LOCUS       NM_017746               3077 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens testis expressed 10 (TEX10), transcript variant 1,
            mRNA.
ACCESSION   NM_017746
VERSION     NM_017746.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3077)
  AUTHORS   Gordon,J., Chapus,F.L., Viverette,E.G., Williams,J.G.,
            Deterding,L.J., Krahn,J.M., Borgnia,M.J., Rodriguez,J., Warren,A.J.
            and Stanley,R.E.
  TITLE     Cryo-EM reveals the architecture of the PELP1-WDR18 molecular
            scaffold
  JOURNAL   Nat Commun 13 (1), 6783 (2022)
   PUBMED   36351913
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3077)
  AUTHORS   Liang,J.H., Xu,Q.D. and Gu,S.G.
  TITLE     LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis
            modulates tumorigenesis and cancer stem cell-like properties in
            liver cancer
  JOURNAL   Bioengineered 13 (2), 4285-4300 (2022)
   PUBMED   35156514
  REMARK    GeneRIF: LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10
            axis modulates tumorigenesis and cancer stem cell-like properties
            in liver cancer.
REFERENCE   3  (bases 1 to 3077)
  AUTHORS   Luo,S., Wang,W., Feng,J. and Li,R.
  TITLE     TEX10 Promotes the Tumorigenesis and Radiotherapy Resistance of
            Urinary Bladder Carcinoma by Stabilizing XRCC6
  JOURNAL   J Immunol Res 2021, 5975893 (2021)
   PUBMED   34966825
  REMARK    GeneRIF: TEX10 Promotes the Tumorigenesis and Radiotherapy
            Resistance of Urinary Bladder Carcinoma by Stabilizing XRCC6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3077)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3077)
  AUTHORS   Liu,Y., Xu,G. and Li,L.
  TITLE     LncRNA GATA3-AS1-miR-30b-5p-Tex10 axis modulates tumorigenesis in
            pancreatic cancer
  JOURNAL   Oncol Rep 45 (5) (2021)
   PUBMED   33760161
  REMARK    GeneRIF: LncRNA GATA3AS1miR30b5pTex10 axis modulates tumorigenesis
            in pancreatic cancer.
REFERENCE   6  (bases 1 to 3077)
  AUTHORS   Ding,J., Huang,X., Shao,N., Zhou,H., Lee,D.F., Faiola,F.,
            Fidalgo,M., Guallar,D., Saunders,A., Shliaha,P.V., Wang,H.,
            Waghray,A., Papatsenko,D., Sanchez-Priego,C., Li,D., Yuan,Y.,
            Lemischka,I.R., Shen,L., Kelley,K., Deng,H., Shen,X. and Wang,J.
  TITLE     Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in
            Pluripotency and Reprogramming
  JOURNAL   Cell Stem Cell 16 (6), 653-668 (2015)
   PUBMED   25936917
  REMARK    GeneRIF: Tex10 is a core component of the pluripotency network.
REFERENCE   7  (bases 1 to 3077)
  AUTHORS   Fanis,P., Gillemans,N., Aghajanirefah,A., Pourfarzad,F.,
            Demmers,J., Esteghamat,F., Vadlamudi,R.K., Grosveld,F.,
            Philipsen,S. and van Dijk,T.B.
  TITLE     Five friends of methylated chromatin target of
            protein-arginine-methyltransferase[prmt]-1 (chtop), a complex
            linking arginine methylation to desumoylation
  JOURNAL   Mol Cell Proteomics 11 (11), 1263-1273 (2012)
   PUBMED   22872859
  REMARK    GeneRIF: Recruitment of the protein complex 5FMC to Zbp-89, a
            zinc-finger transcription factor, affects its sumoylation status
            and transactivation potential.[5FMC]
REFERENCE   8  (bases 1 to 3077)
  AUTHORS   Yoshitake,H., Yokoi,H., Ishikawa,H., Maruyama,M., Endo,S.,
            Nojima,M., Yoshida,K., Yoshikawa,H., Suzuki,F., Takamori,K.,
            Fujiwara,H. and Araki,Y.
  TITLE     Overexpression of TEX101, a potential novel cancer marker, in head
            and neck squamous cell carcinoma
  JOURNAL   Cancer Biomark 12 (3), 141-148 (2012)
   PUBMED   23481573
  REMARK    GeneRIF: Data suggest that TEX101 is a cancer-related protein and
            may be useful as a marker for prognosis/diagnosis of and neck
            squamous cell carcinomas (HNSCC).
REFERENCE   9  (bases 1 to 3077)
  AUTHORS   Finkbeiner,E., Haindl,M. and Muller,S.
  TITLE     The SUMO system controls nucleolar partitioning of a novel
            mammalian ribosome biogenesis complex
  JOURNAL   EMBO J 30 (6), 1067-1078 (2011)
   PUBMED   21326211
  REMARK    GeneRIF: These data define the PELP1-TEX10-WDR18 complex as a
            regulator of ribosome biogenesis and suggests that its
            SUMO-controlled distribution coordinates the rate of ribosome
            formation.
REFERENCE   10 (bases 1 to 3077)
  AUTHORS   Dou,Y., Milne,T.A., Tackett,A.J., Smith,E.R., Fukuda,A.,
            Wysocka,J., Allis,C.D., Chait,B.T., Hess,J.L. and Roeder,R.G.
  TITLE     Physical association and coordinate function of the H3 K4
            methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
  JOURNAL   Cell 121 (6), 873-885 (2005)
   PUBMED   15960975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP336313.1, BC030652.2, AB060968.1 and AA436854.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017746.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB060968.1, BC030652.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374902.9/ ENSP00000364037.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               BP336313.1         36-164
            130-1410            BC030652.2         1-1281
            1411-1756           AB060968.1         1362-1707
            1757-2912           BC030652.2         1628-2783
            2913-3077           AA436854.1         8-172               c
FEATURES             Location/Qualifiers
     source          1..3077
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..3077
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /note="testis expressed 10"
                     /db_xref="GeneID:54881"
                     /db_xref="HGNC:HGNC:25988"
                     /db_xref="MIM:616717"
     exon            1..171
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            172..360
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2970
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testis expressed gene 10; testis-expressed sequence 10
                     protein; testis-expressed protein 10"
                     /codon_start=1
                     /product="testis-expressed protein 10 isoform 1"
                     /protein_id="NP_060216.2"
                     /db_xref="CCDS:CCDS6748.1"
                     /db_xref="GeneID:54881"
                     /db_xref="HGNC:HGNC:25988"
                     /db_xref="MIM:616717"
                     /translation="MTKKRKRQHDFQKVKLKVGKKKPKLQNATPTNFKTKTIHLPEQL
                     KEDGTLPTNNRKLNIKDLLSQMHHYNAGVKQSALLGLKDLLSQYPFIIDAHLSNILSE
                     VTAVFTDKDANVRLAAVQLLQFLAPKIRAEQISPFFPLVSAHLSSAMTHITEGIQEDS
                     LKVLDILLEQYPALITGRSSILLKNFVELISHQQLSKGLINRDRSQSWILSVNPNRRL
                     TSQQWRLKVLVRLSKFLQALADGSSRLRESEGLQEQKENPHATSNSIFINWKEHANDQ
                     QHIQVYENGGSQPNVSSQFRLRYLVGGLSGVDEGLSSTENLKGFIEIIIPLLIECWVE
                     AVPPQLATPVGNGIEREPLQVMQQVLNIISLLWKLSKQQDETHKLESWLRKNYLIDFK
                     HHFMSRFPYVLKEITKHKRKEPNKSIKHCTVLSNNIDHLLLNLTLSDIMVSLANASTL
                     QKDCSWIEMIRKFVTETLEDGSRLNSKQLNRLLGVSWRLMQIQPNREDTETLIKAVYT
                     LYQQRGLILPVRTLLLKFFSKIYQTEELRSCRFRYRSKVLSRWLAGLPLQLAHLGSRN
                     PELSTQLIDIIHTAAARANKELLKSLQATALRIYDPQEGAVVVLPADSQQRLVQLVYF
                     LPSLPADLLSRLSRCCIMGRLSSSLAAMLIGILHMRSSFSGWKYSAKDWLMSDVDYFS
                     FLFSTLTGFSKEELTWLQSLRGVPHVIQTQLSPVLLYLTDLDQFLHHWDVTEAVFHSL
                     LVIPARSQNFDILQSAISKHLVGLTVIPDSTAGCVFGVICKLLDHTCVVSETLLPFLA
                     SCCYSLLYFLLTIEKGEAEHLRKRDKLWGVCVSILALLPRVLRLMLQSLRVNRVGPEE
                     LPVVGQLLRLLLQHAPLRTHMLTNAILVQQIIKNITTLKSGSVQEQWLTDLHYCFNVY
                     ITGHPQGPSALATVY"
     exon            361..1073
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1317
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1430
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1669
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1805
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1981
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2159
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2248
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2382
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2463
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2645
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2856
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..3077
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3055..3060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /note="hexamer: ATTAAA"
     polyA_site      3077
                     /gene="TEX10"
                     /gene_synonym="bA208F1.2; Ipi1"
                     /note="major polyA site"
ORIGIN      
        1 cctgatttcc gggcggcgga aggagacgcg gccgcgtgag gacgaggcta tttgaaaaca
       61 cgctccggga gctagagcct gaggtcggcg gcgcacgctg ttgccccgtg ggcttctgct
      121 ccctcgcttg tcttctcggg cttctcgccc cggccgcggc cgggtcctca gtagtcgaga
      181 atgactaaaa aaagaaaacg ccaacatgat tttcaaaaag taaaattgaa agttggtaaa
      241 aagaagccca agttacaaaa tgctactcct acaaacttta aaacaaagac tatacatctg
      301 cctgagcaac tcaaagagga tggaacactt ccaacaaaca atagaaaact taacataaag
      361 gatttgctgt cacagatgca tcactacaat gctggggtta aacaaagtgc tcttcttgga
      421 cttaaagacc ttttgtctca atacccattt ataattgatg cacacctttc aaacatatta
      481 agtgaagtga ctgctgtgtt tacagataaa gatgctaatg tacgattagc agcagttcaa
      541 cttcttcaat tcctggcccc caaaatacga gctgaacaaa tttctccatt ttttcctttg
      601 gtaagtgccc atctctctag tgccatgact cacattactg aaggaattca ggaggactct
      661 ttaaaagttt tggacattct gctggaacag tacccagctc taattactgg ccgtagcagc
      721 atattgctta agaattttgt agaacttatt tctcatcagc agctgtccaa aggactgata
      781 aatagagaca gatcccagtc ctggatactt tctgtaaatc ctaatcggag actcacttct
      841 cagcaatgga ggctgaaagt cttagtgaga ctcagtaaat tccttcaggc cttggcagat
      901 ggatccagta ggttgagaga aagtgaagga cttcaggaac agaaagaaaa tccccatgcc
      961 actagcaact ccatttttat caactggaag gaacatgcca acgaccagca acacatccag
     1021 gtttatgaaa atgggggttc acagccaaat gtcagttcac agttcaggct acggtatctg
     1081 gttggaggac tgagtggtgt ggatgaaggc ctgtcatcta ctgaaaacct gaaaggattt
     1141 attgagataa taattccatt gctaattgaa tgctgggttg aagctgtacc tccacaacta
     1201 gctactcctg ttgggaatgg tatagaacga gaacctctac aggttatgca gcaagttctt
     1261 aatattattt cccttctgtg gaaactctct aaacaacagg atgaaaccca taaattggag
     1321 tcatggcttc gaaagaacta ccttattgat tttaaacacc attttatgag tcgttttcca
     1381 tatgtcttaa aagaaataac caagcacaaa aggaaagagc caaataaaag catcaagcat
     1441 tgcacagttc tctccaataa catagatcat ctcttactga atttaacact gtctgatatc
     1501 atggtctccc tggcaaatgc gtcaactttg cagaaggatt gcagttggat agaaatgata
     1561 aggaaatttg taacagagac ccttgaagat ggctctaggc taaatagtaa gcaactgaac
     1621 agattgctgg gagtatcctg gaggttaatg caaatacagc caaacagaga ggacacagag
     1681 actcttatta aggcagttta tacattatat cagcagaggg gccttatcct tccagttcgg
     1741 actttgttat tgaagttttt cagtaaaatc tatcagacag aagaactgag atcttgtaga
     1801 ttcagatatc gtagtaaagt gttatcccgt tggctggctg gcttaccatt gcaacttgct
     1861 catcttggct cccgaaatcc tgagctctct acacagctta tcgatatcat tcataccgct
     1921 gcagcacgag caaataaaga attactaaaa agtttacaag ctactgccct ccgaatttat
     1981 gatccacaag aaggtgctgt ggtggttctc cctgcagact ctcagcagcg tttggttcag
     2041 cttgtatatt tcctacccag tctgccggct gatttgcttt ctcggttaag tcgttgctgt
     2101 attatgggaa gactcagttc aagtttggct gccatgctta tcgggatact gcacatgaga
     2161 tcatcatttt ctgggtggaa gtattcagct aaagactggt tgatgagtga tgtagactat
     2221 ttcagcttct tattttccac acttacaggg ttttcgaaag aggagttgac ttggcttcag
     2281 agccttcgag gagttcctca tgtcatccag acacagcttt cccctgtgct tctctacctt
     2341 acagatttgg atcaattttt acaccactgg gatgtaacag aggcagtttt tcacagttta
     2401 ttggttattc ctgcccgaag tcagaacttt gacatcttgc aaagtgccat cagtaagcat
     2461 ttggttgggt tgactgtaat tcctgacagc acggctggct gtgtttttgg tgttatctgt
     2521 aagctcctgg atcatacttg tgtagttagt gagactctac tgccatttct ggcttcttgt
     2581 tgctacagtc ttctttattt tctgctcact atagagaaag gggaagcaga acatctaaga
     2641 aagagggaca agctgtgggg ggtctgtgtc tccatcctgg ctctcttgcc tcgagtcctc
     2701 aggttgatgc tgcagagcct gcgggtgaac agagttgggc ctgaggagct gcctgttgtg
     2761 ggccagctgc ttcgactgct gcttcagcat gcacccctca ggactcatat gttgaccaat
     2821 gcgatcttgg tgcagcagat catcaagaat atcacgacat tgaagagtgg aagtgttcag
     2881 gaacagtggc tcacagactt acattactgc ttcaacgtgt atatcactgg gcatccccaa
     2941 gggcccagtg cactggctac agtgtattga agaggccata gtacctcctg tttgaagttg
     3001 tttattcaca tctatcttat ttgaagaaaa agactgatgt aatagatctt tgtcattaaa
     3061 gctgaacttt taaagaa
//
