LOCUS       NM_001130011            1138 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens testis expressed 101 (TEX101), transcript variant 2,
            mRNA.
ACCESSION   NM_001130011
VERSION     NM_001130011.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1138)
  AUTHORS   Yoshitake,H. and Araki,Y.
  TITLE     Role of the Glycosylphosphatidylinositol-Anchored Protein TEX101
            and Its Related Molecules in Spermatogenesis
  JOURNAL   Int J Mol Sci 21 (18), 6628 (2020)
   PUBMED   32927778
  REMARK    GeneRIF: Role of the Glycosylphosphatidylinositol-Anchored Protein
            TEX101 and Its Related Molecules in Spermatogenesis.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1138)
  AUTHORS   Masutani,M., Sakurai,S., Shimizu,T. and Ohto,U.
  TITLE     Crystal structure of TEX101, a glycoprotein essential for male
            fertility, reveals the presence of tandemly arranged Ly6/uPAR
            domains
  JOURNAL   FEBS Lett 594 (18), 3020-3031 (2020)
   PUBMED   32608065
  REMARK    GeneRIF: Crystal structure of TEX101, a glycoprotein essential for
            male fertility, reveals the presence of tandemly arranged Ly6/uPAR
            domains.
REFERENCE   3  (bases 1 to 1138)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1138)
  AUTHORS   Schiza,C., Korbakis,D., Jarvi,K., Diamandis,E.P. and Drabovich,A.P.
  TITLE     Identification of TEX101-associated Proteins Through Proteomic
            Measurement of Human Spermatozoa Homozygous for the Missense
            Variant rs35033974
  JOURNAL   Mol Cell Proteomics 18 (2), 338-351 (2019)
   PUBMED   30429210
  REMARK    GeneRIF: Study provides evidence that spermatozoa of rs35033974
            homozygous men have substantially reduced levels of TEX101 and
            could be used as a model to elucidate the precise TEX101 function.
            Because TEX101 seminal plasma levels were found significantly lower
            in heterozygous than in WT men, rs35033974 status could be
            considered in TEX101 diagnostics.
REFERENCE   5  (bases 1 to 1138)
  AUTHORS   Schiza,C., Korbakis,D., Panteleli,E., Jarvi,K., Drabovich,A.P. and
            Diamandis,E.P.
  TITLE     Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3
            and Selection of Its Disrupting Antibodies
  JOURNAL   Mol Cell Proteomics 17 (12), 2480-2495 (2018)
   PUBMED   30097533
REFERENCE   6  (bases 1 to 1138)
  AUTHORS   Ghafouri-Fard,S., Abbasi,A., Moslehi,H., Faramarzi,N., Taba Taba
            Vakili,S., Mobasheri,M.B. and Modarressi,M.H.
  TITLE     Elevated expression levels of testis-specific genes TEX101 and
            SPATA19 in basal cell carcinoma and their correlation with clinical
            and pathological features
  JOURNAL   Br J Dermatol 162 (4), 772-779 (2010)
   PUBMED   19886887
  REMARK    GeneRIF: The SPATA19 and TEX101 genes may be possible targets for
            cancer immunotherapy and novel markers for early detection of basal
            cell carcinoma.
REFERENCE   7  (bases 1 to 1138)
  AUTHORS   Yin,L.L., Chung,C.M., Chen,J., Fok,K.L., Ng,C.P., Jia,R.R., Ren,X.,
            Zhou,J., Zhang,T., Zhao,X.H., Lin,M., Zhu,H., Zhang,X.H.,
            Tsang,L.L., Bi,Y., Zhou,Z., Mo,F., Wong,N., Chung,Y.W., Sha,J. and
            Chan,H.C.
  TITLE     A suppressor of multiple extracellular matrix-degrading proteases
            and cancer metastasis
  JOURNAL   J Cell Mol Med 13 (9B), 4034-4041 (2009)
   PUBMED   19017363
  REMARK    GeneRIF: NYD-SP8 has a role in regulating ECM degradation,
            providing a novel mechanism that modulates urokinase signalling in
            the suppression of cancer progression
REFERENCE   8  (bases 1 to 1138)
  AUTHORS   Yin,L., Chung,C.M., Huo,R., Liu,H., Zhou,C., Xu,W., Zhu,H.,
            Zhang,J., Shi,Q., Wong,H.Y., Chen,J., Lu,Y., Bi,Y., Zhao,C., Du,Y.,
            Ma,M., Cai,Y., Chen,W.Y., Fok,K.L., Tsang,L.L., Li,K., Ni,Y.,
            Chung,Y.W., Zhou,Z., Sha,J. and Chan,H.C.
  TITLE     A sperm GPI-anchored protein elicits sperm-cumulus cross-talk
            leading to the acrosome reaction
  JOURNAL   Cell Mol Life Sci 66 (5), 900-908 (2009)
   PUBMED   19153666
  REMARK    GeneRIF: identification & function of a novel sperm GPI-anchored
            membrane protein, NYD-SP8; release of NYD-SP8 during sperm-egg
            interaction & binding to cumulus elicits cross-talk between the
            gametes leading to the acrosome reaction
REFERENCE   9  (bases 1 to 1138)
  AUTHORS   Teng,X., Yang,J., Xie,Y., Ni,Z., Hu,R., Shi,L., Lin,Z., Hu,L.,
            Zhao,G., Ding,X. and Kong,X.
  TITLE     A novel spermatogenesis-specific uPAR gene expressed in human and
            mouse testis
  JOURNAL   Biochem Biophys Res Commun 342 (4), 1223-1227 (2006)
   PUBMED   16516155
REFERENCE   10 (bases 1 to 1138)
  AUTHORS   Takayama,T., Mishima,T., Mori,M., Ishikawa,T., Takizawa,T.,
            Goto,T., Suzuki,M., Araki,Y., Matsubara,S. and Takizawa,T.
  TITLE     TEX101 is shed from the surface of sperm located in the caput
            epididymidis of the mouse
  JOURNAL   Zygote 13 (4), 325-333 (2005)
   PUBMED   16388701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018758.2 and AY359077.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001130011.2.
            
            Transcript Variant: This variant (2) has multiple differences in
            the 5' end and uses a downstream translation start codon, compared
            to variant 1. The resulting protein (isoform 2) is shorter when
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359077.1, AY014285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000598265.2/ ENSP00000472769.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC018758.2         46803-46951
            150-252             AC018758.2         47794-47896
            253-1138            AY359077.1         228-1113
FEATURES             Location/Qualifiers
     source          1..1138
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1138
                     /gene="TEX101"
                     /gene_synonym="CT131; GTPR867; NYD-SP8; PRO1884; SGRG;
                     SPATA44; TES101RP"
                     /note="testis expressed 101"
                     /db_xref="GeneID:83639"
                     /db_xref="HGNC:HGNC:30722"
                     /db_xref="MIM:612665"
     exon            1..149
                     /gene="TEX101"
                     /gene_synonym="CT131; GTPR867; NYD-SP8; PRO1884; SGRG;
                     SPATA44; TES101RP"
                     /inference="alignment:Splign:2.1.0"
     exon            150..252
                     /gene="TEX101"
                     /gene_synonym="CT131; GTPR867; NYD-SP8; PRO1884; SGRG;
                     SPATA44; TES101RP"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..938
                     /gene="TEX101"
                     /gene_synonym="CT131; GTPR867; NYD-SP8; PRO1884; SGRG;
                     SPATA44; TES101RP"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; cancer/testis antigen 131; testis expressed
                     sequence 101; testis-specific protein TES101RP;
                     testis-expressed protein 101; scleroderma-associated
                     autoantigen; cell surface receptor NYD-SP8;
                     spermatogenesis associated 44; spermatogenesis-related
                     gene protein; TES101-reactive protein; testis-expressed
                     sequence 101 protein"
                     /codon_start=1
                     /product="testis-expressed protein 101 isoform 2
                     precursor"
                     /protein_id="NP_001123483.1"
                     /db_xref="CCDS:CCDS59393.1"
                     /db_xref="GeneID:83639"
                     /db_xref="HGNC:HGNC:30722"
                     /db_xref="MIM:612665"
                     /translation="MGTPRIQHLLILLVLGASLLTSGLELYCQKGLSMTVEADPANMF
                     NWTTEEVETCDKGALCQETILIIKAGTETAILATKGCIPEGEEAITIVQHSSPPGLIV
                     TSYSNYCEDSFCNDKDSLSQFWEFSETTASTVSTTLHCPTCVALGTCFSAPSLPCPNG
                     TTRCYQGKLEITGGGIESSVEVKGCTAMIGCRLMSGILAVGPMFVREACPHQLLTQPR
                     KTENGATCLPIPVWGLQLLLPLLLPSFIHFS"
     exon            253..396
                     /gene="TEX101"
                     /gene_synonym="CT131; GTPR867; NYD-SP8; PRO1884; SGRG;
                     SPATA44; TES101RP"
                     /inference="alignment:Splign:2.1.0"
     exon            397..579
                     /gene="TEX101"
                     /gene_synonym="CT131; GTPR867; NYD-SP8; PRO1884; SGRG;
                     SPATA44; TES101RP"
                     /inference="alignment:Splign:2.1.0"
     exon            580..708
                     /gene="TEX101"
                     /gene_synonym="CT131; GTPR867; NYD-SP8; PRO1884; SGRG;
                     SPATA44; TES101RP"
                     /inference="alignment:Splign:2.1.0"
     exon            709..1138
                     /gene="TEX101"
                     /gene_synonym="CT131; GTPR867; NYD-SP8; PRO1884; SGRG;
                     SPATA44; TES101RP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1119..1124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX101"
                     /gene_synonym="CT131; GTPR867; NYD-SP8; PRO1884; SGRG;
                     SPATA44; TES101RP"
                     /note="hexamer: AATAAA"
     polyA_site      1138
                     /gene="TEX101"
                     /gene_synonym="CT131; GTPR867; NYD-SP8; PRO1884; SGRG;
                     SPATA44; TES101RP"
                     /note="major polyA site"
ORIGIN      
        1 aagagaatgc caagcccggg gagaaggcgt tccgggcctc aactttggcg tcgtgagatt
       61 cttgtgaggc gtctgcctgg aagccggcag caattttgct tctttaaaga gaaaaagaag
      121 gctagggact cagattcctg gattctgaga tccagaccag ctcctcccag acctctccag
      181 aagaagccat gggaacccct cgtatccagc atttgctgat cctcctggtc ctaggagcct
      241 ccctcctgac ctcgggccta gagctgtatt gtcaaaaggg tctgtccatg actgtggaag
      301 cagatccagc caatatgttt aactggacca cagaggaagt ggagacttgt gacaaagggg
      361 cactttgcca ggaaaccata ctaataatta aagcagggac tgagacagcc attttggcca
      421 cgaagggctg catcccggaa ggggaggagg ccataacaat tgtccagcac tcttcacctc
      481 ccggcctgat cgtgacctcc tacagtaact actgtgagga ttccttctgt aatgacaaag
      541 acagcctgtc tcagttttgg gagttcagtg agaccacagc ttccactgtg tcaacaaccc
      601 tccattgtcc aacctgtgtg gctttgggga cctgtttcag tgctccttct cttccctgtc
      661 ccaatggtac aactcgatgc tatcaaggaa aacttgagat cactggaggt ggcattgagt
      721 cgtctgtgga ggtcaaaggc tgtacagcca tgattggctg caggctgatg tctggaatct
      781 tagcagtagg acccatgttt gtgagggaag cgtgcccaca tcagctgctc actcaacctc
      841 gaaagactga aaatggggcc acctgtcttc ccattcctgt ttgggggtta cagctactgc
      901 tgccattgct gctgccatca tttattcact tttcctaaga aggcacttct gggcctgggt
      961 ctgaggacat cttttttgac tgggagcctt cttactgttg aggttcaaca agctgaggag
     1021 tagatgggaa tttgagggag aatacagaga tactatgaac gtatttgaca tttttaatac
     1081 aatttctgct ataatttttg tatgcagtag gcgttactaa taaacatttc tgctgtga
//
