LOCUS       XM_017008319            6120 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens tet methylcytosine dioxygenase 2 (TET2),
            transcript variant X8, mRNA.
ACCESSION   XM_017008319
VERSION     XM_017008319.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000004.12) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017008319.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6120
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     gene            1..6120
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /note="tet methylcytosine dioxygenase 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 mRNAs, 1438 long SRA reads, 1 Protein, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 42 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:54790"
                     /db_xref="HGNC:HGNC:25941"
                     /db_xref="MIM:612839"
     CDS             297..3875
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /codon_start=1
                     /product="methylcytosine dioxygenase TET2 isoform X6"
                     /protein_id="XP_016863808.1"
                     /db_xref="GeneID:54790"
                     /db_xref="HGNC:HGNC:25941"
                     /db_xref="MIM:612839"
                     /translation="MEQDRTNHVEGNRLSPFLIPSPPICQTEPLATKLQNGSPLPERA
                     HPEVNGDTKWHSFKSYYGIPCMKGSQNSRVSPDFTQESRGYSKCLQNGGIKRTVSEPS
                     LSGLLQIKKLKQDQKANGERRNFGVSQERNPGESSQPNVSDLSDKKESVSSVAQENAV
                     KDFTSFSTHNCSGPENPELQILNEQEGKSANYHDKNIVLLKNKAVLMPNGATVSASSV
                     EHTHGELLEKTLSQYYPDCVSIAVQKTTSHINAINSQATNELSCEITHPSHTSGQINS
                     AQTSNSELPPKPAAVVSEACDADDADNASKLAAMLNTCSFQKPEQLQQQKSVFEICPS
                     PAENNIQGTTKLASGEEFCSGSSSNLQAPGGSSERYLKQNEMNGAYFKQSSVFTKDSF
                     SATTTPPPPSQLLLSPPPPLPQVPQLPSEGKSTLNGGVLEEHHHYPNQSNTTLLREVK
                     IEGKPEAPPSQSPNPSTHVCSPSPMLSERPQNNCVNRNDIQTAGTMTVPLCSEKTRPM
                     SEHLKHNPPIFGSSGELQDNCQQLMRNKEQEILKGRDKEQTRDLVPPTQHYLKPGWIE
                     LKAPRFHQAESHLKRNEASLPSILQYQPNLSNQMTSKQYTGNSNMPGGLPRQAYTQKT
                     TQLEHKSQMYQVEMNQGQSQGTVDQHLQFQKPSHQVHFSKTDHLPKAHVQSLCGTRFH
                     FQQRADSQTEKLMSPVLKQHLNQQASETEPFSNSHLLQHKPHKQAAQTQPSQSSHLPQ
                     NQQQQQKLQIKNKEEILQTFPHPQSNNDQQREGSFFGQTKVEECFHGENQYSKSSEFE
                     THNVQMGLEEVQNINRRNSPYSQTMKSSACKIQVSCSNNTHLVSENKEQTTHPELFAG
                     NKTQNLHHMQYFPNNVIPKQDLLHRCFQEQEQKSQQASVLQGYKNRNQDMSGQQAAQL
                     AQQRYLIHNHANVFPVPDQGGSHTQTPPQKDTQKHAALRWHLLQKQEQQQTQQPQTES
                     CHSQMHRPIKVEPGCKPHACMHTAPPENKTWKKVTKQENPPASCDNVQQKSIIETMEQ
                     HLKQFHAKSLFDHKALTLKSQKQVKVEMSGPVTVLTRQTTAAELDSHTPALEQQTTSS
                     EKTPTKRTAASVLNNFIESPSKLLDTPIKNLLDTPVKTQYDFPSCRCVAVYSIFIGSI
                     FHLKHSLFIHKKQLLIKFFHDIAVTQPHLQALLLILVLLLHLPHLQ"
     polyA_site      6120
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gtagagaagc agaaggaagc aagatggctg ccctttagga tttgttagaa aggagacccg
       61 actgcaactg ctggattgct gcaaggctga gggacgagaa cgaggctggc aaacattcag
      121 cagcacaccc tctcaagatt gtttacttgc ctttgctcct gttgagttac aacgcttgga
      181 agcaggagat gggctcagca gcagccaata ggacatgatc caggaagagc agtaagggac
      241 tgagctgctg aattcaacta gagggcagcc ttgtggatgg ccccgaagca agcctgatgg
      301 aacaggatag aaccaaccat gttgagggca acagactaag tccattcctg ataccatcac
      361 ctcccatttg ccagacagaa cctctggcta caaagctcca gaatggaagc ccactgcctg
      421 agagagctca tccagaagta aatggagaca ccaagtggca ctctttcaaa agttattatg
      481 gaataccctg tatgaaggga agccagaata gtcgtgtgag tcctgacttt acacaagaaa
      541 gtagagggta ttccaagtgt ttgcaaaatg gaggaataaa acgcacagtt agtgaacctt
      601 ctctctctgg gctccttcag atcaagaaat tgaaacaaga ccaaaaggct aatggagaaa
      661 gacgtaactt cggggtaagc caagaaagaa atccaggtga aagcagtcaa ccaaatgtct
      721 ccgatttgag tgataagaaa gaatctgtga gttctgtagc ccaagaaaat gcagttaaag
      781 atttcaccag tttttcaaca cataactgca gtgggcctga aaatccagag cttcagattc
      841 tgaatgagca ggaggggaaa agtgctaatt accatgacaa gaacattgta ttacttaaaa
      901 acaaggcagt gctaatgcct aatggtgcta cagtttctgc ctcttccgtg gaacacacac
      961 atggtgaact cctggaaaaa acactgtctc aatattatcc agattgtgtt tccattgcgg
     1021 tgcagaaaac cacatctcac ataaatgcca ttaacagtca ggctactaat gagttgtcct
     1081 gtgagatcac tcacccatcg catacctcag ggcagatcaa ttccgcacag acctctaact
     1141 ctgagctgcc tccaaagcca gctgcagtgg tgagtgaggc ctgtgatgct gatgatgctg
     1201 ataatgccag taaactagct gcaatgctaa atacctgttc ctttcagaaa ccagaacaac
     1261 tacaacaaca aaaatcagtt tttgagatat gcccatctcc tgcagaaaat aacatccagg
     1321 gaaccacaaa gctagcgtct ggtgaagaat tctgttcagg ttccagcagc aatttgcaag
     1381 ctcctggtgg cagctctgaa cggtatttaa aacaaaatga aatgaatggt gcttacttca
     1441 agcaaagctc agtgttcact aaggattcct tttctgccac taccacacca ccaccaccat
     1501 cacaattgct tctttctccc cctcctcctc ttccacaggt tcctcagctt ccttcagaag
     1561 gaaaaagcac tctgaatggt ggagttttag aagaacacca ccactacccc aaccaaagta
     1621 acacaacact tttaagggaa gtgaaaatag agggtaaacc tgaggcacca ccttcccaga
     1681 gtcctaatcc atctacacat gtatgcagcc cttctccgat gctttctgaa aggcctcaga
     1741 ataattgtgt gaacaggaat gacatacaga ctgcagggac aatgactgtt ccattgtgtt
     1801 ctgagaaaac aagaccaatg tcagaacacc tcaagcataa cccaccaatt tttggtagca
     1861 gtggagagct acaggacaac tgccagcagt tgatgagaaa caaagagcaa gagattctga
     1921 agggtcgaga caaggagcaa acacgagatc ttgtgccccc aacacagcac tatctgaaac
     1981 caggatggat tgaattgaag gcccctcgtt ttcaccaagc ggaatcccat ctaaaacgta
     2041 atgaggcatc actgccatca attcttcagt atcaacccaa tctctccaat caaatgacct
     2101 ccaaacaata cactggaaat tccaacatgc ctggggggct cccaaggcaa gcttacaccc
     2161 agaaaacaac acagctggag cacaagtcac aaatgtacca agttgaaatg aatcaagggc
     2221 agtcccaagg tacagtggac caacatctcc agttccaaaa accctcacac caggtgcact
     2281 tctccaaaac agaccattta ccaaaagctc atgtgcagtc actgtgtggc actagatttc
     2341 attttcaaca aagagcagat tcccaaactg aaaaacttat gtccccagtg ttgaaacagc
     2401 acttgaatca acaggcttca gagactgagc cattttcaaa ctcacacctt ttgcaacata
     2461 agcctcataa acaggcagca caaacacaac catcccagag ttcacatctc cctcaaaacc
     2521 agcaacagca gcaaaaatta caaataaaga ataaagagga aatactccag acttttcctc
     2581 acccccaaag caacaatgat cagcaaagag aaggatcatt ctttggccag actaaagtgg
     2641 aagaatgttt tcatggtgaa aatcagtatt caaaatcaag cgagttcgag actcataatg
     2701 tccaaatggg actggaggaa gtacagaata taaatcgtag aaattcccct tatagtcaga
     2761 ccatgaaatc aagtgcatgc aaaatacagg tttcttgttc aaacaataca cacctagttt
     2821 cagagaataa agaacagact acacatcctg aactttttgc aggaaacaag acccaaaact
     2881 tgcatcacat gcaatatttt ccaaataatg tgatcccaaa gcaagatctt cttcacaggt
     2941 gctttcaaga acaggagcag aagtcacaac aagcttcagt tctacaggga tataaaaata
     3001 gaaaccaaga tatgtctggt caacaagctg cgcaacttgc tcagcaaagg tacttgatac
     3061 ataaccatgc aaatgttttt cctgtgcctg accagggagg aagtcacact cagacccctc
     3121 cccagaagga cactcaaaag catgctgctc taaggtggca tctcttacag aagcaagaac
     3181 agcagcaaac acagcaaccc caaactgagt cttgccatag tcagatgcac aggccaatta
     3241 aggtggaacc tggatgcaag ccacatgcct gtatgcacac agcaccacca gaaaacaaaa
     3301 catggaaaaa ggtaactaag caagagaatc cacctgcaag ctgtgataat gtgcagcaaa
     3361 agagcatcat tgagaccatg gagcagcatc tgaagcagtt tcacgccaag tcgttatttg
     3421 accataaggc tcttactctc aaatcacaga agcaagtaaa agttgaaatg tcagggccag
     3481 tcacagtttt gactagacaa accactgctg cagaacttga tagccacacc ccagctttag
     3541 agcagcaaac aacttcttca gaaaagacac caaccaaaag aacagctgct tctgttctca
     3601 ataattttat agagtcacct tccaaattac tagatactcc tataaaaaat ttattggata
     3661 cacctgtcaa gactcaatat gatttcccat cttgcagatg tgtagcagtt tacagcatct
     3721 tcattggaag tatattccat ctcaaacatt ctttgttcat ccataagaag caacttctta
     3781 tcaagttttt tcatgacatt gcagtaactc agccccatct tcaggctcta cttctaattc
     3841 tggttctctt gctacatctc cctcatctgc agtgacctct ccacggaagt cttgaactcc
     3901 tcaaagtaat ccatgagggt tggaatcaac ttctaaactc ctgttaatgt tgatatattg
     3961 accccctccc atgaattatg aatgttctta ataacttcta aatggtgata cctttccaga
     4021 aggctttcaa tgtactttgc ccggatccat cagaagacta tcttggcagc tgtagactaa
     4081 caatatattt cttaaatgat aagacttgaa agtcaaaagt actccttaat ccataggctg
     4141 cagaatcaat gttgtattaa caggcacgaa aacagcatta atcttgtgca tctccatcgg
     4201 agctcttggg tgactaggtg ccttgagcag taatattttg aaaggaggtt ttggttttgt
     4261 tttttgtttt ttttttttgt tttttagcag taagtctcaa cactgggctt aaaatattca
     4321 gtaaactatg ttgtaaaaag atgtgttatc atccagactt tgttgttcca ttactctaca
     4381 caagcagggt acacttagca taattcttaa gggccttgga attttcagaa tggtaaatga
     4441 gtatgggctt caacttaaaa tcatcaactg cattagcctg taacaagaga gtcagcctgt
     4501 cctttgaagc aaggcattga cttctatcta tgaaagtctt agatggcacc ttgtttcaat
     4561 agtaggctgt ttagtacagc caccttcatc agtgatctta gctagatctt ctgcataact
     4621 tgctgcagct tctacatcag cacttgctgc ctcaccttgt ccttttatgt tatagagaca
     4681 gctgcgcttc ttaaacttta taaaccaact tctgctagct tccaacttct cttctgcagc
     4741 ttcctcattc tcttcataga actgaaggga gtcaaggcct tgctctggat taagctttgg
     4801 cttaaggaat gttgtggctg acgtgatctt ctatccagac cactaaagcg ctctccatat
     4861 cagcaataag gccgttttgc tttcttacct ttcatgtgtt cactggagta atttccttca
     4921 agaatttttc ctttacattc acaacttggc taactggcat gcaaggccta gctttcagcc
     4981 tgtcttggct tttgacatgc cttcctcact tagctcgtca tatctagctt ttgatttaaa
     5041 gtggcaggca tacaactctt cctttcactt gaacacttag aggccactgt agggttatta
     5101 attggcctaa tttcaatatt gttgtgtttt agggaataga gaggcccagg gagagggaga
     5161 gagcccaaac ggctggttga tagagcaggc agaatgcaca caacatttat cagattatgt
     5221 ttgcaccatt taccagatta tgggtacggt ttgtggcacc ccccaaaaat tagaatagta
     5281 acatcaaaga tcactgatca cagatcgcca taacataaat aataataaac tttaaaatac
     5341 tgtgagaatt accaaaatgt gatacagaga catgaagtga gcacatgctg ttgaaaaaaa
     5401 tgacactgat agacatactt aacacgtggg attgccacaa accttcagtt tgtaaaagtc
     5461 acagtaactg tgactcacaa aagaacaaag cacaataaaa cgaggtatgc ctgtattttt
     5521 aaaaaaagct ttttgttaaa attcaggata tgtaataggt ctgtaggaat agtgaaatat
     5581 ttttgctgat ggatgtagat atatacgtgg atagagatga agatcttaat tatagctatg
     5641 cagcatagat ttagtcaaag acatttgaaa agacaaatgt taaattagtg tggctaatga
     5701 cctacccgtg ccatgttttc cctcttgcaa tgagataccc cacactgtgt agaaggatgg
     5761 agggaggact cctactgtcc ctctttgcgt gtggttatta agttgcctca ctgggctaaa
     5821 acaccacaca tctcatagat aatatttggt aagttgtaat cgtcttcact cttctcttat
     5881 cacccacccc tatcttccca cttttccatc tttgttggtt tgcaacagcc ccttcttttt
     5941 gcctgactct ccaggatttt ctctcatcat aaattgttct aaagtacata ctaatatggg
     6001 tctggattga ctattcttat ttgcaaaaca gcaattaaat gttataggga agtaggaaga
     6061 aaaaggggta tccttgacaa taaaccaagc aatattctgg gggtgggata gagcaggaaa
//
