LOCUS       NM_004923               2535 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens testis expressed metallothionein like protein
            (TESMIN), transcript variant 1, mRNA.
ACCESSION   NM_004923
VERSION     NM_004923.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2535)
  AUTHORS   Cao,L., Zhang,L., Liu,S. and Wang,X.
  TITLE     Clinical Significance and Functional Insights of Tesmin in
            Hepatocellular Carcinoma
  JOURNAL   Genet Res (Camb) 2024, 3058875 (2024)
   PUBMED   38283987
  REMARK    GeneRIF: Clinical Significance and Functional Insights of Tesmin in
            Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2535)
  AUTHORS   Huang,Y., Wu,Q. and Tan,X.
  TITLE     Metallothionein-like 5 expression is correlated with poor prognosis
            and promotes proliferation of cervical squamous cell carcinoma
  JOURNAL   Bioengineered 13 (3), 6955-6965 (2022)
   PUBMED   35249447
  REMARK    GeneRIF: Metallothionein-like 5 expression is correlated with poor
            prognosis and promotes proliferation of cervical squamous cell
            carcinoma.
REFERENCE   3  (bases 1 to 2535)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2535)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   5  (bases 1 to 2535)
  AUTHORS   Olesen,C., Moller,M. and Byskov,A.G.
  TITLE     Tesmin transcription is regulated differently during male and
            female meiosis
  JOURNAL   Mol Reprod Dev 67 (1), 116-126 (2004)
   PUBMED   14648882
REFERENCE   6  (bases 1 to 2535)
  AUTHORS   Sutou,S., Miwa,K., Matsuura,T., Kawasaki,Y., Ohinata,Y. and
            Mitsui,Y.
  TITLE     Native tesmin is a 60-kilodalton protein that undergoes dynamic
            changes in its localization during spermatogenesis in mice
  JOURNAL   Biol Reprod 68 (5), 1861-1869 (2003)
   PUBMED   12606435
REFERENCE   7  (bases 1 to 2535)
  AUTHORS   Matsuura,T., Kawasaki,Y., Miwa,K., Sutou,S., Ohinata,Y., Yoshida,F.
            and Mitsui,Y.
  TITLE     Germ cell-specific nucleocytoplasmic shuttling protein, tesmin,
            responsive to heavy metal stress in mouse testes
  JOURNAL   J Inorg Biochem 88 (2), 183-191 (2002)
   PUBMED   11803038
REFERENCE   8  (bases 1 to 2535)
  AUTHORS   Sugihara,T., Wadhwa,R., Kaul,S.C. and Mitsui,Y.
  TITLE     A novel testis-specific metallothionein-like protein, tesmin, is an
            early marker of male germ cell differentiation
  JOURNAL   Genomics 57 (1), 130-136 (1999)
   PUBMED   10191092
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM790577.1 and BC064579.1.
            
            On Mar 1, 2006 this sequence version replaced NM_004923.2.
            
            Summary: Metallothionein proteins are highly conserved
            low-molecular-weight cysteine-rich proteins that are induced by and
            bind to heavy metal ions and have no enzymatic activity. They may
            play a central role in the regulation of cell growth and
            differentiation and are involved in spermatogenesis. This gene
            encodes a metallothionein-like protein which has been shown to be
            expressed differentially in mouse testis and ovary. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064579.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255087.10/ ENSP00000255087.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-537               BM790577.1         1-537
            538-2535            BC064579.1         505-2502
FEATURES             Location/Qualifiers
     source          1..2535
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3"
     gene            1..2535
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /note="testis expressed metallothionein like protein"
                     /db_xref="GeneID:9633"
                     /db_xref="HGNC:HGNC:7446"
                     /db_xref="MIM:604374"
     exon            1..101
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /inference="alignment:Splign:2.1.0"
     exon            102..611
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1667
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /note="isoform a is encoded by transcript variant 1; CXC
                     domain containing 2; testis-specific metallothionein-like
                     protein; metallothionein-like 5, testis-specific (tesmin)"
                     /codon_start=1
                     /product="tesmin isoform a"
                     /protein_id="NP_004914.2"
                     /db_xref="CCDS:CCDS8184.1"
                     /db_xref="GeneID:9633"
                     /db_xref="HGNC:HGNC:7446"
                     /db_xref="MIM:604374"
                     /translation="MEEGPLPGGLPSPEDAMVTELLSPEGPFASENIGLKAPVKYEED
                     EFHVFKEAYLGPADPKEPVLHAFNPALGADCKGQVKAKLAGGDSDGGELLGEYPGIPE
                     LSALEDVALLQAPQPPACNVHFLSSLLPAHRSPAVLPLGAWVLEGASHPGVRMIPVEI
                     KEAGGTTTSNNPEEATLQNLLAQESCCKFPSSQELEDASCCSLKKDSNPMVICQLKGG
                     TQMLCIDNSRTRELKALHLVPQYQDQNNYLQSDVPKPMTALVGRFLPASTKLNLITQQ
                     LEGALPSVVNGSAFPSGSTLPGPPKITLAGYCDCFASGDFCNNCNCNNCCNNLHHDIE
                     RFKAIKACLGRNPEAFQPKIGKGQLGNVKPQHNKGCNCRRSGCLKNYCECYEAQIMCS
                     SICKCIGCKNYEESPERKTLMSMPNYMQTGGLEGSHYLPPTKFSGLPRFSHDRRPSSC
                     ISWEVVEATCACLLAQGEEAEKEHCSKCLAEQMILEEFGRCLSQILHTEFKSKGLKME
                     "
     exon            612..770
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /inference="alignment:Splign:2.1.0"
     exon            771..891
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /inference="alignment:Splign:2.1.0"
     exon            892..968
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1057
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1160
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1298
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1474
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..2535
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2512..2517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /note="hexamer: AATAAA"
     polyA_site      2535
                     /gene="TESMIN"
                     /gene_synonym="CXCDC2; MTL5; MTLT"
                     /note="major polyA site"
ORIGIN      
        1 acccttcccc cttctccaac cgccaacggc cgcctgcgcc tgaggcccgg cccacgcccc
       61 atcccgctcg ctccacgctg cggcagcccc ggcggcccca ggtgcgcggc ccccgccatc
      121 ccgccccgcc gccctgcgcc atggaggagg gccctctgcc gggcgggctg cccagccccg
      181 aggatgcgat ggtgacggag ctcttaagcc ccgagggtcc gttcgcttcg gagaacatcg
      241 gcctgaaggc ccccgtgaag tacgaggagg acgagttcca cgtcttcaaa gaagcgtacc
      301 tgggcccggc ggaccccaag gaacccgtcc tgcacgcgtt caaccccgcg ctgggcgccg
      361 actgcaaggg ccaggtcaag gcgaagctcg cggggggcga cagcgacggc ggggagctcc
      421 tcggggagta ccccgggatc ccagagctca gcgcgctgga ggacgtcgcg ctcctgcagg
      481 ccccgcagcc gcccgcctgc aacgtgcact tcctgtcctc gctgctaccc gcgcaccgca
      541 gcccggcggt gttgcccctg ggcgcctggg tcctggaagg agcctcccac ccgggcgtcc
      601 gcatgatccc agttgaaatc aaggaagcag gtggtactac tacaagtaat aatccggaag
      661 aagcaacttt gcagaatctt cttgctcagg aatcctgttg caagttccca tcgtcccagg
      721 aactagagga tgcctcctgc tgttctctta agaaagattc caacccaatg gtgatatgcc
      781 aattgaaagg gggcacacaa atgctatgta tagacaattc tagaacaaga gaactaaaag
      841 cactccattt ggttcctcag tatcaagatc aaaataatta tctacagtca gatgtcccta
      901 aaccaatgac tgctttagta gggagatttt tgccagcatc aacaaaatta aatctcatta
      961 cacaacaact tgagggagcc ttaccatcgg tagtcaacgg gtctgctttc ccctcgggat
     1021 caactcttcc aggaccacca aaaataactt tggctgggta ctgtgactgc tttgccagtg
     1081 gggacttttg caacaactgc aattgtaata attgttgcaa caacttgcat catgatattg
     1141 aacggtttaa agccattaag gcatgtcttg gtagaaatcc agaagctttc cagccaaaaa
     1201 ttgggaaggg ccaattgggc aatgtcaagc cccagcacaa caaagggtgc aactgcagga
     1261 ggtcaggctg cctgaagaat tactgcgagt gctatgaggc ccaaattatg tgttcttcta
     1321 tttgcaaatg cattggttgc aaaaattatg aagaaagccc agaacgaaag acactaatga
     1381 gcatgccaaa ctacatgcag actggaggtt tggaaggcag ccattacctg ccaccaacga
     1441 aattttcagg acttccaaga ttcagtcacg ataggcggcc ttcctcatgc atctcctggg
     1501 aggtggtgga ggccacatgc gcctgcctgc ttgctcaggg agaagaggcc gagaaagaac
     1561 actgctccaa gtgcctggca gagcagatga tcctggagga atttggaagg tgcttatcac
     1621 agattctcca cactgagttt aaatctaagg gattgaaaat ggagtagagt ataaagtgtg
     1681 aatgcatgtt gattttgtct tagtctagaa atctctagtt tagaaaggat gtttagggga
     1741 acatgaggct ggctctgcag caacaaccag gctcccctgc atccctgggc ccagggagtt
     1801 tactcagagc tctctgaaga tgtggcaacc catgccccct tttctgagga ggtgcatggc
     1861 ctgagcattg tttgtctggc ccagaggaga gagcttgggt tcccatagtc ctgggagagt
     1921 gtctgcaggg cggcggaggg cagagcaggg caggggaggg cacagcaggc cctgcgaagg
     1981 gcagagcggg gcaggggagg gcagagcagg ccctgcggag agctcactct ggtcgactct
     2041 tcctctcaga gaatgttgct ctggaggctg ctctgcatga aaaccctaat ggtttcttgt
     2101 ttgtttttca aattatttag aaataagttc tccggatggg ctgttgtgat accacttaaa
     2161 atctctagag aactactgaa cacctaaaga ttttctgtag cgtagatatt tccccagagg
     2221 cacgcgaact gtcagtcttt cctaaggccc ccgggagacg caggcaatgg ggcctcgcag
     2281 gccaggcttg caccagcatg tcttgagtta gaggacttaa aattatccag tttcttctgt
     2341 gtttctactt gaattgtgga aaagctctat tatccaatta acttctccat aattattgtt
     2401 gtaatattat tattgtttgt aaaacatggt tcacataact agcttgtgga aaccagcagg
     2461 taaaatgaat tcttaagttg acgcttttgg ttctgttgta aagcaaagat gaataaaaat
     2521 ttccaatgtc ttcaa
//
