LOCUS       NM_001287491           12060 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens tet methylcytosine dioxygenase 3 (TET3), transcript
            variant 1, mRNA.
ACCESSION   NM_001287491 NM_144993 XM_005264187 XM_371501 XM_942026
VERSION     NM_001287491.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12060)
  AUTHORS   Linowiecka,K., Szpotan,J., Godlewska,M., Gawel,D., Zarakowska,E.,
            Gackowski,D., Brozyna,A.A. and Foksinski,M.
  TITLE     Selective Estrogen Receptor Modulators' (SERMs) Influence on TET3
            Expression in Breast Cancer Cell Lines with Distinct Biological
            Subtypes
  JOURNAL   Int J Mol Sci 25 (16), 8561 (2024)
   PUBMED   39201247
  REMARK    GeneRIF: Selective Estrogen Receptor Modulators' (SERMs) Influence
            on TET3 Expression in Breast Cancer Cell Lines with Distinct
            Biological Subtypes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12060)
  AUTHORS   Shekhawat,J.K., Sharma,J., Choudhury,B., Purohit,P., Sharma,P. and
            Banerjee,M.
  TITLE     TET3 downregulation and low 5-hydroxymethylcytosine are epigenetic
            signatures of head and neck carcinoma
  JOURNAL   Mol Biol Rep 51 (1), 877 (2024)
   PUBMED   39083093
  REMARK    GeneRIF: TET3 downregulation and low 5-hydroxymethylcytosine are
            epigenetic signatures of head and neck carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12060)
  AUTHORS   Sun,F., Yang,Y., Jia,L., Dong,Q.Q., Hu,W., Tao,H., Lu,C. and
            Yang,J.J.
  TITLE     TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty
            liver disease by increasing ENPP1 promoter hypomethylation
  JOURNAL   Free Radic Biol Med 218, 166-177 (2024)
   PUBMED   38582229
  REMARK    GeneRIF: TET3 boosts hepatocyte autophagy and impairs non-alcoholic
            fatty liver disease by increasing ENPP1 promoter hypomethylation.
REFERENCE   4  (bases 1 to 12060)
  AUTHORS   Ye,W., Zhang,C. and Fan,Z.
  TITLE     MiR-26b-5p/TET3 regulates the osteogenic differentiation of human
            bone mesenchymal stem cells and bone reconstruction in female rats
            with calvarial defects
  JOURNAL   Mol Biol Rep 51 (1), 632 (2024)
   PUBMED   38724827
  REMARK    GeneRIF: MiR-26b-5p/TET3 regulates the osteogenic differentiation
            of human bone mesenchymal stem cells and bone reconstruction in
            female rats with calvarial defects.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12060)
  AUTHORS   Hang,S., Cui,B., Wei,A., Li,Z. and Sun,H.
  TITLE     TET3 Protein Represses Proliferation of the MG-63 Human
            Osteosarcoma Cell Line by Regulating DNA Demethylation: an
            Epigenetic Study
  JOURNAL   Folia Biol (Praha) 70 (2), 113-122 (2024)
   PUBMED   39231319
  REMARK    GeneRIF: TET3 Protein Represses Proliferation of the MG-63 Human
            Osteosarcoma Cell Line by Regulating DNA Demethylation: an
            Epigenetic Study.
REFERENCE   6  (bases 1 to 12060)
  AUTHORS   Xu,Y., Xu,C., Kato,A., Tempel,W., Abreu,J.G., Bian,C., Hu,Y.,
            Hu,D., Zhao,B., Cerovina,T., Diao,J., Wu,F., He,H.H., Cui,Q.,
            Clark,E., Ma,C., Barbara,A., Veenstra,G.J., Xu,G., Kaiser,U.B.,
            Liu,X.S., Sugrue,S.P., He,X., Min,J., Kato,Y. and Shi,Y.G.
  TITLE     Tet3 CXXC domain and dioxygenase activity cooperatively regulate
            key genes for Xenopus eye and neural development
  JOURNAL   Cell 151 (6), 1200-1213 (2012)
   PUBMED   23217707
REFERENCE   7  (bases 1 to 12060)
  AUTHORS   Murea,M., Lu,L., Ma,L., Hicks,P.J., Divers,J., McDonough,C.W.,
            Langefeld,C.D., Bowden,D.W. and Freedman,B.I.
  TITLE     Genome-wide association scan for survival on dialysis in
            African-Americans with type 2 diabetes
  JOURNAL   Am J Nephrol 33 (6), 502-509 (2011)
   PUBMED   21546767
REFERENCE   8  (bases 1 to 12060)
  AUTHORS   Langemeijer,S.M., Aslanyan,M.G. and Jansen,J.H.
  TITLE     TET proteins in malignant hematopoiesis
  JOURNAL   Cell Cycle 8 (24), 4044-4048 (2009)
   PUBMED   19923888
  REMARK    GeneRIF: TET family influences DNA methylation in hematopoietic
            malignancy
REFERENCE   9  (bases 1 to 12060)
  AUTHORS   Abdel-Wahab,O., Mullally,A., Hedvat,C., Garcia-Manero,G., Patel,J.,
            Wadleigh,M., Malinge,S., Yao,J., Kilpivaara,O., Bhat,R.,
            Huberman,K., Thomas,S., Dolgalev,I., Heguy,A., Paietta,E., Le
            Beau,M.M., Beran,M., Tallman,M.S., Ebert,B.L., Kantarjian,H.M.,
            Stone,R.M., Gilliland,D.G., Crispino,J.D. and Levine,R.L.
  TITLE     Genetic characterization of TET1, TET2, and TET3 alterations in
            myeloid malignancies
  JOURNAL   Blood 114 (1), 144-147 (2009)
   PUBMED   19420352
  REMARK    GeneRIF: mutational status of TET1, TET2, and TET3 in
            myeloproliferative neoplasms (MPNs), chronic myelomonocytic
            leukemia (CMML), and acute myeloid leukemia (AML)
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 12060)
  AUTHORS   Fahrner,J.A.
  TITLE     TET3-Related Beck-Fahrner Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37200470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073046.7, AI438961.1, HQ220209.1 and AC073263.5.
            
            On or before Sep 20, 2018 this sequence version replaced
            XM_005264187.3, NM_001287491.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: HQ220209.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968540, SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000409262.8/ ENSP00000386869.3
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AC073046.7         165004-165225
            223-612             AI438961.1         1-390
            613-672             AC073046.7         166438-166497
            673-6060            HQ220209.1         1-5388
            6061-12060          AC073263.5         30660-36659
FEATURES             Location/Qualifiers
     source          1..12060
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..12060
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /note="tet methylcytosine dioxygenase 3"
                     /db_xref="GeneID:200424"
                     /db_xref="HGNC:HGNC:28313"
                     /db_xref="MIM:613555"
     exon            1..248
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /inference="alignment:Splign:2.1.0"
     exon            249..975
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /inference="alignment:Splign:2.1.0"
     CDS             673..6060
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /EC_number="1.14.11.80"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable methylcytosine dioxygenase TET3; tet oncogene
                     family member 3; putative methylcytosine dioxygenase;
                     ten-eleven translocation 3"
                     /codon_start=1
                     /product="methylcytosine dioxygenase TET3 isoform 1"
                     /protein_id="NP_001274420.1"
                     /db_xref="CCDS:CCDS46339.2"
                     /db_xref="GeneID:200424"
                     /db_xref="HGNC:HGNC:28313"
                     /db_xref="MIM:613555"
                     /translation="MSQFQVPLAVQPDLPGLYDFPQRQVMVGSFPGSGLSMAGSESQL
                     RGGGDGRKKRKRCGTCEPCRRLENCGACTSCTNRRTHQICKLRKCEVLKKKVGLLKEV
                     EIKAGEGAGPWGQGAAVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSASGVPVNGAR
                     EPAGPSLLGTGGPWRVDQKPDWEAAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALST
                     RLYETFNREMSREAGNNSRGPRPGPEGCSAGSEDLDTLQTALALARHGMKPPNCNCDG
                     PECPDYLEWLEGKIKSVVMEGGEERPRLPGPLPPGEAGLPAPSTRPLLSSEVPQISPQ
                     EGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTPQASCPLPEALSPPA
                     PFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSW
                     PMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPAPSPVLQ
                     REAPTPSSEPDTHQKAQTALQQHLHHKRSLFLEQVHDTSFPAPSEPSAPGWWPPPSSP
                     VPRLPDRPPKEKKKKLPTPAGGPVGTEKAAPGIKPSVRKPIQIKKSRPREAQPLFPPV
                     RQIVLEGLRSPASQEVQAHPPAPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQE
                     MRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQQT
                     CLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGF
                     LESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIR
                     ELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGH
                     HCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKD
                     PNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKSFQDLATEVAP
                     LYKRLAPQAYQNQVTNEEIAIDCRLGLKEGRPFAGVTACMDFCAHAHKDQHNLYNGCT
                     VVCTLTKEDNRCVGKIPEDEQLHVLPLYKMANTDEFGSEENQNAKVGSGAIQVLTAFP
                     REVRRLPEPAKSCRQRQLEARKAAAEKKKIQKEKLSTPEKIKQEALELAGITSDPGLS
                     LKGGLSQQGLKPSLKVEPQNHFSSFKYSGNAVVESYSVLGNCRPSDPYSMNSVYSYHS
                     YYAQPSLTSVNGFHSKYALPSFSYYGFPSSNPVFPSQFLGPGAWGHSGSSGSFEKKPD
                     LHALHNSLSPAYGGAEFAELPSQAVPTDAHHPTPHHQQPAYPGPKEYLLPKAPLLHSV
                     SRDPSPFAQSSNCYNRSIKQEPVDPLTQAEPVPRDAGKMGKTPLSEVSQNGGPSHLWG
                     QYSGGPSMSPKRTNGVGGSWGVFSSGESPAIVPDKLSSFGASCLAPSHFTDGQWGLFP
                     GEGQQAASHSGGRLRGKPWSPCKFGNSTSALAGPSLTEKPWALGAGDFNSALKGSPGF
                     QDKLWNPMKGEEGRIPAAGASQLDRAWQSFGLPLGSSEKLFGALKSEEKLWDPFSLEE
                     GPAEEPPSKGAVKEEKGGGGAEEEEEELWSDSEHNFLDENIGGVAVAPAHGSILIECA
                     RRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARARQEE
                     AARLGLGQQEAKLYGKKRKWGGTVVAEPQQKEKKGVVPTRQALAVPTDSAVTVSSYAY
                     TKVTGPYSRWI"
     exon            976..1032
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..3166
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3257
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3351
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /inference="alignment:Splign:2.1.0"
     exon            3352..3560
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3711
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..3801
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /inference="alignment:Splign:2.1.0"
     exon            3802..3939
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4276
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /inference="alignment:Splign:2.1.0"
     exon            4277..12060
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12029..12034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /note="hexamer: AATAAA"
     polyA_site      12060
                     /gene="TET3"
                     /gene_synonym="BEFAHRS; hCG_40738"
                     /note="major polyA site"
ORIGIN      
        1 gagtcccgcg gacgccttca ttgctgctgc tgctgccgcc gcggccgccg ctgcctcttc
       61 cttcctcctg cgccgtcccc tcctcggccc gggcgggggg ctccgcgcgc tgagctcggt
      121 cgggccgggc gctccgggag gcgggagccc caggcggcgg cggcggcggc cgcgacggtg
      181 gtggcggcgg cggcgcgggc cgggaaactt tgcccctttg tgcgctccgc cccggaggcg
      241 gcgggcaggc agcactgcct tctccagcgt ccagaccctg gaggaaaaat accaggagaa
      301 actgctcact cagctctgcc cccaccacac ccctacctgc tcaactcatg cctgggtcca
      361 gggtgggtga gggtgaagaa cccaccgggc caagatgatc ccttttctga gggctgctgc
      421 tggtgtcctc ccccagatcc tgggccccag caggtgggag agtggccccc tacggagtcc
      481 gatcagactg ctgcagagga ggtgaagagg ggttgagaag aggcatccat ccacgagact
      541 gaagccactt gccttcaccc ttgtagactc ttgactgttc taggcgagaa ggacctgttg
      601 gtggcctttg gaggtggcag gaaacgactg tggttctgcc ccagcaccta tgaccccacc
      661 tctggcagca tcatgagcca gtttcaggtg cccctggccg tccagccgga cctgccaggc
      721 ctttatgact tccctcagcg ccaggtgatg gtagggagct tcccggggtc tgggctctcc
      781 atggctggga gtgagtccca actccgaggg ggtggagatg gtcgaaagaa acggaaacgg
      841 tgtggtactt gtgagccctg ccggcggctg gaaaactgtg gcgcttgcac tagctgtacc
      901 aaccgccgca cgcaccagat ctgcaaactg cgaaaatgtg aggtgctgaa gaaaaaagta
      961 gggcttctca aggaggtgga aataaaggct ggtgaaggag ccgggccgtg gggacaagga
     1021 gcggctgtca agacaggctc agagctcagc ccagttgatg gacctgttcc aggtcagatg
     1081 gactcagggc cagtgtacca tggggactca cggcagctaa gcgcctcagg ggtgccggtc
     1141 aatggtgcta gagagcccgc tggacccagt ctgctgggga ctgggggtcc ttggcgggta
     1201 gaccaaaagc ccgactggga ggctgcccca ggcccagctc atactgctcg cctggaagat
     1261 gcccacgatc tggtggcctt ttcggctgtg gccgaagctg tgtcctctta tggggccctt
     1321 agcacccggc tctatgaaac cttcaaccgt gagatgagtc gtgaggctgg gaacaacagc
     1381 aggggacccc ggccagggcc tgagggctgc tctgctggca gcgaagacct tgacacactg
     1441 cagacggccc tggccctcgc gcggcatggt atgaaaccac ccaactgcaa ctgcgatggc
     1501 ccagaatgcc ctgactacct cgagtggctg gaggggaaga tcaagtctgt ggtcatggaa
     1561 ggaggggagg agcggcccag gctcccaggg cctctgcctc ctggtgaggc cggcctccca
     1621 gcaccaagca ccaggccact cctcagctca gaggtgcccc agatctctcc ccaagagggc
     1681 ctgcccctgt cccagagtgc cctgagcatt gccaaggaaa aaaacatcag cttgcagacc
     1741 gccattgcca ttgaggccct cacacagctc tcctctgccc tcccgcagcc ttctcattcc
     1801 accccccagg cttcttgccc ccttcctgag gccttgtcac ctcctgcccc tttcagatct
     1861 ccccagtctt acctccgggc tccctcatgg cctgtggttc ctcctgaaga gcactcatct
     1921 tttgctcctg atagctctgc cttccctcca gcaactccta gaactgagtt ccctgaagcc
     1981 tggggcactg acacccctcc agcaacgccc cggagctcct ggcccatgcc tcgcccaagc
     2041 cccgatccca tggctgaact ggagcagttg ttgggcagcg ccagtgatta catccagtca
     2101 gtattcaagc ggcctgaggc cctgcctacc aagcccaagg tcaaggtgga ggcaccctct
     2161 tcctccccgg ccccggcccc atcccctgta cttcagaggg aggctcccac gccatcctcg
     2221 gagcccgaca cccaccagaa ggcccagacc gccctgcagc agcacctcca ccacaagcgc
     2281 agcctcttcc tagaacaggt gcacgacacc tccttccctg ctccttcaga gccttctgct
     2341 cctggctggt ggcccccacc aagttcacct gtcccacggc ttccagacag accacccaag
     2401 gagaagaaga agaagctccc aacaccagct ggaggtcccg tgggaacgga gaaagctgcc
     2461 cctgggatca agcccagtgt ccgaaagccc attcagatca agaagtccag gccccgggaa
     2521 gcacagcccc tcttcccacc tgtccgacag attgtcctgg aagggcttag gtccccagcc
     2581 tcccaggaag tgcaggctca tccaccggcc cctctgcctg cctcacaggg ctctgctgtg
     2641 cccctgcccc cagaaccttc tcttgcgcta tttgcaccta gtccctccag ggacagcctg
     2701 ctgcccccta ctcaggaaat gaggtccccc agccccatga cagccttgca gccaggctcc
     2761 actggccctc ttccccctgc cgatgacaag ctggaagagc tcatccggca gtttgaggct
     2821 gaatttggag atagctttgg gcttcccggc cccccttctg tgcccattca ggaccccgag
     2881 aaccagcaaa catgtctccc agcccctgag agcccctttg ctacccgttc ccccaagcaa
     2941 atcaagattg agtcttcggg ggctgtgact gtgctctcaa ccacctgctt ccattcagag
     3001 gagggaggac aggaggccac acccaccaag gctgagaacc cactcacacc caccctcagt
     3061 ggcttcttgg agtcacctct taagtacctg gacacaccca ccaagagtct gctggacaca
     3121 cctgccaaga gagcccaggc cgagttcccc acctgcgatt gcgtcgaaca aatagtggag
     3181 aaagatgaag gtccatatta tactcacttg ggatctggcc ccacggtcgc ctctatccgg
     3241 gaactcatgg aggagcggta tggagagaag gggaaagcca tccggatcga gaaggtcatc
     3301 tacacgggga aggagggaaa gagctcccgc ggttgcccca ttgcaaagtg ggtgatccgc
     3361 aggcacacgc tggaggagaa gctactctgc ctggtgcggc accgggcagg ccaccactgc
     3421 cagaacgctg tgatcgtcat cctcatcctg gcctgggagg gcattccccg tagcctcgga
     3481 gacaccctct accaggagct caccgacacc ctccggaagt atgggaaccc caccagccgg
     3541 agatgcggcc tcaacgatga ccggacctgc gcttgccaag gcaaagaccc caacacctgt
     3601 ggtgcctcct tctcctttgg ttgttcctgg agcatgtact tcaacggctg caagtatgct
     3661 cggagcaaga cacctcgcaa gttccgcctc gcaggggaca atcccaaaga ggaagaagtg
     3721 ctccggaaga gtttccagga cctggccacc gaagtcgctc ccctgtacaa gcgactggcc
     3781 cctcaggcct atcagaacca ggtgaccaac gaggaaatag cgattgactg ccgtctgggg
     3841 ctgaaggaag gacggccctt cgcgggggtc acggcctgca tggacttctg tgcccacgcc
     3901 cacaaggacc agcataacct ctacaatggg tgcaccgtgg tctgcaccct gaccaaggaa
     3961 gacaatcgct gcgtgggcaa gattcccgag gatgagcagc tgcatgttct ccccctgtac
     4021 aagatggcca acacggatga gtttggtagc gaggagaacc agaatgcaaa ggtgggcagc
     4081 ggagccatcc aggtgctcac cgccttcccc cgcgaggtcc gacgcctgcc cgagcctgcc
     4141 aagtcctgcc gccagcggca gctggaagcc agaaaggcag cagccgagaa gaagaagatt
     4201 cagaaggaga agctgagcac tccggagaag atcaagcagg aggccctgga gctggcgggc
     4261 attacgtcgg acccaggcct gtctctgaag ggtggattgt cccagcaagg cctgaagccc
     4321 tccctcaagg tggagccgca gaaccacttc agctccttca agtacagcgg caacgcggtg
     4381 gtggagagct actcggtgct gggcaactgc cggccctccg acccttacag catgaacagc
     4441 gtgtactcct accactccta ctatgcacag cccagcctga cctccgtcaa tggcttccac
     4501 tccaagtacg ctctcccgtc ttttagctac tatggctttc catccagcaa ccccgtcttc
     4561 ccctctcagt tcctgggtcc tggtgcctgg gggcacagtg gcagcagtgg cagttttgag
     4621 aagaagccag acctccacgc tctgcacaac agcctgagcc cggcctacgg tggtgctgag
     4681 tttgccgagc tgcccagcca ggctgttccc acagacgccc accaccccac tcctcaccac
     4741 cagcagcctg cgtacccagg ccccaaggag tatctgcttc ccaaggcccc cctactccac
     4801 tcagtgtcca gggacccctc cccctttgcc cagagctcca actgctacaa cagatccatc
     4861 aagcaagagc cagtagaccc gctgacccag gctgagcctg tgcccagaga cgctggcaag
     4921 atgggcaaga cacctctgtc cgaggtgtct cagaatggag gacccagtca cctttgggga
     4981 cagtactcag gaggcccaag catgtccccc aagaggacta acggtgtggg tggcagctgg
     5041 ggtgtgttct cgtctgggga gagtcctgcc atcgtccctg acaagctcag ttcctttggg
     5101 gccagctgcc tggccccttc ccacttcaca gatggccagt gggggctgtt ccccggtgag
     5161 gggcagcagg cagcttccca ctctggagga cggctgcgag gcaaaccgtg gagcccctgc
     5221 aagtttggga acagcacctc ggccttggct gggcccagcc tgactgagaa gccgtgggcg
     5281 ctgggggcag gggatttcaa ctcggccctg aaaggtagtc ctgggttcca agacaagctg
     5341 tggaacccca tgaaaggaga ggagggcagg attccagccg caggggccag ccagctggac
     5401 agggcctggc agtcctttgg tctgcccctg ggatccagcg agaagctgtt tggggctctg
     5461 aagtcagagg agaagctgtg ggaccccttc agcctggagg aggggccggc tgaggagccc
     5521 cccagcaagg gagcggtgaa ggaggagaag ggcggtggtg gtgcggagga ggaagaggag
     5581 gagctgtggt cggacagtga acacaacttc ctggacgaga acatcggcgg cgtggccgtg
     5641 gccccagccc acggctccat cctcatcgag tgtgcccggc gggagctgca cgccaccacg
     5701 ccgcttaaga agcccaaccg ctgccacccc acccgcatct cgctggtctt ctaccagcac
     5761 aagaacctca accagcccaa ccacgggctg gccctctggg aagccaagat gaagcagctg
     5821 gcggagaggg cacgggcacg gcaggaggag gctgcccggc tgggcctggg ccagcaggag
     5881 gccaagctct acgggaagaa gcgcaagtgg gggggcactg tggttgctga gccccagcag
     5941 aaagagaaga agggggtcgt ccccacccgg caggcactgg ctgtgcccac agactcggcg
     6001 gtcaccgtgt cctcctatgc ctacacgaag gtcactggcc cctacagccg ctggatctag
     6061 gtgccaggga gccagcgtac ctcagcgtcg ggcctggccc gagctgtctc tgtggtgctt
     6121 ttgccctcat acctgggggc gggttggggg tgcagaagtc tttttatctc tatatacata
     6181 tatagatgcg catatcatat atatgtattt atggtccaaa cctcagaact gacccgcccc
     6241 tcccttaccc ccacttcccc agcactttga agaagaaact acggctgtcg ggtgattttt
     6301 ccgtgatctt aatatttata tctccaagtt gtcccccccc cttgtctggg gggtttttat
     6361 ttttattttc tctttgtttt taaaactcta tccttgtata tcacaataat ggaaagaaag
     6421 tttatagtat cctttcacaa aggagtagtt ttaaattcca tttaaaatgt gtatttattg
     6481 gattttttaa aagcgacaat agtaatggta aaggatgggc aggaaaggcc agtagtgctc
     6541 ccccgcccag tctcgctggg tctggcgagc caagcccctc gggcgctggc gaggtcctca
     6601 gccatctgcc cctcgagagc caagcgcgga cggtagccac ccagttcatc cctcccgaca
     6661 tacacccctt ccctttgggg aagggagcct caggacagct tctgtcctct ctgataggat
     6721 gggagagtct gcagaaaacc atctggggtc ccttttccag tccccggctt ggagtcgaag
     6781 ggcagatgca ccccaggcca gccccacgag atgctggcat agctttcccc agaaaccagg
     6841 ttggaagtag atggcttcaa gcttgctagt ctccacactg aatcctctgt ccgttattta
     6901 tggagtcaca cgatgtcatg gttcactagg cagcacctca cgctggagct ggagtgcgag
     6961 gttcttaggg gccgtgccca ccatgttgcc aagccaatgc atgctgagct gaaggaattt
     7021 gtcttagtgg cagtttttta aaaaatgccc ccaaagtcta tgctgatact gaaaaagggc
     7081 tactgtatct ttaaaaacag gaagttgaac ccaagctgtg aaaagccagt ggtgctctgt
     7141 gcatggtgct gtgcggagcc tggtgctgta gtgttgtgct gggactttct tgactcttgg
     7201 gcaggtcaca tcctacagga gctcagcaga ccagtgtaac aacagttaat gcatctatcc
     7261 tgatccctga atttccacat tggacaatgg tgcatgcctc acacctgagc ctgcttcctc
     7321 catgctgtca ttgggttcgg gggcctacac ttaacaattt taaagtgcaa gagtcaaaca
     7381 ttttcaacag gttgctataa ttttcctccc taattggtgc catttctcca tttgatcatt
     7441 ttcttttttt cctttctccc ctcttcatcc actttaatat agctgttctg aaattctggt
     7501 gcattcattc ggttctttga aatgagaatg tggtgcttaa tttttgtgac gttgtcgaga
     7561 gaggttgggc ctgatgggag caacactcat catcaccaag tcaaactttg ttggagtgtt
     7621 ggtttttctt gtgatattag cagaaatgat ctcatgctag ccatgtggat gtgtgtgtgg
     7681 tgaatggggg gcttcatcag gacacacaga ggggaatgtg gccacacggt ggatgaccac
     7741 caagccctga gatgaacagg tatttactga gcagttgtat tcagatatgg gtcttcatga
     7801 atcatgttta acaatcagat gaccgctata ggcaagttcc tgagcttccg ggtgccttga
     7861 gtaagagctg agaaccggcc tgctgggtgt ttactgtatc tgtttggaag cactggcgga
     7921 gggtcgttgt aagatgtcct gagcatttat gtggtctggt tttaactgta aatagtgaaa
     7981 gattttttta agcacttttg cctagattta aacagcaact tgaaaaaaaa agtatgtttt
     8041 aacatgtaat tgtgggagaa attgtaaata gtagccgaat atttaatgtg ctttgtctat
     8101 cctccacttt taccatattc tgtaaagttg catttatttt acaggacaaa aaaatgaaat
     8161 attattgctt ttgaaataaa tacccaagag cttatcagga cttagaatta ttcagaactc
     8221 agatttatag gaaaacctct gaccttcagt ttgacaagct aaaggaagca gagtctttaa
     8281 tgagcatgct aattttctag ttttgaggaa aaattgggtc ctttaaatgc tattttgctt
     8341 atcgcatcag tacttttatg caggtctcat ttgactccgt gcttaggtag atgcgggggt
     8401 gccttgaaaa cttcatttta aatgatctta agcaagaaat acaatatttt acgaaacatt
     8461 tggagaatgt gaccgtctgt atgacccgtg gaagccccag gttggctgtt ggtttggaag
     8521 gtcccgagtg taacccaggt gattctgata cttggcatgt gtgaatcttc ctgatgtatg
     8581 ttaaataaac tcttcccctc atcacccttt ggtaggaaag ccattagatg aaaggagaaa
     8641 ccaatacaag ctaaaagcat gcgacgtctg tcccccagcc caaacagcct tggttcatca
     8701 gtttctgcag taggagatag gctgctgaga ggtgagtcaa gaggcagtct ccattggatg
     8761 tccccactcc ccgcagaatg gcgtttccag agttaggcgg tgtggttgcc gtgctcaagc
     8821 ccatgctgat ttgtacacta catgtctaac ctacctcaaa tctcagtcat taaaattagc
     8881 atgctttaga catatattta aaaagtaact atgcacagct ctttatcccc cccttgctgc
     8941 tgaagctttc ttaaagagaa aaatcaaatt tttatttttt actggcacta tcatttttta
     9001 agtcctaaag atgattaaca gacattttta tcatgagaag aaaaataaag ccattgcaac
     9061 taaagaacct aacagcatga ccaagttcga agagtcatat tatagcaacg gaaatcgatg
     9121 gcgtcttagt catctcccca gtgtgccctg tccacggaca ccatccacgt gcagtgcaaa
     9181 catttggttc cttttctgct ctgttttgtt ttccctgcct gttgcgtgca agggaagtgc
     9241 ttgtaaagtt ctgtgctacg agatttttaa aataaaaatc gcttcgcagc aggttctcac
     9301 aaaataactg gtgctagctc aagaaatcat catctgacca tcagaaatct tgactaaagg
     9361 tgttgcatgg atttgggggt ctttcggttt ttggttttgg gtctggcttt tagcagggcc
     9421 aatgtttccc acaccccggc ttcatgggta ctgctttgcc ttctcaccaa ggtgacgatg
     9481 gtgtgcgtgg aaagagatga taccccaccg ccccctcttg gtccttccac cagcctcttt
     9541 tgggaacagt agtttgcaga gcaagggatt tttaaagcgc taaagcaagg aaagaagtag
     9601 cagagcttaa ctgctttgta ccacacagca gtagatgtgc aaggacggtt gacaatgagt
     9661 cgatgataac ctaatttcat tgagagaaac ccagccagac ttgcttctag aggtttaatc
     9721 accatgagat ctcaaaccaa ggcaaagctg gtggaaaact atatgatatc cctgacgtgc
     9781 ctcaaccagt atctctttcc ttttgttact gaagtgtgtt ttatggacta ggaagcattt
     9841 ttatgaattg aaatagtcta aataaaatgg tgctatggtg ttttaatgtg actgtccctg
     9901 atcctgtctt gctgaggtgc tatcaacgtt ctgaaaccac aaccaaccaa aaacaaggtg
     9961 ggctccagtc tcttggcttt tttttttccc tcccctcttt tggtgctgtc ttagacccgt
    10021 ttaccgtgct ataatctgct ctgagcagtg ttgtgttgtg ttgtattgtt cttcccttgg
    10081 tggccaaaca aagcaagtcg agaaggcagc tatctccctt tctgtgatcg ggagtgggcc
    10141 tgcctggctt ggcaggtgct ttttggttcc acacctgtct tctcaggctt gatgtgaaag
    10201 aaagggcgaa gggttttttg agtttttgtt tttgaggaag gggagttggg tacttctgcc
    10261 tctcctagca tgataggcat tctcatagcc agggacagat tttctcctgc agcccagggt
    10321 gctaagcaga catctctggg agtcccaagg gcacaccaag ggagaccaga tggatctcct
    10381 tcctcccctg gcactggctg ggaccatggt gggcaggggc ttcattctct gacccagcgt
    10441 tgcttctgcc tctcattggt aaccccttat gttcggacta aaggaaggag ctttctttgc
    10501 tcactcgatg ccactgaggc tgctttttag ttggtgctaa cctaaatttc ttcttgggtc
    10561 cacagaagtt gatgttttaa aaactcacca ggaagctcca ttttgtgtca tccactgtca
    10621 caataatttt tttaaatacc tcaaaaacag gacatcatga caacttcagt aaagtagatt
    10681 ccatgagggt ctgatacctg caggttgtcc gtctgatgac atacttgacc ttgaaaaatc
    10741 tggggtcatt ttgtttttca ttcttcagca gttaagatag cggaacgccg aaaggaagga
    10801 gcgtagttgg ctgtatttca tgtttaagtt ttgcttttga ataaaatgtg aatttcctat
    10861 gcccatctca ttgagctttc tcagtcattg ttgctgtcat ttgaaatgac tccctcaaaa
    10921 cctagtttta ttagccagct gcctctgctg tagtacatgg ccaacttcaa cataccctgg
    10981 accaaaacat ttttgaggtg cataccccca acataagtta cacagtccca catccaggtg
    11041 cacagagtgc gagtgcactc cgcgagtgcg gggggagggg cggccccctc tggtgctccc
    11101 agcccttcct cctgcagagc tgcaggcaag agcagagcaa taggcttctc ccctgagcag
    11161 agaccgcagc acagaaatgc aaggtctaaa gttgcttttt gcctaagaat cagcgagcga
    11221 tttggcctac ttcctcattg gcttctattc tgatatcagg gatgcttttt gtagtggtat
    11281 tgtttgctcc ctcttcgcgt tttgactacc cgtcattcag gggtaactca tcactcttca
    11341 cacggggatt taaattaaga aactaattgg ctcatgtgaa cattccaaat tttcttggtt
    11401 tcaataccct tttttttctt ttgaggggaa aagaggggag aaaaacagga gtgatgtcat
    11461 ttctttttca tgtattccaa ttaaagaaac aagggcaggt cgtataatgg catattaata
    11521 cattagactt aatctagaac ccctgtagct ttttgatgtg ttttatttct tatctctttg
    11581 aattcctgtt tggttacttg gcttccaatg gaggtgaact taacaaccat acttgaatat
    11641 tccgtcttga ctttgtaaac tgtggctact tgaaatgaag tttatctggg gttgatggat
    11701 gaatggtaga tttttgcaat gtctcaaggc aataggatgt gtattaaact gtagatattc
    11761 ttagtacagt aaatttatgc tgataatttt attttgtata atttttacct ttttgttaat
    11821 attttttcct tccactttat tggtttgcct cctgagctac ccctccttac cctcccttct
    11881 ccctcagtgt ttcagtaaat ttaatttagg gtgcctagaa attgcaagta tgtatccttt
    11941 ttgatttgta ttttattata atttacacaa acaactgggt ttgtgaactg tattactcct
    12001 ggtatcttta aaatattgtg ggtgttttaa taaattttat atttattttt tgcactcaaa
//
