LOCUS       NM_001127208            9589 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens tet methylcytosine dioxygenase 2 (TET2), transcript
            variant 1, mRNA.
ACCESSION   NM_001127208
VERSION     NM_001127208.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9589)
  AUTHORS   Zou,Z., Dou,X., Li,Y., Zhang,Z., Wang,J., Gao,B., Xiao,Y., Wang,Y.,
            Zhao,L., Sun,C., Liu,Q., Yu,X., Wang,H., Hong,J., Dai,Q.,
            Yang,F.C., Xu,M. and He,C.
  TITLE     RNA m5C oxidation by TET2 regulates chromatin state and
            leukaemogenesis
  JOURNAL   Nature 634 (8035), 986-994 (2024)
   PUBMED   39358506
  REMARK    GeneRIF: RNA m[5]C oxidation by TET2 regulates chromatin state and
            leukaemogenesis.
REFERENCE   2  (bases 1 to 9589)
  AUTHORS   de la Calle-Fabregat,C., Calafell-Segura,J., Gardet,M.,
            Dunsmore,G., Mulder,K., Ciudad,L., Silvin,A., Moreno-Caceres,J.,
            Corbi,A.L., Munoz-Pinedo,C., Michels,J., Gouy,S., Dutertre,C.A.,
            Rodriguez-Ubreva,J., Ginhoux,F. and Ballestar,E.
  TITLE     NF-kappaB and TET2 promote macrophage reprogramming in hypoxia that
            overrides the immunosuppressive effects of the tumor
            microenvironment
  JOURNAL   Sci Adv 10 (38), eadq5226 (2024)
   PUBMED   39292770
  REMARK    GeneRIF: NF-kappaB and TET2 promote macrophage reprogramming in
            hypoxia that overrides the immunosuppressive effects of the tumor
            microenvironment.
REFERENCE   3  (bases 1 to 9589)
  AUTHORS   Shen,Z., Liu,Z., Li,M., Han,L., Wang,J., Wu,X. and Sang,S.
  TITLE     Effects of TET2-mediated methylation reconstruction on A2058
            melanoma cell sensitivity to matrix stiffness in a 3D culture
            system
  JOURNAL   Exp Cell Res 442 (1), 114224 (2024)
   PUBMED   39187151
  REMARK    GeneRIF: Effects of TET2-mediated methylation reconstruction on
            A2058 melanoma cell sensitivity to matrix stiffness in a 3D culture
            system.
REFERENCE   4  (bases 1 to 9589)
  AUTHORS   Zeng,X., An,R., Guo,R. and Li,H.
  TITLE     Hypermethylated RASAL1's promotive role in chemoresistance and
            tumorigenesis of choriocarcinoma was regulated by TET2 but not
            DNMTs
  JOURNAL   BMC Cancer 24 (1), 977 (2024)
   PUBMED   39118077
  REMARK    GeneRIF: Hypermethylated RASAL1's promotive role in chemoresistance
            and tumorigenesis of choriocarcinoma was regulated by TET2 but not
            DNMTs.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9589)
  AUTHORS   Wang,M., Zhao,H.Y., Li,D.Q. and Chen,P.
  TITLE     [Relationship between DTA Mutations and Thromboembolism in Patients
            with Myeloproliferative Neoplasms]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 32 (3), 819-824 (2024)
   PUBMED   38926973
  REMARK    GeneRIF: [Relationship between DTA Mutations and Thromboembolism in
            Patients with Myeloproliferative Neoplasms].
REFERENCE   6  (bases 1 to 9589)
  AUTHORS   Tefferi,A., Lim,K.H., Abdel-Wahab,O., Lasho,T.L., Patel,J.,
            Patnaik,M.M., Hanson,C.A., Pardanani,A., Gilliland,D.G. and
            Levine,R.L.
  TITLE     Detection of mutant TET2 in myeloid malignancies other than
            myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML
  JOURNAL   Leukemia 23 (7), 1343-1345 (2009)
   PUBMED   19295549
  REMARK    GeneRIF: looked for the presence of TET2 mutations in myeloid
            malignancies other than MPN, including chronic myelomonocytic
            leukemia (CMML), myelodysplastic syndrome (MDS), 'MDS/MPN' and
            acute myeloid leukemia (AML)
REFERENCE   7  (bases 1 to 9589)
  AUTHORS   Tefferi,A., Pardanani,A., Lim,K.H., Abdel-Wahab,O., Lasho,T.L.,
            Patel,J., Gangat,N., Finke,C.M., Schwager,S., Mullally,A., Li,C.Y.,
            Hanson,C.A., Mesa,R., Bernard,O., Delhommeau,F., Vainchenker,W.,
            Gilliland,D.G. and Levine,R.L.
  TITLE     TET2 mutations and their clinical correlates in polycythemia vera,
            essential thrombocythemia and myelofibrosis
  JOURNAL   Leukemia 23 (5), 905-911 (2009)
   PUBMED   19262601
  REMARK    GeneRIF: TET2 mutations occur in both JAK2V617F-positive and
            -negative myeloproliferative neoplasms.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 9589)
  AUTHORS   Tefferi,A., Levine,R.L., Lim,K.H., Abdel-Wahab,O., Lasho,T.L.,
            Patel,J., Finke,C.M., Mullally,A., Li,C.Y., Pardanani,A. and
            Gilliland,D.G.
  TITLE     Frequent TET2 mutations in systemic mastocytosis: clinical,
            KITD816V and FIP1L1-PDGFRA correlates
  JOURNAL   Leukemia 23 (5), 900-904 (2009)
   PUBMED   19262599
  REMARK    GeneRIF: Loss-of-function mutations in TET2 occur at a high
            frequency in systemic mastocytosis, and are associated with
            KITD816V mutations.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 9589)
  AUTHORS   Lorsbach,R.B., Moore,J., Mathew,S., Raimondi,S.C., Mukatira,S.T.
            and Downing,J.R.
  TITLE     TET1, a member of a novel protein family, is fused to MLL in acute
            myeloid leukemia containing the t(10;11)(q22;q23)
  JOURNAL   Leukemia 17 (3), 637-641 (2003)
   PUBMED   12646957
REFERENCE   10 (bases 1 to 9589)
  AUTHORS   Austin,E.D., Phillips,J.A. III and Loyd,J.E.
  TITLE     Heritable Pulmonary Arterial Hypertension Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004069.1 and AC026029.8.
            
            On Apr 29, 2020 this sequence version replaced NM_001127208.2.
            
            Summary: The protein encoded by this gene is a methylcytosine
            dioxygenase that catalyzes the conversion of methylcytosine to
            5-hydroxymethylcytosine. The encoded protein is involved in
            myelopoiesis, and defects in this gene have been associated with
            several myeloproliferative disorders. Two variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.279361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380013.9/ ENSP00000369351.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC004069.1         50652-50755         c
            105-250             AC004069.1         7126-7271           c
            251-3705            AC026029.8         38267-41721
            3706-3796           AC026029.8         45709-45799
            3797-3890           AC026029.8         47204-47297
            3891-4099           AC026029.8         47940-48148
            4100-4250           AC026029.8         63989-64139
            4251-4340           AC026029.8         66129-66218
            4341-4478           AC026029.8         73980-74117
            4479-4833           AC026029.8         76934-77288
            4834-9589           AC026029.8         79418-84173
FEATURES             Location/Qualifiers
     source          1..9589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q24"
     gene            1..9589
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /note="tet methylcytosine dioxygenase 2"
                     /db_xref="GeneID:54790"
                     /db_xref="HGNC:HGNC:25941"
                     /db_xref="MIM:612839"
     exon            1..104
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            105..250
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            251..3705
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..6305
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /EC_number="1.14.11.80"
                     /note="isoform a is encoded by transcript variant 1;
                     probable methylcytosine dioxygenase TET2; tet oncogene
                     family member 2; ten-eleven translocation 2"
                     /codon_start=1
                     /product="methylcytosine dioxygenase TET2 isoform a"
                     /protein_id="NP_001120680.1"
                     /db_xref="CCDS:CCDS47120.1"
                     /db_xref="GeneID:54790"
                     /db_xref="HGNC:HGNC:25941"
                     /db_xref="MIM:612839"
                     /translation="MEQDRTNHVEGNRLSPFLIPSPPICQTEPLATKLQNGSPLPERA
                     HPEVNGDTKWHSFKSYYGIPCMKGSQNSRVSPDFTQESRGYSKCLQNGGIKRTVSEPS
                     LSGLLQIKKLKQDQKANGERRNFGVSQERNPGESSQPNVSDLSDKKESVSSVAQENAV
                     KDFTSFSTHNCSGPENPELQILNEQEGKSANYHDKNIVLLKNKAVLMPNGATVSASSV
                     EHTHGELLEKTLSQYYPDCVSIAVQKTTSHINAINSQATNELSCEITHPSHTSGQINS
                     AQTSNSELPPKPAAVVSEACDADDADNASKLAAMLNTCSFQKPEQLQQQKSVFEICPS
                     PAENNIQGTTKLASGEEFCSGSSSNLQAPGGSSERYLKQNEMNGAYFKQSSVFTKDSF
                     SATTTPPPPSQLLLSPPPPLPQVPQLPSEGKSTLNGGVLEEHHHYPNQSNTTLLREVK
                     IEGKPEAPPSQSPNPSTHVCSPSPMLSERPQNNCVNRNDIQTAGTMTVPLCSEKTRPM
                     SEHLKHNPPIFGSSGELQDNCQQLMRNKEQEILKGRDKEQTRDLVPPTQHYLKPGWIE
                     LKAPRFHQAESHLKRNEASLPSILQYQPNLSNQMTSKQYTGNSNMPGGLPRQAYTQKT
                     TQLEHKSQMYQVEMNQGQSQGTVDQHLQFQKPSHQVHFSKTDHLPKAHVQSLCGTRFH
                     FQQRADSQTEKLMSPVLKQHLNQQASETEPFSNSHLLQHKPHKQAAQTQPSQSSHLPQ
                     NQQQQQKLQIKNKEEILQTFPHPQSNNDQQREGSFFGQTKVEECFHGENQYSKSSEFE
                     THNVQMGLEEVQNINRRNSPYSQTMKSSACKIQVSCSNNTHLVSENKEQTTHPELFAG
                     NKTQNLHHMQYFPNNVIPKQDLLHRCFQEQEQKSQQASVLQGYKNRNQDMSGQQAAQL
                     AQQRYLIHNHANVFPVPDQGGSHTQTPPQKDTQKHAALRWHLLQKQEQQQTQQPQTES
                     CHSQMHRPIKVEPGCKPHACMHTAPPENKTWKKVTKQENPPASCDNVQQKSIIETMEQ
                     HLKQFHAKSLFDHKALTLKSQKQVKVEMSGPVTVLTRQTTAAELDSHTPALEQQTTSS
                     EKTPTKRTAASVLNNFIESPSKLLDTPIKNLLDTPVKTQYDFPSCRCVEQIIEKDEGP
                     FYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYTGKEGKSSQGCPIAKWVVRRSS
                     SEEKLLCLVRERAGHTCEAAVIVILILVWEGIPLSLADKLYSELTETLRKYGTLTNRR
                     CALNEERTCACQGLDPETCGASFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEE
                     KLESHLQNLSTLMAPTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFC
                     AHAHRDLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVEAQE
                     EKKRSGAIQVLSSFRRKVRMLAEPVKTCRQRKLEAKKAAAEKLSSLENSSNKNEKEKS
                     APSRTKQTENASQAKQLAELLRLSGPVMQQSQQPQPLQKQPPQPQQQQRPQQQQPHHP
                     QTESVNSYSASGSTNPYMRRPNPVSPYPNSSHTSDIYGSTSPMNFYSTSSQAAGSYLN
                     SSNPMNPYPGLLNQNTQYPSYQCNGNLSVDNCSPYLGSYSPQSQPMDLYRYPSQDPLS
                     KLSLPPIHTLYQPRFGNSQSFTSKYLGYGNQNMQGDGFSSCTIRPNVHHVGKLPPYPT
                     HEMDGHFMGATSRLPPNLSNPNMDYKNGEHHSPSHIIHNYSAAPGMFNSSLHALHLQN
                     KENDMLSHTANGLSKMLPALNHDRTACVQGGLHKLSDANGQEKQPLALVQGVASGAED
                     NDEVWSDSEQSFLDPDIGGVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLV
                     FYQHKSMNEPKHGLALWEAKMAEKAREKEEECEKYGPDYVPQKSHGKKVKREPAEPHE
                     TSEPTYLRFIKSLAERTMSVTTDSTVTTSPYAFTRVTGPYNRYI"
     exon            3706..3796
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            3797..3890
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..4099
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            4100..4250
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            4251..4340
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            4341..4478
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            4479..4833
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /inference="alignment:Splign:2.1.0"
     exon            4834..9589
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9558..9563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /note="hexamer: AATAAA"
     polyA_site      9589
                     /gene="TET2"
                     /gene_synonym="IMD75; KIAA1546; MDS"
                     /note="major polyA site"
ORIGIN      
        1 gtagagaagc agaaggaagc aagatggctg ccctttagga tttgttagaa aggagacccg
       61 actgcaactg ctggattgct gcaaggctga gggacgagaa cgaggctggc aaacattcag
      121 cagcacaccc tctcaagatt gtttacttgc ctttgctcct gttgagttac aacgcttgga
      181 agcaggagat gggctcagca gcagccaata ggacatgatc caggaagagc agtaagggac
      241 tgagctgctg aattcaacta gagggcagcc ttgtggatgg ccccgaagca agcctgatgg
      301 aacaggatag aaccaaccat gttgagggca acagactaag tccattcctg ataccatcac
      361 ctcccatttg ccagacagaa cctctggcta caaagctcca gaatggaagc ccactgcctg
      421 agagagctca tccagaagta aatggagaca ccaagtggca ctctttcaaa agttattatg
      481 gaataccctg tatgaaggga agccagaata gtcgtgtgag tcctgacttt acacaagaaa
      541 gtagagggta ttccaagtgt ttgcaaaatg gaggaataaa acgcacagtt agtgaacctt
      601 ctctctctgg gctccttcag atcaagaaat tgaaacaaga ccaaaaggct aatggagaaa
      661 gacgtaactt cggggtaagc caagaaagaa atccaggtga aagcagtcaa ccaaatgtct
      721 ccgatttgag tgataagaaa gaatctgtga gttctgtagc ccaagaaaat gcagttaaag
      781 atttcaccag tttttcaaca cataactgca gtgggcctga aaatccagag cttcagattc
      841 tgaatgagca ggaggggaaa agtgctaatt accatgacaa gaacattgta ttacttaaaa
      901 acaaggcagt gctaatgcct aatggtgcta cagtttctgc ctcttccgtg gaacacacac
      961 atggtgaact cctggaaaaa acactgtctc aatattatcc agattgtgtt tccattgcgg
     1021 tgcagaaaac cacatctcac ataaatgcca ttaacagtca ggctactaat gagttgtcct
     1081 gtgagatcac tcacccatcg catacctcag ggcagatcaa ttccgcacag acctctaact
     1141 ctgagctgcc tccaaagcca gctgcagtgg tgagtgaggc ctgtgatgct gatgatgctg
     1201 ataatgccag taaactagct gcaatgctaa atacctgttc ctttcagaaa ccagaacaac
     1261 tacaacaaca aaaatcagtt tttgagatat gcccatctcc tgcagaaaat aacatccagg
     1321 gaaccacaaa gctagcgtct ggtgaagaat tctgttcagg ttccagcagc aatttgcaag
     1381 ctcctggtgg cagctctgaa cggtatttaa aacaaaatga aatgaatggt gcttacttca
     1441 agcaaagctc agtgttcact aaggattcct tttctgccac taccacacca ccaccaccat
     1501 cacaattgct tctttctccc cctcctcctc ttccacaggt tcctcagctt ccttcagaag
     1561 gaaaaagcac tctgaatggt ggagttttag aagaacacca ccactacccc aaccaaagta
     1621 acacaacact tttaagggaa gtgaaaatag agggtaaacc tgaggcacca ccttcccaga
     1681 gtcctaatcc atctacacat gtatgcagcc cttctccgat gctttctgaa aggcctcaga
     1741 ataattgtgt gaacaggaat gacatacaga ctgcagggac aatgactgtt ccattgtgtt
     1801 ctgagaaaac aagaccaatg tcagaacacc tcaagcataa cccaccaatt tttggtagca
     1861 gtggagagct acaggacaac tgccagcagt tgatgagaaa caaagagcaa gagattctga
     1921 agggtcgaga caaggagcaa acacgagatc ttgtgccccc aacacagcac tatctgaaac
     1981 caggatggat tgaattgaag gcccctcgtt ttcaccaagc ggaatcccat ctaaaacgta
     2041 atgaggcatc actgccatca attcttcagt atcaacccaa tctctccaat caaatgacct
     2101 ccaaacaata cactggaaat tccaacatgc ctggggggct cccaaggcaa gcttacaccc
     2161 agaaaacaac acagctggag cacaagtcac aaatgtacca agttgaaatg aatcaagggc
     2221 agtcccaagg tacagtggac caacatctcc agttccaaaa accctcacac caggtgcact
     2281 tctccaaaac agaccattta ccaaaagctc atgtgcagtc actgtgtggc actagatttc
     2341 attttcaaca aagagcagat tcccaaactg aaaaacttat gtccccagtg ttgaaacagc
     2401 acttgaatca acaggcttca gagactgagc cattttcaaa ctcacacctt ttgcaacata
     2461 agcctcataa acaggcagca caaacacaac catcccagag ttcacatctc cctcaaaacc
     2521 agcaacagca gcaaaaatta caaataaaga ataaagagga aatactccag acttttcctc
     2581 acccccaaag caacaatgat cagcaaagag aaggatcatt ctttggccag actaaagtgg
     2641 aagaatgttt tcatggtgaa aatcagtatt caaaatcaag cgagttcgag actcataatg
     2701 tccaaatggg actggaggaa gtacagaata taaatcgtag aaattcccct tatagtcaga
     2761 ccatgaaatc aagtgcatgc aaaatacagg tttcttgttc aaacaataca cacctagttt
     2821 cagagaataa agaacagact acacatcctg aactttttgc aggaaacaag acccaaaact
     2881 tgcatcacat gcaatatttt ccaaataatg tgatcccaaa gcaagatctt cttcacaggt
     2941 gctttcaaga acaggagcag aagtcacaac aagcttcagt tctacaggga tataaaaata
     3001 gaaaccaaga tatgtctggt caacaagctg cgcaacttgc tcagcaaagg tacttgatac
     3061 ataaccatgc aaatgttttt cctgtgcctg accagggagg aagtcacact cagacccctc
     3121 cccagaagga cactcaaaag catgctgctc taaggtggca tctcttacag aagcaagaac
     3181 agcagcaaac acagcaaccc caaactgagt cttgccatag tcagatgcac aggccaatta
     3241 aggtggaacc tggatgcaag ccacatgcct gtatgcacac agcaccacca gaaaacaaaa
     3301 catggaaaaa ggtaactaag caagagaatc cacctgcaag ctgtgataat gtgcagcaaa
     3361 agagcatcat tgagaccatg gagcagcatc tgaagcagtt tcacgccaag tcgttatttg
     3421 accataaggc tcttactctc aaatcacaga agcaagtaaa agttgaaatg tcagggccag
     3481 tcacagtttt gactagacaa accactgctg cagaacttga tagccacacc ccagctttag
     3541 agcagcaaac aacttcttca gaaaagacac caaccaaaag aacagctgct tctgttctca
     3601 ataattttat agagtcacct tccaaattac tagatactcc tataaaaaat ttattggata
     3661 cacctgtcaa gactcaatat gatttcccat cttgcagatg tgtagagcaa attattgaaa
     3721 aagatgaagg tcctttttat acccatctag gagcaggtcc taatgtggca gctattagag
     3781 aaatcatgga agaaaggttt ggacagaagg gtaaagctat taggattgaa agagtcatct
     3841 atactggtaa agaaggcaaa agttctcagg gatgtcctat tgctaagtgg gtggttcgca
     3901 gaagcagcag tgaagagaag ctactgtgtt tggtgcggga gcgagctggc cacacctgtg
     3961 aggctgcagt gattgtgatt ctcatcctgg tgtgggaagg aatcccgctg tctctggctg
     4021 acaaactcta ctcggagctt accgagacgc tgaggaaata cggcacgctc accaatcgcc
     4081 ggtgtgcctt gaatgaagag agaacttgcg cctgtcaggg gctggatcca gaaacctgtg
     4141 gtgcctcctt ctcttttggt tgttcatgga gcatgtacta caatggatgt aagtttgcca
     4201 gaagcaagat cccaaggaag tttaagctgc ttggggatga cccaaaagag gaagagaaac
     4261 tggagtctca tttgcaaaac ctgtccactc ttatggcacc aacatataag aaacttgcac
     4321 ctgatgcata taataatcag attgaatatg aacacagagc accagagtgc cgtctgggtc
     4381 tgaaggaagg ccgtccattc tcaggggtca ctgcatgttt ggacttctgt gctcatgccc
     4441 acagagactt gcacaacatg cagaatggca gcacattggt atgcactctc actagagaag
     4501 acaatcgaga atttggagga aaacctgagg atgagcagct tcacgttctg cctttataca
     4561 aagtctctga cgtggatgag tttgggagtg tggaagctca ggaggagaaa aaacggagtg
     4621 gtgccattca ggtactgagt tcttttcggc gaaaagtcag gatgttagca gagccagtca
     4681 agacttgccg acaaaggaaa ctagaagcca agaaagctgc agctgaaaag ctttcctccc
     4741 tggagaacag ctcaaataaa aatgaaaagg aaaagtcagc cccatcacgt acaaaacaaa
     4801 ctgaaaacgc aagccaggct aaacagttgg cagaactttt gcgactttca ggaccagtca
     4861 tgcagcagtc ccagcagccc cagcctctac agaagcagcc accacagccc cagcagcagc
     4921 agagacccca gcagcagcag ccacatcacc ctcagacaga gtctgtcaac tcttattctg
     4981 cttctggatc caccaatcca tacatgagac ggcccaatcc agttagtcct tatccaaact
     5041 cttcacacac ttcagatatc tatggaagca ccagccctat gaacttctat tccacctcat
     5101 ctcaagctgc aggttcatat ttgaattctt ctaatcccat gaacccttac cctgggcttt
     5161 tgaatcagaa tacccaatat ccatcatatc aatgcaatgg aaacctatca gtggacaact
     5221 gctccccata tctgggttcc tattctcccc agtctcagcc gatggatctg tataggtatc
     5281 caagccaaga ccctctgtct aagctcagtc taccacccat ccatacactt taccagccaa
     5341 ggtttggaaa tagccagagt tttacatcta aatacttagg ttatggaaac caaaatatgc
     5401 agggagatgg tttcagcagt tgtaccatta gaccaaatgt acatcatgta gggaaattgc
     5461 ctccttatcc cactcatgag atggatggcc acttcatggg agccacctct agattaccac
     5521 ccaatctgag caatccaaac atggactata aaaatggtga acatcattca ccttctcaca
     5581 taatccataa ctacagtgca gctccgggca tgttcaacag ctctcttcat gccctgcatc
     5641 tccaaaacaa ggagaatgac atgctttccc acacagctaa tgggttatca aagatgcttc
     5701 cagctcttaa ccatgataga actgcttgtg tccaaggagg cttacacaaa ttaagtgatg
     5761 ctaatggtca ggaaaagcag ccattggcac tagtccaggg tgtggcttct ggtgcagagg
     5821 acaacgatga ggtctggtca gacagcgagc agagctttct ggatcctgac attgggggag
     5881 tggccgtggc tccaactcat gggtcaattc tcattgagtg tgcaaagcgt gagctgcatg
     5941 ccacaacccc tttaaagaat cccaatagga atcaccccac caggatctcc ctcgtctttt
     6001 accagcataa gagcatgaat gagccaaaac atggcttggc tctttgggaa gccaaaatgg
     6061 ctgaaaaagc ccgtgagaaa gaggaagagt gtgaaaagta tggcccagac tatgtgcctc
     6121 agaaatccca tggcaaaaaa gtgaaacggg agcctgctga gccacatgaa acttcagagc
     6181 ccacttacct gcgtttcatc aagtctcttg ccgaaaggac catgtccgtg accacagact
     6241 ccacagtaac tacatctcca tatgccttca ctcgggtcac agggccttac aacagatata
     6301 tatgatatca cccccttttg ttggttacct cacttgaaaa gaccacaacc aacctgtcag
     6361 tagtatagtt ctcatgacgt gggcagtggg gaaaggtcac agtattcatg acaaatgtgg
     6421 tgggaaaaac ctcagctcac cagcaacaaa agaggttatc ttaccatagc acttaatttt
     6481 cactggctcc caagtggtca cagatggcat ctaggaaaag accaaagcat tctatgcaaa
     6541 aagaaggtgg ggaagaaagt gttccgcaat ttacattttt aaacactggt tctattattg
     6601 gacgagatga tatgtaaatg tgatcccccc cccccgctta caactctaca catctgtgac
     6661 cacttttaat aatatcaagt ttgcatagtc atggaacaca aatcaaacaa gtactgtagt
     6721 attacagtga caggaatctt aaaataccat ctggtgctga atatatgatg tactgaaata
     6781 ctggaattat ggctttttga aatgcagttt ttactgtaat cttaactttt atttatcaaa
     6841 atagctacag gaaacatgaa tagcaggaaa acactgaatt tgtttggatg ttctaagaaa
     6901 tggtgctaag aaaatggtgt ctttaatagc taaaaattta atgcctttat atcatcaaga
     6961 tgctatcagt gtactccagt gcccttgaat aataggggta ccttttcatt caagttttta
     7021 tcataattac ctattcttac acaagcttag tttttaaaat gtggacattt taaaggcctc
     7081 tggattttgc tcatccagtg aagtccttgt aggacaataa acgtatatat gtacatatat
     7141 acacaaacat gtatatgtgc acacacatgt atatgtataa atattttaaa tggtgtttta
     7201 gaagcacttt gtctacctaa gctttgacaa cttgaacaat gctaaggtac tgagatgttt
     7261 aaaaaacaag tttactttca ttttagaatg caaagttgat ttttttaagg aaacaaagaa
     7321 agcttttaaa atatttttgc ttttagccat gcatctgctg atgagcaatt gtgtccattt
     7381 ttaacacagc cagttaaatc caccatgggg cttactggat tcaagggaat acgttagtcc
     7441 acaaaacatg ttttctggtg ctcatctcac atgctatact gtaaaacagt tttatacaaa
     7501 attgtatgac aagttcattg ctcaaaaatg tacagtttta agaattttct attaactgca
     7561 ggtaataatt agctgcatgc tgcagactca acaaagctag ttcactgaag cctatgctat
     7621 tttatggatc ataggctctt cagagaactg aatggcagtc tgcctttgtg ttgataatta
     7681 tgtacattgt gacgttgtca tttcttagct taagtgtcct ctttaacaag aggattgagc
     7741 agactgatgc ctgcataaga tgaataaaca gggttagttc catgtgaatc tgtcagttaa
     7801 aaagaaacaa aaacaggcag ctggtttgct gtggtggttt taaatcatta atttgtataa
     7861 agaagtgaaa gagttgtata gtaaattaaa ttgtaaacaa aactttttta atgcaatgct
     7921 ttagtatttt agtactgtaa aaaaattaaa tatatacata tatatatata tatatatata
     7981 tatatatatg agtttgaagc agaattcaca tcatgatggt gctactcagc ctgctacaaa
     8041 tatatcataa tgtgagctaa gaattcatta aatgtttgag tgatgttcct acttgtcata
     8101 tacctcaaca ctagtttggc aataggatat tgaactgaga gtgaaagcat tgtgtaccat
     8161 catttttttc caagtccttt tttttattgt taaaaaaaaa agcatacctt ttttcaatac
     8221 ttgatttctt agcaagtata acttgaactt caaccttttt gttctaaaaa ttcagggata
     8281 tttcagctca tgctctccct atgccaacat gtcacctgtg tttatgtaaa attgttgtag
     8341 gttaataaat atattctttg tcagggattt aaccctttta ttttgaatcc cttctatttt
     8401 acttgtacat gtgctgatgt aactaaaact aattttgtaa atctgttggc tctttttatt
     8461 gtaaagaaaa gcattttaaa agtttgagga atcttttgac tgtttcaagc aggaaaaaaa
     8521 aattacatga aaatagaatg cactgagttg ataaagggaa aaattgtaag gcaggagttt
     8581 ggcaagtggc tgttggccag agacttactt gtaactctct aaatgaagtt tttttgatcc
     8641 tgtaatcact gaaggtacat actccatgtg gacttccctt aaacaggcaa acacctacag
     8701 gtatggtgtg caacagattg tacaattaca ttttggccta aatacatttt tgcttactag
     8761 tatttaaaat aaattcttaa tcagaggagg cctttgggtt ttattggtca aatctttgta
     8821 agctggcttt tgtcttttta aaaaatttct tgaatttgtg gttgtgtcca atttgcaaac
     8881 atttccaaaa atgtttgctt tgcttacaaa ccacatgatt ttaatgtttt ttgtatacca
     8941 taatatctag ccccaaacat ttgattacta catgtgcatt ggtgattttg atcatccatt
     9001 cttaatattt gatttctgtg tcacctactg tcatttgtta aactgctggc caacaagaac
     9061 aggaagtata gtttgggggg ttggggagag tttacataag gaagagaaga aattgagtgg
     9121 catattgtaa atatcagatc tataattgta aatataaaac ctgcctcagt tagaatgaat
     9181 ggaaagcaga tctacaattt gctaatatag gaatatcagg ttgactatat agccatactt
     9241 gaaaatgctt ctgagtggtg tcaactttac ttgaatgaat ttttcatctt gattgacgca
     9301 cagtgatgta cagttcactt ctgaagctag tggttaactt gtgtaggaaa cttttgcagt
     9361 ttgacactaa gataacttct gtgtgcattt ttctatgctt ttttaaaaac tagtttcatt
     9421 tcattttcat gagatgtttg gtttataaga tctgaggatg gttataaata ctgtaagtat
     9481 tgtaatgtta tgaatgcagg ttatttgaaa gctgtttatt attatatcat tcctgataat
     9541 gctatgtgag tgtttttaat aaaatttata tttatttaat gcactctaa
//
