     /gene="TEX12"
                     /inference="alignment:Splign:2.1.0"
     exon            117..195
                     /gene="TEX12"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..504
                     /gene="TEX12"
                     /note="testis expressed sequence 12"
                     /codon_start=1
                     /product="testis-expressed protein 12"
                     /protein_id="NP_112565.1"
                     /db_xref="CCDS:CCDS31679.1"
                     /db_xref="GeneID:56158"
                     /db_xref="HGNC:HGNC:11734"
                     /db_xref="MIM:605791"
                     /translation="MMANHLVKPDNRNCKRPRELESPVPDSPQLSSLGKSDSSFSEIS
                     GLFYKDEALEKDLNDVSKEINLMLSTYAKLLSERAAVDASYIDEIDELFKEANAIENF
                     LIQKREFLRQRFTVIANTLHR"
     exon            196..307
                     /gene="TEX12"
                     /inference="alignment:Splign:2.1.0"
     exon            308..359
                     /gene="TEX12"
                     /inference="alignment:Splign:2.1.0"
     exon            360..1144
                     /gene="TEX12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1072..1077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX12"
                     /note="hexamer: AATAAA"
     polyA_site      1096
                     /gene="TEX12"
     regulatory      1120..1125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX12"
                     /note="hexamer: AATAAA"
     polyA_site      1144
                     /gene="TEX12"
                     /note="major polyA site"
ORIGIN      
        1 actccctcgc gttcgctgac gaggaaggtc cccataccgc gaagtacatt ggccttgggg
       61 tggggctgga gggatgggcg cctgtgagaa tgtgacggac tgtgacacaa ggaaggctgg
      121 tgccttcgga atatgatggc aaatcacctt gtaaagcctg ataatagaaa ttgcaagagg
      181 ccaagagaat tggagtctcc agtgccagat agtccacagc tgtcctctct tggaaaatca
      241 gattcatctt tctctgaaat ttccggacta ttttataaag atgaagcctt ggagaaagat
      301 ttaaatgatg tgagcaagga aattaatcta atgttgtcta cctatgcaaa gcttttaagt
      361 gagagagcag cagtagatgc atcttacatt gatgagatag atgaactctt caaagaagcc
      421 aatgctattg aaaactttct aatacaaaaa agagagttcc tgcgacagag gtttacagtg
      481 attgcaaaca cattacacag ataaaatata tacttgaaat aagctgagaa tttaaaccta
      541 ttattgttat aatgaaagaa tgacatttat gctttgaaag ctctcgagtt gttaaagaaa
      601 atgtatatct cgaatagaga aggggaaact ccttgaattt ctaggtttaa aaaggaactt
      661 ttaaattcct taatgttaat attaatgttc atgttaatgt cctaagctgg ccattaacat
      721 gaactacgtc acttttcttt tgagggtcaa atatttagtg cattttatag aagtgtaaat
      781 tatttaaatc ttatgtggat tcttttattt tttccttaaa cttcttagtg tttctgaaac
      841 ttctaaaaaa ggattcagtt aatttataat gtttaataat attatacttt tagaatattt
      901 tgtttaaata tcagatagtt ttggagataa ttttgaaatt ttttttatgg tcaggattat
      961 aaaagaagat taaaacctta gaggtgattt ttccagtttc ttagaatata atgacataac
     1021 tgtgtgctat ttccatttga ttattttcac tattagttat tatgtatgac taataaaagc
     1081 tctcggctta aaattatttt cttgtggtaa aagtagtaaa ataaaaacca gaaattactc
     1141 acca
//
