LOCUS       NM_030625               9612 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens tet methylcytosine dioxygenase 1 (TET1), transcript
            variant 2, mRNA.
ACCESSION   NM_030625 XM_001129234 XM_001130016
VERSION     NM_030625.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9612)
  AUTHORS   Ren,J., Chen,X., Li,J., Zan,Y., Wang,S., Tan,Y. and Ding,Y.
  TITLE     TET1 inhibits the migration and invasion of cervical cancer cells
            by regulating autophagy
  JOURNAL   Epigenetics 19 (1), 2323751 (2024)
   PUBMED   38431880
  REMARK    GeneRIF: TET1 inhibits the migration and invasion of cervical
            cancer cells by regulating autophagy.
REFERENCE   2  (bases 1 to 9612)
  AUTHORS   Wang,J., Zhang,Y., Ma,Y., Zhao,S., Wang,J., Chen,H., Zhang,J. and
            Liu,J.
  TITLE     TET1 inhibits liver fibrosis by blocking hepatic stellate cell
            activation
  JOURNAL   J Gastroenterol Hepatol 39 (7), 1403-1412 (2024)
   PUBMED   38369780
  REMARK    GeneRIF: TET1 inhibits liver fibrosis by blocking hepatic stellate
            cell activation.
REFERENCE   3  (bases 1 to 9612)
  AUTHORS   Pandey,A., Hoover,M., Singla,M., Bedi,Y., Storaci,H., Goodman,S.B.,
            Chan,C. and Bhutani,N.
  TITLE     TET1 Regulates Skeletal Stem-Cell Mediated Cartilage Regeneration
  JOURNAL   Arthritis Rheumatol 76 (2), 216-230 (2024)
   PUBMED   37610277
  REMARK    GeneRIF: TET1 Regulates Skeletal Stem-Cell Mediated Cartilage
            Regeneration.
REFERENCE   4  (bases 1 to 9612)
  AUTHORS   Ghazimoradi,M.H., Pakravan,K., Khalafizadeh,A. and Babashah,S.
  TITLE     TET1 regulates stem cell properties and cell cycle of Cancer stem
            cells in triple-negative breast cancer via DNA demethylation
  JOURNAL   Biochem Pharmacol 219, 115913 (2024)
   PUBMED   37995981
  REMARK    GeneRIF: TET1 regulates stem cell properties and cell cycle of
            Cancer stem cells in triple-negative breast cancer via DNA
            demethylation.
REFERENCE   5  (bases 1 to 9612)
  AUTHORS   Zhang,S. and Chen,R.
  TITLE     LINC00891 Attenuates the Proliferation and Metastasis of
            Osteosarcoma Cells via miR-27a-3p/TET1 Axis
  JOURNAL   Genet Test Mol Biomarkers 27 (8), 248-257 (2023)
   PUBMED   37643326
  REMARK    GeneRIF: LINC00891 Attenuates the Proliferation and Metastasis of
            Osteosarcoma Cells via miR-27a-3p/TET1 Axis.
REFERENCE   6  (bases 1 to 9612)
  AUTHORS   Morgan,A.R., Hamilton,G., Turic,D., Jehu,L., Harold,D., Abraham,R.,
            Hollingworth,P., Moskvina,V., Brayne,C., Rubinsztein,D.C.,
            Lynch,A., Lawlor,B., Gill,M., O'Donovan,M., Powell,J.,
            Lovestone,S., Williams,J. and Owen,M.J.
  TITLE     Association analysis of 528 intra-genic SNPs in a region of
            chromosome 10 linked to late onset Alzheimer's disease
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (6), 727-731 (2008)
   PUBMED   18163421
  REMARK    GeneRIF: Significant association with late-onset Alzheimer's
            disease for 4 SNPs: rs1881747 near DKK1, rs2279420 in ANK3,
            rs2306402 in CTNNA3, and rs5030882 in CXXC6 in 1,160 cases and
            1,389 controls.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 9612)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 9612)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 9612)
  AUTHORS   Lorsbach,R.B., Moore,J., Mathew,S., Raimondi,S.C., Mukatira,S.T.
            and Downing,J.R.
  TITLE     TET1, a member of a novel protein family, is fused to MLL in acute
            myeloid leukemia containing the t(10;11)(q22;q23)
  JOURNAL   Leukemia 17 (3), 637-641 (2003)
   PUBMED   12646957
  REMARK    GeneRIF: demonstrated that TET1 is fused to MLL in a case of
            pediatric acute myeloid leukemia containing the t(10;11)(q22;q23)
REFERENCE   10 (bases 1 to 9612)
  AUTHORS   Ono,R., Taki,T., Taketani,T., Taniwaki,M., Kobayashi,H. and
            Hayashi,Y.
  TITLE     LCX, leukemia-associated protein with a CXXC domain, is fused to
            MLL in acute myeloid leukemia with trilineage dysplasia having
            t(10;11)(q22;q23)
  JOURNAL   Cancer Res 62 (14), 4075-4080 (2002)
   PUBMED   12124344
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL713888.10, AF430147.1,
            AL513534.17, AK123436.1 and AL832334.1.
            
            On Nov 23, 2018 this sequence version replaced NM_030625.2.
            
            Summary: DNA methylation is an epigenetic mechanism that is
            important for controlling gene expression. The protein encoded by
            this gene is a demethylase that belongs to the TET (ten-eleven
            translocation) family. Members of the TET protein family play a
            role in the DNA methylation process and gene activation. [provided
            by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF430147.1, SRR14038196.2911806.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2467143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373644.5/ ENSP00000362748.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL713888.10        79574-79596
            24-390              AL713888.10        79597-79963
            391-498             AF430147.1         72-179
            499-499             AL713888.10        91546-91546
            500-3896            AF430147.1         181-3577
            3897-3897           AL513534.17        24120-24120
            3898-7838           AF430147.1         3579-7519
            7839-7839           AL513534.17        70736-70736
            7840-9594           AK123436.1         3733-5487
            9595-9607           AL832334.1         3772-3784
            9608-9612           AL513534.17        72505-72509
FEATURES             Location/Qualifiers
     source          1..9612
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.3"
     gene            1..9612
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /note="tet methylcytosine dioxygenase 1"
                     /db_xref="GeneID:80312"
                     /db_xref="HGNC:HGNC:29484"
                     /db_xref="MIM:607790"
     exon            1..406
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /inference="alignment:Splign:2.1.0"
     exon            407..2442
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /inference="alignment:Splign:2.1.0"
     CDS             529..6939
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /EC_number="1.14.11.80"
                     /note="isoform 2 is encoded by transcript variant 2; CXXC
                     finger 6; leukemia-associated protein with a CXXC domain;
                     methylcytosine dioxygenase TET1; ten-eleven
                     translocation-1; CXXC-type zinc finger protein 6; tet
                     oncogene 1; CXXC zinc finger 6; ten-eleven translocation 1
                     gene protein"
                     /codon_start=1
                     /product="methylcytosine dioxygenase TET1 isoform 2"
                     /protein_id="NP_085128.2"
                     /db_xref="CCDS:CCDS7281.1"
                     /db_xref="GeneID:80312"
                     /db_xref="HGNC:HGNC:29484"
                     /db_xref="MIM:607790"
                     /translation="MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTL
                     SPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGAARMNLDRTEVLFQNPESLTCNGF
                     TMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPM
                     QDTQVLPDIETLIGVQNPSLLKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPL
                     EGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPKVTSQGNPSIQLEELGSR
                     VESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGS
                     KQATLGAKPDHQEAFEATANQQEVSDTTSFLGQAFGAIPHQWELPGADPVHGEALGET
                     PDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNPIATFNAPSKWP
                     EPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFL
                     PANTQGFPLAPERGLFHASLGIAQLSQAGPSKSDRGSSQVSVTSTVHVVNTTVVTMPV
                     PMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQICKKRKC
                     EELKKKPSVVVPLEVIKENKRPQREKKPKVLKADFDNKPVNGPKSESMDYSRCGHGEE
                     QKLELNPHTVENVTKNEDSMTGIEVEKWTQNKKSQLTDHVKGDFSANVPEAEKSKNSE
                     VDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIEEFGKTLENNSYKFLKDTA
                     NHKNAMSSVATDMSCDHLKGRSNVLVFQQPGFNCSSIPHSSHSIINHHASIHNEGDQP
                     KTPENIPSKEPKDGSPVQPSLLSLMKDRRLTLEQVVAIEALTQLSEAPSENSSPSKSE
                     KDEESEQRTASLLNSCKAILYTVRKDLQDPNLQGEPPKLNHCPSLEKQSSCNTVVFNG
                     QTTTLSNSHINSATNQASTKSHEYSKVTNSLSLFIPKSNSSKIDTNKSIAQGIITLDN
                     CSNDLHQLPPRNNEVEYCNQLLDSSKKLDSDDLSCQDATHTQIEEDVATQLTQLASII
                     KINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVHNNHGSSLTKQKNPT
                     QKKTKSTPSRDRRKKKPTVVSYQENDRQKWEKLSYMYGTICDIWIASKFQNFGQFCPH
                     DFPTVFGKISSSTKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPESAEEKVKVEPLDS
                     LSLFHLKTESNGKAFTDKAYNSQVQLTVNANQKAHPLTQPSSPPNQCANVMAGDDQIR
                     FQQVVKEQLMHQRLPTLPGISHETPLPESALTLRNVNVVCSGGITVVSTKSEEEVCSS
                     SFGTSEFSTVDSAQKNFNDYAMNFFTNPTKNLVSITKDSELPTCSCLDRVIQKDKGPY
                     YTHLGAGPSVAAVREIMENRYGQKGNAIRIEIVVYTGKEGKSSHGCPIAKWVLRRSSD
                     EEKVLCLVRQRTGHHCPTAVMVVLIMVWDGIPLPMADRLYTELTENLKSYNGHPTDRR
                     CTLNENRTCTCQGIDPETCGASFSFGCSWSMYFNGCKFGRSPSPRRFRIDPSSPLHEK
                     NLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVARECRLGSKEGRPFSGVTACLDFC
                     AHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGME
                     AKIKSGAIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRK
                     NNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFILKSSDNTKTYSLMPSAPHPVK
                     EASPGFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPG
                     ISQLGEVAPLPTLSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPME
                     EDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFLDANIGGVAIAPAHG
                     SVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAK
                     NKKMKASEQKDQAANEGPEQSSEVNELNQIPSHKALTLTHDNVVTVSPYALTHVAGPY
                     NHWV"
     exon            2443..2496
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..4804
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /inference="alignment:Splign:2.1.0"
     exon            4805..4895
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /inference="alignment:Splign:2.1.0"
     exon            4896..4989
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /inference="alignment:Splign:2.1.0"
     exon            4990..5201
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5202..5352
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5353..5442
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5443..5580
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5581..5932
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /inference="alignment:Splign:2.1.0"
     exon            5933..9612
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7448..7453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /note="hexamer: AATAAA"
     polyA_site      7479
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /note="major polyA site"
     regulatory      9576..9581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /note="hexamer: AATAAA"
     polyA_site      9612
                     /gene="TET1"
                     /gene_synonym="bA119F7.1; CXXC6; LCX"
                     /note="major polyA site"
ORIGIN      
        1 actccctgag gtctgtcctg gggagacact gctgctccgg ggggctgacc tggcggggag
       61 tggccgcgca gtctgctccg gcgccgcttt gtgcgcgcag ccgctggccc ctctactccc
      121 gggtctgccc cccgggacac ccctctgcct cgcccaagtc atgcagccct acctgcctct
      181 ccactgtgga cctttgggaa ccgactcctc acctcggggg ctcgggcctt gactgtgctg
      241 ggagccggta ggcgtcctcc gcgacccgcc cgcgcccctc gcgcccgccg gggccccggg
      301 ctccaaagtt gtggggaccg gcgcgagttg gaaagtttgc ccgagggctg gtgcaggctt
      361 ggagctgggg gccgtgcgct gccctgggaa tgtgacccgg ccagcgacca aaaccttgtg
      421 tgactgagct gaagagcagt gcatccagat tctcctcaga agtgagactt tccaaaggac
      481 caatgactct gtttcctgcg ccctttcatt ttttcctact ctgtagctat gtctcgatcc
      541 cgccatgcaa ggccttccag attagtcagg aaggaagatg taaacaaaaa aaagaaaaac
      601 agccaactac gaaagacaac caagggagcc aacaaaaatg tggcatcagt caagacttta
      661 agccctggaa aattaaagca attaattcaa gaaagagatg ttaagaaaaa aacagaacct
      721 aaaccacccg tgccagtcag aagccttctg acaagagctg gagcagcacg catgaatttg
      781 gataggactg aggttctttt tcagaaccca gagtccttaa cctgcaatgg gtttacaatg
      841 gcgctacgaa gcacctctct tagcaggcga ctctcccaac ccccactggt cgtagccaaa
      901 tccaaaaagg ttccactttc taagggttta gaaaagcaac atgattgtga ttataagata
      961 ctccctgctt tgggagtaaa gcactcagaa aatgattcgg ttccaatgca agacacccaa
     1021 gtccttcctg atatagagac tctaattggt gtacaaaatc cctctttact taaaggtaag
     1081 agccaagaga caactcagtt ttggtcccaa agagttgagg attccaagat caatatccct
     1141 acccacagtg gccctgcagc tgagatcctt cctgggccac tggaagggac acgctgtggt
     1201 gaaggactat tctctgaaga gacattgaat gataccagtg gttccccaaa aatgtttgct
     1261 caggacacag tgtgtgctcc ttttccccaa agagcaaccc ccaaagttac ctctcaagga
     1321 aaccccagca ttcagttaga agagttgggt tcacgagtag aatctcttaa gttatctgat
     1381 tcttacctgg atcccattaa aagtgaacat gattgctacc ccacctccag tcttaataag
     1441 gttatacctg acttgaacct tagaaactgc ttggctcttg gtgggtctac gtctcctacc
     1501 tctgtaataa aattcctctt ggcaggctca aaacaagcga cccttggtgc taaaccagat
     1561 catcaagagg ccttcgaagc tactgcaaat caacaggaag tttctgatac cacctctttc
     1621 ctaggacagg cctttggtgc tatcccacat caatgggaac ttcctggtgc tgacccagtt
     1681 catggtgagg ccctgggtga gaccccagat ctaccagaga ttcctggtgc tattccagtc
     1741 caaggagagg tctttggtac tattttagac caacaagaaa ctcttggtat gagtgggagt
     1801 gttgtcccag acttgcctgt cttccttcct gttcctccaa atccaattgc tacctttaat
     1861 gctccttcca aatggcctga gccccaaagc actgtctcat atggacttgc agtccagggt
     1921 gctatacaga ttttgccttt gggctcagga cacactcctc aatcatcatc aaactcagag
     1981 aaaaattcat tacctccagt aatggctata agcaatgtag aaaatgagaa gcaggttcat
     2041 ataagcttcc tgccagctaa cactcagggg ttcccattag cccctgagag aggactcttc
     2101 catgcttcac tgggtatagc ccaactctct caggctggtc ctagcaaatc agacagaggg
     2161 agctcccagg tcagtgtaac cagcacagtt catgttgtca acaccacagt ggtgactatg
     2221 ccagtgccaa tggtcagtac ctcctcttct tcctatacca ctttgctacc gactttggaa
     2281 aagaagaaaa gaaagcgatg tggggtctgt gaaccctgcc agcagaagac caactgtggt
     2341 gaatgcactt actgcaagaa cagaaagaac agccatcaga tctgtaagaa aagaaaatgt
     2401 gaggagctga aaaagaaacc atctgttgtt gtgcctctgg aggttataaa ggaaaacaag
     2461 aggccccaga gggaaaagaa gcccaaagtt ttaaaggcag attttgacaa caaaccagta
     2521 aatggcccca agtcagaatc catggactac agtagatgtg gtcatgggga agaacaaaaa
     2581 ttggaattga acccacatac tgttgaaaat gtaactaaaa atgaagacag catgacaggc
     2641 atcgaggtgg agaagtggac acaaaacaag aaatcacagt taactgatca cgtgaaagga
     2701 gattttagtg ctaatgtccc agaagctgaa aaatcgaaaa actctgaagt tgacaagaaa
     2761 cgaaccaaat ctccaaaatt gtttgtacaa accgtaagaa atggcattaa acatgtacac
     2821 tgtttaccag ctgaaacaaa tgtttcattt aaaaaattca atattgaaga attcggcaag
     2881 acattggaaa acaattctta taaattccta aaagacactg caaaccataa aaacgctatg
     2941 agctctgttg ctactgatat gagttgtgat catctcaagg ggagaagtaa cgttttagta
     3001 ttccagcagc ctggctttaa ctgcagttcc attccacatt cttcacactc catcataaat
     3061 catcatgcta gtatacacaa tgaaggtgat caaccaaaaa ctcctgagaa tataccaagt
     3121 aaagaaccaa aagatggatc tcccgttcaa ccaagtctct tatcgttaat gaaagatagg
     3181 agattaacat tggagcaagt ggtagccata gaggccctga ctcaactctc agaagcccca
     3241 tcagagaatt cctccccatc aaagtcagag aaggatgagg aatcagagca gagaacagcc
     3301 agtttgctta atagctgcaa agctatcctc tacactgtaa gaaaagacct ccaagaccca
     3361 aacttacagg gagagccacc aaaacttaat cactgtccat ctttggaaaa acaaagttca
     3421 tgcaacacgg tggttttcaa tgggcaaact actacccttt ccaactcaca tatcaactca
     3481 gctactaacc aagcatccac aaagtcacat gaatattcaa aagtcacaaa ttcattatct
     3541 ctttttatac caaaatcaaa ttcatccaag attgacacca ataaaagtat tgctcaaggg
     3601 ataattactc ttgacaattg ttccaatgat ttgcatcagt tgccaccaag aaataatgaa
     3661 gtggagtatt gcaaccagtt actggacagc agcaaaaaat tggactcaga tgatctatca
     3721 tgtcaggatg caacccatac ccaaattgag gaagatgttg caacacagtt gacacaactt
     3781 gcttcgataa ttaagatcaa ttatataaaa ccagaggaca aaaaagttga aagtacacca
     3841 acaagccttg tcacatgtaa tgtacagcaa aaatacaatc aggagaaggg cacaatacaa
     3901 cagaaaccac cttcaagtgt acacaataat catggttcat cattaacaaa acaaaagaac
     3961 ccaacccaga aaaagacaaa atccacccca tcaagagatc ggcggaaaaa gaagcccaca
     4021 gttgtaagtt atcaagaaaa tgatcggcag aagtgggaaa agttgtccta tatgtatggc
     4081 acaatatgcg acatttggat agcatcgaaa tttcaaaatt ttgggcaatt ttgtccacat
     4141 gattttccta ctgtatttgg gaaaatttct tcctcgacca aaatatggaa accactggct
     4201 caaacgaggt ccattatgca acccaaaaca gtatttccac cactcactca gataaaatta
     4261 cagagatatc ctgaatcagc agaggaaaag gtgaaggttg aaccattgga ttcactcagc
     4321 ttatttcatc ttaaaacgga atccaacggg aaggcattca ctgataaagc ttataattct
     4381 caggtacagt taacggtgaa tgccaatcag aaagcccatc ctttgaccca gccctcctct
     4441 ccacctaacc agtgtgctaa cgtgatggca ggcgatgacc aaatacggtt tcagcaggtt
     4501 gttaaggagc aactcatgca tcagagactg ccaacattgc ctggtatctc tcatgaaaca
     4561 cccttaccgg agtcagcact aactctcagg aatgtaaatg tagtgtgttc aggtggaatt
     4621 acagtggttt ctaccaaaag tgaagaggaa gtctgttcat ccagttttgg aacatcagaa
     4681 ttttccacag tggacagtgc acagaaaaat tttaatgatt atgccatgaa cttctttact
     4741 aaccctacaa aaaacctagt gtctataact aaagattctg aactgcccac ctgcagctgt
     4801 cttgatcgag ttatacaaaa agacaaaggc ccatattata cacaccttgg ggcaggacca
     4861 agtgttgctg ctgtcaggga aatcatggag aataggtatg gtcaaaaagg aaacgcaata
     4921 aggatagaaa tagtagtgta caccggtaaa gaagggaaaa gctctcatgg gtgtccaatt
     4981 gctaagtggg ttttaagaag aagcagtgat gaagaaaaag ttctttgttt ggtccggcag
     5041 cgtacaggcc accactgtcc aactgctgtg atggtggtgc tcatcatggt gtgggatggc
     5101 atccctcttc caatggccga ccggctatac acagagctca cagagaatct aaagtcatac
     5161 aatgggcacc ctaccgacag aagatgcacc ctcaatgaaa atcgtacctg tacatgtcaa
     5221 ggaattgatc cagagacttg tggagcttca ttctcttttg gctgttcatg gagtatgtac
     5281 tttaatggct gtaagtttgg tagaagccca agccccagaa gatttagaat tgatccaagc
     5341 tctcccttac atgaaaaaaa ccttgaagat aacttacaga gtttggctac acgattagct
     5401 ccaatttata agcagtatgc tccagtagct taccaaaatc aggtggaata tgaaaatgtt
     5461 gcccgagaat gtcggcttgg cagcaaggaa ggtcgtccct tctctggggt cactgcttgc
     5521 ctggacttct gtgctcatcc ccacagggac attcacaaca tgaataatgg aagcactgtg
     5581 gtttgtacct taactcgaga agataaccgc tctttgggtg ttattcctca agatgagcag
     5641 ctccatgtgc tacctcttta taagctttca gacacagatg agtttggctc caaggaagga
     5701 atggaagcca agatcaaatc tggggccatc gaggtcctgg caccccgccg caaaaaaaga
     5761 acgtgtttca ctcagcctgt tccccgttct ggaaagaaga gggctgcgat gatgacagag
     5821 gttcttgcac ataagataag ggcagtggaa aagaaaccta ttccccgaat caagcggaag
     5881 aataactcaa caacaacaaa caacagtaag ccttcgtcac tgccaacctt agggagtaac
     5941 actgagaccg tgcaacctga agtaaaaagt gaaaccgaac cccattttat cttaaaaagt
     6001 tcagacaaca ctaaaactta ttcgctgatg ccatccgctc ctcacccagt gaaagaggca
     6061 tctccaggct tctcctggtc cccgaagact gcttcagcca caccagctcc actgaagaat
     6121 gacgcaacag cctcatgcgg gttttcagaa agaagcagca ctccccactg tacgatgcct
     6181 tcgggaagac tcagtggtgc caatgcagct gctgctgatg gccctggcat ttcacagctt
     6241 ggcgaagtgg ctcctctccc caccctgtct gctcctgtga tggagcccct cattaattct
     6301 gagccttcca ctggtgtgac tgagccgcta acgcctcatc agccaaacca ccagccctcc
     6361 ttcctcacct ctcctcaaga ccttgcctct tctccaatgg aagaagatga gcagcattct
     6421 gaagcagatg agcctccatc agacgaaccc ctatctgatg accccctgtc acctgctgag
     6481 gagaaattgc cccacattga tgagtattgg tcagacagtg agcacatctt tttggatgca
     6541 aatattggtg gggtggccat cgcacctgct cacggctcgg ttttgattga gtgtgcccgg
     6601 cgagagctgc acgctaccac tcctgttgag caccccaacc gtaatcatcc aacccgcctc
     6661 tcccttgtct tttaccagca caaaaaccta aataagcccc aacatggttt tgaactaaac
     6721 aagattaagt ttgaggctaa agaagctaag aataagaaaa tgaaggcctc agagcaaaaa
     6781 gaccaggcag ctaatgaagg tccagaacag tcctctgaag taaatgaatt gaaccaaatt
     6841 ccttctcata aagcattaac attaacccat gacaatgttg tcaccgtgtc cccttatgct
     6901 ctcacacacg ttgcggggcc ctataaccat tgggtctgaa ggcttttctc cccctcttaa
     6961 tgcctttgct agtgcagtgt attttttcaa ggtgctgtta aaagaaagtc atgttgtcgt
     7021 ttactatctt catctcaccc atttcaagtc tgaggtaaaa aaataataat gataacaaaa
     7081 cggggtgggt attcttaact gtgactatat tttgacaatt ggtagaaggt gcacatttta
     7141 agcaaaaata aaagttttat agttttaaat acataaagaa atgtttcagt taggcattaa
     7201 ccttgataga atcactcagt ttggtgcttt aaattaagtc tgtttactat gaaacaagag
     7261 tcatttttag aggattttaa caggttcatg ttctatgatg taaaatcaag acacacagtg
     7321 ttaactctac acagcttctg gtgcttaacc acatccacac agttaaaaat aagctgaatt
     7381 attatttcat ggtgccattg ttccaacatc ttccaatcat tgctagaaaa ttggcatatt
     7441 cctttgaaat aaacttatga aatgttttct ctcttaaaat atttctcctg tgtaaaataa
     7501 atcattgttg ttagtaatgg ttggaggctg ttcataaatt gtaaatatat attttaaaag
     7561 cactttctat ttttaaaagt aacttgaaat aatatagtat aagaatccta ttgtctattg
     7621 tttgtgcata tttgcataca agagaaatca tttatccttg ctgtgtagag ttccatcttg
     7681 ttaactgcag tatgtattct aatcatgtat atggtttgtg ttcttttact gtgtcctctc
     7741 acattcaagt attagcaact tgcagtatat aaaatagtta gataatgaga agttgttaat
     7801 tatctctaaa attggaatta ggaagcatat caccaatact gattaacatt ctctttggaa
     7861 ctaggtaaga gtggtctctt cttattgaac aacctcaatt tagtttcatc ccacctttct
     7921 cagtataatc catgagaggt gtttccaaaa ggagatgagg gaacaggata ggtttcagaa
     7981 gagtcaaatg cttctaatgt ctcaaggtga taaaatacaa aaactaagta gacagatatt
     8041 tgtactgaag tctgatacag aattagaaaa aaaaaattct tgttgaaata ttttgaaaac
     8101 aaattcccta ctatcatcac atgcctcccc aaccccaagt caaaaacaag aggaatggta
     8161 ctacaaacat ggctttgtcc attaagagct aattcatttg tttatcttag catactagat
     8221 ttgggaaaat gataactcat cttttctgat aattgcctat gttctaggta acaggaaaac
     8281 aggcattaag tttattttag tcttcccatt ttcttcctat tactttattg actcatttta
     8341 ttgcaaaaca aaaaggatta cccaaacaac atgtttcgaa caaggagaat tttcaatgaa
     8401 atacttgatt ctgttaaaat gcagaggtgc tataacattc aaagtgtcag attccttggg
     8461 agtatggaaa acctaatggt gcttctccct tggaaatgcc ataggaagcc cacaaccgct
     8521 aacacttaca attttggtgc aaaagcaaac agttccagca ggctctctaa agaaaaactc
     8581 attgtaactt attaaaataa tatctggtgc aaagtatctg ttttgagctt ttgactaatc
     8641 caagtaaagg aatatgaagg gattgtaaaa aacaaaatgt ccattgatag accatcgtgt
     8701 acaagtagat ttctgcttgt tgaatatgta aaatagggta attcattgac ttgttttagt
     8761 attttgtgtg ccttagattt ccgttttaag acatgtatat ttttgtgagc ctaaggtttc
     8821 ttatatacat ataagtatat aaataagtga ttgtttattg cttcagctgc ttcaacaaga
     8881 tatttactag tattagacta tcaggaatac acccttgcga gattatgttt tagattttag
     8941 gccttagctc ccactagaaa ttatttcttc accagattta atggataaag ttttatggct
     9001 ctttatgcat ccactcatct actcattctt cgagtctaca cttattgaat gcctgcaaaa
     9061 tctaagtatc acttttattt ttctttggat caccacctat gacatagtaa acttgaagaa
     9121 taaaaactac cctcagaaat atttttaaaa gaagtagcaa attatcttca gtataatcca
     9181 tggtaatgta tgcagtaatt caaattgatc tctctctcaa taggtttctt aacaatctaa
     9241 acttgaaaca tcaatgttaa tttttggaac tattgggatt tgtgacgctt gttgcagttt
     9301 accaaaacaa gtatttgaaa atatatagta tcaactgaaa tgtttccatt ccgttgttgt
     9361 agttaacatc atgaatggac ttcttaagct gattacccca ctgtgggaac caaattggat
     9421 tcctactttg ttggactctc tttcctgatt ttaacaattt accatcccat tctctgccct
     9481 gtgatttttt ttaaaagctt attcaatgtt ctgcagcatt gtgattgtat gctggctaca
     9541 ctgcttttag aatgctcttt ctcatgaagc aaggaaataa atttgtttga aatgacattt
     9601 tctctcataa aa
//
